Detailed information for compound 313470

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 842.932 | Formula: C41H58N6O13
  • H donors: 8 H acceptors: 12 LogP: 1.89 Rotable bonds: 28
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC(=O)CC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1C[C@H](C[C@H]1C(=O)NC1(CC1)C(=O)O)OCc1ccccc1)C(C)C)CC1CCCCC1)NC(=O)[C@@H](NC(=O)C)CC(=O)O
  • InChi: 1S/C41H58N6O13/c1-23(2)34(39(57)47-21-27(60-22-26-12-8-5-9-13-26)19-31(47)38(56)46-41(16-17-41)40(58)59)45-37(55)29(18-25-10-6-4-7-11-25)44-35(53)28(14-15-32(49)50)43-36(54)30(20-33(51)52)42-24(3)48/h5,8-9,12-13,23,25,27-31,34H,4,6-7,10-11,14-22H2,1-3H3,(H,42,48)(H,43,54)(H,44,53)(H,45,55)(H,46,56)(H,49,50)(H,51,52)(H,58,59)/t27-,28-,29-,30-,31-,34-/m0/s1
  • InChiKey: DDYNDQYNGBVAAZ-HWKKFYSMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Hepatitis C virus Hepatitis C virus NS3 protease/helicase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania infantum eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Entamoeba histolytica DEAD/DEAH box helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Toxoplasma gondii eukaryotic initiation factor-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma congolense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-III, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium parvum eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania braziliensis eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Neospora caninum DEAD-box ATP-dependent RNA helicase 34 (EC 3.6.1.-), related Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei gambiense eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum ATP-dependent RNA helicase eIF4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Theileria parva RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania major eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Brugia malayi eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Onchocerca volvulus Eukaryotic initiation factor 4A homolog Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma japonicum Eukaryotic initiation factor 4A-II, putative Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus multilocularis eukaryotic initiation factor 4A III Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania donovani Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Candida albicans similar to S. cerevisiae TIF1 (YKR059W) and TIF2 (YJL138C) translation initiation factor eIF4A subunit Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma brucei Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Cryptosporidium hominis eukaryotic initiation factor 4A (eIF4A) (eIF-4A) Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium knowlesi eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Schistosoma mansoni DEAD box ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium vivax RNA helicase-1, putative Get druggable targets OG5_126984 All targets in OG5_126984
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 Get druggable targets OG5_126984 All targets in OG5_126984
Leishmania mexicana Get druggable targets OG5_126984 All targets in OG5_126984
Babesia bovis eukaryotic translation initiation factor 4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Giardia lamblia Translation initiation factor eIF-4A, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium falciparum eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Echinococcus granulosus eukaryotic initiation factor 4A Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium yoelii RNA helicase-1 Get druggable targets OG5_126984 All targets in OG5_126984
Plasmodium berghei eukaryotic initiation factor 4a, putative Get druggable targets OG5_126984 All targets in OG5_126984
Treponema pallidum ATP-dependent RNA helicase Get druggable targets OG5_126984 All targets in OG5_126984
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative Get druggable targets OG5_126984 All targets in OG5_126984
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.2844 0.5908
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0467 0.0466
Echinococcus granulosus neural cadherin 0.0107 0.0626 0.0626
Toxoplasma gondii PHD-finger domain-containing protein 0.0128 0.0831 0.0615
Echinococcus multilocularis peroxidasin 0.0091 0.0467 0.0467
Echinococcus granulosus geminin 0.0193 0.1469 0.1469
Echinococcus multilocularis netrin receptor unc 5 0.0051 0.0074 0.0074
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0328 0.063
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0156 0.1111 0.1104
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0241 0.0241
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0467 0.0466
Brugia malayi Cyclin, N-terminal domain containing protein 0.0098 0.0538 0.0537
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0207 0.1613 0.1611
Brugia malayi Cadherin domain containing protein 0.0107 0.0626 0.0625
Schistosoma mansoni neuroglian 0.0091 0.0467 0.046
Schistosoma mansoni titin 0.0091 0.0467 0.046
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0097 0.0532 0.1056
Brugia malayi Immunoglobulin domain containing protein 0.0051 0.0074 0.0073
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0097 0.0532 0.0532
Schistosoma mansoni serine/threonine protein kinase 0.0126 0.0818 0.081
Brugia malayi EGF-like domain containing protein 0.0107 0.0626 0.0625
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0367 0.3186 0.2803
Loa Loa (eye worm) hypothetical protein 0.0198 0.1518 0.1516
Brugia malayi PHD-finger family protein 0.0128 0.0831 0.083
Loa Loa (eye worm) hypothetical protein 0.0046 0.0028 0.0027
Echinococcus granulosus basement membrane specific heparan sulfate 0.0051 0.0074 0.0074
Trypanosoma cruzi trypanothione reductase, putative 0.0367 0.3186 0.2803
Loa Loa (eye worm) hypothetical protein 0.0091 0.0467 0.0465
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.023 0.023
Plasmodium vivax ferrodoxin reductase, putative 0.0097 0.0532 0.0308
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0162 0.1171 0.0675
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Onchocerca volvulus 0.0198 0.1518 0.3125
Echinococcus granulosus protein jagged 1 0.0107 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Loa Loa (eye worm) hypothetical protein 0.0198 0.1518 0.1516
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0097 0.0532 0.0532
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0091 0.0467 0.0465
Entamoeba histolytica cyclin C, putative 0.0099 0.0552 0.0088
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0367 0.3186 0.2803
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0051 0.0074 0.0074
Schistosoma mansoni basigin related 0.0051 0.0074 0.0066
Loa Loa (eye worm) Notch2 0.0107 0.0626 0.0624
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.2844 0.5908
Schistosoma mansoni notch 0.0107 0.0626 0.0618
Brugia malayi jmjC domain containing protein 0.0418 0.3694 0.3694
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0091 0.0467 0.0467
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0051 0.0074 0.0074
Echinococcus multilocularis fibropellin Ia 0.0107 0.0626 0.0626
Onchocerca volvulus 0.0107 0.0626 0.1254
Loa Loa (eye worm) hypothetical protein 0.0051 0.0074 0.0072
Onchocerca volvulus 0.0198 0.1518 0.3125
Brugia malayi EGF-like domain containing protein 0.0107 0.0626 0.0625
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0051 0.0074 0.0074
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0097 0.0532 0.0532
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.0126 0.0818 0.0816
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0367 0.3186 0.2803
Schistosoma mansoni jumonji/arid domain-containing protein 0.0157 0.1117 0.111
Loa Loa (eye worm) hypothetical protein 0.0097 0.0532 0.053
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0051 0.0074 0.0072
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0269 0.2227 0.2226
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0074 0.0073
Schistosoma mansoni basigin related 0.0051 0.0074 0.0066
Toxoplasma gondii rhoptry neck protein RON9 0.0198 0.1518 0.1318
Schistosoma mansoni hypothetical protein 0.0107 0.0626 0.0618
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Plasmodium falciparum apical sushi protein 0.0198 0.1518 0.1042
Schistosoma mansoni notch 0.0107 0.0626 0.0618
Schistosoma mansoni sulfide quinone reductase 0.0097 0.0532 0.0524
Echinococcus multilocularis Immunoglobulin 0.0051 0.0074 0.0074
Brugia malayi Immunoglobulin domain containing protein 0.0051 0.0074 0.0073
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0418 0.3694 0.3694
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0112 0.0674 0.0672
Onchocerca volvulus Slit protein homolog 0.0107 0.0626 0.1254
Schistosoma mansoni c4b-binding protein beta chain 0.0198 0.1518 0.1511
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0098 0.0538 0.0538
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0051 0.0074 0.0066
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Schistosoma mansoni netrin receptor unc5 0.0051 0.0074 0.0066
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Loa Loa (eye worm) LAD-2 short isoform 0.0051 0.0074 0.0072
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.2844 0.5908
Echinococcus granulosus neurogenic locus notch protein 0.0107 0.0626 0.0626
Schistosoma mansoni glutamate synthase 0.0097 0.0532 0.0524
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0467 0.0466
Echinococcus granulosus Immunoglobulin 0.0051 0.0074 0.0074
Echinococcus multilocularis neural cadherin 0.0107 0.0626 0.0626
Echinococcus granulosus neurogenic locus notch protein 4 0.0107 0.0626 0.0626
Echinococcus granulosus protein jagged 2 0.0107 0.0626 0.0626
Onchocerca volvulus 0.0107 0.0626 0.1254
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0128 0.0831 0.0824
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0269 0.2227 0.2226
Echinococcus multilocularis tyrosine protein kinase otk 0.0091 0.0467 0.0467
Echinococcus granulosus low density lipoprotein receptor ldl 0.0051 0.0074 0.0074
Trichomonas vaginalis mercuric reductase, putative 0.0367 0.3186 0.6625
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0367 0.3186 0.3025
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.2844 0.5908
Schistosoma mansoni hypothetical protein 0.0107 0.0626 0.0618
Loa Loa (eye worm) thioredoxin reductase 0.1059 1 1
Brugia malayi notch-like transmembrane receptor 0.0107 0.0626 0.0625
Echinococcus multilocularis lysine specific demethylase 5A 0.0155 0.1096 0.1096
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0367 0.3186 0.2803
Loa Loa (eye worm) hypothetical protein 0.0247 0.2006 0.2004
Echinococcus granulosus Immunoglobulin 0.0051 0.0074 0.0074
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0367 0.3186 0.2803
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Schistosoma mansoni septate junction protein 0.0091 0.0467 0.046
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0107 0.0626 0.0625
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0467 0.0466
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0097 0.0532 0.0308
Schistosoma mansoni peroxidasin 0.0051 0.0074 0.0066
Echinococcus granulosus histone lysine methyltransferase setb 0.0086 0.0421 0.0421
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0367 0.3186 0.3025
Loa Loa (eye worm) hypothetical protein 0.0198 0.1518 0.1516
Brugia malayi hypothetical protein 0.0198 0.1518 0.1517
Brugia malayi hypothetical protein 0.0198 0.1518 0.1517
Schistosoma mansoni glutamate synthase 0.0097 0.0532 0.0524
Echinococcus multilocularis thioredoxin glutathione reductase 0.1059 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0097 0.0532 0.1056
Echinococcus granulosus protein jagged 1 0.0107 0.0626 0.0626
Echinococcus multilocularis neurogenic locus notch protein 0.0107 0.0626 0.0626
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0367 0.3186 0.318
Brugia malayi Muscle positioning protein 4 0.0107 0.0626 0.0625
Echinococcus multilocularis geminin 0.0193 0.1469 0.1469
Brugia malayi hypothetical protein 0.0198 0.1518 0.1517
Onchocerca volvulus 0.0079 0.0354 0.0684
Brugia malayi EGF-like domain containing protein 0.0107 0.0626 0.0625
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0091 0.0467 0.0465
Brugia malayi hypothetical protein 0.0198 0.1518 0.1517
Onchocerca volvulus 0.0107 0.0626 0.1254
Loa Loa (eye worm) hypothetical protein 0.0091 0.0467 0.0465
Trichomonas vaginalis set domain proteins, putative 0.053 0.4795 1
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0051 0.0074 0.0074
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0241 0.0241
Schistosoma mansoni nephrin 0.0196 0.1504 0.1498
Schistosoma mansoni hypothetical protein 0.0107 0.0626 0.0618
Brugia malayi EGF-like domain containing protein 0.0107 0.0626 0.0625
Brugia malayi pregnancy-associated plasma protein-A 0.0198 0.1518 0.1517
Loa Loa (eye worm) notch protein 0.0107 0.0626 0.0624
Echinococcus multilocularis neurogenic locus notch protein 0.0107 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0219 0.173 0.1729
Schistosoma mansoni tyrosine kinase 0.0091 0.0467 0.046
Schistosoma mansoni hypothetical protein 0.0107 0.0626 0.0618
Echinococcus granulosus neuroglian 0.0196 0.1504 0.1504
Loa Loa (eye worm) PHD-finger family protein 0.0128 0.0831 0.0829
Schistosoma mansoni glutamate synthase 0.0097 0.0532 0.0524
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0091 0.0467 0.0467
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0367 0.3186 1
Brugia malayi Fibronectin type III domain containing protein 0.0156 0.1111 0.111
Echinococcus granulosus jumonji domain containing protein 0.0178 0.1324 0.1324
Schistosoma mansoni cell adhesion molecule 0.0091 0.0467 0.046
Brugia malayi Pre-SET motif family protein 0.0466 0.4161 0.416
Loa Loa (eye worm) hypothetical protein 0.0304 0.2571 0.257
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0367 0.3186 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0367 0.3186 0.2803
Echinococcus granulosus contactin 0.0091 0.0467 0.0467
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0367 0.3186 0.2803
Brugia malayi hypothetical protein 0.0198 0.1518 0.1517
Brugia malayi GCC2 and GCC3 family protein 0.0304 0.2571 0.2571
Trichomonas vaginalis apoptosis inducing factor, putative 0.0097 0.0532 0.1056
Echinococcus granulosus neurogenic locus notch protein 0.0107 0.0626 0.0626
Echinococcus multilocularis lachesin 0.0091 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0051 0.0074 0.0072
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0097 0.0532 0.0308
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0156 0.1111 0.111
Giardia lamblia High cysteine protein 0.0107 0.0626 0.0356
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0162 0.1171 0.2408
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0097 0.0532 0.0532
Echinococcus granulosus roundabout 2 0.0091 0.0467 0.0467
Treponema pallidum NADH oxidase 0.0367 0.3186 1
Brugia malayi Cyclin C 0.0197 0.1517 0.1517
Loa Loa (eye worm) hypothetical protein 0.0207 0.1613 0.1611
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0097 0.0532 0.1056
Echinococcus granulosus cyclin dependent kinase 19 0.0126 0.0818 0.0818
Echinococcus multilocularis hemicentin 1 0.0091 0.0467 0.0467
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.023 0.0223
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0097 0.0532 0.0308
Schistosoma mansoni hypothetical protein 0.0107 0.0626 0.0618
Echinococcus granulosus slit 2 protein 0.0107 0.0626 0.0626
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0097 0.0532 0.1056
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0367 0.3186 0.2803
Toxoplasma gondii EGF family domain-containing protein 0.0107 0.0626 0.0405
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0097 0.0532 0.1056
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Toxoplasma gondii NADPH-glutathione reductase 0.0367 0.3186 0.3025
Trichomonas vaginalis glutathione reductase, putative 0.0367 0.3186 0.6625
Schistosoma mansoni cell adhesion molecule 0.0207 0.1613 0.1606
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Loa Loa (eye worm) heterochromatin protein 1 0.0077 0.0328 0.0327
Schistosoma mansoni hypothetical protein 0.0193 0.1469 0.1463
Echinococcus granulosus delta-like protein 1 0.0107 0.0626 0.0626
Echinococcus multilocularis cyclin dependent kinase 19 0.0126 0.0818 0.0818
Loa Loa (eye worm) hypothetical protein 0.0156 0.1111 0.111
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0367 0.3186 0.2803
Schistosoma mansoni septate junction protein 0.0091 0.0467 0.046
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0097 0.0532 0.0532
Loa Loa (eye worm) gastrulation defective protein 1 0.0126 0.0813 0.0812
Echinococcus multilocularis PHD finger protein rhinoceros 0.0128 0.0831 0.0831
Schistosoma mansoni hypothetical protein 0.0076 0.0325 0.0318
Brugia malayi Calcium binding EGF domain containing protein 0.0107 0.0626 0.0625
Loa Loa (eye worm) hypothetical protein 0.0051 0.0074 0.0072
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0367 0.3186 0.3186
Echinococcus multilocularis roundabout 2 0.0247 0.2006 0.2006
Echinococcus granulosus hemicentin 1 0.0091 0.0467 0.0467
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0467 0.0466
Plasmodium falciparum phd finger protein, putative 0.0128 0.0831 0.0316
Echinococcus granulosus defective proboscis extension response 0.0156 0.1111 0.1111
Brugia malayi Thioredoxin reductase 0.1059 1 1
Brugia malayi hypothetical protein 0.0198 0.1518 0.1517
Echinococcus granulosus lachesin 0.0091 0.0467 0.0467
Echinococcus granulosus tyrosine protein kinase otk 0.0091 0.0467 0.0467
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0074 0.0073
Schistosoma mansoni bromodomain containing protein 0.0072 0.0281 0.0273
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.2844 0.5908
Giardia lamblia PHD finger protein 15 0.0128 0.0831 0.1128
Schistosoma mansoni cell adhesion molecule 0.0051 0.0074 0.0066
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0467 0.0466
Brugia malayi Cadherin domain containing protein 0.0107 0.0626 0.0625
Mycobacterium tuberculosis Probable oxidoreductase 0.0367 0.3186 0.2803
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Onchocerca volvulus Alhambra homolog 0.0128 0.0831 0.1684
Onchocerca volvulus 0.0198 0.1518 0.3125
Schistosoma mansoni hypothetical protein 0.0051 0.0074 0.0066
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0051 0.0074 0.0072
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0467 0.0466
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0097 0.0532 0.0532
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0367 0.3186 0.2803
Brugia malayi Calcium binding EGF domain containing protein 0.0107 0.0626 0.0625
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0091 0.0467 0.0467
Schistosoma mansoni notch 0.0107 0.0626 0.0618
Schistosoma mansoni roundabout 0.0091 0.0467 0.046
Schistosoma mansoni disulfide oxidoreductase 0.0097 0.0532 0.0524
Echinococcus granulosus netrin receptor unc 5 0.0051 0.0074 0.0074
Echinococcus granulosus chromobox protein 1 0.0077 0.0328 0.0328
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0079 0.0354 0.0347
Schistosoma mansoni hypothetical protein 0.0051 0.0074 0.0066
Onchocerca volvulus Neurogenic locus notch homolog 0.0107 0.0626 0.1254
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0074 0.0073
Brugia malayi Immunoglobulin I-set domain containing protein 0.0156 0.1111 0.111
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0051 0.0074 0.0074
Brugia malayi basement membrane proteoglycan 0.0051 0.0074 0.0073
Brugia malayi Peroxidasin 0.0091 0.0467 0.0466
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0097 0.0532 0.1056
Giardia lamblia NADH oxidase lateral transfer candidate 0.0367 0.3186 1
Onchocerca volvulus 0.0198 0.1518 0.3125
Brugia malayi Heparan sulfate 0.0051 0.0074 0.0073
Loa Loa (eye worm) hypothetical protein 0.0156 0.1111 0.111
Schistosoma mansoni laminin gamma-3 chain 0.0107 0.0626 0.0618
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0156 0.1111 0.1111
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Echinococcus multilocularis neurogenic locus protein delta 0.0107 0.0626 0.0626
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0097 0.0532 0.0308
Schistosoma mansoni cell polarity protein 0.0107 0.0626 0.0618
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.2844 0.5908
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0367 0.3186 0.2803
Schistosoma mansoni netrin receptor unc5 0.0051 0.0074 0.0066
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0097 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0091 0.0467 0.0465
Brugia malayi Bromodomain containing protein 0.013 0.0857 0.0856
Loa Loa (eye worm) hypothetical protein 0.0051 0.0074 0.0072
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0207 0.1613 0.1613
Schistosoma mansoni hypothetical protein 0.0193 0.1469 0.1463
Echinococcus granulosus cyclin 0.0098 0.0538 0.0538
Brugia malayi hypothetical protein 0.0051 0.0074 0.0073
Schistosoma mansoni septate junction protein 0.0051 0.0074 0.0066
Schistosoma mansoni hypothetical protein 0.0107 0.0626 0.0618
Trichomonas vaginalis chromobox protein, putative 0.0077 0.0328 0.063
Onchocerca volvulus 0.0198 0.1518 0.3125
Echinococcus granulosus fibropellin Ia 0.0107 0.0626 0.0626
Brugia malayi EGF-like domain containing protein 0.0107 0.0626 0.0625
Echinococcus multilocularis chromobox protein 1 0.0077 0.0328 0.0328
Brugia malayi PHD-finger family protein 0.0044 0.0005 0.0004
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0367 0.3186 0.3185
Schistosoma mansoni sulfide quinone reductase 0.0097 0.0532 0.0524
Echinococcus multilocularis protein jagged 1 0.0107 0.0626 0.0626
Echinococcus multilocularis fat cadherin tumor suppressor 0.0107 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0128 0.0831 0.0829
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0367 0.3186 1
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0051 0.0074 0.0074
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0051 0.0074 0.0074
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0091 0.0467 0.0467
Toxoplasma gondii rhoptry neck protein RON1 0.0198 0.1518 0.1318
Echinococcus multilocularis protein jagged 1 0.0107 0.0626 0.0626
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0091 0.0467 0.0467
Plasmodium vivax hypothetical protein, conserved 0.0128 0.0831 0.0615
Brugia malayi EGF-like domain containing protein 0.0107 0.0626 0.0625
Echinococcus granulosus neuroglian 0.0091 0.0467 0.0467
Schistosoma mansoni cell adhesion molecule 0.0051 0.0074 0.0066
Echinococcus granulosus C type lectin domian containing protein 0.0198 0.1518 0.1518
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0098 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0198 0.1518 0.1516
Brugia malayi Delta serrate ligand family protein 0.0107 0.0626 0.0625
Echinococcus multilocularis protein jagged 2 0.0107 0.0626 0.0626
Schistosoma mansoni hypothetical protein 0.0128 0.0831 0.0824
Echinococcus multilocularis Immunoglobulin 0.0051 0.0074 0.0074
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0097 0.0532 0.1056
Echinococcus multilocularis Immunoglobulin subtype 0.0051 0.0074 0.0074
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.1059 1 1
Trichomonas vaginalis glutamate synthase, putative 0.0097 0.0532 0.1056
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0091 0.0467 0.0465
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0367 0.3186 0.2803
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Plasmodium falciparum glutathione reductase 0.0367 0.3186 0.2803
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0367 0.3186 0.2803
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0367 0.3186 0.2803
Schistosoma mansoni septate junction protein 0.0107 0.0626 0.0618
Brugia malayi Pre-SET motif family protein 0.0067 0.023 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.0421 0.0414
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0097 0.0532 0.0308
Schistosoma mansoni g1/s-specific cyclin C 0.0197 0.1517 0.1511
Schistosoma mansoni cell adhesion molecule 0.0091 0.0467 0.046
Brugia malayi Calcium binding EGF domain containing protein 0.0107 0.0626 0.0625
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0097 0.0532 0.1056
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0162 0.1171 0.2408
Echinococcus granulosus Immunoglobulin subtype 0.0051 0.0074 0.0074
Onchocerca volvulus 0.0107 0.0626 0.1254
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0367 0.3186 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Echinococcus multilocularis peregrin 0.013 0.0857 0.0857
Plasmodium falciparum thioredoxin reductase 0.1059 1 1
Brugia malayi jmjC domain containing protein 0.0157 0.1117 0.1116
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0051 0.0074 0.0066
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Echinococcus granulosus peregrin 0.013 0.0857 0.0857
Schistosoma mansoni jumonji/arid domain-containing protein 0.0157 0.1117 0.111
Loa Loa (eye worm) hypothetical protein 0.0076 0.0325 0.0324
Loa Loa (eye worm) hypothetical protein 0.022 0.1736 0.1735
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0051 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Echinococcus multilocularis neurogenic locus protein delta 0.0107 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0044 0.0005 0.0003
Brugia malayi Sushi domain 0.0198 0.1518 0.1517
Loa Loa (eye worm) cyclin domain-containing protein 0.0098 0.0538 0.0536
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0097 0.0532 0.053
Plasmodium vivax glutathione reductase, putative 0.1059 1 1
Schistosoma mansoni hypothetical protein 0.0107 0.0626 0.0618
Onchocerca volvulus 0.0198 0.1518 0.3125
Plasmodium falciparum glutathione reductase 0.1059 1 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0367 0.3186 0.2803
Brugia malayi glutamate synthase 0.0097 0.0532 0.053
Loa Loa (eye worm) hypothetical protein 0.0198 0.1518 0.1516
Loa Loa (eye worm) hypothetical protein 0.0051 0.0074 0.0072
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0467 0.0466
Toxoplasma gondii PHD-finger domain-containing protein 0.0128 0.0831 0.0615
Echinococcus multilocularis neuroglian 0.0196 0.1504 0.1504
Onchocerca volvulus 0.0107 0.0626 0.1254
Loa Loa (eye worm) hypothetical protein 0.0091 0.0467 0.0465
Schistosoma mansoni slit 0.0107 0.0626 0.0618
Echinococcus multilocularis notch 0.0107 0.0626 0.0626
Brugia malayi Heterochromatin protein 1 0.0077 0.0328 0.0327
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0091 0.0467 0.046
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0051 0.0074 0.0066
Schistosoma mansoni hypothetical protein 0.0097 0.0532 0.0524
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0097 0.0532 0.053
Echinococcus multilocularis jumonji domain containing protein 0.0178 0.1324 0.1324
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0097 0.0532 0.053
Schistosoma mansoni nephrin 0.0091 0.0467 0.046
Echinococcus granulosus roundabout 2 0.0247 0.2006 0.2006
Onchocerca volvulus 0.0198 0.1518 0.3125
Brugia malayi EGF-like domain containing protein 0.0107 0.0626 0.0625
Toxoplasma gondii thioredoxin reductase 0.1059 1 1
Schistosoma mansoni hypothetical protein 0.0051 0.0074 0.0066
Loa Loa (eye worm) programmed cell death 8 0.0097 0.0532 0.053
Echinococcus multilocularis c4b binding protein beta chain 0.0198 0.1518 0.1518
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0367 0.3186 0.3186
Loa Loa (eye worm) glutathione reductase 0.1059 1 1
Brugia malayi Immunoglobulin domain containing protein 0.0051 0.0074 0.0073
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0091 0.0467 0.046
Echinococcus multilocularis hemicentin 1 0.0091 0.0467 0.0467
Treponema pallidum fructose-bisphosphate aldolase 0.0332 0.2844 0.8713
Onchocerca volvulus Putative cubilin 0.0107 0.0626 0.1254
Loa Loa (eye worm) hypothetical protein 0.0198 0.1518 0.1516
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0097 0.0532 0.0308
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0367 0.3186 0.2803
Echinococcus multilocularis C type lectin domian containing protein 0.0198 0.1518 0.1518
Onchocerca volvulus 0.053 0.4795 1
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Echinococcus granulosus roundabout 2 0.0091 0.0467 0.0467
Echinococcus multilocularis Immunoglobulin 0.0156 0.1111 0.1111
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Onchocerca volvulus 0.0198 0.1518 0.3125
Plasmodium vivax thioredoxin reductase, putative 0.1059 1 1
Trichomonas vaginalis glutamate synthase, putative 0.0097 0.0532 0.1056
Onchocerca volvulus 0.0198 0.1518 0.3125
Brugia malayi F/Y-rich N-terminus family protein 0.0046 0.0029 0.0028
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0418 0.3694 0.3694
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0466 0.4161 0.416
Loa Loa (eye worm) jmjC domain-containing protein 0.0157 0.1117 0.1115
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0091 0.0467 0.0921
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0367 0.3186 1
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0156 0.1111 0.1104
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0086 0.0421 0.0421
Echinococcus granulosus PHD finger protein rhinoceros 0.0128 0.0831 0.0831
Echinococcus multilocularis glutamate synthase 0.0097 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0156 0.1111 0.111
Schistosoma mansoni hypothetical protein 0.0051 0.0074 0.0066
Trypanosoma brucei trypanothione reductase 0.1059 1 1
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0051 0.0074 0.0066
Giardia lamblia Fructose-bisphosphate aldolase 0.0332 0.2844 0.8713
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0074 0.0073
Brugia malayi Bromodomain containing protein 0.0085 0.0412 0.0411
Echinococcus multilocularis cyclin 0.0098 0.0538 0.0538
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0097 0.0532 0.0308
Echinococcus granulosus lysine specific demethylase 5A 0.0157 0.1117 0.1117
Plasmodium falciparum thioredoxin reductase 0.0367 0.3186 0.2803
Schistosoma mansoni hypothetical protein 0.0051 0.0074 0.0066
Loa Loa (eye worm) hypothetical protein 0.0112 0.0674 0.0672
Plasmodium vivax apical sushi protein, putative 0.0198 0.1518 0.1318
Loa Loa (eye worm) hypothetical protein 0.0091 0.0467 0.0465
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Onchocerca volvulus 0.0097 0.0532 0.1056
Echinococcus multilocularis Immunoglobulin 0.0156 0.1111 0.1111
Echinococcus granulosus Immunoglobulin 0.0156 0.1111 0.1111
Echinococcus granulosus notch 0.0107 0.0626 0.0626
Brugia malayi Calcitonin receptor-like protein seb-1 0.0112 0.0674 0.0673
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0091 0.0471 0.047
Echinococcus granulosus chromobox protein 1 0.0077 0.0328 0.0328
Schistosoma mansoni hypothetical protein 0.0051 0.0074 0.0066
Loa Loa (eye worm) hypothetical protein 0.0156 0.1111 0.111
Echinococcus multilocularis slit 2 protein 0.0107 0.0626 0.0626
Toxoplasma gondii selenide, water dikinase 0.0097 0.0532 0.0308
Echinococcus multilocularis roundabout 2 0.0091 0.0467 0.0467
Brugia malayi basement membrane proteoglycan precursor 0.0051 0.0074 0.0073
Echinococcus granulosus protein jagged 2 0.0107 0.0626 0.0626
Brugia malayi hypothetical protein 0.0198 0.1518 0.1517
Schistosoma mansoni cell adhesion molecule 0.0091 0.0467 0.046
Loa Loa (eye worm) hypothetical protein 0.0048 0.005 0.0048
Leishmania major trypanothione reductase 0.1059 1 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0467 0.0465
Schistosoma mansoni chromobox protein 0.0077 0.0328 0.0321
Loa Loa (eye worm) jmjC domain-containing protein 0.0264 0.2171 0.217
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0367 0.3186 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.0107 0.0626 0.0626
Onchocerca volvulus 0.0198 0.1518 0.3125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0367 0.3186 0.2803
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0097 0.0532 0.053
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.0421 0.0414
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0107 0.0626 0.0618
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0051 0.0074 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.2844 0.5908
Loa Loa (eye worm) hypothetical protein 0.0198 0.1518 0.1516
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0367 0.3186 0.2803
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0332 0.2844 1
Loa Loa (eye worm) cyclin C 0.0197 0.1517 0.1516
Echinococcus multilocularis chromobox protein 1 0.0077 0.0328 0.0328
Echinococcus granulosus neurogenic locus protein delta 0.0107 0.0626 0.0626
Loa Loa (eye worm) hypothetical protein 0.0247 0.2006 0.2004
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0091 0.0467 0.0467
Schistosoma mansoni nephrin related 0.0051 0.0074 0.0066
Loa Loa (eye worm) hypothetical protein 0.0086 0.0421 0.042
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0107 0.0626 0.1254
Schistosoma mansoni notch 0.0107 0.0626 0.0618
Brugia malayi hypothetical protein 0.0156 0.1111 0.111
Schistosoma mansoni vesicular amine transporter 0.0156 0.1111 0.1104
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0097 0.0532 0.0532
Brugia malayi Immunoglobulin I-set domain containing protein 0.0207 0.1613 0.1612
Echinococcus granulosus c4b binding protein beta chain 0.0198 0.1518 0.1518
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0097 0.0532 0.0532
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0367 0.3186 0.3025
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0097 0.0532 0.1056
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0097 0.0532 0.0532
Brugia malayi Immunoglobulin I-set domain containing protein 0.0051 0.0074 0.0073
Schistosoma mansoni notch 0.0107 0.0626 0.0618
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0332 0.2844 0.5908
Brugia malayi Immunoglobulin I-set domain containing protein 0.0091 0.0467 0.0466
Echinococcus multilocularis roundabout 2 0.0091 0.0467 0.0467
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0367 0.3186 1
Schistosoma mansoni chromobox protein 0.0077 0.0328 0.0321
Schistosoma mansoni notch 0.0107 0.0626 0.0618
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0367 0.3186 0.2803
Echinococcus granulosus peroxidasin 0.0091 0.0467 0.0467
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0097 0.0532 0.0532
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0051 0.0074 0.0066
Brugia malayi Protein kinase domain containing protein 0.0126 0.0818 0.0817
Loa Loa (eye worm) hypothetical protein 0.0091 0.0467 0.0465
Loa Loa (eye worm) hypothetical protein 0.0156 0.1111 0.111
Brugia malayi Prion-like- 0.0091 0.0467 0.0466
Loa Loa (eye worm) hypothetical protein 0.0107 0.0626 0.0624
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0112 0.0674 0.0673
Brugia malayi latrophilin 2 splice variant baaae 0.0076 0.0325 0.0324
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0198 0.1518 0.1516
Schistosoma mansoni jumonji domain containing protein 0.0332 0.2847 0.2842
Echinococcus multilocularis neuroglian 0.0091 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0091 0.0467 0.0465
Schistosoma mansoni septate junction protein 0.0051 0.0074 0.0066
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0332 0.2844 1
Echinococcus granulosus thioredoxin glutathione reductase 0.1059 1 1
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0097 0.0532 0.1056
Echinococcus granulosus twitchin 0.0197 0.1509 0.1509
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0367 0.3186 0.2803
Trypanosoma cruzi trypanothione reductase, putative 0.1059 1 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0364 0.0362
Echinococcus granulosus glutamate synthase 0.0097 0.0532 0.0532
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0097 0.0532 0.0532
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0367 0.3186 1
Schistosoma mansoni basigin related 0.0051 0.0074 0.0066

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.051 uM Inhibitory concentration of the compound against hepatitis C virus NS3 protease ChEMBL. 15633995
IC50 (binding) = 0.051 uM Inhibitory concentration of the compound against hepatitis C virus NS3 protease ChEMBL. 15633995

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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