Detailed information for compound 314167

Basic information

Technical information
  • TDR Targets ID: 314167
  • Name: Acide tiludronique [INN-French]
  • MW: 318.608 | Formula: C7H9ClO6P2S
  • H donors: 4 H acceptors: 6 LogP: -0.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)SC(P(=O)(O)O)P(=O)(O)O
  • InChi: 1S/C7H9ClO6P2S/c8-5-1-3-6(4-2-5)17-7(15(9,10)11)16(12,13)14/h1-4,7H,(H2,9,10,11)(H2,12,13,14)
  • InChiKey: DKJJVAGXPKPDRL-UHFFFAOYSA-N  

Network

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Synonyms

  • Acido tiludronico [INN-Spanish]
  • Acidum tiludronicum [INN-Latin]
  • Tiludronate
  • Tiludronate disodium
  • Tiludronic Acid Disodium Salt
  • Tiludronic acid
  • [(4-chlorophenyl)sulfanyl-phosphonomethyl]phosphonic acid
  • [(4-chlorophenyl)sulfanyl-phosphono-methyl]phosphonic acid
  • [[(4-chlorophenyl)thio]-phosphonomethyl]phosphonic acid
  • [[(4-chlorophenyl)thio]-phosphono-methyl]phosphonic acid
  • SR 41319
  • 96538-83-9
  • C08141
  • (((p-Chlorophenyl)thio)methylene)diphosphonic acid
  • Acidum tiludronicum
  • Tiludronic acid [BAN:INN]

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Entamoeba histolytica protein kinase domain containing protein 0.0265 0.0459 0.2405
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0222 0.0205
Onchocerca volvulus 0.0328 0.064 0.28
Leishmania major casein kinase II, putative 0.0206 0.0289 0.021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1235 0.3264 0.3252
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Brugia malayi hypothetical protein 0.0665 0.1615 0.1601
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0332 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0669 0.1625 0.1618
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0373 0.0772 0.0772
Loa Loa (eye worm) hypothetical protein 0.0362 0.0739 0.0731
Schistosoma mansoni cell adhesion molecule 0.0183 0.0222 0.0222
Entamoeba histolytica PH domain containing protein kinase, putative 0.0249 0.0411 0.2152
Trypanosoma brucei protein kinase A catalytic subunit, putative 0.0233 0.0366 0.0288
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0176 0.0201 0.0192
Plasmodium falciparum casein kinase 2, alpha subunit 0.0206 0.0289 0.021
Loa Loa (eye worm) hypothetical protein 0.0249 0.0413 0.0404
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0373 0.0772 0.0772
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1235 0.3264 0.3252
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0328 0.0641 0.0565
Loa Loa (eye worm) hypothetical protein 0.1012 0.2619 0.2612
Echinococcus granulosus phosphorylase kinase gamma subunit 0.0339 0.0671 0.0671
Echinococcus granulosus nervana 2 0.0255 0.043 0.043
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0245 0.04 0.0322
Plasmodium vivax calcium-dependent protein kinase, putative 0.0208 0.0293 0.0121
Brugia malayi hypothetical protein 0.0665 0.1615 0.1601
Echinococcus multilocularis titin 0.0165 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.038 0.0789 0.0781
Echinococcus granulosus casein kinase I delta 0.0224 0.034 0.034
Echinococcus multilocularis serine:threonine protein kinase TAO1 0.0459 0.1018 0.1018
Loa Loa (eye worm) CMGC/CK2 protein kinase 0.0206 0.0289 0.028
Schistosoma mansoni hypothetical protein 0.0165 0.0168 0.0168
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0545 0.1269 0.1262
Brugia malayi putative serine/threonine kinase SADA gamma 0.0161 0.0157 0.014
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.021 0.03 0.0292
Echinococcus granulosus cyclin dependent kinase 1 0.0245 0.04 0.04
Loa Loa (eye worm) hypothetical protein 0.0397 0.084 0.0832
Loa Loa (eye worm) hypothetical protein 0.0406 0.0865 0.0857
Trypanosoma brucei kinetoplastid kinetochore protein 19 0.0317 0.0608 0.0532
Brugia malayi Immunoglobulin I-set domain containing protein 0.0257 0.0435 0.0419
Entamoeba histolytica PH domain containing protein kinase, putative 0.0339 0.0671 0.3517
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0757 0.1882 0.1882
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Schistosoma mansoni serine/threonine protein kinase 0.0232 0.0364 0.0364
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0242 0.0391 0.2047
Giardia lamblia Kinase, NEK 0.0281 0.0504 0.105
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0156 0.0144 0.0127
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.1235 0.3264 0.2803
Brugia malayi Immunoglobulin I-set domain containing protein 0.0251 0.0418 0.0401
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0173 0.0191 0.0182
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Echinococcus granulosus cyclin 0.0756 0.1877 0.1877
Brugia malayi Serine/threonine-protein kinase SULU 0.0459 0.1018 0.1003
Trichomonas vaginalis mercuric reductase, putative 0.1235 0.3264 1
Loa Loa (eye worm) hypothetical protein 0.0669 0.1625 0.1618
Brugia malayi Sex muscle abnormal protein 5 0.0126 0.0056 0.0039
Trichomonas vaginalis AGC family protein kinase 0.0603 0.1436 0.4384
Echinococcus granulosus tyrosine protein kinase 0.0313 0.0598 0.0598
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1235 0.3264 0.3252
Echinococcus granulosus serine:threonine protein kinase 3 0.053 0.1225 0.1225
Echinococcus multilocularis Immunoglobulin 0.065 0.1571 0.1571
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.0366 0.0366
Trypanosoma cruzi trypanothione reductase, putative 0.1235 0.3264 0.3252
Brugia malayi hypothetical protein 0.0665 0.1615 0.1601
Onchocerca volvulus 0.0165 0.017 0.0666
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0289 0.086
Toxoplasma gondii selenide, water dikinase 0.0328 0.064 0.0564
Trypanosoma cruzi polo-like protein kinase, putative 0.0558 0.1305 0.129
Schistosoma mansoni tyrosine kinase 0.0314 0.0598 0.0598
Brugia malayi Protein kinase domain containing protein 0.0332 0.0652 0.0636
Toxoplasma gondii rhoptry neck protein RON1 0.0665 0.1615 0.1547
Schistosoma mansoni titin 0.0165 0.0168 0.0168
Echinococcus granulosus serine:threonine protein kinase N2 0.0268 0.0466 0.0466
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1235 0.3264 0.3252
Loa Loa (eye worm) hypothetical protein 0.0231 0.0359 0.0351
Schistosoma mansoni titin 0.0362 0.0739 0.0739
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.1235 0.3264 0.3144
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0896 0.2283 0.2283
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0323 0.0626 0.0626
Trichomonas vaginalis CMGC family protein kinase 0.0317 0.0608 0.1843
Brugia malayi Prion-like- 0.0165 0.0168 0.0151
Schistosoma mansoni tyrosine kinase 0.0429 0.0932 0.0932
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0339 0.0671 0.0656
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0281 0.0504 0.0427
Echinococcus multilocularis titin 0.0165 0.0168 0.0168
Brugia malayi map kinase activated protein kinase protein 2 0.0814 0.2046 0.2032
Schistosoma mansoni tyrosine kinase 0.0411 0.0879 0.0879
Brugia malayi hypothetical protein 0.0665 0.1615 0.1601
Echinococcus granulosus neurogenic locus protein delta 0.036 0.0733 0.0733
Plasmodium vivax glutathione reductase, putative 0.3564 1 1
Giardia lamblia Kinase, NEK 0.0281 0.0504 0.105
Entamoeba histolytica hypothetical protein 0.0252 0.0421 0.2204
Leishmania major casein kinase, putative 0.0224 0.034 0.0261
Echinococcus granulosus netrin receptor unc 5 0.0257 0.0435 0.0435
Echinococcus granulosus tyrosine protein kinase Fyn 0.0314 0.0598 0.0598
Onchocerca volvulus Tyrosine kinase homolog 0.0877 0.2227 1
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0299 0.0555 0.0555
Schistosoma mansoni serine/threonine-protein kinase 0.0339 0.0671 0.0671
Loa Loa (eye worm) animal heme peroxidase 0.0165 0.0168 0.016
Echinococcus multilocularis casein kinase I alpha 0.0224 0.034 0.034
Entamoeba histolytica protein kinase, putative 0.0171 0.0187 0.0979
Echinococcus multilocularis leucine rich repeats and immunoglobulin 0.0165 0.017 0.017
Loa Loa (eye worm) hypothetical protein 0.0126 0.0056 0.0047
Treponema pallidum NADH oxidase 0.1235 0.3264 1
Brugia malayi Protein kinase domain containing protein 0.0185 0.0227 0.021
Echinococcus multilocularis cyclin dependent kinase 1 0.0245 0.04 0.04
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.0652 0.0652
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0328 0.064 0.1939
Schistosoma mansoni basigin related 0.0197 0.0263 0.0263
Brugia malayi Muscle positioning protein 4 0.036 0.0733 0.0717
Echinococcus granulosus dual specificity protein kinase clk2 0.0317 0.0608 0.0608
Loa Loa (eye worm) TK/FER protein kinase 0.0134 0.008 0.0072
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Trypanosoma brucei 2,4-dienoyl-coa reductase-like protein 0.0328 0.064 0.0564
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0328 0.064 0.1939
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.1305 0.3983
Leishmania major protein kinase, putative 0.0174 0.0196 0.0117
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0699 0.1712 0.1705
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0174 0.0196 0.1028
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.1235 0.3264 0.3144
Trypanosoma cruzi dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0287 0.0521 0.0505
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0328 0.064 0.1939
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Trichomonas vaginalis AGC family protein kinase 0.0603 0.1436 0.4384
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0328 0.064 0.1939
Loa Loa (eye worm) CMGC/DYRK/DYRK2 protein kinase 0.0287 0.0521 0.0513
Loa Loa (eye worm) hypothetical protein 0.021 0.03 0.0292
Leishmania major protein kinase A catalytic subunit isoform 2 0.0233 0.0366 0.0288
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0456 0.1009 0.1009
Brugia malayi Protein kinase domain containing protein 0.0757 0.1882 0.1868
Giardia lamblia Kinase, CMGC DYRK 0.0287 0.0521 0.1104
Loa Loa (eye worm) LAD-2 short isoform 0.0197 0.0263 0.0254
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0174 0.0196 0.018
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0265 0.0459 0.0382
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0688 0.1682 0.1667
Onchocerca volvulus 0.0165 0.0168 0.0659
Loa Loa (eye worm) hypothetical protein 0.0231 0.0359 0.0351
Entamoeba histolytica protein kinase, putative 0.0188 0.0234 0.1227
Entamoeba histolytica cell division protein kinase 2, putative 0.0245 0.04 0.2097
Brugia malayi Protein kinase domain 0.0177 0.0204 0.0188
Echinococcus granulosus Serine:threonine protein kinase PLK4 0.0299 0.0556 0.0556
Brugia malayi Calcium binding EGF domain containing protein 0.036 0.0733 0.0717
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0328 0.064 0.0564
Trypanosoma brucei kinetoplastid kinetochore protein 10 0.0317 0.0608 0.0532
Entamoeba histolytica casein kinase, putative 0.0206 0.0289 0.1512
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0208 0.0293 0.0293
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0245 0.04 0.04
Echinococcus multilocularis tyrosine protein kinase Abl 0.0193 0.0249 0.0249
Onchocerca volvulus Putative titin 0.0165 0.0168 0.0659
Trypanosoma cruzi serine/arginine-rich protein specific kinase SRPK, putative 0.0171 0.0187 0.017
Loa Loa (eye worm) notch protein 0.036 0.0733 0.0725
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0224 0.034 0.0331
Echinococcus granulosus cyclin dependent kinase 9 0.0122 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0177 0.0204 0.0196
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0328 0.064 0.0624
Echinococcus multilocularis protein kinase c epsilon type 0.0421 0.0909 0.0909
Echinococcus granulosus lachesin 0.0362 0.0739 0.0739
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0265 0.0459 0.0443
Echinococcus multilocularis neurotracting:lsamp:neurotrimin:obcam 0.0362 0.0739 0.0739
Trichomonas vaginalis AGC family protein kinase 0.0242 0.0391 0.1174
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.1235 0.3264 1
Toxoplasma gondii protein kinase, cAMP-dependent, catalytic chain 0.0233 0.0366 0.0288
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Loa Loa (eye worm) hypothetical protein 0.0168 0.0178 0.017
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0328 0.0641 0.0633
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0245 0.04 0.0322
Echinococcus granulosus cyclin dependent kinase 0.0245 0.04 0.04
Schistosoma mansoni serine/threonine protein kinase 0.0526 0.1214 0.1214
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 1 0.0233 0.0366 0.0349
Echinococcus granulosus tyrosine kinase 0.0255 0.043 0.043
Brugia malayi Fibronectin type III domain containing protein 0.0669 0.1625 0.1611
Echinococcus multilocularis notch 0.036 0.0733 0.0733
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.1235 0.3264 0.3252
Schistosoma mansoni hypothetical protein 0.036 0.0733 0.0733
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0328 0.064 0.1939
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0317 0.0608 0.0592
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Echinococcus multilocularis c src tyrosine kinase 0.0193 0.0249 0.0249
Echinococcus granulosus c-Jun N-terminal kinases 0.0545 0.1269 0.1269
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0814 0.2046 0.2046
Schistosoma mansoni serine/threonine-protein kinase 0.0339 0.0671 0.0671
Echinococcus multilocularis lachesin 0.0362 0.0739 0.0739
Schistosoma mansoni hypothetical protein 0.0165 0.0168 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0459 0.1018 0.1018
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0165 0.0168 0.0168
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0446 0.0982 0.0982
Onchocerca volvulus 0.0397 0.084 0.3708
Echinococcus granulosus growth factor receptor bound protein 2 0.0128 0.0062 0.0062
Echinococcus granulosus protein kinase shaggy 0.0265 0.0459 0.0459
Echinococcus granulosus Immunoglobulin subtype 0.0197 0.0263 0.0263
Echinococcus granulosus basement membrane specific heparan sulfate 0.0197 0.0263 0.0263
Brugia malayi MAP kinase sur-1 0.0173 0.0191 0.0174
Echinococcus multilocularis serine:threonine kinase SAD 1 0.0161 0.0157 0.0157
Echinococcus multilocularis Immunoglobulin subtype 0.0197 0.0263 0.0263
Echinococcus multilocularis NCK adaptor protein 0.0128 0.0062 0.0062
Brugia malayi GCC2 and GCC3 family protein 0.1025 0.2656 0.2644
Echinococcus granulosus calcium dependent protein kinase 0.014 0.0097 0.0097
Entamoeba histolytica protein kinase, putative 0.0132 0.0075 0.0392
Brugia malayi hypothetical protein 0.0665 0.1615 0.1601
Echinococcus granulosus serine:threonine protein kinase 0.0235 0.0372 0.0372
Echinococcus granulosus tyrosine protein kinase Fyn 0.0314 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0214 0.0311 0.0302
Onchocerca volvulus Serine\/threonine protein kinase homolog 0.0728 0.1797 0.805
Plasmodium falciparum serine/threonine protein kinase KIN 0.0161 0.0157 0.0077
Echinococcus multilocularis activin receptor type 0.0134 0.008 0.008
Brugia malayi Egg laying defective protein 4 0.0172 0.019 0.0173
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0449 0.0991 0.0983
Schistosoma mansoni serine/threonine protein kinase 0.0446 0.0981 0.0981
Schistosoma mansoni serine/threonine protein kinase 0.0985 0.254 0.254
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0299 0.0555 0.0555
Brugia malayi glutamate synthase 0.0328 0.064 0.0624
Loa Loa (eye worm) CDC7 protein kinase 0.0185 0.0227 0.0218
Onchocerca volvulus 0.036 0.0733 0.3223
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0323 0.0626 0.055
Giardia lamblia Kinase, CMGC CDK 0.0245 0.04 0.0714
Brugia malayi Fes/CIP4 homology domain containing protein 0.0211 0.0301 0.0285
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0231 0.0359 0.0359
Echinococcus multilocularis basement membrane specific heparan sulfate 0.065 0.1571 0.1571
Echinococcus multilocularis netrin receptor unc 5 0.0257 0.0435 0.0435
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1235 0.3264 0.3209
Echinococcus granulosus NDR protein kinase 0.0332 0.0652 0.0652
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0165 0.0168 0.016
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0314 0.0598 0.0598
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0896 0.2283 0.2283
Echinococcus multilocularis cyclin dependent kinase 5 0.0245 0.04 0.04
Echinococcus granulosus mitogen activated protein kinase 11 0.0328 0.0641 0.0641
Entamoeba histolytica protein kinase, putative 0.0603 0.1436 0.7521
Leishmania major dihydrolipoamide dehydrogenase, putative 0.1235 0.3264 0.3209
Echinococcus multilocularis 0.0316 0.0605 0.0605
Entamoeba histolytica protein kinase, putative 0.0287 0.0521 0.2728
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Loa Loa (eye worm) TK/KIN16 protein kinase 0.1559 0.4201 0.4196
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Echinococcus multilocularis aurora kinase A 0.0242 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.0381 0.0795 0.0787
Onchocerca volvulus Slit protein homolog 0.0406 0.0865 0.3823
Echinococcus granulosus roundabout 2 0.0381 0.0793 0.0793
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0154 0.0137 0.0137
Brugia malayi cell division control protein 2 homolog 0.0245 0.04 0.0384
Echinococcus multilocularis casein kinase I alpha 0.0224 0.034 0.034
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0126 0.0056 0.0047
Echinococcus multilocularis 0.0249 0.0413 0.0413
Loa Loa (eye worm) gastrulation defective protein 1 0.0963 0.2476 0.247
Schistosoma mansoni growth factor receptor-bound protein 0.0126 0.0056 0.0056
Trichomonas vaginalis AGC family protein kinase 0.0369 0.0758 0.2301
Trypanosoma brucei protein kinase, putative 0.0265 0.0459 0.0382
Echinococcus granulosus defective proboscis extension response 0.065 0.1571 0.1571
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0177 0.0204 0.0204
Loa Loa (eye worm) cyclin C 0.1516 0.4075 0.407
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Onchocerca volvulus 0.0665 0.1615 0.7224
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Schistosoma mansoni notch 0.036 0.0733 0.0733
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0114 0.0021 0.0012
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.1235 0.3264 1
Schistosoma mansoni serine/threonine protein kinase 0.0485 0.1094 0.1094
Schistosoma mansoni serine/threonine protein kinase 0.0287 0.0521 0.0521
Brugia malayi Protein kinase domain containing protein 0.0171 0.0187 0.017
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0208 0.0293 0.0276
Schistosoma mansoni cell adhesion molecule 0.0197 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0362 0.0739 0.0731
Echinococcus multilocularis dual specificity 0.0287 0.0521 0.0521
Giardia lamblia Thioredoxin reductase 0.0328 0.064 0.149
Echinococcus granulosus cyclin dependent kinase 9 0.0114 0.0021 0.0021
Loa Loa (eye worm) TK/FER protein kinase 0.0134 0.008 0.0072
Onchocerca volvulus 0.036 0.0733 0.3223
Onchocerca volvulus 0.0165 0.0168 0.0659
Trypanosoma cruzi pyridine nucleotide-disulphide oxidoreductase, putative 0.0328 0.064 0.0624
Entamoeba histolytica protein kinase domain containing protein 0.0134 0.008 0.0421
Entamoeba histolytica serine/threonine protein kinase, putative 0.0558 0.1305 0.6837
Echinococcus granulosus roundabout 2 0.1031 0.2673 0.2673
Schistosoma mansoni serine/threonine protein kinase 0.0114 0.0021 0.0021
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0193 0.0249 0.0249
Trichomonas vaginalis CAMK family protein kinase 0.0566 0.1329 0.4055
Trypanosoma cruzi casein kinase, putative 0.0224 0.034 0.0323
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0756 0.1877 0.1877
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0242 0.0391 0.0391
Leishmania major 2,4-dienoyl-coa reductase-like protein 0.0328 0.064 0.0564
Brugia malayi Immunoglobulin domain containing protein 0.0197 0.0263 0.0246
Trichomonas vaginalis CMGC family protein kinase 0.0245 0.04 0.1203
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Schistosoma mansoni serine/threonine protein kinase 0.0168 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0165 0.0168 0.0168
Echinococcus granulosus cyclin dependent kinase 5 0.0245 0.04 0.04
Schistosoma mansoni mitogen-activated protein kinase kinase kinase 3 mapkkk3 mekk3 0.0231 0.0359 0.0359
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0242 0.0391 0.022
Brugia malayi notch-like transmembrane receptor 0.036 0.0733 0.0717
Brugia malayi Cyclin C 0.1516 0.4075 0.4065
Echinococcus granulosus titin 0.0165 0.0168 0.0168
Loa Loa (eye worm) TK/FER protein kinase 0.0134 0.008 0.0072
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0197 0.0263 0.0263
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0323 0.0626 0.046
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0847 0.2142 0.2142
Leishmania major acetoin dehydrogenase e3 component-like protein 0.1235 0.3264 0.3209
Echinococcus multilocularis leucine rich repeat containing protein 4 0.0197 0.0263 0.0263
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.0496 0.0496
Echinococcus granulosus serine/threonine protein kinase 0.0339 0.0671 0.0671
Onchocerca volvulus Neurogenic locus notch homolog 0.036 0.0733 0.3223
Schistosoma mansoni glutamate synthase 0.0328 0.064 0.064
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0231 0.0361 0.0361
Entamoeba histolytica protein kinase, putative 0.0211 0.03 0.1574
Schistosoma mansoni ephrin receptor 0.0199 0.0267 0.0267
Onchocerca volvulus 0.0132 0.0074 0.0233
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0172 0.019 0.019
Schistosoma mansoni serine/threonine protein kinase 0.044 0.0964 0.0964
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1235 0.3264 0.3252
Echinococcus multilocularis tyrosine protein kinase shark 0.0354 0.0715 0.0715
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0017 0.0017
Brugia malayi Protein kinase c protein 2 0.0239 0.0382 0.0365
Echinococcus multilocularis protein jagged 2 0.036 0.0733 0.0733
Trypanosoma cruzi kinetoplastid kinetochore protein 10, putative 0.0317 0.0608 0.0592
Schistosoma mansoni hypothetical protein 0.036 0.0733 0.0733
Onchocerca volvulus 0.0604 0.1437 0.6418
Trypanosoma brucei polo-like protein kinase 0.0558 0.1305 0.1235
Trichomonas vaginalis glutamate synthase, putative 0.0328 0.064 0.1939
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0378 0.1135
Echinococcus granulosus protein kinase 0.0316 0.0605 0.0605
Entamoeba histolytica protein kinase, putative 0.0242 0.0391 0.2047
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0208 0.0293 0.0121
Onchocerca volvulus Peroxidasin homolog 0.0165 0.0168 0.0659
Entamoeba histolytica protein kinase domain containing protein 0.0265 0.0459 0.2405
Brugia malayi basement membrane proteoglycan precursor 0.0197 0.0263 0.0246
Echinococcus granulosus fibropellin Ia 0.036 0.0733 0.0733
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0222 0.0205
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0208 0.0293 0.0285
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0285 0.0517 0.1561
Onchocerca volvulus 0.0134 0.008 0.026
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Echinococcus granulosus homeodomain interacting protein kinase 3 0.0418 0.0901 0.0901
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Echinococcus multilocularis mitogen activated protein kinase 14 0.0328 0.0641 0.0641
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0245 0.04 0.0392
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.1945 0.5318 0.5314
Trypanosoma brucei SNF1-related protein kinases, putative 0.0161 0.0157 0.0077
Loa Loa (eye worm) hypothetical protein 0.0197 0.0263 0.0254
Echinococcus multilocularis serine threonine protein kinase 0.0416 0.0896 0.0896
Echinococcus multilocularis Opioid binding protein:cell adhesion molecule 0.0165 0.0168 0.0168
Echinococcus multilocularis transfer RNA-Phe 0.0183 0.0222 0.0222
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0231 0.0361 0.0361
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0177 0.0204 0.0204
Schistosoma mansoni septate junction protein 0.0362 0.0739 0.0739
Trypanosoma brucei cdc2-related kinase 1 0.0245 0.04 0.0322
Echinococcus multilocularis cyclin dependent kinase 1 0.0245 0.04 0.04
Echinococcus granulosus tyrosine protein kinase ABL1 0.0134 0.008 0.008
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0373 0.0772 0.0772
Trichomonas vaginalis CAMK family protein kinase 0.0448 0.0987 0.3005
Entamoeba histolytica protein kinase, putative 0.0148 0.012 0.0628
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0208 0.0293 0.0214
Echinococcus granulosus Immunoglobulin 0.0197 0.0263 0.0263
Schistosoma mansoni neuroglian 0.0381 0.0793 0.0793
Schistosoma mansoni hypothetical protein 0.0165 0.0168 0.0168
Loa Loa (eye worm) CK1/CK1/CK1-D protein kinase 0.0224 0.034 0.0331
Loa Loa (eye worm) hypothetical protein 0.0295 0.0545 0.0537
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0328 0.064 0.0632
Schistosoma mansoni serine/threonine protein kinase 0.103 0.2672 0.2672
Echinococcus granulosus serine:threonine protein kinase PAK 4 0.0414 0.089 0.089
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0169 0.018 0.0006
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.1235 0.3264 0.2803
Schistosoma mansoni serine/threonine protein kinase 0.019 0.0241 0.0241
Brugia malayi protein unc-22 0.0251 0.0418 0.0401
Trypanosoma cruzi hypothetical protein, conserved 0.0328 0.064 0.0624
Schistosoma mansoni nephrin 0.0381 0.0793 0.0793
Echinococcus multilocularis dual specificity protein kinase clk2 0.0317 0.0608 0.0608
Brugia malayi hypothetical protein 0.0134 0.008 0.0063
Toxoplasma gondii NADPH-glutathione reductase 0.1235 0.3264 0.3209
Echinococcus multilocularis hemicentin 1 0.0362 0.0739 0.0739
Echinococcus granulosus tyrosine protein kinase shark 0.0354 0.0715 0.0715
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0314 0.0598 0.0598
Echinococcus multilocularis N chimaerin 0.0154 0.0137 0.0137
Schistosoma mansoni growth factor receptor-bound protein 0.0128 0.0062 0.0062
Echinococcus granulosus tyrosine protein kinase Srms 0.0553 0.1292 0.1292
Loa Loa (eye worm) CMGC/DYRK/HIPK protein kinase 0.0418 0.0901 0.0893
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0756 0.1877 0.1877
Entamoeba histolytica protein kinase domain containing protein 0.0418 0.0901 0.472
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.0496 0.0496
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0222 0.0205
Echinococcus granulosus titin 0.0165 0.0168 0.0168
Brugia malayi Protein kinase domain containing protein 0.1945 0.5318 0.531
Echinococcus multilocularis Down syndrome cell adhesion molecule 0.0216 0.0316 0.0316
Echinococcus granulosus cGMP dependent protein kinase 0.0172 0.019 0.019
Onchocerca volvulus 0.0165 0.0168 0.0659
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Brugia malayi Immunoglobulin I-set domain containing protein 0.0381 0.0793 0.0777
Onchocerca volvulus 0.0265 0.0459 0.198
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0328 0.064 0.0624
Trypanosoma cruzi cdc2-related kinase 1 0.0245 0.04 0.0384
Echinococcus granulosus protein jagged 1 0.036 0.0733 0.0733
Loa Loa (eye worm) TK/ROR protein kinase 0.0231 0.0361 0.0353
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0281 0.0504 0.0335
Trichomonas vaginalis CMGC family protein kinase 0.0173 0.0191 0.056
Trichomonas vaginalis STE family protein kinase 0.0177 0.0204 0.0601
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.1305 0.3983
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0328 0.064 0.0624
Trypanosoma cruzi NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0328 0.064 0.0624
Trichomonas vaginalis CMGC family protein kinase 0.0287 0.0521 0.1573
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0446 0.0981 0.0981
Echinococcus multilocularis insulin growth factor binding 0.0165 0.0168 0.0168
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0332 0.0652 0.0652
Loa Loa (eye worm) CMGC/SRPK protein kinase 0.0171 0.0187 0.0179
Brugia malayi Protein kinase domain containing protein 0.0252 0.0421 0.0405
Echinococcus granulosus casein kinase I delta 0.0224 0.034 0.034
Onchocerca volvulus 0.036 0.0733 0.3223
Entamoeba histolytica disulphide oxidoreductase, putative 0.0328 0.064 0.3352
Brugia malayi Protein kinase domain containing protein 0.0317 0.0608 0.0592
Echinococcus multilocularis expressed protein 0.0171 0.0187 0.0187
Trichomonas vaginalis AGC family protein kinase 0.0242 0.0391 0.1174
Loa Loa (eye worm) hypothetical protein 0.0184 0.0225 0.0217
Echinococcus multilocularis serine:threonine protein kinase 0.0235 0.0372 0.0372
Echinococcus multilocularis protein kinase c iota type 0.059 0.1397 0.1397
Schistosoma mansoni serine/threonine protein kinase 0.0153 0.0134 0.0134
Schistosoma mansoni hypothetical protein 0.0197 0.0263 0.0263
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 1 0.0233 0.0366 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.0191 0.0191
Trypanosoma cruzi casein kinase, putative 0.0224 0.034 0.0323
Brugia malayi EGF-like domain containing protein 0.036 0.0733 0.0717
Onchocerca volvulus Serine\/threonine kinase homolog 0.0558 0.1305 0.5819
Echinococcus multilocularis maternal embryonic leucine zipper kinase 0.0237 0.0378 0.0378
Echinococcus multilocularis slit 2 protein 0.0406 0.0865 0.0865
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0251 0.0418 0.0409
Brugia malayi SH2 domain containing protein 0.0446 0.0982 0.0967
Echinococcus multilocularis calcium activated potassium channel 0.0278 0.0496 0.0496
Brugia malayi Dual-specificity tyrosine-phosphorylation regulated kinase 2 0.0287 0.0521 0.0505
Echinococcus granulosus cGMP dependent protein kinase 1 0.0172 0.019 0.019
Brugia malayi Immunoglobulin I-set domain containing protein 0.0362 0.0739 0.0723
Loa Loa (eye worm) TK protein kinase 0.0188 0.0234 0.0226
Echinococcus granulosus tyrosine protein kinase Src42A 0.0314 0.0598 0.0598
Echinococcus multilocularis expressed conserved protein 0.0172 0.019 0.019
Echinococcus granulosus C type lectin domian containing protein 0.0665 0.1615 0.1615
Loa Loa (eye worm) hypothetical protein 0.0161 0.0157 0.0148
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0328 0.0641 0.0565
Schistosoma mansoni serine/threonine protein kinase 0.0332 0.0652 0.0652
Loa Loa (eye worm) AUR protein kinase 0.0242 0.0391 0.0383
Schistosoma mansoni hypothetical protein 0.0165 0.0168 0.0168
Brugia malayi Myb-like DNA-binding domain containing protein 0.0165 0.0168 0.0151
Loa Loa (eye worm) hypothetical protein 0.0381 0.0793 0.0785
Onchocerca volvulus 0.0134 0.008 0.026
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0328 0.064 0.1939
Loa Loa (eye worm) TK/EGFR protein kinase 0.0709 0.1741 0.1734
Brugia malayi Protein kinase domain containing protein 0.0313 0.0598 0.0582
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0165 0.0168 0.016
Loa Loa (eye worm) hypothetical protein 0.0328 0.064 0.0632
Loa Loa (eye worm) hypothetical protein 0.065 0.1571 0.1564
Trypanosoma cruzi SNF1-related protein kinases, putative 0.0161 0.0157 0.014
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0728 0.1797 0.179
Schistosoma mansoni hypothetical protein 0.0197 0.0263 0.0263
Echinococcus granulosus calcium activated potassium channel 0.0278 0.0496 0.0496
Echinococcus granulosus hemicentin 1 0.0362 0.0739 0.0739
Schistosoma mansoni tyrosine kinase 0.0314 0.0598 0.0598
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.1235 0.3264 0.3209
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0328 0.064 0.0564
Brugia malayi hypothetical protein 0.0459 0.1018 0.1003
Brugia malayi hypothetical protein 0.0197 0.0263 0.0246
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0314 0.0598 0.0598
Brugia malayi Protein kinase domain containing protein 0.0414 0.089 0.0874
Plasmodium vivax protein kinase Crk2 0.0245 0.04 0.023
Trypanosoma cruzi cdc2-related kinase 3 0.0245 0.04 0.0384
Toxoplasma gondii cell-cycle-associated protein kinase DYRK2, putative 0.0287 0.0521 0.0444
Trypanosoma cruzi 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0161 0.0157 0.014
Schistosoma mansoni serine/threonine kinase 0.0332 0.0652 0.0652
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0233 0.0366 0.0366
Echinococcus granulosus 5' AMP activated protein kinase catalytic 0.026 0.0443 0.0443
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.1305 0.3983
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0157 0.0157
Echinococcus granulosus GTPase activating Rap:RanGAP domain 3 0.0231 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0262 0.0449 0.0441
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.036 0.0733 0.0717
Plasmodium vivax serine/threonine protein kinase, putative 0.0171 0.0187 0.0013
Onchocerca volvulus 0.0665 0.1615 0.7224
Brugia malayi casein kinase I 0.0224 0.034 0.0323
Schistosoma mansoni serine/threonine protein kinase 0.0503 0.1146 0.1146
Schistosoma mansoni hypothetical protein 0.036 0.0733 0.0733
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.3564 1 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0208 0.0293 0.0293
Echinococcus multilocularis C type lectin domian containing protein 0.0665 0.1615 0.1615
Schistosoma mansoni cell adhesion molecule 0.0381 0.0793 0.0793
Echinococcus granulosus neuroglian 0.0815 0.2048 0.2048
Trichomonas vaginalis CMGC family protein kinase 0.0287 0.0521 0.1573
Brugia malayi Protein kinase domain containing protein 0.0168 0.0177 0.0161
Brugia malayi Variant SH3 domain containing protein 0.0154 0.0137 0.012
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0558 0.1305 0.1298
Trypanosoma brucei serine/arginine-rich protein specific kinase SRPK, putative 0.0171 0.0187 0.0107
Brugia malayi Immunoglobulin I-set domain containing protein 0.0362 0.0739 0.0723
Echinococcus multilocularis serine:threonine protein kinase PAK 4 0.0414 0.089 0.089
Echinococcus granulosus neurogenic locus notch protein 0.036 0.0733 0.0733
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Schistosoma mansoni titin 0.0165 0.0168 0.0168
Schistosoma mansoni serine/threonine protein kinase 0.0208 0.0293 0.0293
Echinococcus granulosus neuroglian 0.0381 0.0793 0.0793
Echinococcus granulosus mitogen activated protein kinase 3 0.0173 0.0191 0.0191
Brugia malayi Protein kinase domain containing protein 0.0593 0.1408 0.1393
Brugia malayi Protein kinase domain containing protein 0.0339 0.0671 0.0655
Brugia malayi EGF-like domain containing protein 0.036 0.0733 0.0717
Onchocerca volvulus 0.0183 0.0222 0.0903
Toxoplasma gondii non-proton pumping type-II NADH dehydrogenase I 0.0328 0.064 0.0564
Brugia malayi Protein kinase domain containing protein 0.0134 0.008 0.0063
Echinococcus granulosus Opioid binding protein:cell adhesion molecule 0.0165 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0363 0.0741 0.0733
Loa Loa (eye worm) TK/ALK protein kinase 0.031 0.0588 0.058
Onchocerca volvulus 0.0134 0.008 0.026
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0165 0.0168 0.016
Brugia malayi Protein kinase domain containing protein 0.044 0.0964 0.0949
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0233 0.0366 0.0366
Trichomonas vaginalis CK1 family protein kinase 0.0224 0.034 0.1017
Trichomonas vaginalis CK1 family protein kinase 0.0224 0.034 0.1017
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0197 0.0263 0.0263
Echinococcus granulosus tyrosine protein kinase HCK 0.0188 0.0234 0.0234
Schistosoma mansoni serine/threonine protein kinase 0.0242 0.0391 0.0391
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0314 0.0598 0.0598
Schistosoma mansoni cell adhesion molecule 0.0183 0.0222 0.0222
Trypanosoma cruzi 2,4-dienoyl-coa reductase fadh1, putative 0.0328 0.064 0.0624
Echinococcus granulosus CDC7 cell division cycle 7 0.0185 0.0227 0.0227
Onchocerca volvulus 0.0165 0.0168 0.0659
Echinococcus granulosus serine threonine protein kinase nrc 0.0323 0.0626 0.0626
Brugia malayi Leucine Rich Repeat family protein 0.0165 0.017 0.0153
Brugia malayi Furin-like cysteine rich region family protein 0.0709 0.1741 0.1727
Onchocerca volvulus Putative cubilin 0.036 0.0733 0.3223
Trypanosoma brucei 5'-AMP-activated protein kinase catalytic subunit alpha, putative 0.0161 0.0157 0.0077
Brugia malayi probable protein kinase 0.0547 0.1273 0.1258
Echinococcus multilocularis epidermal growth factor receptor 0.0709 0.1741 0.1741
Trichomonas vaginalis STE family protein kinase 0.0177 0.0204 0.0601
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0157 0.0157
Loa Loa (eye worm) one IG domain family member 0.0165 0.0168 0.016
Trypanosoma cruzi cdc2-related kinase 3 0.0245 0.04 0.0384
Loa Loa (eye worm) CAMK/PIM protein kinase 0.0728 0.1797 0.179
Schistosoma mansoni hypothetical protein 0.0183 0.0222 0.0222
Schistosoma mansoni adapter molecule crk 0.0126 0.0056 0.0056
Echinococcus granulosus casein kinase i 0.0224 0.034 0.034
Schistosoma mansoni hypothetical protein 0.0197 0.0263 0.0263
Trichomonas vaginalis AGC family protein kinase 0.0168 0.0177 0.0518
Plasmodium falciparum casein kinase 1 0.0224 0.034 0.0261
Schistosoma mansoni netrin receptor unc5 0.0257 0.0435 0.0435
Giardia lamblia Aurora kinase 0.0242 0.0391 0.0683
Loa Loa (eye worm) TK/FER protein kinase 0.0134 0.008 0.0072
Schistosoma mansoni serine/threonine protein kinase 0.0503 0.1146 0.1146
Brugia malayi STE20-like kinase MST 0.053 0.1225 0.121
Schistosoma mansoni titin 0.0165 0.0168 0.0168
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0314 0.0598 0.0598
Echinococcus granulosus casein kinase I gamma 0.044 0.0964 0.0964
Echinococcus granulosus c4b binding protein beta chain 0.0665 0.1615 0.1615
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0635 0.1527 0.1527
Schistosoma mansoni serine/threonine protein kinase 0.0252 0.0421 0.0421
Echinococcus multilocularis casein kinase I gamma 0.044 0.0964 0.0964
Trichomonas vaginalis AGC family protein kinase 0.0353 0.0712 0.2162
Loa Loa (eye worm) hypothetical protein 0.0287 0.0521 0.0513
Echinococcus granulosus tyrosine kinase 0.0134 0.008 0.008
Brugia malayi Immunoglobulin domain containing protein 0.0197 0.0263 0.0246
Plasmodium falciparum glutathione reductase 0.3564 1 1
Onchocerca volvulus 0.0231 0.0359 0.1527
Echinococcus multilocularis 0.0165 0.0168 0.0168
Echinococcus granulosus tyrosine protein kinase Blk 0.0255 0.043 0.043
Entamoeba histolytica cyclin C, putative 0.0767 0.1909 1
Loa Loa (eye worm) hypothetical protein 0.0479 0.1077 0.107
Giardia lamblia Glutamate synthase 0.0328 0.064 0.149
Onchocerca volvulus Neurogenic locus notch protein homolog 0.036 0.0733 0.3223
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0328 0.064 0.1939
Brugia malayi Immunoglobulin I-set domain containing protein 0.0538 0.1248 0.1233
Loa Loa (eye worm) AGC/NDR protein kinase 0.0332 0.0652 0.0644
Brugia malayi Immunoglobulin I-set domain containing protein 0.021 0.03 0.0284
Trichomonas vaginalis STE family protein kinase 0.0281 0.0504 0.1521
Brugia malayi Protein kinase domain containing protein 0.031 0.0588 0.0572
Brugia malayi Stress-activated protein kinase jnk-1 0.0545 0.1269 0.1254
Plasmodium vivax serine/threonine kinase-1, putative 0.0317 0.0608 0.0442
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0242 0.0391 0.2047
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0314 0.0598 0.0598
Onchocerca volvulus 0.0665 0.1615 0.7224
Trypanosoma brucei casein kinase I, isoform 2 0.0224 0.034 0.0261
Loa Loa (eye worm) TK/FER protein kinase 0.0134 0.008 0.0072
Plasmodium vivax NAD(P)H-dependent glutamate synthase, putative 0.0328 0.064 0.0474
Schistosoma mansoni hypothetical protein 0.021 0.03 0.03
Schistosoma mansoni notch 0.036 0.0733 0.0733
Onchocerca volvulus 0.0251 0.0418 0.1792
Brugia malayi Protein kinase domain containing protein 0.0134 0.008 0.0063
Echinococcus multilocularis fibropellin Ia 0.036 0.0733 0.0733
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0134 0.008 0.008
Echinococcus granulosus fibroblast growth factor receptor 4 0.0373 0.0772 0.0772
Brugia malayi Immunoglobulin I-set domain containing protein 0.0381 0.0793 0.0777
Loa Loa (eye worm) STE/STE20/SLK protein kinase 0.0398 0.0842 0.0835
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Schistosoma mansoni septate junction protein 0.0197 0.0263 0.0263
Brugia malayi Protein kinase domain containing protein 0.0651 0.1574 0.1559
Brugia malayi Immunoglobulin I-set domain containing protein 0.0362 0.0739 0.0723
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0173 0.0191 0.0174
Toxoplasma gondii aurora kinase 0.0242 0.0391 0.0313
Schistosoma mansoni cell adhesion molecule 0.0197 0.0263 0.0263
Loa Loa (eye worm) TK protein kinase 0.0538 0.1248 0.1241
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.04 0.04
Entamoeba histolytica p21-activated kinase 0.0193 0.0249 0.1307
Toxoplasma gondii NADH dehydrogenase (NDH2-II) 0.0328 0.064 0.0564
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0233 0.0366 0.0349
Echinococcus granulosus hypothetical protein 0.0249 0.0413 0.0413
Schistosoma mansoni nephrin related 0.0197 0.0263 0.0263
Leishmania major trypanothione reductase 0.3564 1 1
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0328 0.0641 0.0625
Echinococcus granulosus low density lipoprotein receptor ldl 0.0197 0.0263 0.0263
Echinococcus granulosus STE20 serine:threonine protein kinase 0.1021 0.2644 0.2644
Loa Loa (eye worm) AGC/PKN protein kinase 0.06 0.1426 0.1419
Trypanosoma brucei Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0231 0.0359 0.0281
Schistosoma mansoni Neurotrimin precursor (hNT) 0.065 0.1571 0.1571
Trichomonas vaginalis AGC family protein kinase 0.0603 0.1436 0.4384
Echinococcus granulosus tyrosine protein kinase Lyn 0.0381 0.0794 0.0794
Echinococcus granulosus protein jagged 1 0.036 0.0733 0.0733
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0208 0.0293 0.0285
Schistosoma mansoni tyrosine kinase 0.0354 0.0715 0.0715
Schistosoma mansoni hypothetical protein 0.036 0.0733 0.0733
Plasmodium vivax apical sushi protein, putative 0.0665 0.1615 0.1466
Schistosoma mansoni sulfide quinone reductase 0.0328 0.064 0.064
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0328 0.064 0.064
Brugia malayi Protein kinase domain containing protein 0.0235 0.0372 0.0356
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0503 0.1146 0.1146
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0314 0.0598 0.0598
Echinococcus multilocularis death associated protein kinase 1 0.0906 0.2312 0.2312
Plasmodium falciparum serine/threonine protein kinase 0.0171 0.0187 0.0107
Onchocerca volvulus 0.0156 0.0144 0.055
Loa Loa (eye worm) TK/FER protein kinase 0.0134 0.008 0.0072
Loa Loa (eye worm) hypothetical protein 0.0184 0.0225 0.0217
Onchocerca volvulus 0.0665 0.1615 0.7224
Trypanosoma cruzi casein kinase, putative 0.0224 0.034 0.0323
Schistosoma mansoni protein kinase C mu 0.0449 0.0991 0.0991
Toxoplasma gondii cell-cycle-associated protein kinase CLK, putative 0.0317 0.0608 0.0532
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0328 0.064 0.064
Brugia malayi Prion-like- 0.0165 0.0168 0.0151
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0332 0.0652 0.0652
Brugia malayi serine/threonine-protein kinase PAK 7 0.0479 0.1077 0.1062
Schistosoma mansoni cell adhesion molecule 0.0165 0.0168 0.0168
Echinococcus multilocularis roundabout 2 0.0381 0.0793 0.0793
Onchocerca volvulus Basement membrane proteoglycan homolog 0.0362 0.0739 0.3251
Plasmodium falciparum calcium-dependent protein kinase 4 0.0208 0.0293 0.0214
Entamoeba histolytica protein kinase, putative 0.0252 0.0421 0.2204
Loa Loa (eye worm) hypothetical protein 0.0183 0.0222 0.0213
Onchocerca volvulus 0.0665 0.1615 0.7224
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0227 0.067
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.1235 0.3264 1
Trichomonas vaginalis glutamate synthase, putative 0.0328 0.064 0.1939
Brugia malayi Immunoglobulin I-set domain containing protein 0.1559 0.4201 0.4191
Plasmodium falciparum glutathione reductase 0.1235 0.3264 0.3209
Echinococcus multilocularis neurogenic locus notch protein 0.036 0.0733 0.0733
Entamoeba histolytica protein kinase, putative 0.0587 0.1391 0.7285
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Echinococcus granulosus neurogenic locus notch protein 4 0.036 0.0733 0.0733
Schistosoma mansoni tyrosine kinase 0.0286 0.0519 0.0519
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0265 0.0459 0.0382
Schistosoma mansoni serine/threonine protein kinase 0.0545 0.1269 0.1269
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.1235 0.3264 0.2803
Brugia malayi Temporarily assigned gene name protein 59 0.0231 0.0359 0.0343
Trichomonas vaginalis AGC family protein kinase 0.0168 0.0177 0.0518
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0134 0.008 0.0064
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0154 0.0137 0.0128
Schistosoma mansoni titin 0.0165 0.0168 0.0168
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Leishmania major NADH dehydrogenase, putative 0.0328 0.064 0.0564
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0314 0.0598 0.0598
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0265 0.0459 0.0451
Trichomonas vaginalis CAMK family protein kinase 0.0237 0.0378 0.1135
Echinococcus multilocularis serine:threonine protein kinase N2 0.0268 0.0466 0.0466
Echinococcus granulosus 3'partial|cell adhesion molecule:down regulated by 0.0197 0.0263 0.0263
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0314 0.0598 0.0598
Echinococcus multilocularis c4b binding protein beta chain 0.0665 0.1615 0.1615
Schistosoma mansoni serine/threonine protein kinase 0.0485 0.1094 0.1094
Schistosoma mansoni hypothetical protein 0.0165 0.0168 0.0168
Echinococcus granulosus titin 0.0251 0.0418 0.0418
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Trypanosoma cruzi trypanothione reductase, putative 0.3564 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0134 0.008 0.0419
Echinococcus multilocularis hypothetical protein 0.021 0.03 0.03
Echinococcus granulosus peroxidasin 0.0363 0.0741 0.0741
Loa Loa (eye worm) hypothetical protein 0.0669 0.1625 0.1618
Echinococcus multilocularis low density lipoprotein receptor (ldl) 0.0197 0.0263 0.0263
Trichomonas vaginalis CMGC family protein kinase 0.0173 0.0191 0.056
Echinococcus granulosus NCK adaptor protein 0.0126 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0197 0.0263 0.0263
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Brugia malayi serine/threonine-protein kinase 6 0.0242 0.0391 0.0375
Schistosoma mansoni subfamily M23B non-peptidase homologue (M23 family) 0.0165 0.0168 0.0168
Plasmodium falciparum protein serine/threonine kinase-1 0.0317 0.0608 0.0532
Leishmania major hypothetical protein, conserved 0.0328 0.064 0.0564
Schistosoma mansoni basigin related 0.0197 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0381 0.0793 0.0785
Trichomonas vaginalis CAMK family protein kinase 0.0235 0.0372 0.1117
Schistosoma mansoni sulfide quinone reductase 0.0328 0.064 0.064
Brugia malayi EGF-like domain containing protein 0.036 0.0733 0.0717
Brugia malayi Immunoglobulin I-set domain containing protein 0.0669 0.1625 0.1611
Echinococcus granulosus Glutaredoxin protein 5 0.0255 0.043 0.043
Echinococcus multilocularis serine:threonine protein kinase 3 0.053 0.1225 0.1225
Echinococcus multilocularis cyclin dependent kinase 9 0.0122 0.0044 0.0044
Echinococcus granulosus serine:threonine protein kinase mig 15 0.0479 0.1077 0.1077
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0252 0.0421 0.0343
Loa Loa (eye worm) TK/FAK protein kinase 0.0593 0.1408 0.14
Loa Loa (eye worm) CAMK/CAMKL/BRSK protein kinase 0.0161 0.0157 0.0148
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0289 0.086
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Brugia malayi EGF-like domain containing protein 0.036 0.0733 0.0717
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Onchocerca volvulus 0.0381 0.0795 0.3503
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Echinococcus granulosus mitogen activated protein kinase 14 0.0328 0.0641 0.0641
Trichomonas vaginalis STE family protein kinase 0.0177 0.0204 0.0601
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0231 0.0359 0.0343
Echinococcus multilocularis homeodomain interacting protein kinase 3 0.0418 0.0901 0.0901
Echinococcus multilocularis thioredoxin glutathione reductase 0.3564 1 1
Schistosoma mansoni protein kinase 0.0242 0.0391 0.0391
Brugia malayi Sushi domain 0.0665 0.1615 0.1601
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Plasmodium vivax ferrodoxin reductase, putative 0.0328 0.064 0.0474
Plasmodium falciparum serine/threonine protein kinase, putative 0.0242 0.0391 0.0313
Brugia malayi C1-like domain containing protein 0.0449 0.0991 0.0975
Leishmania major dihydrolipoamide dehydrogenase, putative 0.1235 0.3264 0.3209
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0154 0.0137 0.0137
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0208 0.0293 0.0121
Echinococcus granulosus activin receptor type 0.0134 0.008 0.008
Echinococcus granulosus nephrin 0.0183 0.0222 0.0222
Trypanosoma brucei aurora B kinase 0.0242 0.0391 0.0313
Echinococcus granulosus p21 activated protein kinase 1 Dpak1 0.0177 0.0204 0.0204
Echinococcus granulosus cGMP dependent protein kinase 1 0.0172 0.019 0.019
Echinococcus granulosus dual specificity 0.0252 0.0421 0.0421
Echinococcus granulosus casein kinase I alpha 0.0224 0.034 0.034
Brugia malayi Prion-like- 0.0165 0.0168 0.0151
Giardia lamblia Kinase, CMGC SRPK 0.0171 0.0187 0.0022
Trypanosoma cruzi casein kinase II, putative 0.0206 0.0289 0.0272
Entamoeba histolytica protein kinase domain containing protein 0.0114 0.0021 0.0108
Toxoplasma gondii thioredoxin reductase 0.3564 1 1
Entamoeba histolytica protein kinase, putative 0.0148 0.012 0.0628
Echinococcus multilocularis insulin receptor 0.0616 0.1473 0.1473
Brugia malayi Immunoglobulin I-set domain containing protein 0.0197 0.0263 0.0246
Giardia lamblia Kinase, CDC7 0.0185 0.0227 0.0151
Echinococcus granulosus tyrosine protein kinase Src64B 0.0314 0.0598 0.0598
Schistosoma mansoni serine/threonine protein kinase 0.0814 0.2046 0.2046
Loa Loa (eye worm) hypothetical protein 0.0183 0.0222 0.0213
Echinococcus multilocularis neurogenic locus notch protein 0.036 0.0733 0.0733
Echinococcus multilocularis protein kinase shaggy 0.0265 0.0459 0.0459
Trypanosoma brucei protein kinase, putative 0.0181 0.0214 0.0135
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0289 0.086
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.0366 0.0366
Schistosoma mansoni serine/threonine kinase 0.0456 0.101 0.101
Echinococcus granulosus c src tyrosine kinase 0.0193 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0362 0.0739 0.0731
Echinococcus multilocularis PAK box P21 Rho binding 0.0132 0.0075 0.0075
Schistosoma mansoni serine/threonine protein kinase 0.0421 0.0909 0.0909
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.019 0.019
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.053 0.1225 0.1217
Echinococcus multilocularis Immunoglobulin 0.0197 0.0263 0.0263
Schistosoma mansoni nephrin 0.0833 0.2102 0.2102
Loa Loa (eye worm) hypothetical protein 0.0231 0.0359 0.0351
Loa Loa (eye worm) glutathione reductase 0.3564 1 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.1235 0.3264 0.3209
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0448 0.0989 0.0981
Echinococcus multilocularis roundabout 2 0.0381 0.0793 0.0793
Brugia malayi Immunoglobulin I-set domain containing protein 0.0381 0.0793 0.0777
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0328 0.064 0.1939
Loa Loa (eye worm) hypothetical protein 0.0197 0.0263 0.0254
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0171 0.0187 0.0107
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0265 0.0459 0.0451
Trichomonas vaginalis STE family protein kinase 0.0177 0.0204 0.0601
Loa Loa (eye worm) CAMK protein kinase 0.0251 0.0418 0.0409
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0172 0.019 0.019
Brugia malayi SRC-1 0.0314 0.0598 0.0582
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.0757 0.1882 0.1875
Onchocerca volvulus 0.0224 0.034 0.1438
Echinococcus multilocularis calcium dependent protein kinase 0.014 0.0097 0.0097
Echinococcus granulosus casein kinase I alpha 0.0224 0.034 0.034
Schistosoma mansoni tyrosine kinase 0.0428 0.0929 0.0929
Echinococcus granulosus Immunoglobulin 0.0197 0.0263 0.0263
Plasmodium vivax thioredoxin reductase, putative 0.3564 1 1
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0328 0.064 0.064
Loa Loa (eye worm) CAMK/PHK protein kinase 0.0339 0.0671 0.0663
Entamoeba histolytica PH domain containing protein kinase, putative 0.0339 0.0671 0.3517
Schistosoma mansoni protein kinase 0.0896 0.2283 0.2283
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0328 0.064 0.064
Loa Loa (eye worm) hypothetical protein 0.0953 0.2448 0.2442
Loa Loa (eye worm) STE/STE20/MSN protein kinase 0.0316 0.0605 0.0597
Echinococcus multilocularis dual specificity 0.0252 0.0421 0.0421
Schistosoma mansoni hypothetical protein 0.0231 0.0359 0.0359
Echinococcus multilocularis neuroglian 0.0381 0.0793 0.0793
Brugia malayi EST embl|AI107989|AI107989 comes from the 3' UTR, putative 0.026 0.0443 0.0427
Schistosoma mansoni tyrosine kinase 0.0132 0.0072 0.0072
Plasmodium vivax cAMP-dependent protein kinase catalytic subunit, putative 0.0233 0.0366 0.0195
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0338 0.0669 0.0661
Brugia malayi Protein kinase domain containing protein 0.04 0.0848 0.0832
Plasmodium falciparum calcium-dependent protein kinase 1 0.0208 0.0293 0.0214
Echinococcus multilocularis mitogen activated protein kinase 0.0173 0.0191 0.0191
Echinococcus granulosus leucine rich repeat containing protein 4 0.0165 0.0168 0.0168
Giardia lamblia Kinase, CMGC CDK 0.0245 0.04 0.0714
Brugia malayi Temporarily assigned gene name protein 59 0.0266 0.0462 0.0446
Schistosoma mansoni cell polarity protein 0.036 0.0733 0.0733
Leishmania major protein kinase, putative 0.0317 0.0608 0.0532
Echinococcus multilocularis mitogen activated protein kinase 11 0.0328 0.0641 0.0641
Brugia malayi Immunoglobulin I-set domain containing protein 0.0362 0.0739 0.0723
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0314 0.0598 0.0598
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0328 0.064 0.064
Leishmania major serine/threonine protein kinase, putative,protein kinase, putative 0.0161 0.0157 0.0077
Echinococcus multilocularis epidermal growth factor receptor 0.0495 0.1122 0.1122
Echinococcus multilocularis Serine:threonine protein kinase PLK4 0.0299 0.0556 0.0556
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Schistosoma mansoni tyrosine kinase 0.0373 0.0772 0.0772
Trichomonas vaginalis AGC family protein kinase 0.0242 0.0391 0.1174
Brugia malayi Protein kinase domain containing protein 0.0353 0.0712 0.0697
Brugia malayi cyclin-dependent kinase 9 0.0114 0.0021 0.0004
Brugia malayi Prion-like- 0.0362 0.0739 0.0723
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0126 0.0056 0.0047
Echinococcus granulosus serine:threonine protein kinase N2 0.06 0.1426 0.1426
Loa Loa (eye worm) hypothetical protein 0.0197 0.0263 0.0254
Echinococcus multilocularis neural cadherin 0.036 0.0733 0.0733
Brugia malayi Cadherin domain containing protein 0.036 0.0733 0.0718
Trichomonas vaginalis CAMK family protein kinase 0.0261 0.0445 0.1342
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.1235 0.3264 1
Brugia malayi hypothetical protein 0.0665 0.1615 0.1601
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.1235 0.3264 0.3264
Loa Loa (eye worm) SRC-1 0.0314 0.0598 0.059
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0173 0.0191 0.0174
Leishmania major protein kinase, putative 0.0208 0.0293 0.0214
Trypanosoma brucei NADH dehydrogenase 0.0328 0.064 0.0564
Schistosoma mansoni serine/threonine protein kinase 0.026 0.0443 0.0443
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0328 0.064 0.3352
Loa Loa (eye worm) hypothetical protein 0.1012 0.2619 0.2612
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0173 0.0191 0.0174
Echinococcus granulosus serine:threonine protein kinase PAK 3 0.0177 0.0204 0.0204
Echinococcus multilocularis twitchin 0.0232 0.0364 0.0364
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0381 0.0793 0.0793
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0233 0.0366 0.0366
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0456 0.1009 0.1009
Schistosoma mansoni slit 0.0361 0.0735 0.0735
Trichomonas vaginalis AGC family protein kinase 0.0353 0.0712 0.2162
Trichomonas vaginalis CMGC family protein kinase 0.0173 0.0191 0.056
Trypanosoma brucei pyridine nucleotide-disulphide oxidoreductase, putative 0.0328 0.064 0.0564
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0174 0.0196 0.1028
Brugia malayi Protein kinase domain containing protein 0.0134 0.008 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0242 0.0391 0.1174
Brugia malayi Calcium binding EGF domain containing protein 0.036 0.0733 0.0717
Schistosoma mansoni nephrin related 0.0165 0.0168 0.0168
Schistosoma mansoni ste20-related kinase 0.0423 0.0916 0.0916
Loa Loa (eye worm) hypothetical protein 0.0208 0.0293 0.0285
Echinococcus multilocularis phosphorylase kinase gamma subunit 0.0339 0.0671 0.0671
Echinococcus multilocularis dual specificity 0.0287 0.0521 0.0521
Plasmodium falciparum NAD(P)H-dependent glutamate synthase, putative 0.0328 0.064 0.0564
Trichomonas vaginalis AGC family protein kinase 0.034 0.0675 0.2047
Brugia malayi Immunoglobulin I-set domain containing protein 0.0198 0.0264 0.0248
Echinococcus granulosus roundabout 2 0.0381 0.0793 0.0793
Echinococcus granulosus glutamate synthase 0.0328 0.064 0.064
Echinococcus granulosus Protein kinase C brain isozyme 0.0503 0.1146 0.1146
Echinococcus granulosus proto oncogene serine:threonine protein kinase 0.0728 0.1797 0.1797
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0242 0.0391 0.2047
Brugia malayi Cadherin domain containing protein 0.036 0.0733 0.0718
Brugia malayi Tyrosine-protein kinase abl-1 0.0193 0.0249 0.0232
Trypanosoma cruzi aurora B kinase, putative 0.0242 0.0391 0.0375
Echinococcus multilocularis roundabout 2 0.1031 0.2673 0.2673
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0328 0.064 0.0624
Toxoplasma gondii AGC kinase 0.0233 0.0366 0.0288
Schistosoma mansoni serine/threonine protein kinase 0.0251 0.0418 0.0418
Loa Loa (eye worm) hypothetical protein 0.0847 0.2142 0.2136
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0323 0.0626 0.061
Echinococcus multilocularis titin 0.0251 0.0418 0.0418
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0381 0.0793 0.0793
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Echinococcus multilocularis rho associated protein kinase 0.0671 0.1633 0.1633
Brugia malayi Protein kinase domain containing protein 0.0289 0.0527 0.0511
Schistosoma mansoni cell adhesion molecule 0.0381 0.0793 0.0793
Plasmodium falciparum ferrodoxin reductase-like protein 0.0328 0.064 0.0564
Onchocerca volvulus 0.0671 0.1633 0.7306
Schistosoma mansoni glutamate synthase 0.0328 0.064 0.064
Echinococcus multilocularis neurogenic locus notch protein 4 0.036 0.0733 0.0733
Schistosoma mansoni vesicular amine transporter 0.065 0.1571 0.1571
Echinococcus granulosus leucine rich repeats and immunoglobulin 0.0165 0.017 0.017
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0208 0.0293 0.0293
Brugia malayi p70 ribosomal S6 kinase beta 0.0587 0.1391 0.1376
Echinococcus granulosus serine:threonine kinase SAD 1 0.0161 0.0157 0.0157
Onchocerca volvulus 0.0165 0.0168 0.0659
Brugia malayi serine/threonine protein kinase 6 0.0242 0.0391 0.0375
Schistosoma mansoni nck2/grb4 0.0126 0.0056 0.0056
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0289 0.086
Echinococcus multilocularis cyclin dependent kinase 19 0.103 0.2672 0.2672
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0328 0.064 0.064
Echinococcus granulosus contactin 0.0381 0.0793 0.0793
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0926 0.237 0.2364
Entamoeba histolytica casein kinase, putative 0.0224 0.034 0.1779
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.065 0.1571 0.1571
Loa Loa (eye worm) TK protein kinase 0.0379 0.0787 0.0779
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Trichomonas vaginalis glutathione reductase, putative 0.1235 0.3264 1
Entamoeba histolytica protein kinase, putative 0.0135 0.0083 0.0433
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0328 0.064 0.0564
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Echinococcus multilocularis raf serine:threonine protein kinase 0.0153 0.0134 0.0134
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0907 0.2316 0.2303
Schistosoma mansoni protein kinase 0.0547 0.1273 0.1273
Plasmodium falciparum cGMP-dependent protein kinase 0.0172 0.019 0.011
Echinococcus multilocularis rac serine:threonine kinase 0.0339 0.0671 0.0671
Echinococcus multilocularis protein tyrosine kinase 0.0587 0.139 0.139
Echinococcus granulosus protein tyrosine kinase 0.0587 0.139 0.139
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0252 0.0421 0.0343
Echinococcus granulosus enhancer of mRNA decapping protein 4 0.0165 0.017 0.017
Trypanosoma brucei Casein kinase II 0.0206 0.0289 0.021
Loa Loa (eye worm) camk/dcamkl protein kinase 0.0311 0.0591 0.0583
Schistosoma mansoni protein kinase 0.0134 0.008 0.008
Leishmania major protein kinase, putative,SNF1-related protein kinases, putative 0.0161 0.0157 0.0077
Trichomonas vaginalis STE family protein kinase 0.0174 0.0196 0.0576
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0154 0.0137 0.0137
Schistosoma mansoni peroxidasin 0.0198 0.0264 0.0264
Loa Loa (eye worm) casein kinase 0.0372 0.0769 0.0761
Echinococcus granulosus dual specificity 0.0287 0.0521 0.0521
Loa Loa (eye worm) TK/FER protein kinase 0.0134 0.008 0.0072
Brugia malayi kettin 0.0165 0.0168 0.0151
Brugia malayi ephrin receptor 1 precursor 0.0129 0.0065 0.0048
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0362 0.0739 0.0739
Schistosoma mansoni septate junction protein 0.0362 0.0739 0.0739
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0154 0.0137 0.0137
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0168 0.0177 0.0177
Schistosoma mansoni titin 0.0251 0.0418 0.0418
Toxoplasma gondii AGC kinase 0.0587 0.1391 0.1321
Echinococcus granulosus insulin receptor 0.0616 0.1473 0.1473
Plasmodium vivax glycogen synthase kinase 3, putative 0.0265 0.0459 0.029
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0328 0.0641 0.0625
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0506 0.1154 0.1147
Schistosoma mansoni protein kinase 0.0896 0.2283 0.2283
Echinococcus multilocularis hemicentin 1 0.0362 0.0739 0.0739
Echinococcus granulosus mitogen activated protein kinase 0.0173 0.0191 0.0191
Brugia malayi EGF-like domain containing protein 0.0406 0.0865 0.085
Plasmodium falciparum calcium-dependent protein kinase 5 0.0208 0.0293 0.0214
Plasmodium falciparum thioredoxin reductase 0.1235 0.3264 0.3209
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0328 0.064 0.1939
Toxoplasma gondii AGC kinase 0.0233 0.0366 0.0288
Loa Loa (eye worm) TK/FER protein kinase 0.0134 0.008 0.0072
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0252 0.0421 0.0405
Entamoeba histolytica hypothetical protein 0.0391 0.0822 0.4305
Brugia malayi SH2 domain containing protein 0.0134 0.008 0.0063
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0134 0.008 0.0064
Brugia malayi EGF-like domain containing protein 0.036 0.0733 0.0717
Schistosoma mansoni tyrosine kinase 0.0495 0.1122 0.1122
Loa Loa (eye worm) hypothetical protein 0.0651 0.1574 0.1566
Plasmodium falciparum apical sushi protein 0.0665 0.1615 0.1547
Trichomonas vaginalis AGC family protein kinase 0.0233 0.0366 0.1097
Schistosoma mansoni glutamate synthase 0.0328 0.064 0.064
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Schistosoma mansoni serine/threonine protein kinase 0.0418 0.0901 0.0901
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.1235 0.3264 0.3264
Loa Loa (eye worm) hypothetical protein 0.0665 0.1615 0.1608
Plasmodium falciparum NIMA related kinase 1 0.0281 0.0504 0.0427
Brugia malayi Wrapper/rega-1/klingon homolog protein 1 0.0165 0.0168 0.0151
Schistosoma mansoni kinase 0.0114 0.0021 0.0021
Schistosoma mansoni notch 0.036 0.0733 0.0733
Entamoeba histolytica protein kinase, putative 0.0265 0.0459 0.2405
Brugia malayi Kinase associated domain 1 family protein 0.021 0.03 0.0284
Schistosoma mansoni laminin gamma-3 chain 0.036 0.0733 0.0733
Schistosoma mansoni c4b-binding protein beta chain 0.0665 0.1615 0.1615
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0173 0.0191 0.0111
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0168 0.0177 0.0169
Echinococcus multilocularis 5' AMP activated protein kinase catalytic 0.026 0.0443 0.0443
Schistosoma mansoni hypothetical protein 0.0328 0.064 0.064
Echinococcus multilocularis glutamate synthase 0.0328 0.064 0.064
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0112 0.0017 0.0008
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0208 0.0293 0.0293
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.1305 0.3983
Schistosoma mansoni serine/threonine protein kinase 0.06 0.1426 0.1426
Echinococcus multilocularis growth factor receptor bound protein 2 0.0126 0.0056 0.0056
Echinococcus multilocularis tyrosine protein kinase 0.0313 0.0598 0.0598
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0446 0.0981 0.0981
Schistosoma mansoni protein kinase 0.0177 0.0204 0.0204
Echinococcus multilocularis serine:threonine protein kinase 38 0.0332 0.0652 0.0652
Leishmania major hypothetical protein, conserved 0.0328 0.064 0.0564
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0208 0.0293 0.0293
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0446 0.0982 0.0982
Echinococcus granulosus slit 2 protein 0.0406 0.0865 0.0865
Loa Loa (eye worm) hypothetical protein 0.0134 0.008 0.0072
Echinococcus multilocularis neuroglian 0.0815 0.2048 0.2048
Loa Loa (eye worm) hypothetical protein 0.1025 0.2656 0.265
Echinococcus multilocularis neurogenic locus protein delta 0.036 0.0733 0.0733
Loa Loa (eye worm) TK/FER protein kinase 0.0134 0.008 0.0072
Schistosoma mansoni protein kinase 0.0757 0.1882 0.1882
Brugia malayi Variant SH3 domain containing protein 0.0126 0.0056 0.0039
Loa Loa (eye worm) TK/EPH protein kinase 0.0235 0.0372 0.0364
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0126 0.0056 0.0056
Loa Loa (eye worm) AGC/AKT protein kinase 0.0603 0.1436 0.1428
Entamoeba histolytica protein kinase 2, putative 0.0323 0.0626 0.328
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0907 0.2316 0.2303
Echinococcus multilocularis casein kinase ii subunit alpha 0.0206 0.0289 0.0289
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0216 0.0316 0.0308
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Loa Loa (eye worm) TK protein kinase 0.0313 0.0598 0.059
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0183 0.0222 0.0213
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0255 0.043 0.043
Schistosoma mansoni netrin receptor unc5 0.0197 0.0263 0.0263
Brugia malayi Cyclin, N-terminal domain containing protein 0.0756 0.1877 0.1864
Onchocerca volvulus Peroxidasin homolog 0.0165 0.017 0.0666
Echinococcus granulosus protein jagged 2 0.036 0.0733 0.0733
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0245 0.04 0.0322
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0208 0.0293 0.0214
Trypanosoma brucei hypothetical protein, conserved 0.0328 0.064 0.0564
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Trichomonas vaginalis CAMK family protein kinase 0.0261 0.0445 0.1342
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Schistosoma mansoni serine/threonine protein kinase 0.0172 0.019 0.019
Brugia malayi Protein kinase domain containing protein 0.0127 0.006 0.0043
Onchocerca volvulus 0.0665 0.1615 0.7224
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.1235 0.3264 0.3252
Mycobacterium ulcerans flavoprotein disulfide reductase 0.1235 0.3264 1
Echinococcus granulosus pro neuregulin 2 membrane bound 0.0197 0.0263 0.0263
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0222 0.0205
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0635 0.1527 0.1527
Loa Loa (eye worm) hypothetical protein 0.0287 0.0521 0.0513
Loa Loa (eye worm) hypothetical protein 0.0665 0.1615 0.1608
Loa Loa (eye worm) TK/ABL protein kinase 0.0134 0.008 0.0072
Loa Loa (eye worm) hypothetical protein 0.038 0.0789 0.0781
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0197 0.0263 0.0263
Loa Loa (eye worm) AGC/PKA protein kinase 0.0233 0.0366 0.0357
Schistosoma mansoni serine/threonine protein kinase 0.0506 0.1154 0.1154
Onchocerca volvulus 0.0134 0.008 0.026
Echinococcus multilocularis casein kinase I delta 0.0224 0.034 0.034
Trichomonas vaginalis apoptosis inducing factor, putative 0.0328 0.064 0.1939
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.1235 0.3264 0.3264
Trichomonas vaginalis CMGC family protein kinase 0.0173 0.0191 0.056
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.1235 0.3264 0.3209
Onchocerca volvulus 0.0134 0.008 0.026
Loa Loa (eye worm) hypothetical protein 0.065 0.1573 0.1566
Loa Loa (eye worm) hypothetical protein 0.0665 0.1615 0.1608
Giardia lamblia Kinase, PLK 0.0558 0.1305 0.3648
Echinococcus granulosus tyrosine protein kinase Src42A 0.019 0.0242 0.0242
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0545 0.1269 0.1269
Schistosoma mansoni notch 0.036 0.0733 0.0733
Echinococcus granulosus titin 0.0251 0.0418 0.0418
Echinococcus multilocularis cyclin dependent kinase 9 0.0114 0.0021 0.0021
Brugia malayi Protein kinase domain containing protein 0.0134 0.008 0.0063
Echinococcus multilocularis tyrosine protein kinase HCK 0.0188 0.0234 0.0234
Brugia malayi RhoGAP domain containing protein 0.0154 0.0137 0.012
Schistosoma mansoni tyrosine kinase 0.0495 0.1122 0.1122
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.1235 0.3264 0.3209
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Loa Loa (eye worm) Notch2 0.036 0.0733 0.0725
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0587 0.1391 0.1383
Trypanosoma brucei rac serine-threonine kinase, putative 0.0603 0.1436 0.1366
Brugia malayi cAMP-dependent protein kinase catalytic subunit, putative 0.0233 0.0366 0.0349
Loa Loa (eye worm) cyclin domain-containing protein 0.0756 0.1877 0.187
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0328 0.064 0.3352
Plasmodium falciparum cAMP-dependent protein kinase catalytic subunit 0.0233 0.0366 0.0288
Brugia malayi Serine/threonine-protein kinase Pim-3 0.0728 0.1797 0.1783
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.1305 0.3983
Echinococcus granulosus casein kinase I alpha 0.0224 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0665 0.1615 0.1608
Trypanosoma cruzi NADH dehydrogenase, putative 0.0328 0.064 0.0624
Leishmania major protein kinase, putative 0.0242 0.0391 0.0313
Entamoeba histolytica glutamate synthase beta subunit, putative 0.0328 0.064 0.3352
Echinococcus granulosus serine:threonine protein kinase 0.0235 0.0372 0.0372
Trichomonas vaginalis CMGC family protein kinase 0.0245 0.04 0.1203
Echinococcus granulosus ephrin type A receptor 4 A 0.0199 0.0267 0.0267
Plasmodium falciparum calcium-dependent protein kinase 2 0.0208 0.0293 0.0214
Plasmodium falciparum protein kinase 5 0.0245 0.04 0.0322
Echinococcus multilocularis titin 0.0165 0.0168 0.0168
Echinococcus granulosus epidermal growth factor receptor 0.0495 0.1122 0.1122
Brugia malayi hypothetical protein 0.0231 0.0359 0.0343
Plasmodium falciparum tyrosine kinase-like protein, putative 0.0167 0.0174 0.0095
Loa Loa (eye worm) hypothetical protein 0.0197 0.0263 0.0254
Loa Loa (eye worm) hypothetical protein 0.065 0.1571 0.1564
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Brugia malayi protein kinase C3,putative 0.0325 0.0632 0.0617
Brugia malayi phosphoinositide-dependent protein kinase I 0.0168 0.0177 0.0161
Echinococcus multilocularis serine:threonine protein kinase 0.0235 0.0372 0.0372
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0506 0.1154 0.1154
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0467 0.1042 0.1042
Schistosoma mansoni protein kinase 0.0206 0.0289 0.0289
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0328 0.064 0.064
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0558 0.1305 0.1305
Leishmania major protein kinase A catalytic subunit 0.0233 0.0366 0.0288
Echinococcus granulosus expressed protein 0.0171 0.0187 0.0187
Entamoeba histolytica protein kinase, putative 0.0177 0.0204 0.107
Echinococcus multilocularis ephrin type A receptor 4 A 0.0199 0.0267 0.0267
Loa Loa (eye worm) immunoglobulin domain-containing protein 0.0197 0.0263 0.0254
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0222 0.0205
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0317 0.0608 0.0592
Echinococcus multilocularis casein kinase i 0.0224 0.034 0.034
Loa Loa (eye worm) hypothetical protein 0.0233 0.0366 0.0357
Schistosoma mansoni tyrosine kinase 0.0709 0.1741 0.1741
Giardia lamblia Kinase, CMGC GSK 0.0265 0.0459 0.0905
Echinococcus granulosus maternal embryonic leucine zipper kinase 0.0237 0.0378 0.0378
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0167 0.0174 0.0095
Trypanosoma cruzi cdc2-related kinase 1 0.0245 0.04 0.0384
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0265 0.0459 0.0459
Schistosoma mansoni protein kinase 0.0224 0.034 0.034
Brugia malayi P38 map kinase family protein 2 0.0328 0.0641 0.0625
Echinococcus multilocularis Immunoglobulin 0.0197 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0197 0.0263 0.0254
Trichomonas vaginalis STE family protein kinase 0.0132 0.0075 0.0203
Trichomonas vaginalis AGC family protein kinase 0.0603 0.1436 0.4384
Toxoplasma gondii EGF family domain-containing protein 0.036 0.0733 0.0658
Brugia malayi Variant SH3 domain containing protein 0.0126 0.0056 0.0039
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0227 0.067
Schistosoma mansoni hypothetical protein 0.036 0.0733 0.0733
Loa Loa (eye worm) hypothetical protein 0.0247 0.0405 0.0396
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0328 0.064 0.1939
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0323 0.0626 0.0626
Schistosoma mansoni protein kinase 0.0456 0.1009 0.1009
Brugia malayi protein-tyrosine kinase 0.0255 0.043 0.0413
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0381 0.0793 0.0793
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0165 0.0168 0.016
Giardia lamblia Kinase, AGC PKA 0.0233 0.0366 0.0602
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0381 0.0793 0.0793
Plasmodium falciparum thioredoxin reductase 0.3564 1 1
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Trichomonas vaginalis CMGC family protein kinase 0.0185 0.0227 0.067
Trichomonas vaginalis CMGC family protein kinase 0.0287 0.0521 0.1573
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Entamoeba histolytica protein kinase, putative 0.0252 0.0421 0.2204
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0328 0.064 0.064
Echinococcus granulosus cyclin dependent kinase 19 0.103 0.2672 0.2672
Entamoeba histolytica protein kinase, putative 0.0208 0.0293 0.1534
Loa Loa (eye worm) hypothetical protein 0.0362 0.0739 0.0731
Echinococcus granulosus rho-associated protein kinase 1 0.0671 0.1633 0.1633
Schistosoma mansoni hypothetical protein 0.0197 0.0263 0.0263
Schistosoma mansoni vam6/vps39 related 0.0231 0.0359 0.0359
Brugia malayi Calcium binding EGF domain containing protein 0.036 0.0733 0.0717
Plasmodium vivax casein kinase 1, putative 0.0224 0.034 0.0168
Brugia malayi intracellular kinase 0.0265 0.0459 0.0443
Echinococcus granulosus delta-like protein 1 0.036 0.0733 0.0733
Loa Loa (eye worm) CAMK/CAMKL/PASK protein kinase 0.0114 0.0023 0.0014
Loa Loa (eye worm) CMGC/CDK/CDK8 protein kinase 0.103 0.2672 0.2666
Trypanosoma cruzi Protein kinase B 0.0339 0.0671 0.0656
Trichomonas vaginalis AGC family protein kinase 0.0603 0.1436 0.4384
Toxoplasma gondii casein kinase I 0.0224 0.034 0.0261
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0506 0.1154 0.1154
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0252 0.0421 0.0413
Echinococcus multilocularis GTPase activating Rap:RanGAP domain 3 0.0231 0.0359 0.0359
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0257 0.0435 0.0358
Brugia malayi Peroxidasin 0.0363 0.0741 0.0725
Loa Loa (eye worm) CAMK/CAMKL/MELK protein kinase 0.0448 0.0987 0.0979
Trichomonas vaginalis CMGC family protein kinase 0.0245 0.04 0.1203
Loa Loa (eye worm) protein kinase domain-containing protein 0.044 0.0964 0.0957
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0328 0.064 0.064
Toxoplasma gondii cell-cycle-associated protein kinase SRPK, putative 0.0171 0.0187 0.0107
Trypanosoma brucei NADPH:adrenodoxin oxidoreductase, mitochondrial, putative 0.0328 0.064 0.0564
Loa Loa (eye worm) hypothetical protein 0.0665 0.1615 0.1608
Giardia lamblia High cysteine protein 0.036 0.0733 0.1793
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.1498 0.4023 0.4023
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0485 0.1094 0.1094
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0332 0.0652 0.0652
Plasmodium vivax type II NADH:ubiquinone oxidoreductase, putative 0.0328 0.064 0.0474
Echinococcus multilocularis p21 activated protein kinase 1 Dpak1 0.0177 0.0204 0.0204
Echinococcus granulosus serine:threonine protein kinase MARK2 0.0446 0.0981 0.0981
Echinococcus granulosus Immunoglobulin 0.065 0.1571 0.1571
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.1235 0.3264 0.3209
Schistosoma mansoni titin 0.0165 0.0168 0.0168
Loa Loa (eye worm) programmed cell death 8 0.0328 0.064 0.0632
Loa Loa (eye worm) hypothetical protein 0.0362 0.0739 0.0731
Onchocerca volvulus 0.0165 0.0168 0.0659
Entamoeba histolytica protein kinase, putative 0.0332 0.0652 0.3414
Schistosoma mansoni tyrosine kinase 0.0587 0.139 0.139
Echinococcus granulosus tyrosine protein kinase otk 0.0362 0.0739 0.0739
Echinococcus multilocularis nervana 2 0.0255 0.043 0.043
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0757 0.1882 0.1882
Schistosoma mansoni vav2 0.017 0.0182 0.0182
Giardia lamblia Kinase, STE STE20 0.0174 0.0196 0.0052
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0233 0.0366 0.0366
Brugia malayi serine/threonine kinase 12 0.0242 0.0391 0.0375
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0665 0.1615 0.1608
Echinococcus multilocularis myosin iiia 0.0174 0.0196 0.0196
Loa Loa (eye worm) projectin 0.0183 0.0222 0.0213
Brugia malayi Hr1 repeat family protein 0.06 0.1426 0.1412
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.0608 0.0608
Echinococcus multilocularis proto oncogene serine:threonine protein kinase 0.0728 0.1797 0.1797
Leishmania major 2,4-dienoyl-coa reductase fadh1, putative 0.0328 0.064 0.0564
Schistosoma mansoni tyrosine kinase 0.0428 0.0929 0.0929
Trichomonas vaginalis CMGC family protein kinase 0.0287 0.0521 0.1573
Brugia malayi basement membrane proteoglycan 0.0197 0.0263 0.0246
Loa Loa (eye worm) hypothetical protein 0.0665 0.1615 0.1608
Echinococcus multilocularis casein kinase I alpha 0.0224 0.034 0.034
Leishmania major protein kinase, putative,dual-specificity protein kinase, putative 0.0287 0.0521 0.0444
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0814 0.2046 0.2046
Schistosoma mansoni hypothetical protein 0.0197 0.0263 0.0263
Loa Loa (eye worm) AGC/PKG protein kinase 0.0172 0.019 0.0181
Trypanosoma cruzi 2,4-dienoyl-coa reductase-like protein, putative 0.0328 0.064 0.0624
Schistosoma mansoni protein kinase 0.0132 0.0075 0.0075
Echinococcus granulosus epidermal growth factor receptor 0.0709 0.1741 0.1741
Brugia malayi Doublecortin family protein 0.0311 0.0591 0.0576
Giardia lamblia NADH oxidase lateral transfer candidate 0.1235 0.3264 1
Loa Loa (eye worm) STE/STE20/PAKA protein kinase 0.0112 0.0017 0.0008
Onchocerca volvulus Netrin receptor homolog 0.0224 0.0341 0.1443
Loa Loa (eye worm) hypothetical protein 0.0373 0.0771 0.0763
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0558 0.1305 0.1305
Toxoplasma gondii rhoptry neck protein RON9 0.0665 0.1615 0.1547
Echinococcus granulosus thioredoxin glutathione reductase 0.3564 1 1
Echinococcus granulosus insulin growth factor binding 0.0165 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0246 0.0402 0.0394
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Schistosoma mansoni serine/threonine protein kinase 0.0671 0.1633 0.1633
Loa Loa (eye worm) thyroid receptor interactor 0.0211 0.0301 0.0293
Trichomonas vaginalis CAMK family protein kinase 0.0208 0.0293 0.0874
Echinococcus multilocularis dual specificity 0.0287 0.0521 0.0521
Toxoplasma gondii histone kinase SNF1, putative 0.0161 0.0157 0.0077
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0363 0.0741 0.0733
Entamoeba histolytica protein kinase , putative 0.0242 0.0391 0.2047
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0172 0.019 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0185 0.0227 0.0227
Echinococcus granulosus dual specificity 0.0287 0.0521 0.0521
Echinococcus multilocularis serine:threonine protein kinase MARK2 0.0446 0.0981 0.0981
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.1235 0.3264 1
Loa Loa (eye worm) CK1/CK1/CK1-A protein kinase 0.0224 0.034 0.0331
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0174 0.0196 0.018
Trichomonas vaginalis mitogen-activated protein kinase kinase kinase 3, MAPKKK3, MEKK3, putative 0.0112 0.0017 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0728 0.1797 0.1797
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.1235 0.3264 0.3252
Echinococcus multilocularis fat cadherin tumor suppressor 0.036 0.0733 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0157 0.0157
Echinococcus multilocularis tyrosine protein kinase Srms 0.0255 0.043 0.043
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0381 0.0793 0.0793
Brugia malayi Protein kinase domain containing protein 0.0616 0.1473 0.1459
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0197 0.0263 0.0263
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0328 0.064 0.149
Brugia malayi casein kinase 1, delta 0.0224 0.034 0.0323
Entamoeba histolytica protein kinase, putative 0.0603 0.1436 0.7521
Trichomonas vaginalis AGC family protein kinase 0.0176 0.0201 0.059
Echinococcus granulosus titin 0.0165 0.0168 0.0168
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Brugia malayi Protein kinase domain containing protein 0.0603 0.1436 0.1421
Schistosoma mansoni serine/threonine protein kinase 0.0278 0.0496 0.0496
Plasmodium falciparum calcium-dependent protein kinase 3 0.0208 0.0293 0.0214
Schistosoma mansoni protein kinase 0.0456 0.1009 0.1009
Brugia malayi Protein kinase domain containing protein 0.0926 0.237 0.2357
Brugia malayi EGF-like domain containing protein 0.036 0.0733 0.0717
Echinococcus multilocularis serine:threonine protein kinase N2 0.06 0.1426 0.1426
Echinococcus granulosus Vam6:Vps39 protein 0.0231 0.0359 0.0359
Echinococcus multilocularis casein kinase I delta 0.0224 0.034 0.034
Schistosoma mansoni atypical protein kinase C 0.0602 0.1433 0.1433
Loa Loa (eye worm) STE/STE20/TAO protein kinase 0.0459 0.1018 0.101
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0173 0.0191 0.0111
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0173 0.0191 0.0111
Echinococcus multilocularis Glutaredoxin protein 5 0.0255 0.043 0.043
Schistosoma mansoni protein kinase 0.0398 0.0842 0.0842
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.0222 0.0205
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.1235 0.3264 0.3252
Schistosoma mansoni roundabout 0.0362 0.0739 0.0739
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0362 0.0739 0.0731
Onchocerca volvulus 0.0665 0.1615 0.7224
Brugia malayi Disorganized muscle protein 1 0.0165 0.0168 0.0151
Brugia malayi pregnancy-associated plasma protein-A 0.0665 0.1615 0.1601
Giardia lamblia Kinase, STE STE20 0.0177 0.0204 0.0078
Schistosoma mansoni serine/threonine protein kinase 0.0245 0.04 0.04
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0168 0.0177 0.0177
Schistosoma mansoni notch 0.036 0.0733 0.0733
Schistosoma mansoni serine/threonine protein kinase 0.0414 0.089 0.089
Echinococcus granulosus tyrosine protein kinase Fyn 0.0314 0.0598 0.0598
Echinococcus granulosus Down syndrome cell adhesion molecule 0.0216 0.0316 0.0316
Echinococcus multilocularis cell adhesion molecule:down regulated by 0.0197 0.0263 0.0263
Echinococcus multilocularis CDC7 cell division cycle 7 0.0185 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Trypanosoma cruzi casein kinase, putative 0.0224 0.034 0.0323
Plasmodium falciparum glycogen synthase kinase 3 0.0265 0.0459 0.0382
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0255 0.043 0.043
Echinococcus multilocularis contactin neuroglian septate junction protein 0.0381 0.0793 0.0793
Echinococcus granulosus notch 0.036 0.0733 0.0733
Schistosoma mansoni septate junction protein 0.0197 0.0263 0.0263
Echinococcus multilocularis protein jagged 1 0.036 0.0733 0.0733
Schistosoma mansoni titin 0.0183 0.0222 0.0222
Echinococcus multilocularis tyrosine protein kinase Src42A 0.019 0.0242 0.0242
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.1235 0.3264 0.3209
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0152 0.0132 0.0123
Trichomonas vaginalis CAMK family protein kinase 0.0558 0.1305 0.3983
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0485 0.1094 0.1094
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0135 0.0083 0.0433
Brugia malayi Heparan sulfate 0.0197 0.0263 0.0246
Echinococcus multilocularis neurogenic locus protein delta 0.036 0.0733 0.0733
Entamoeba histolytica protein kinase domain containing protein 0.0242 0.0391 0.2047
Trypanosoma cruzi casein kinase, putative 0.0224 0.034 0.0323
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0233 0.0366 0.0366
Trypanosoma brucei dual specificity tyrosine-phosphorylation-regulated kinase 2, putative 0.0287 0.0521 0.0444
Plasmodium vivax casein kinase 2, alpha subunit, putative 0.0206 0.0289 0.0116
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0328 0.064 0.064
Schistosoma mansoni serine/threonine protein kinase 0.0317 0.0608 0.0608
Entamoeba histolytica protein kinase, putative 0.0168 0.0177 0.0928
Schistosoma mansoni cell adhesion molecule 0.0866 0.2196 0.2196
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0265 0.0459 0.0459
Loa Loa (eye worm) hypothetical protein 0.0665 0.1615 0.1608
Echinococcus multilocularis STE20 serine:threonine protein kinase 0.1021 0.2644 0.2644
Echinococcus multilocularis tyrosine protein kinase otk 0.0362 0.0739 0.0739
Brugia malayi Protein kinase domain containing protein 0.0448 0.0987 0.0971
Echinococcus granulosus protein kinase c epsilon type 0.0421 0.0909 0.0909
Echinococcus multilocularis tyrosine kinase 0.0134 0.008 0.008
Leishmania major hypothetical protein, conserved 0.0328 0.064 0.0564
Brugia malayi Immunoglobulin I-set domain containing protein 0.0362 0.0739 0.0723
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.036 0.0733 0.0733
Brugia malayi Thioredoxin reductase 0.3564 1 1
Loa Loa (eye worm) disorganized muscle protein 1 0.0165 0.0168 0.016
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0558 0.1305 0.1235
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0173 0.0191 0.0174
Giardia lamblia Kinase, NEK 0.0281 0.0504 0.105
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0174 0.0196 0.0117
Entamoeba histolytica cell division protein kinase 2, putative 0.0253 0.0424 0.2219
Loa Loa (eye worm) hypothetical protein 0.0132 0.0074 0.0066
Loa Loa (eye worm) AUR protein kinase 0.0242 0.0391 0.0383
Brugia malayi Immunoglobulin I-set domain containing protein 0.0165 0.0168 0.0151
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0495 0.1122 0.1122
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0255 0.043 0.043
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0242 0.0391 0.0391
Loa Loa (eye worm) hypothetical protein 0.036 0.0733 0.0725
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0289 0.086
Schistosoma mansoni neurotracting/lsamp/neurotrimin/obcam related cell adhesion molecule 0.0197 0.0263 0.0263
Schistosoma mansoni notch 0.036 0.0733 0.0733
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0414 0.089 0.0882
Echinococcus multilocularis serine:threonine protein kinase PAK 3 0.0177 0.0204 0.0204
Echinococcus multilocularis peroxidasin 0.0363 0.0741 0.0741
Schistosoma mansoni hypothetical protein 0.036 0.0733 0.0733
Brugia malayi Delta serrate ligand family protein 0.036 0.0733 0.0717
Entamoeba histolytica thioredoxin reductase, putative 0.0328 0.064 0.3352
Loa Loa (eye worm) hypothetical protein 0.074 0.1831 0.1824
Echinococcus granulosus cAMP dependent protein kinase catalytic subunit 0.0233 0.0366 0.0366
Onchocerca volvulus 0.036 0.0733 0.3223
Onchocerca volvulus 0.0295 0.0545 0.2369
Schistosoma mansoni disulfide oxidoreductase 0.0328 0.064 0.064
Schistosoma mansoni serine/threonine protein kinase 0.0233 0.0366 0.0366
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Echinococcus multilocularis pro neuregulin 2, membrane bound 0.0165 0.0168 0.0168
Giardia lamblia Kinase, AGC AKT 0.0241 0.039 0.068
Echinococcus multilocularis cAMP dependent protein kinase catalytic subunit 0.0233 0.0366 0.0366
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.1235 0.3264 1
Entamoeba histolytica protein kinase domain containing protein 0.0206 0.0289 0.1512
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0255 0.043 0.043
Toxoplasma gondii CMGC kinase, CK2 family 0.0206 0.0289 0.021
Loa Loa (eye worm) hypothetical protein 0.0165 0.0168 0.016
Brugia malayi hypothetical protein 0.0665 0.1615 0.1601
Trichomonas vaginalis CK1 family protein kinase 0.0224 0.034 0.1017
Entamoeba histolytica pyridine nucleotide-disulfide oxidoreductase family protein 0.0328 0.064 0.3352
Entamoeba histolytica serine/threonine protein kinase, putative 0.0161 0.0157 0.0821
Trypanosoma cruzi hypothetical protein, conserved 0.0328 0.064 0.0624
Toxoplasma gondii pyridine nucleotide-disulfide oxidoreductase domain-containing protein 0.0328 0.064 0.0564
Schistosoma mansoni serine/threonine protein kinase 0.0161 0.0157 0.0157
Leishmania major protein kinase A catalytic subunit isoform 1 0.0233 0.0366 0.0288
Echinococcus granulosus protein kinase c iota type 0.059 0.1397 0.1397
Schistosoma mansoni protein kinase 0.0896 0.2283 0.2283
Echinococcus granulosus protein jagged 2 0.036 0.0733 0.0733
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Echinococcus granulosus nervana 2 0.0255 0.043 0.043
Schistosoma mansoni basigin related 0.0197 0.0263 0.0263
Schistosoma mansoni tyrosine kinase 0.0193 0.0249 0.0249
Entamoeba histolytica protein kinase, putative 0.0242 0.0391 0.2047
Onchocerca volvulus 0.0134 0.008 0.026
Brugia malayi Homeodomain interacting protein kinase protein 1 0.0418 0.0901 0.0886
Onchocerca volvulus 0.0183 0.0222 0.0903
Brugia malayi Protein kinase domain containing protein 0.0134 0.008 0.0063
Onchocerca volvulus 0.0645 0.1557 0.6962
Schistosoma mansoni low-density lipoprotein receptor (ldl) 0.0197 0.0263 0.0263
Loa Loa (eye worm) CAMK/CAMKL/AMPK protein kinase 0.026 0.0443 0.0435
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0208 0.0293 0.0293
Loa Loa (eye worm) STE/STE20/PAKB protein kinase 0.0479 0.1077 0.1069
Echinococcus multilocularis nervana 2 0.0255 0.043 0.043
Brugia malayi Protein kinase domain containing protein 0.0398 0.0842 0.0827
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0688 0.1682 0.1674
Loa Loa (eye worm) hypothetical protein 0.0287 0.0521 0.0513
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0245 0.04 0.0392
Schistosoma mansoni tyrosine kinase 0.0616 0.1473 0.1473
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0245 0.04 0.0392
Schistosoma mansoni septate junction protein 0.036 0.0733 0.0733
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0449 0.0991 0.0975
Brugia malayi Protein kinase domain containing protein 0.0651 0.1574 0.1559
Echinococcus granulosus casein kinase ii subunit alpha 0.0206 0.0289 0.0289
Schistosoma mansoni g1/s-specific cyclin C 0.1516 0.4075 0.4075
Giardia lamblia Kinase, CMGC CK2 0.0206 0.0289 0.0351
Loa Loa (eye worm) thioredoxin reductase 0.3564 1 1
Schistosoma mansoni hypothetical protein 0.036 0.0733 0.0733
Echinococcus granulosus protein kinase C gamma type 0.0416 0.0896 0.0896
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0289 0.086
Loa Loa (eye worm) hypothetical protein 0.0362 0.0739 0.0731
Echinococcus multilocularis mitogen activated protein kinase 11 0.0328 0.0641 0.0641
Brugia malayi Casein kinase II, alpha chain 0.0206 0.0289 0.0272
Echinococcus granulosus N chimaerin 0.0154 0.0137 0.0137
Schistosoma mansoni hemicentin 0.0183 0.0222 0.0222
Schistosoma mansoni kinase 0.0596 0.1415 0.1415
Echinococcus multilocularis cyclin dependent kinase 0.0245 0.04 0.04
Plasmodium vivax unspecified product 0.0206 0.0289 0.0116
Onchocerca volvulus 0.0665 0.1615 0.7224
Echinococcus granulosus dual specificity 0.0287 0.0521 0.0521
Entamoeba histolytica casein kinase 1, putative 0.0224 0.034 0.1779
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0183 0.0222 0.0222
Trichomonas vaginalis AGC family protein kinase 0.0603 0.1436 0.4384
Trichomonas vaginalis AGC family protein kinase 0.0281 0.0504 0.1521
Loa Loa (eye worm) hypothetical protein 0.0295 0.0545 0.0537
Trypanosoma cruzi kinetoplastid kinetochore protein 19, putative 0.0317 0.0608 0.0592
Schistosoma mansoni protein kinase 0.0177 0.0204 0.0204
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0208 0.0293 0.0214
Echinococcus multilocularis serine:threonine protein kinase N2 0.0332 0.0652 0.0652
Brugia malayi Protein kinase domain containing protein 0.0728 0.1797 0.1783
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0183 0.0222 0.0213
Echinococcus multilocularis protein jagged 1 0.036 0.0733 0.0733
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0252 0.0421 0.0405
Brugia malayi Animal haem peroxidase family protein 0.0165 0.0168 0.0151
Schistosoma mansoni serine/threonine protein kinase 0.0558 0.1305 0.1305
Schistosoma mansoni myosin-binding protein-related 0.0183 0.0222 0.0222
Trichomonas vaginalis CMGC family protein kinase 0.0265 0.0459 0.1384
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Echinococcus granulosus aurora kinase A 0.0242 0.0391 0.0391
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0362 0.0739 0.0731
Trypanosoma brucei cdc2-related kinase 3 0.0245 0.04 0.0322
Brugia malayi Protein kinase domain containing protein 0.0245 0.04 0.0384
Loa Loa (eye worm) AUR protein kinase 0.0242 0.0391 0.0383
Loa Loa (eye worm) CAMK/CAMKL/MARK protein kinase 0.0235 0.0372 0.0364
Trichomonas vaginalis CAMK family protein kinase 0.0161 0.0157 0.0455
Trypanosoma cruzi polo-like protein kinase, putative 0.0558 0.1305 0.129
Brugia malayi Protein kinase domain containing protein 0.103 0.2672 0.2659
Brugia malayi ribosomal protein S6 kinase alpha 3 0.0241 0.039 0.0374
Trypanosoma brucei cAMP-dependent protein kinase catalytic subunit 2 0.0233 0.0366 0.0288
Echinococcus multilocularis enhancer of mRNA decapping protein 4 0.0165 0.017 0.017
Onchocerca volvulus 0.013 0.0068 0.0207
Brugia malayi Cam kinase protein 1 0.0208 0.0293 0.0276
Schistosoma mansoni hypothetical protein 0.021 0.03 0.03
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0183 0.0222 0.0213
Entamoeba histolytica protein kinase domain containing protein 0.0252 0.0421 0.2204
Giardia lamblia Kinase, CK1 Casein kinase 0.0224 0.034 0.0517
Entamoeba histolytica protein kinase, putative 0.0171 0.0187 0.0979
Schistosoma mansoni rap gtpase-activating protein 0.0231 0.0359 0.0359
Giardia lamblia Kinase, CMGC MAPK 0.0173 0.0191 0.0034
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0173 0.0191 0.0111
Leishmania major protein kinase, putative 0.0317 0.0608 0.0532
Onchocerca volvulus 0.0165 0.0168 0.0659
Trichomonas vaginalis CMGC family protein kinase 0.0265 0.0459 0.1384
Entamoeba histolytica PH domain containing protein kinase, putative 0.0249 0.0411 0.2152
Brugia malayi Immunoglobulin domain containing protein 0.0197 0.0263 0.0246
Trichomonas vaginalis CMGC family protein kinase 0.0287 0.0521 0.1573
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0328 0.064 0.3352
Trichomonas vaginalis CMGC family protein kinase 0.0287 0.0521 0.1573
Loa Loa (eye worm) hypothetical protein 0.0619 0.1481 0.1474
Onchocerca volvulus Serine\/threonine kinase homolog 0.0339 0.0671 0.294
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0265 0.0459 0.0459
Echinococcus granulosus twitchin 0.0882 0.2243 0.2243
Brugia malayi Immunoglobulin I-set domain containing protein 0.0362 0.0739 0.0723
Loa Loa (eye worm) AGC/PKA protein kinase 0.0233 0.0366 0.0357
Echinococcus multilocularis 0.0196 0.026 0.026
Echinococcus multilocularis cyclin 0.0756 0.1877 0.1877
Onchocerca volvulus 0.0185 0.0227 0.0926
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0421 0.0909 0.0901
Schistosoma mansoni protein kinase 0.0316 0.0605 0.0605
Brugia malayi Immunoglobulin I-set domain containing protein 0.0216 0.0316 0.03
Echinococcus multilocularis down syndrome cell adhesion 0.0165 0.0168 0.0168
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0651 0.1574 0.1566
Loa Loa (eye worm) CMGC/CLK protein kinase 0.0317 0.0608 0.06
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.1235 0.3264 0.3209
Plasmodium falciparum type II NADH:ubiquinone oxidoreductase 0.0328 0.064 0.0564
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0314 0.0598 0.0598
Schistosoma mansoni serine/threonine protein kinase 0.0446 0.0981 0.0981
Onchocerca volvulus 0.0665 0.1615 0.7224
Echinococcus granulosus neurogenic locus notch protein 0.036 0.0733 0.0733
Onchocerca volvulus 0.0287 0.0521 0.226
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0208 0.0293 0.0214
Echinococcus multilocularis Immunoglobulin 0.065 0.1571 0.1571
Schistosoma mansoni cell adhesion molecule 0.0362 0.0739 0.0739
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0208 0.0293 0.0121
Echinococcus granulosus serine:threonine protein kinase TAO1 0.0459 0.1018 0.1018
Entamoeba histolytica protein kinase domain containing protein 0.0287 0.0521 0.2728
Giardia lamblia Kinase, CMGC GSK 0.0265 0.0459 0.0905
Echinococcus granulosus raf serine:threonine protein kinase 0.0153 0.0134 0.0134
Schistosoma mansoni serine/threonine protein kinase 0.0171 0.0187 0.0187
Loa Loa (eye worm) TK/FER protein kinase 0.0446 0.0982 0.0974
Schistosoma mansoni slit 0.0165 0.017 0.017
Trichomonas vaginalis AGC family protein kinase 0.0603 0.1436 0.4384
Trypanosoma cruzi casein kinase, delta isoform, putative 0.0224 0.034 0.0323
Loa Loa (eye worm) TK protein kinase 0.0255 0.043 0.0421
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0814 0.2046 0.2039
Onchocerca volvulus 0.0185 0.0227 0.0926
Echinococcus multilocularis mitogen activated protein kinase 14 0.0328 0.0641 0.0641
Echinococcus multilocularis mitogen activated protein kinase 3 0.0173 0.0191 0.0191
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0197 0.0263 0.0263
Onchocerca volvulus 0.0665 0.1615 0.7224
Schistosoma mansoni tyrosine kinase 0.0616 0.1473 0.1473
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 3 0.0233 0.0366 0.0349
Giardia lamblia Kinase, CMGC CLK 0.0317 0.0608 0.1389
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0467 0.1042 0.1042
Trypanosoma cruzi NADH dehydrogenase, putative 0.0328 0.064 0.0624
Brugia malayi Immunoglobulin I-set domain containing protein 0.0197 0.0263 0.0246
Trypanosoma cruzi cAMP-dependent protein kinase catalytic subunit 2 0.0233 0.0366 0.0349
Schistosoma mansoni serine/threonine protein kinase 0.0339 0.0671 0.0671
Loa Loa (eye worm) hypothetical protein 0.0222 0.0334 0.0326
Mycobacterium tuberculosis Probable oxidoreductase 0.1235 0.3264 0.2803
Loa Loa (eye worm) hypothetical protein 0.0235 0.0372 0.0364
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0353 0.0712 0.0705
Echinococcus granulosus neural cadherin 0.036 0.0733 0.0733
Trichomonas vaginalis CMGC family protein kinase 0.0206 0.0289 0.086
Giardia lamblia Kinase, AGC PKA 0.0323 0.0626 0.1446
Loa Loa (eye worm) CAMK/TSSK protein kinase 0.0651 0.1574 0.1566
Schistosoma mansoni tyrosine kinase 0.0193 0.0249 0.0249
Schistosoma mansoni serine/threonine protein kinase 0.0112 0.0017 0.0017
Brugia malayi hypothetical protein 0.0669 0.1625 0.1611
Onchocerca volvulus 0.036 0.0733 0.3223
Echinococcus multilocularis tyrosine protein kinase Blk 0.0255 0.043 0.043
Echinococcus granulosus down syndrome cell adhesion 0.0165 0.0168 0.0168
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0328 0.064 0.064
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0328 0.064 0.064
Loa Loa (eye worm) TK/INSR protein kinase 0.0616 0.1473 0.1466
Brugia malayi protein kinase C II. 0.0421 0.0909 0.0894
Schistosoma mansoni tyrosine kinase 0.0428 0.0929 0.0929
Trypanosoma brucei trypanothione reductase 0.3564 1 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0558 0.1305 0.129
Trypanosoma cruzi Vacuolar sorting protein 39 domain 1/Vacuolar sorting protein 39 domain 2, putative 0.0231 0.0359 0.0343

Activities

Activity type Activity value Assay description Source Reference
Activity (ADMET) = 61 % Cytotoxicity against human HepG2 cells assessed as cell viability at 100 uM after 48 hrs by MTT assay ChEMBL. 24071448
Affinity (functional) = 58.4 % Affinity of the compound for hydroxyapatite after 24 hours ChEMBL. 15743175
Biodistribution (ADMET) 0 Uptake ratio of the compound in bone to that of blood at 2 hours; NT is not tested ChEMBL. 15743175
Biodistribution (ADMET) 0 Uptake ratio of the compound in bone to that of blood at 4 hours; NT is not tested ChEMBL. 15743175
Biodistribution (ADMET) 0 Uptake ratio of the compound in bone to that of muscle at 2 hours; NT is not tested ChEMBL. 15743175
Biodistribution (ADMET) 0 Uptake ratio of the compound in bone to that of muscle at 4 hours; NT is not tested ChEMBL. 15743175
IC50 (binding) = 7.2 uM Inhibition of APMA-activated recombinant human MMP2 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate addition measured after 2 to 4 hrs by fluorometric assay ChEMBL. 24071448
IC50 (binding) = 30.5 uM Inhibition of MMP14 catalytic domain (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate addition measured after 2 to 4 hrs by fluorometric assay ChEMBL. 24071448
IC50 (binding) = 32 uM Inhibition of MMP8 catalytic domain (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate addition measured after 2 to 4 hrs by fluorometric assay ChEMBL. 24071448
IC50 (binding) > 100 uM Inhibition of MMP9 catalytic domain (unknown origin) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate incubated for 30 mins prior to substrate addition measured after 2 to 4 hrs by fluorometric assay ChEMBL. 24071448
pKa1 (functional) < 1.5 Dissociation constant of the compound determined by the pH-metric method ChEMBL. 15743175
pKa2 (functional) = 2.27 Dissociation constant of the compound determined by the pH-metric method ChEMBL. 15743175
pKa3 (functional) = 6.31 Dissociation constant of the compound determined by the pH-metric method ChEMBL. 15743175
pKa4 (functional) = 10.6 Dissociation constant of the compound determined by the pH-metric method ChEMBL. 15743175

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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