Detailed information for compound 313471

Basic information

Technical information
  • TDR Targets ID: 313471
  • Name: 2-[4-[[3-[5-amino-2-(furan-2-yl)-[1,2,4]triaz olo[5,1-f]pyrimidin-7-yl]phenyl]methyl]pipera zin-1-yl]-5-(2-methoxyethoxy)benzonitrile
  • MW: 550.611 | Formula: C30H30N8O3
  • H donors: 1 H acceptors: 4 LogP: 3.14 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: COCCOc1ccc(c(c1)C#N)N1CCN(CC1)Cc1cccc(c1)c1nc(N)n2c(c1)nc(n2)c1ccco1
  • InChi: 1S/C30H30N8O3/c1-39-14-15-40-24-7-8-26(23(17-24)19-31)37-11-9-36(10-12-37)20-21-4-2-5-22(16-21)25-18-28-34-29(27-6-3-13-41-27)35-38(28)30(32)33-25/h2-8,13,16-18H,9-12,14-15,20H2,1H3,(H2,32,33)
  • InChiKey: XKZYORMXFAIYCV-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-[4-[[3-[5-amino-2-(2-furyl)-[1,2,4]triazolo[5,1-f]pyrimidin-7-yl]phenyl]methyl]piperazin-1-yl]-5-(2-methoxyethoxy)benzonitrile
  • 2-[4-[[3-[5-amino-2-(2-furyl)-[1,2,4]triazolo[5,1-f]pyrimidin-7-yl]phenyl]methyl]-1-piperazinyl]-5-(2-methoxyethoxy)benzonitrile
  • 2-[4-[[3-[5-azanyl-2-(furan-2-yl)-[1,2,4]triazolo[5,1-f]pyrimidin-7-yl]phenyl]methyl]piperazin-1-yl]-5-(2-methoxyethoxy)benzenecarbonitrile
  • 2-[4-[3-[5-amino-2-(2-furyl)-[1,2,4]triazolo[5,1-f]pyrimidin-7-yl]benzyl]piperazino]-5-(2-methoxyethoxy)benzonitrile
  • 2-[4-[[3-(5-amino-2-furan-2-yl-[1,2,4]triazolo[5,1-f]pyrimidin-7-yl)phenyl]methyl]piperazin-1-yl]-5-(2-methoxyethoxy)benzonitrile
  • 2-[4-[3-[5-amino-2-(2-furyl)-[1,2,4]triazolo[5,1-f]pyrimidin-7-yl]benzyl]piperazin-1-yl]-5-(2-methoxyethoxy)benzonitrile

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adenosine A2a receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Adenosine A2a receptor   410 aa 352 aa 23.6 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 337 aa 23.1 %
Schistosoma mansoni biogenic amine (5HT) receptor Adenosine A2a receptor   410 aa 399 aa 28.1 %
Echinococcus granulosus thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Echinococcus multilocularis allatostatin A receptor Adenosine A2a receptor   410 aa 372 aa 22.8 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Adenosine A2a receptor   410 aa 366 aa 25.4 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Adenosine A2a receptor   410 aa 340 aa 27.9 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Adenosine A2a receptor   410 aa 342 aa 23.1 %
Echinococcus granulosus allatostatin A receptor Adenosine A2a receptor   410 aa 368 aa 22.6 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Adenosine A2a receptor   410 aa 346 aa 28.3 %
Onchocerca volvulus Adenosine A2a receptor   410 aa 356 aa 23.9 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0368 0.0368
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0035 0.0461 0.0461
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0131 0.3135 0.313
Echinococcus multilocularis neurogenic locus protein delta 0.0038 0.0556 0.0556
Echinococcus granulosus defective proboscis extension response 0.0056 0.1045 0.1045
Trypanosoma brucei metacaspase MCA3 0.0052 0.0927 0.092
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Brugia malayi GCC2 and GCC3 family protein 0.0109 0.2516 0.2516
Trypanosoma brucei metacaspase 0.0052 0.0927 0.092
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0396 0.0396
Entamoeba histolytica disulphide oxidoreductase, putative 0.0035 0.0461 0.6071
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0396 0.0396
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0032 0.0396 0.0396
Mycobacterium tuberculosis Probable NADPH:adrenodoxin oxidoreductase FprB (adrenodoxin reductase) (AR) (ferredoxin-NADP(+) reductase) 0.0035 0.0461 0.0361
Plasmodium falciparum metacaspase-like protein 0.0052 0.0927 0.0832
Toxoplasma gondii thioredoxin reductase 0.0378 1 1
Onchocerca volvulus 0.007 0.1455 0.574
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0927 0.2716
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0035 0.0461 0.0461
Echinococcus granulosus apoptotic protease activating factor 1 0.0048 0.0829 0.0829
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0052 0.0927 0.0927
Echinococcus multilocularis protein jagged 1 0.0038 0.0556 0.0556
Schistosoma mansoni intermediate filament proteins 0.0031 0.0368 0.0368
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0032 0.0396 0.0396
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0461 0.1179
Brugia malayi Immunoglobulin I-set domain containing protein 0.0074 0.155 0.155
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0131 0.3135 0.3063
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0035 0.0461 0.0461
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0035 0.0461 0.0461
Echinococcus granulosus neurogenic locus protein delta 0.0038 0.0556 0.0556
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0927 0.2716
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0692 0.1941
Trichomonas vaginalis mercuric reductase, putative 0.0131 0.3135 1
Mycobacterium ulcerans NADPH dependent 2,4-dienoyl-CoA reductase FadH 0.0035 0.0461 0.145
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0096 0.2169 0.2169
Echinococcus granulosus slit 2 protein 0.0038 0.0556 0.0556
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0131 0.3135 0.313
Echinococcus granulosus neurogenic locus notch protein 0.0038 0.0556 0.0556
Echinococcus multilocularis fat cadherin tumor suppressor 0.0038 0.0556 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0927 0.2716
Brugia malayi notch-like transmembrane receptor 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Onchocerca volvulus 0.007 0.1455 0.574
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0927 0.2716
Echinococcus multilocularis roundabout 2 0.0032 0.0396 0.0396
Echinococcus granulosus neurogenic locus notch protein 0.0038 0.0556 0.0556
Schistosoma mansoni nephrin 0.0032 0.0396 0.0396
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0035 0.0461 0.6071
Treponema pallidum NADH oxidase 0.0131 0.3135 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0035 0.0461 0.1179
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0035 0.0461 0.0361
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0032 0.0396 0.0396
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0104 0.0104
Brugia malayi Calcium binding EGF domain containing protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0032 0.0396 0.0396
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0927 0.2716
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0692 0.0685
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0035 0.0461 0.0461
Mycobacterium tuberculosis Probable dehydrogenase 0.0035 0.0461 0.0361
Brugia malayi Peroxidasin 0.0032 0.0396 0.0396
Plasmodium falciparum glutathione reductase 0.0131 0.3135 0.3063
Giardia lamblia High cysteine protein 0.0038 0.0556 0.1492
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0035 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0032 0.0396 0.0396
Echinococcus multilocularis neural cadherin 0.0038 0.0556 0.0556
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0035 0.0461 0.0361
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0035 0.0461 0.0461
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0131 0.3135 0.3063
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.3135 1
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0035 0.0461 0.6071
Brugia malayi Sushi domain 0.007 0.1455 0.1455
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0131 0.3135 1
Mycobacterium ulcerans ferredoxin reductase 0.0035 0.0461 0.145
Trichomonas vaginalis glutamate synthase, putative 0.0035 0.0461 0.1179
Trypanosoma cruzi metacaspase, putative 0.0052 0.0927 0.092
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0131 0.3135 0.3135
Schistosoma mansoni caspase-7 (C14 family) 0.0136 0.3282 0.3282
Brugia malayi hypothetical protein 0.0056 0.1045 0.1045
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0035 0.0461 0.1179
Echinococcus multilocularis caspase 3 0.0085 0.185 0.185
Brugia malayi Delta serrate ligand family protein 0.0038 0.0556 0.0556
Onchocerca volvulus 0.007 0.1455 0.574
Brugia malayi EGF-like domain containing protein 0.0038 0.0556 0.0556
Echinococcus multilocularis protein jagged 2 0.0038 0.0556 0.0556
Brugia malayi glutamate synthase 0.0035 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Echinococcus multilocularis neuroglian 0.007 0.1441 0.1441
Brugia malayi EGF-like domain containing protein 0.0038 0.0556 0.0556
Brugia malayi hypothetical protein 0.0048 0.0829 0.0829
Loa Loa (eye worm) hypothetical protein 0.0056 0.1045 0.1045
Schistosoma mansoni titin 0.0032 0.0396 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.0056 0.1045 0.1045
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0035 0.0461 0.6071
Brugia malayi EGF-like domain containing protein 0.0038 0.0556 0.0556
Schistosoma mansoni caspase-3 (C14 family) 0.0136 0.3282 0.3282
Schistosoma mansoni lamin 0.0031 0.0368 0.0368
Schistosoma mansoni vesicular amine transporter 0.0056 0.1045 0.1045
Brugia malayi EGF-like domain containing protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.007 0.1455 0.1455
Plasmodium vivax apical sushi protein, putative 0.007 0.1455 0.1365
Trichomonas vaginalis glutamate synthase, putative 0.0035 0.0461 0.1179
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0035 0.0461 0.0461
Echinococcus multilocularis notch 0.0038 0.0556 0.0556
Schistosoma mansoni c4b-binding protein beta chain 0.007 0.1455 0.1455
Mycobacterium ulcerans NADH dehydrogenase Ndh 0.0035 0.0461 0.145
Onchocerca volvulus 0.007 0.1455 0.574
Trypanosoma brucei trypanothione reductase 0.0378 1 1
Schistosoma mansoni hypothetical protein 0.0038 0.0556 0.0556
Schistosoma mansoni sulfide quinone reductase 0.0035 0.0461 0.0461
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0131 0.3135 1
Schistosoma mansoni notch 0.0038 0.0556 0.0556
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0007 0.0007
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0035 0.0461 0.1179
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0396 0.0396
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0131 0.3135 0.3135
Brugia malayi Fibronectin type III domain containing protein 0.0056 0.1045 0.1045
Toxoplasma gondii rhoptry neck protein RON9 0.007 0.1455 0.1365
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Echinococcus multilocularis hemicentin 1 0.0032 0.0396 0.0396
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0056 0.1045 0.1045
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0038 0.0556 0.0994
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0131 0.3135 0.313
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0131 0.3135 0.313
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0131 0.3135 0.313
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0035 0.0461 0.0454
Mycobacterium ulcerans hypothetical protein 0.0035 0.0461 0.145
Loa Loa (eye worm) hypothetical protein 0.0043 0.0692 0.0692
Onchocerca volvulus 0.0048 0.0829 0.2434
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0461 0.1179
Loa Loa (eye worm) Notch2 0.0038 0.0556 0.0556
Mycobacterium ulcerans monoxygenase 0.0035 0.0461 0.145
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0396 0.0396
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0131 0.3135 0.313
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0035 0.0461 0.1179
Loa Loa (eye worm) hypothetical protein 0.007 0.1455 0.1455
Loa Loa (eye worm) hypothetical protein 0.0056 0.1045 0.1045
Schistosoma mansoni glutamate synthase 0.0035 0.0461 0.0461
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0927 0.0832
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0035 0.0461 0.0454
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0035 0.0461 0.0361
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0032 0.0396 0.0396
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0035 0.0461 0.0454
Echinococcus granulosus caspase 8 0.0052 0.0927 0.0927
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Echinococcus granulosus caspase 3 0.0085 0.185 0.185
Schistosoma mansoni hypothetical protein 0.0038 0.0556 0.0556
Mycobacterium ulcerans NADH dehydrogenase Ndh1 0.0035 0.0461 0.145
Schistosoma mansoni cell polarity protein 0.0038 0.0556 0.0556
Echinococcus multilocularis neurogenic locus notch protein 4 0.0038 0.0556 0.0556
Echinococcus granulosus lachesin 0.0032 0.0396 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.007 0.1455 0.1455
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0692 1
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0136 0.3282 0.3282
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0038 0.0556 0.0556
Schistosoma mansoni hypothetical protein 0.0035 0.0461 0.0461
Schistosoma mansoni roundabout 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0032 0.0396 0.0396
Schistosoma mansoni ap endonuclease 0.0022 0.0104 0.0104
Onchocerca volvulus 0.007 0.1455 0.574
Schistosoma mansoni tyrosine kinase 0.0032 0.0396 0.0396
Brugia malayi Cadherin domain containing protein 0.0038 0.0556 0.0556
Brugia malayi Muscle positioning protein 4 0.0038 0.0556 0.0556
Echinococcus multilocularis neurogenic locus notch protein 0.0038 0.0556 0.0556
Brugia malayi hypothetical protein 0.007 0.1455 0.1455
Trypanosoma cruzi NADH dehydrogenase, putative 0.0035 0.0461 0.0454
Schistosoma mansoni septate junction protein 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0078 0.1675 0.1675
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0131 0.3135 0.313
Plasmodium vivax metacaspase 1, putative 0.0052 0.0927 0.0832
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0035 0.0461 0.0454
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0104 0.0096
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0692 0.1941
Giardia lamblia Thioredoxin reductase 0.0035 0.0461 0.1179
Trypanosoma brucei NADH dehydrogenase 0.0035 0.0461 0.0454
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0368 0.0368
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.3135 0.3063
Onchocerca volvulus 0.007 0.1455 0.574
Echinococcus granulosus glutamate synthase 0.0035 0.0461 0.0461
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0692 0.1941
Onchocerca volvulus 0.0038 0.0556 0.0994
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0378 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0131 0.3135 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Trypanosoma cruzi metacaspase, putative 0.0052 0.0927 0.092
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0035 0.0461 0.1179
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0131 0.3135 0.313
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0131 0.3135 0.3063
Echinococcus granulosus neuroglian 0.0032 0.0396 0.0396
Echinococcus granulosus roundabout 2 0.0088 0.1946 0.1946
Brugia malayi Cytochrome P450 family protein 0.0018 0.0007 0.0007
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0074 0.155 0.155
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0692 0.0685
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0692 0.0685
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Schistosoma mansoni hypothetical protein 0.0048 0.0829 0.0829
Leishmania major NADH dehydrogenase, putative 0.0035 0.0461 0.0454
Loa Loa (eye worm) hypothetical protein 0.0031 0.0368 0.0368
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0692 0.0692
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0396 0.0396
Loa Loa (eye worm) CYP4Cod1 0.0018 0.0007 0.0007
Onchocerca volvulus Cell death protein 3 homolog 0.0099 0.2261 1
Schistosoma mansoni disulfide oxidoreductase 0.0035 0.0461 0.0461
Schistosoma mansoni notch 0.0038 0.0556 0.0556
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0692 0.0692
Echinococcus granulosus delta-like protein 1 0.0038 0.0556 0.0556
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0131 0.3135 1
Toxoplasma gondii rhoptry neck protein RON1 0.007 0.1455 0.1365
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0368 0.0368
Plasmodium falciparum metacaspase 1 0.0052 0.0927 0.0832
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0104 0.0096
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0032 0.0396 0.0396
Echinococcus granulosus notch 0.0038 0.0556 0.0556
Treponema pallidum oxidoreductase 0.0035 0.0461 0.1179
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0035 0.0461 0.0461
Leishmania major hypothetical protein, conserved 0.0035 0.0461 0.0454
Onchocerca volvulus 0.007 0.1455 0.574
Onchocerca volvulus Putative cubilin 0.0038 0.0556 0.0994
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0035 0.0461 0.0361
Schistosoma mansoni notch 0.0038 0.0556 0.0556
Echinococcus multilocularis neuroglian 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0056 0.1045 0.1045
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0927 0.2716
Echinococcus multilocularis roundabout 2 0.0032 0.0396 0.0396
Schistosoma mansoni cell adhesion molecule 0.0032 0.0396 0.0396
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0692 0.0692
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0927 0.092
Mycobacterium ulcerans glutamate synthase subunit beta 0.0035 0.0461 0.145
Echinococcus granulosus caspase 2 0.0099 0.2261 0.2261
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0035 0.0461 0.0454
Brugia malayi Calcium binding EGF domain containing protein 0.0038 0.0556 0.0556
Schistosoma mansoni septate junction protein 0.0032 0.0396 0.0396
Brugia malayi hypothetical protein 0.007 0.1455 0.1455
Echinococcus granulosus caspase 0.0136 0.3282 0.3282
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0035 0.0461 0.0461
Schistosoma mansoni lamin 0.0031 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0104 0.0307
Echinococcus multilocularis musashi 0.0031 0.0368 0.0368
Echinococcus granulosus protein jagged 2 0.0038 0.0556 0.0556
Brugia malayi Cell death protein 3 precursor 0.0099 0.2261 0.2261
Schistosoma mansoni notch 0.0038 0.0556 0.0556
Wolbachia endosymbiont of Brugia malayi NADPH-dependent glutamate synthase beta chain 0.0035 0.0461 0.1179
Echinococcus granulosus fibropellin Ia 0.0038 0.0556 0.0556
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0131 0.3135 0.313
Loa Loa (eye worm) programmed cell death 8 0.0035 0.0461 0.0461
Echinococcus multilocularis protein jagged 1 0.0038 0.0556 0.0556
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0927 0.2716
Brugia malayi hypothetical protein 0.007 0.1455 0.1455
Brugia malayi Calcium binding EGF domain containing protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.007 0.1455 0.1455
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0032 0.0396 0.0148
Trypanosoma cruzi NADH dehydrogenase, putative 0.0035 0.0461 0.0454
Mycobacterium tuberculosis Probable NADPH dependent 2,4-dienoyl-CoA reductase FadH (2,4-dienoyl coenzyme A reductase) (4-enoyl-CoA reductase) 0.0035 0.0461 0.0361
Loa Loa (eye worm) hypothetical protein 0.0109 0.2516 0.2516
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0035 0.0461 0.0361
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0035 0.0461 0.0461
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0035 0.0461 0.0461
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0035 0.0461 0.145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0131 0.3135 0.313
Mycobacterium ulcerans NADH dehydrogenase 0.0035 0.0461 0.145
Loa Loa (eye worm) hypothetical protein 0.0032 0.0396 0.0396
Schistosoma mansoni septate junction protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0088 0.1946 0.1946
Brugia malayi Prion-like- 0.0032 0.0396 0.0396
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0035 0.0461 0.0361
Trypanosoma brucei metacaspase 5, putative 0.0052 0.0927 0.092
Echinococcus granulosus protein jagged 1 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Trypanosoma cruzi metacaspase, putative 0.0052 0.0927 0.092
Brugia malayi hypothetical protein 0.007 0.1455 0.1455
Mycobacterium ulcerans dehydrogenase 0.0035 0.0461 0.145
Loa Loa (eye worm) hypothetical protein 0.007 0.1455 0.1455
Schistosoma mansoni hypothetical protein 0.0038 0.0556 0.0556
Schistosoma mansoni cell adhesion molecule 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0074 0.155 0.155
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprB 0.0035 0.0461 0.145
Schistosoma mansoni hypothetical protein 0.0038 0.0556 0.0556
Trichomonas vaginalis apoptosis inducing factor, putative 0.0035 0.0461 0.1179
Loa Loa (eye worm) hypothetical protein 0.0099 0.2261 0.2261
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0104 0.0104
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0056 0.1045 0.1045
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0131 0.3135 0.313
Echinococcus multilocularis Immunoglobulin 0.0056 0.1045 0.1045
Echinococcus multilocularis caspase 2 0.0099 0.2261 0.2261
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0461 0.0454
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0032 0.0396 0.0396
Schistosoma mansoni cell adhesion molecule 0.0074 0.155 0.155
Plasmodium falciparum thioredoxin reductase 0.0131 0.3135 0.3063
Schistosoma mansoni nephrin 0.007 0.1441 0.1441
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.3135 0.3063
Leishmania major hypothetical protein, conserved 0.0035 0.0461 0.0454
Mycobacterium tuberculosis Possible dehydrogenase/reductase 0.0035 0.0461 0.0361
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0104 0.0104
Loa Loa (eye worm) thioredoxin reductase 0.0378 1 1
Onchocerca volvulus 0.007 0.1455 0.574
Loa Loa (eye worm) glutathione reductase 0.0378 1 1
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0035 0.0461 0.1179
Loa Loa (eye worm) hypothetical protein 0.0035 0.0461 0.0461
Echinococcus granulosus neurogenic locus notch protein 4 0.0038 0.0556 0.0556
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0131 0.3135 0.313
Loa Loa (eye worm) hypothetical protein 0.0032 0.0396 0.0396
Schistosoma mansoni sulfide quinone reductase 0.0035 0.0461 0.0461
Plasmodium vivax glutathione reductase, putative 0.0378 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.3135 0.3063
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0056 0.1045 0.1045
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0461 0.1179
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0396 0.0396
Echinococcus multilocularis roundabout 2 0.0088 0.1946 0.1946
Schistosoma mansoni cell adhesion molecule 0.0032 0.0396 0.0396
Echinococcus granulosus Immunoglobulin 0.0056 0.1045 0.1045
Onchocerca volvulus 0.0035 0.0461 0.0491
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0096 0.2169 0.2169
Onchocerca volvulus 0.0038 0.0556 0.0994
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0692 0.0692
Echinococcus granulosus roundabout 2 0.0032 0.0396 0.0396
Entamoeba histolytica thioredoxin reductase, putative 0.0035 0.0461 0.6071
Echinococcus multilocularis apoptotic protease activating factor 1 0.0048 0.0829 0.0829
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0035 0.0461 0.0361
Echinococcus multilocularis caspase 8 0.0052 0.0927 0.0927
Plasmodium falciparum ferrodoxin reductase-like protein 0.0035 0.0461 0.0361
Schistosoma mansoni glutamate synthase 0.0035 0.0461 0.0461
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0461 0.1179
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0131 0.3135 0.313
Onchocerca volvulus Neurogenic locus notch homolog 0.0038 0.0556 0.0994
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0131 0.3135 1
Trypanosoma cruzi trypanothione reductase, putative 0.0131 0.3135 0.313
Giardia lamblia Glutamate synthase 0.0035 0.0461 0.1179
Trypanosoma brucei metacaspase MCA2 0.0052 0.0927 0.092
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0104 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0927 0.2716
Echinococcus multilocularis caspase 0.0136 0.3282 0.3282
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0131 0.3135 1
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0035 0.0461 0.0461
Onchocerca volvulus 0.007 0.1455 0.574
Onchocerca volvulus 0.0038 0.0556 0.0994
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0035 0.0461 0.0361
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0692 0.0692
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0052 0.0927 0.0927
Echinococcus multilocularis thioredoxin glutathione reductase 0.0378 1 1
Echinococcus multilocularis C type lectin domian containing protein 0.007 0.1455 0.1455
Schistosoma mansoni slit 0.0038 0.0556 0.0556
Echinococcus multilocularis glutamate synthase 0.0035 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.007 0.1455 0.1455
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0131 0.3135 0.3063
Echinococcus multilocularis c4b binding protein beta chain 0.007 0.1455 0.1455
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0136 0.3282 0.3282
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0035 0.0461 0.0461
Schistosoma mansoni caspase-7 (C14 family) 0.0099 0.2261 0.2261
Brugia malayi hypothetical protein 0.007 0.1455 0.1455
Schistosoma mansoni ap endonuclease 0.0022 0.0104 0.0104
Leishmania major hypothetical protein, conserved 0.0035 0.0461 0.0454
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0131 0.3135 0.313
Echinococcus granulosus thioredoxin glutathione reductase 0.0378 1 1
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0035 0.0461 0.0361
Echinococcus granulosus intermediate filament protein 0.0031 0.0368 0.0368
Brugia malayi Thioredoxin reductase 0.0378 1 1
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0692 0.0692
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0035 0.0461 0.6071
Toxoplasma gondii selenide, water dikinase 0.0035 0.0461 0.0361
Loa Loa (eye worm) hypothetical protein 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Echinococcus multilocularis hemicentin 1 0.0032 0.0396 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0396 0.0396
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0927 0.2716
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0927 0.2716
Schistosoma mansoni notch 0.0038 0.0556 0.0556
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0692 0.0692
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0035 0.0461 0.0454
Giardia lamblia NADH oxidase lateral transfer candidate 0.0131 0.3135 1
Echinococcus granulosus neuroglian 0.007 0.1441 0.1441
Echinococcus granulosus roundabout 2 0.0032 0.0396 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0692 0.1941
Mycobacterium tuberculosis Probable reductase 0.0035 0.0461 0.0361
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0035 0.0461 0.0361
Echinococcus multilocularis fibropellin Ia 0.0038 0.0556 0.0556
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0927 0.2716
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0035 0.0461 0.0454
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0927 0.2716
Mycobacterium tuberculosis Probable NADH-dependent glutamate synthase (small subunit) GltD (L-glutamate synthase) (L-glutamate synthetase) (NADH-glutamate 0.0035 0.0461 0.0361
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0396 0.0396
Brugia malayi EGF-like domain containing protein 0.0038 0.0556 0.0556
Schistosoma mansoni glutamate synthase 0.0035 0.0461 0.0461
Plasmodium falciparum glutathione reductase 0.0378 1 1
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0927 0.2716
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0396 0.0396
Echinococcus granulosus tyrosine protein kinase otk 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0088 0.1946 0.1946
Plasmodium vivax ferrodoxin reductase, putative 0.0035 0.0461 0.0361
Leishmania major metacaspase, putative 0.0052 0.0927 0.092
Onchocerca volvulus 0.0038 0.0556 0.0994
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0692 0.0692
Loa Loa (eye worm) hypothetical protein 0.0052 0.0927 0.0927
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0032 0.0396 0.0396
Onchocerca volvulus 0.007 0.1455 0.574
Echinococcus granulosus lamin dm0 0.0031 0.0368 0.0368
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0927 0.2716
Loa Loa (eye worm) hypothetical protein 0.0032 0.0396 0.0396
Echinococcus multilocularis neurogenic locus protein delta 0.0038 0.0556 0.0556
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0927 0.0832
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0131 0.3135 0.313
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0927 0.0832
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Plasmodium falciparum thioredoxin reductase 0.0378 1 1
Echinococcus granulosus lamin 0.0031 0.0368 0.0368
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0035 0.0461 0.0454
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0052 0.0927 0.2716
Schistosoma mansoni hypothetical protein 0.0038 0.0556 0.0556
Mycobacterium ulcerans NADPH:adrenodoxin oxidoreductase FprA 0.0035 0.0461 0.145
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0035 0.0461 0.0461
Loa Loa (eye worm) hypothetical protein 0.0056 0.1045 0.1045
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0692 0.0692
Echinococcus multilocularis lachesin 0.0032 0.0396 0.0396
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0461 0.1179
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0035 0.0461 0.0361
Brugia malayi EGF-like domain containing protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0074 0.155 0.155
Brugia malayi pregnancy-associated plasma protein-A 0.007 0.1455 0.1455
Brugia malayi EGF-like domain containing protein 0.0038 0.0556 0.0556
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0035 0.0461 0.0454
Echinococcus multilocularis Immunoglobulin 0.0056 0.1045 0.1045
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0035 0.0461 0.145
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0032 0.0396 0.0396
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0035 0.0461 0.6071
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0396 0.0396
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0692 0.0685
Echinococcus granulosus c4b binding protein beta chain 0.007 0.1455 0.1455
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0035 0.0461 0.1179
Trypanosoma cruzi metacaspase 5, putative 0.0052 0.0927 0.092
Echinococcus granulosus peroxidasin 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0056 0.1045 0.1045
Mycobacterium tuberculosis NADPH:adrenodoxin oxidoreductase FprA (NADPH-ferredoxin reductase) 0.0035 0.0461 0.0361
Schistosoma mansoni hypothetical protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Leishmania major trypanothione reductase 0.0378 1 1
Echinococcus granulosus protein jagged 2 0.0038 0.0556 0.0556
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0131 0.3135 0.3135
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0035 0.0461 0.0454
Echinococcus granulosus protein jagged 1 0.0038 0.0556 0.0556
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0038 0.0556 0.0556
Trypanosoma cruzi trypanothione reductase, putative 0.0378 1 1
Plasmodium falciparum apical sushi protein 0.007 0.1455 0.1365
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0104 0.0096
Loa Loa (eye worm) hypothetical protein 0.007 0.1455 0.1455
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0461 0.0454
Loa Loa (eye worm) notch protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0396 0.0396
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0131 0.3135 0.3063
Trypanosoma brucei Metacaspase-4 0.0052 0.0927 0.092
Toxoplasma gondii EGF family domain-containing protein 0.0038 0.0556 0.0457
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0104 0.0096
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0131 0.3135 0.3135
Echinococcus multilocularis peroxidasin 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Brugia malayi hypothetical protein 0.007 0.1455 0.1455
Echinococcus multilocularis tyrosine protein kinase otk 0.0032 0.0396 0.0396
Onchocerca volvulus Slit protein homolog 0.0038 0.0556 0.0994
Loa Loa (eye worm) hypothetical protein 0.0056 0.1045 0.1045
Schistosoma mansoni laminin gamma-3 chain 0.0038 0.0556 0.0556
Echinococcus multilocularis lamin dm0 0.0031 0.0368 0.0368
Brugia malayi intermediate filament protein 0.0031 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) cytochrome P450 family protein 0.0018 0.0007 0.0007
Brugia malayi hypothetical protein 0.007 0.1455 0.1455
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0461 0.0454
Trypanosoma cruzi metacaspase, putative 0.0052 0.0927 0.092
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0035 0.0461 0.0461
Echinococcus granulosus contactin 0.0032 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0031 0.0352 0.0352
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0131 0.3135 0.313
Schistosoma mansoni notch 0.0038 0.0556 0.0556
Trichomonas vaginalis glutathione reductase, putative 0.0131 0.3135 1
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0035 0.0461 0.0361
Echinococcus multilocularis slit 2 protein 0.0038 0.0556 0.0556
Toxoplasma gondii NADPH-glutathione reductase 0.0131 0.3135 0.3063
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0131 0.3135 0.3063
Brugia malayi Cadherin domain containing protein 0.0038 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.0048 0.0829 0.0829
Schistosoma mansoni neuroglian 0.0032 0.0396 0.0396
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0396 0.0396
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0035 0.0461 0.0454
Plasmodium vivax thioredoxin reductase, putative 0.0378 1 1
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0035 0.0461 0.0361
Schistosoma mansoni hypothetical protein 0.0038 0.0556 0.0556
Echinococcus multilocularis neurogenic locus notch protein 0.0038 0.0556 0.0556
Echinococcus granulosus twitchin 0.007 0.1441 0.1441
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0035 0.0461 0.0361
Echinococcus granulosus neural cadherin 0.0038 0.0556 0.0556
Echinococcus granulosus hemicentin 1 0.0032 0.0396 0.0396
Echinococcus granulosus C type lectin domian containing protein 0.007 0.1455 0.1455
Treponema pallidum thioredoxin reductase (trxB) 0.0035 0.0461 0.1179
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0052 0.0927 0.0832
Loa Loa (eye worm) hypothetical protein 0.007 0.1455 0.1455
Onchocerca volvulus 0.0038 0.0556 0.0994
Brugia malayi Cytochrome P450 family protein 0.0018 0.0007 0.0007
Echinococcus multilocularis lamin 0.0031 0.0368 0.0368
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0035 0.0461 0.1179

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Anti-cataleptic activity of the compound in Rat at oral dose of 3 mg/kg retested at 1 and 4 hr after administration; Activity Not Traced ChEMBL. 15978806
Index (binding) = 85 Selectivity index of Adenosine A2A over A1 in Rat ChEMBL. 15978806
Ki (binding) = 3.6 nM In vitro ability to displace [3H]-SCH-58,261 from A2A adenosine receptor in Rat ChEMBL. 15978806
Ki (binding) = 3.6 nM In vitro ability to displace [3H]-SCH-58,261 from A2A adenosine receptor in Rat ChEMBL. 15978806

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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