TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 674.954 | Formula: C28H50N4O9SSi2
H donors: 2 H acceptors: 5 LogP: 3.33 Rotable bonds: 12
Rule of 5 violations (Lipinski): 2
SMILES: CCNC(=O)NC1=CS(=O)(=O)OC21C(CO[Si](C(C)(C)C)(C)C)OC(C2O[Si](C(C)(C)C)(C)C)n1cc(C)c(=O)n(c1=O)C
InChi: 1S/C28H50N4O9SSi2/c1-14-29-24(34)30-19-17-42(36,37)41-28(19)20(16-38-43(10,11)26(3,4)5)39-23(21(28)40-44(12,13)27(6,7)8)32-15-18(2)22(33)31(9)25(32)35/h15,17,20-21,23H,14,16H2,1-13H3,(H2,29,30,34)
InChiKey: XVPYEPXZELVCOE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0131	0.0308
Trypanosoma brucei	mitochondrial DNA polymerase beta	0.0357	0.5164	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.1224	0.3088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0148	0.187	0.1856
Echinococcus granulosus	geminin	0.0172	0.225	0.3522
Echinococcus granulosus	suppression of tumorigenicity 18 protein	0.0122	0.1458	0.2282
Brugia malayi	hypothetical protein	0.0052	0.0354	0.0857
Echinococcus multilocularis	survival motor neuron protein 1	0.028	0.3942	0.6161
Schistosoma mansoni	lamin	0.0031	0.0018	0.0001
Schistosoma mansoni	amine oxidase	0.0045	0.0247	0.023
Echinococcus granulosus	polycomb protein SCMH1	0.0107	0.1224	0.1916
Schistosoma mansoni	ap endonuclease	0.0062	0.0515	0.0499
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.3686	0.3675
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0062	0.0515	0.0765
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0169	0.2199	0.411
Brugia malayi	exodeoxyribonuclease III family protein	0.0062	0.0515	0.1268
Mycobacterium ulcerans	adenosylmethionine-8-amino-7-oxononanoate aminotransferase	0.0161	0.2071	0.1941
Toxoplasma gondii	histone lysine-specific demethylase LSD1/BHC110/KDMA1A	0.0045	0.0247	0.2915
Brugia malayi	RNA recognition motif domain containing protein	0.0264	0.3686	0.9347
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.3686	0.3675
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0247	0.0603
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0086	0.0892	0.3538
Loa Loa (eye worm)	mbt repeat family protein	0.0107	0.1224	0.3088
Echinococcus granulosus	tar DNA binding protein	0.0264	0.3686	0.577
Mycobacterium tuberculosis	Possible oxidoreductase	0.0045	0.0247	0.0133
Echinococcus multilocularis	tar DNA binding protein	0.0264	0.3686	0.5758
Schistosoma mansoni	hypothetical protein	0.0038	0.0131	0.0113
Trypanosoma cruzi	PAB1-binding protein , putative	0.0081	0.0804	0.1339
Trypanosoma brucei	DNA polymerase beta thumb, putative	0.005	0.0327	0.039
Echinococcus multilocularis	histone acetyltransferase MYST2	0.0122	0.1458	0.226
Echinococcus multilocularis		0.0045	0.0247	0.036
Leishmania major	mitochondrial DNA polymerase beta-PAK, putative	0.0169	0.2199	0.411
Brugia malayi	Intermediate filament tail domain containing protein	0.0031	0.0018	0.0002
Echinococcus multilocularis	lysine specific histone demethylase 1A	0.0045	0.0247	0.036
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0036	0.0104	0.0136
Brugia malayi	amine oxidase, flavin-containing family protein	0.0045	0.0247	0.0584
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0018	0.0022
Mycobacterium tuberculosis	Probable reductase	0.0086	0.0892	0.0866
Mycobacterium leprae	PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA	0.0161	0.2071	1
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0045	0.0247	0.0232
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0148	0.187	0.2927
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0642	0.9645	1
Echinococcus multilocularis	lamin dm0	0.0031	0.0018	0.0001
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0357	0.5164	1
Brugia malayi	RNA binding protein	0.0264	0.3686	0.9347
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0148	0.187	0.4719
Trichomonas vaginalis	acetylornithine aminotransferase, putative	0.0161	0.2071	0.5458
Schistosoma mansoni	lamin	0.0031	0.0018	0.0001
Plasmodium falciparum	conserved Plasmodium protein, unknown function	0.0045	0.0247	0.1735
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0148	0.187	0.2907
Toxoplasma gondii	histone lysine-specific demethylase	0.0045	0.0247	0.2915
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0096	0.1044	0.1038
Plasmodium falciparum	ataxin-2 like protein, putative	0.0081	0.0804	1
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0086	0.0892	0.0866
Mycobacterium ulcerans	hypothetical protein	0.0188	0.25	0.2397
Loa Loa (eye worm)	hypothetical protein	0.017	0.2213	0.5603
Toxoplasma gondii	hypothetical protein	0.0058	0.0443	0.5408
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0247	0.0603
Echinococcus granulosus	SAM and MBT domain containing protein	0.0107	0.1224	0.1916
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0148	0.187	0.1856
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0045	0.0247	0.0387
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0096	0.1044	0.1038
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0062	0.0515	0.5
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0247	0.0603
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.005	0.0327	0.039
Echinococcus multilocularis	protoporphyrinogen oxidase	0.0045	0.0247	0.036
Trypanosoma cruzi	PAB1-binding protein , putative	0.0081	0.0804	0.1339
Onchocerca volvulus		0.0107	0.1224	0.3603
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0062	0.0515	0.0807
Brugia malayi	latrophilin 2 splice variant baaae	0.0038	0.0131	0.0288
Leishmania major	hypothetical protein, conserved	0.0081	0.0804	0.1339
Echinococcus granulosus	lamin dm0	0.0031	0.0018	0.0029
Onchocerca volvulus		0.0045	0.0247	0.0685
Echinococcus granulosus	thioredoxin glutathione reductase	0.0038	0.0138	0.0216
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0018	0.0028
Mycobacterium tuberculosis	Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA	0.0161	0.2071	0.2205
Leishmania major	mitochondrial DNA polymerase beta	0.0357	0.5164	1
Mycobacterium tuberculosis	Probable dehydrogenase	0.0086	0.0892	0.0866
Onchocerca volvulus		0.0243	0.3366	1
Schistosoma mansoni	Lysine-specific histone demethylase 1	0.0045	0.0247	0.023
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0062	0.0515	0.6329
Trypanosoma cruzi	UDP-galactopyranose mutase	0.0045	0.0247	0.0232
Echinococcus granulosus	muscleblind protein	0.017	0.2213	0.3464
Echinococcus granulosus	endonuclease exonuclease phosphatase	0.0435	0.6388	1
Loa Loa (eye worm)	hypothetical protein	0.028	0.3942	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0086	0.0892	0.0866
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0804	0.202
Schistosoma mansoni	myelin transcription factor 1 myt1	0.0122	0.1458	0.1442
Echinococcus multilocularis	muscleblind protein	0.017	0.2213	0.3446
Schistosoma mansoni	sex comb on midleg homolog	0.0107	0.1224	0.1208
Schistosoma mansoni	sex comb on midleg homolog	0.0107	0.1224	0.1208
Toxoplasma gondii	LsmAD domain-containing protein	0.0081	0.0804	1
Echinococcus granulosus	histone acetyltransferase MYST2	0.0122	0.1458	0.2282
Loa Loa (eye worm)	hypothetical protein	0.017	0.2213	0.5603
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0247	0.2915
Toxoplasma gondii	thioredoxin reductase	0.0038	0.013	0.1428
Plasmodium vivax	lysine-specific histone demethylase 1, putative	0.0045	0.0247	0.2915
Echinococcus multilocularis	suppression of tumorigenicity 18 protein	0.0122	0.1458	0.226
Mycobacterium tuberculosis	Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO)	0.0597	0.8933	1
Plasmodium falciparum	protoporphyrinogen oxidase	0.0045	0.0247	0.1735
Schistosoma mansoni	survival motor neuron protein	0.0057	0.0434	0.0417
Loa Loa (eye worm)	hypothetical protein	0.0122	0.1458	0.3682
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0148	0.187	0.2907
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0086	0.0892	0.0866
Plasmodium falciparum	ataxin-2 like protein, putative	0.0081	0.0804	1
Loa Loa (eye worm)	glutathione reductase	0.0038	0.013	0.0306
Plasmodium falciparum	lysine-specific histone demethylase 1, putative	0.0045	0.0247	0.1735
Brugia malayi	Thioredoxin reductase	0.0038	0.013	0.0286
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0247	0.0603
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0264	0.3686	0.9348
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0036	0.0104	0.0163
Brugia malayi	Muscleblind-like protein	0.017	0.2213	0.5594
Loa Loa (eye worm)	MH2 domain-containing protein	0.0257	0.3584	0.909
Onchocerca volvulus		0.0057	0.0434	0.1243
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0062	0.0515	0.0781
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0045	0.0247	0.0133
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0057	0.0434	0.1061
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0148	0.187	0.2927
Schistosoma mansoni	hypothetical protein	0.0057	0.0434	0.0417
Onchocerca volvulus	Polycomb protein Sfmbt homolog	0.0107	0.1224	0.3603
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0148	0.187	0.473
Echinococcus multilocularis	polycomb protein SCMH1	0.0107	0.1224	0.1893
Echinococcus multilocularis	SAM and MBT domain containing protein	0.0107	0.1224	0.1893
Brugia malayi	hypothetical protein	0.028	0.3942	1
Echinococcus multilocularis	muscleblind protein 1	0.017	0.2213	0.3446
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0214	0.2901	0.7351
Brugia malayi	intermediate filament protein	0.0031	0.0018	0.0002
Plasmodium vivax	hypothetical protein, conserved	0.0045	0.0247	0.2915
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.0061	0.05	0.0734
Schistosoma mansoni	hypothetical protein	0.0172	0.225	0.2236
Echinococcus multilocularis	endonuclease exonuclease phosphatase	0.0435	0.6388	1
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.3686	0.3675
Echinococcus granulosus	lamin	0.0031	0.0018	0.0029
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0062	0.0515	0.1286
Brugia malayi	Pre-SET motif family protein	0.0214	0.2901	0.7346
Schistosoma mansoni	intermediate filament proteins	0.0031	0.0018	0.0001
Brugia malayi	hypothetical protein	0.0045	0.0247	0.0584
Brugia malayi	SWIRM domain containing protein	0.0045	0.0247	0.0584
Echinococcus granulosus	intermediate filament protein	0.0031	0.0018	0.0029
Chlamydia trachomatis	protoporphyrinogen oxidase	0.0045	0.0247	0.5
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0086	0.0892	0.0866
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0062	0.0515	0.5
Trypanosoma brucei	PAB1-binding protein , putative	0.0081	0.0804	0.1339
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0247	0.0603
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0018	0.0021
Trypanosoma cruzi	mitochondrial DNA polymerase beta, putative	0.0357	0.5164	1
Mycobacterium tuberculosis	Probable oxidoreductase	0.0096	0.1044	0.1038
Brugia malayi	mbt repeat family protein	0.0107	0.1224	0.3073
Echinococcus multilocularis	lamin	0.0031	0.0018	0.0001
Mycobacterium ulcerans	hypothetical protein	0.0161	0.2071	0.1941
Mycobacterium tuberculosis	Probable aminotransferase	0.0161	0.2071	0.2205
Echinococcus granulosus	lysine specific histone demethylase 1A	0.0045	0.0247	0.0387
Brugia malayi	TAR-binding protein	0.0264	0.3686	0.9347
Schistosoma mansoni	hypothetical protein	0.0036	0.0104	0.0087
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0031	0.0018	0.0022
Schistosoma mansoni	scm-relatedprotein containing 4 mbt domains (sfmbt)	0.0107	0.1224	0.1208
Brugia malayi	hypothetical protein	0.0081	0.0804	0.2003
Schistosoma mansoni	Protoporphyrinogen oxidase chloroplast/mitochondrial precursor	0.0045	0.0247	0.023
Echinococcus granulosus	survival motor neuron protein 1	0.028	0.3942	0.6171
Brugia malayi	MH2 domain containing protein	0.0257	0.3584	0.9088
Plasmodium vivax	protoporphyrinogen oxidase, putative	0.0045	0.0247	0.2915
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.3686	0.3675
Schistosoma mansoni	tar DNA-binding protein	0.0264	0.3686	0.3675
Loa Loa (eye worm)	intermediate filament protein	0.0031	0.0018	0.0022
Loa Loa (eye worm)	RNA binding protein	0.0264	0.3686	0.9348
Schistosoma mansoni	hypothetical protein	0.0172	0.225	0.2236
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0062	0.0515	0.0765
Toxoplasma gondii	exonuclease III APE	0.0062	0.0515	0.6329
Mycobacterium ulcerans	flavin-containing monoamine oxidase AofH	0.0642	0.9645	1
Echinococcus multilocularis	musashi	0.0031	0.0018	0.0001
Trypanosoma cruzi	mitochondrial DNA polymerase beta-PAK, putative	0.005	0.0327	0.039
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0062	0.0515	0.5718
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0038	0.0138	0.0189
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0062	0.0515	0.0286
Trypanosoma brucei	mitochondrial DNA polymerase beta-PAK	0.0169	0.2199	0.411
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0055	0.0406	0.099
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0062	0.0515	0.0765
Onchocerca volvulus		0.0031	0.0018	0.0002
Loa Loa (eye worm)	TAR-binding protein	0.0264	0.3686	0.9348
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0062	0.0515	0.0765
Schistosoma mansoni	ap endonuclease	0.0062	0.0515	0.0499
Echinococcus multilocularis	geminin	0.0172	0.225	0.3504
Loa Loa (eye worm)	thioredoxin reductase	0.0038	0.013	0.0306
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0406	0.1009
Trichomonas vaginalis	set domain proteins, putative	0.0243	0.3366	1
Schistosoma mansoni	amine oxidase	0.0045	0.0247	0.023
Loa Loa (eye worm)	MBCTL1	0.0122	0.1458	0.3682
Brugia malayi	mbt repeat family protein	0.0107	0.1224	0.3073
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0148	0.187	0.1856
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0055	0.0406	0.099
Trypanosoma cruzi	DNA polymerase beta thumb, putative	0.005	0.0327	0.039
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0055	0.0406	0.1009
Onchocerca volvulus		0.0031	0.0018	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0247	0.0603
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0062	0.0515	0.5
Leishmania major	UDP-galactopyranose mutase	0.0045	0.0247	0.0232
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0062	0.0515	0.0438
Plasmodium vivax	glutathione reductase, putative	0.0038	0.013	0.1428
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0188	0.25	0.2692
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0062	0.0515	0.5
Brugia malayi	glutathione reductase	0.0038	0.013	0.0286
Plasmodium vivax	ataxin-2 like protein, putative	0.0081	0.0804	1
Loa Loa (eye worm)	transcription factor SMAD2	0.0257	0.3584	0.909
Plasmodium vivax	thioredoxin reductase, putative	0.0038	0.013	0.1428
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0096	0.1044	0.4369
Brugia malayi	C2-HC type zinc finger protein C.e-MyT1	0.0122	0.1458	0.3669

Activities

Activity type	Activity value	Assay description	Source	Reference
CC50 (functional)	= 4.26 uM	Cytostatic concentration of the compound required to inhibit CEM cell proliferation	ChEMBL.	15715482
CC50 (functional)	= 10 uM	Cytostatic concentration required to inhibit HEL cell proliferation	ChEMBL.	15715482
EC50 (functional)	= 1.8 uM	Effective concentration of the compound required to inhibit HCMV AD-169 in HEL Cells	ChEMBL.	15715482
EC50 (functional)	> 2 uM	Effective concentration of the compound required to inhibit HIV-1 IIIB in MT-4 cell culture	ChEMBL.	15715482
EC50 (functional)	> 2 uM	Effective concentration of the compound required to inhibit HIV-2 ROD in MT-4 cell culture	ChEMBL.	15715482
EC50 (functional)	> 2 uM	Effective concentration of the compound required to inhibit HIV-1 IIIB in CEM cell culture	ChEMBL.	15715482
EC50 (functional)	> 2 uM	Effective concentration of the compound required to inhibit HIV-2 ROD in CEM cell culture	ChEMBL.	15715482
EC50 (functional)	= 2 uM	Effective concentration of the compound required to inhibit HCMV Davis in HEL Cells	ChEMBL.	15715482
MCC (functional)	>= 3.2 uM	Minimal cytotoxic concentration required to cause microscopically visible alteration of cell morphology in HEL Cells	ChEMBL.	15715482

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 399207

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 313840