Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.1103 | 1 | 1 |
Brugia malayi | amidase | 0.0512 | 0.0892 | 0.0892 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0512 | 0.0892 | 0.0892 |
Schistosoma mansoni | amidase | 0.0512 | 0.0892 | 0.0892 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0512 | 0.0892 | 0.0892 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1103 | 1 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0512 | 0.0892 | 0.0892 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.1103 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1103 | 1 | 0.5 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.1103 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.1103 | 1 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.1103 | 1 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.1103 | 1 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0512 | 0.0892 | 0.0892 |
Loa Loa (eye worm) | hypothetical protein | 0.0512 | 0.0892 | 0.0892 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0518 | 0.0976 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0518 | 0.0976 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0512 | 0.0892 | 0.0892 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0518 | 0.0976 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1103 | 1 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0518 | 0.0976 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.98 nM | Inhibitiory constant towards Human melanin-concentrating hormone receptor | ChEMBL. | 15953726 |
Ki (binding) | = 0.98 nM | Inhibition of 125I-MCH binding to human MCH-R1 expressed in CHO cell membranes | ChEMBL. | 17251014 |
Ki (binding) | = 0.98 nM | Inhibitiory constant towards Human melanin-concentrating hormone receptor | ChEMBL. | 15953726 |
Ki (binding) | = 0.98 nM | Inhibition of 125I-MCH binding to human MCH-R1 expressed in CHO cell membranes | ChEMBL. | 17251014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.