Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | sigma non-opioid intracellular receptor 1 | Starlite/ChEMBL | References |
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0681 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0445 | 0.5547 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.054 | 0.7345 | 0.7345 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0681 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.054 | 0.7345 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.054 | 0.7345 | 0.7345 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0227 | 0.1456 | 0.1982 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0445 | 0.5547 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0681 | 1 | 0.5 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0681 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0445 | 0.5547 | 0.7553 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0681 | 1 | 0.5 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0681 | 1 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0445 | 0.5547 | 0.5 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Echinococcus granulosus | inosine guanosine and xanthosine phosphorylase | 0.054 | 0.7345 | 0.7345 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0681 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 3.9 % | Percentage inhibition of dopamine D2 receptor at 10 uM concentration using 0.2 nM [3H]-spiperone | ChEMBL. | 15634021 |
Inhibition (binding) | = 3.9 % | Percentage inhibition of dopamine D2 receptor at 10 uM concentration using 0.2 nM [3H]-spiperone | ChEMBL. | 15634021 |
Ki (binding) | 0 nM | Inhibitory constant against dopamine D2 receptor using 0.2 nM [3H]-spiperone; Not determined | ChEMBL. | 15634021 |
Ki (binding) | = 3.8 nM | Inhibitory constant against sigma receptor type 1 using 3 nM [3H]-pentazocine | ChEMBL. | 15634021 |
Ki (binding) | = 3.8 nM | Inhibitory constant against sigma receptor type 1 using 3 nM [3H]-pentazocine | ChEMBL. | 15634021 |
Ki (binding) | = 14.1 nM | Inhibitory constant against sigma receptor type 2 using 3 nM [3H]-ditolylguanidine | ChEMBL. | 15634021 |
Ki (binding) | = 14.1 nM | Inhibitory constant against sigma receptor type 2 using 3 nM [3H]-ditolylguanidine | ChEMBL. | 15634021 |
Ki (binding) | > 1000 nM | Inhibitory constant was determined against 5-hydroxytryptamine 1A receptor using 1.2 nM [3H]-8-OH-DPAT | ChEMBL. | 15634021 |
Ki (binding) | > 1000 nM | Inhibitory constant was determined against 5-hydroxytryptamine 1A receptor using 1.2 nM [3H]-8-OH-DPAT | ChEMBL. | 15634021 |
Ratio (binding) | = 4 | Ratio of Ki against Sigma receptor type 1 and 2 | ChEMBL. | 15634021 |
Ratio (binding) | = 4 | Ratio of Ki against Sigma receptor type 1 and 2 | ChEMBL. | 15634021 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.