Detailed information for compound 314447

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 674.954 | Formula: C28H50N4O9SSi2
  • H donors: 2 H acceptors: 5 LogP: 3.34 Rotable bonds: 12
    Rule of 5 violations (Lipinski): 2
  • SMILES: NC(=O)CCNC1=CS(=O)(=O)OC21C(CO[Si](C(C)(C)C)(C)C)OC(C2O[Si](C(C)(C)C)(C)C)n1cc(C)c(=O)n(c1=O)C
  • InChi: 1S/C28H50N4O9SSi2/c1-18-15-32(25(35)31(8)23(18)34)24-22(40-44(11,12)27(5,6)7)28(20(39-24)16-38-43(9,10)26(2,3)4)19(17-42(36,37)41-28)30-14-13-21(29)33/h15,17,20,22,24,30H,13-14,16H2,1-12H3,(H2,29,33)
  • InChiKey: SACLIFVLXIJVKJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0262 0.4484
Plasmodium vivax importin-beta 2, putative 0.0028 0.0342 0.0468
Loa Loa (eye worm) hypothetical protein 0.0098 0.1378 0.1885
Loa Loa (eye worm) hypothetical protein 0.0047 0.0618 0.0846
Echinococcus granulosus dna polymerase kappa 0.0019 0.0203 0.0203
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0262 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0284 0.4163 0.4163
Schistosoma mansoni nuclear hormone receptor 0.001 0.0068 0.0068
Plasmodium vivax metal transporter, putative 0.0495 0.7309 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0589 0.0589
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0231 0.0316
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0381 0.0521
Echinococcus multilocularis Smad4 0.0008 0.0039 0.0039
Mycobacterium leprae DIVALENT CATION-TRANSPORT INTEGRAL MEMBRANE PROTEIN MNTH (BRAMP) (MRAMP) 0.0306 0.4487 1
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0715 0.0715
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0068 0.0093
Loa Loa (eye worm) hypothetical protein 0.0495 0.7309 1
Brugia malayi MH2 domain containing protein 0.0008 0.0039 0.0054
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.1667 0.2281
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0015 0.0582
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0068 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0203 0.3432
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0151 0.2523
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0203 0.0203
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0618 0.076
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0068 0.0068
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0618 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0015 0.0582
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0203 0.0203
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.267 0.267
Schistosoma mansoni DNA polymerase eta 0.0044 0.0575 0.0575
Brugia malayi MH2 domain containing protein 0.0008 0.0039 0.0054
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0115 0.1998
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0015 0.0582
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0068 0.0068
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0068 0.0068
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0618 0.0618
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Brugia malayi polk-prov protein 0.0006 0.0008 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0015 0.0582
Echinococcus granulosus snurportin 1 0.0302 0.4424 0.4424
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0068 0.0093
Schistosoma mansoni ran 0.0021 0.0231 0.0231
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0231 0.3928
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0068 0.0068
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0008 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0068 0.0093
Mycobacterium ulcerans divalent cation-transport integral membrane protein 0.0189 0.2742 0.3745
Schistosoma mansoni hypothetical protein 0.0031 0.0381 0.0381
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0589 0.0806
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0006 0.0008 0.0011
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0024 0.0024
Echinococcus multilocularis geminin 0.0166 0.2395 0.2395
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0068 0.0093
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0068 0.0068
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.4424 0.6053
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0342 0.5947
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0381 0.0381
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.034 0.0465
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0342 0.0468
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0203 0.3432
Echinococcus granulosus cpg binding protein 0.003 0.0364 0.0364
Loa Loa (eye worm) Smad1 0.0008 0.0039 0.0054
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0151 0.2625
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0203 0.0267
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0115 0.1998
Brugia malayi Importin beta-1 subunit 0.0028 0.0342 0.0468
Echinococcus multilocularis divalent metal transporter DMT1B 0.0495 0.7309 0.7309
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0151 0.2625
Brugia malayi Smad1 0.0008 0.0039 0.0054
Schistosoma mansoni hypothetical protein 0.0031 0.0381 0.0381
Trypanosoma brucei DNA damage repair protein, putative 0.0006 0.0008 0.0136
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0006 0.0008 0.0011
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0068 0.0068
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0342 0.5947
Brugia malayi Calcitonin receptor-like protein seb-1 0.0098 0.1378 0.1885
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0015 0.0582
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.0039 0.0039
Trichomonas vaginalis helicase, putative 0.0006 0.0015 0.0582
Leishmania major DNA damage repair protein, putative 0.0006 0.0008 0.0136
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0068 0.0068
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0008 0.0136
Echinococcus granulosus muscleblind protein 0.0146 0.2106 0.2106
Plasmodium falciparum transporter, putative 0.0495 0.7309 1
Trypanosoma brucei chrX additional, unordered contigs 0.0006 0.0008 0.0136
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0589 0.0589
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0715 0.0978
Mycobacterium ulcerans divalent cation-transport integral membrane protein 0.0189 0.2742 0.3745
Schistosoma mansoni coup transcription factor 0.001 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0575 0.0787
Schistosoma mansoni divalent metal transporter DMT1B 0.0495 0.7309 0.7309
Brugia malayi Muscleblind-like protein 0.0146 0.2106 0.2881
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0068 0.0093
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0203 0.3521
Brugia malayi MH1 domain containing protein 0.0008 0.0039 0.0054
Brugia malayi ecdysteroid receptor 0.001 0.0068 0.0093
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0068 0.0093
Schistosoma mansoni importin beta-1 0.0028 0.0342 0.0342
Echinococcus multilocularis smad 0.0008 0.0039 0.0039
Trypanosoma brucei unspecified product 0.0019 0.0203 0.3521
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0203 0.0203
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0008 0.0136
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0068 0.0093
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0589 0.0589
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0589 0.0589
Schistosoma mansoni microtubule-associated protein tau 0.0675 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0381 0.0381
Schistosoma mansoni hypothetical protein 0.0031 0.0381 0.0381
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0231 0.401
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0015 0.0582
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Echinococcus granulosus divalent metal transporter DMT1B 0.0495 0.7309 0.7309
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0618 0.0846
Echinococcus multilocularis cpg binding protein 0.003 0.0364 0.0364
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0068 0.0093
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0381 0.6568
Schistosoma mansoni cpg binding protein 0.0028 0.034 0.034
Entamoeba histolytica Ran family GTPase 0.0021 0.0231 0.8795
Onchocerca volvulus Protein Malvolio homolog 0.0495 0.7309 1
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0015 0.0582
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0151 0.2523
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0068 0.0068
Trypanosoma brucei unspecified product 0.0013 0.0115 0.1998
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0231 0.0316
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0151 0.0151
Toxoplasma gondii divalent metal transporter, putative 0.0495 0.7309 1
Brugia malayi mbt repeat family protein 0.0047 0.0618 0.0846
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0015 0.0582
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0203 0.7723
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.081 0.081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0068 0.0093
Loa Loa (eye worm) hypothetical protein 0.0053 0.0715 0.0978
Loa Loa (eye worm) hypothetical protein 0.0028 0.0342 0.0468
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0151 0.0151
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0589 0.0589
Brugia malayi CXXC zinc finger family protein 0.0028 0.034 0.0465
Leishmania major DNA polymerase kappa, putative 0.0006 0.0008 0.0136
Brugia malayi nuclear receptor NHR-88 0.001 0.0068 0.0093
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0068 0.0093
Schistosoma mansoni hypothetical protein 0.0166 0.2395 0.2395
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0575 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0068 0.0093
Loa Loa (eye worm) hypothetical protein 0.0146 0.2106 0.2881
Loa Loa (eye worm) hypothetical protein 0.0067 0.0917 0.1254
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0151 0.0207
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.0039 0.0039
Leishmania major DNA polymerase eta, putative 0.0031 0.0381 0.6615
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.267 0.267
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0203 0.0203
Echinococcus multilocularis dna polymerase eta 0.0044 0.0575 0.0575
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0151 0.2625
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0068 0.0068
Brugia malayi MH1 domain containing protein 0.0008 0.0039 0.0054
Onchocerca volvulus 0.0047 0.0618 0.076
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0015 0.0582
Loa Loa (eye worm) MBCTL1 0.0053 0.0715 0.0978
Trypanosoma brucei unspecified product 0.0013 0.0115 0.1998
Schistosoma mansoni cpg binding protein 0.003 0.0364 0.0364
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0203 0.0267
Echinococcus multilocularis snurportin 1 0.0302 0.4424 0.4424
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0068 0.0068
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0015 0.0582
Schistosoma mansoni hypothetical protein 0.0166 0.2395 0.2395
Schistosoma mansoni divalent metal transporter DMT1B 0.0495 0.7309 0.7309
Loa Loa (eye worm) histone methyltransferase 0.0009 0.005 0.0068
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0203 0.7723
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0589 0.0589
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0098 0.1378 0.1885
Schistosoma mansoni thyroid hormone receptor 0.001 0.0068 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0068 0.0093
Brugia malayi isocitrate dehydrogenase 0.0015 0.0151 0.0207
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0381 0.0381
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0151 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0068 0.0093
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0151 0.0151
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0203 0.0119
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.005 0.005
Brugia malayi steroid hormone receptor 0.001 0.0068 0.0093
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0015 0.0582
Trichomonas vaginalis ran, putative 0.0021 0.0231 0.8795
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0151 0.0207
Plasmodium falciparum importin beta, putative 0.0028 0.0342 0.0468
Schistosoma mansoni hypothetical protein 0.0302 0.4424 0.4424
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0231 0.0316
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0618 0.0618
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.0039 0.0054
Echinococcus granulosus geminin 0.0166 0.2395 0.2395
Echinococcus granulosus FTZ F1 alpha 0.001 0.0068 0.0068
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0203 0.0119
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0068 0.0093
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0618 0.0618
Onchocerca volvulus 0.0028 0.034 0.0375
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0618 0.0618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0068 0.0093
Schistosoma mansoni smad1 5 8 and 0.0008 0.0039 0.0039
Schistosoma mansoni ran 0.0021 0.0231 0.0231
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0015 0.0582
Entamoeba histolytica hypothetical protein 0.0023 0.0262 1
Schistosoma mansoni hypothetical protein 0.0067 0.0917 0.0917
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0203 0.3521
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0203 0.3521
Mycobacterium tuberculosis Divalent cation-transport integral membrane protein MntH (BRAMP) (MRAMP) 0.0306 0.4487 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0015 0.0582
Brugia malayi nuclear hormone receptor 0.001 0.0068 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0068 0.0093
Echinococcus multilocularis muscleblind protein 1 0.0146 0.2106 0.2106
Trichomonas vaginalis conserved hypothetical protein 0.0006 0.0015 0.0582
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0068 0.0068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0098 0.1378 0.1885
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0589 0.0806
Trypanosoma brucei DNA polymerase kappa, putative 0.0006 0.0008 0.0136
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0024 0.0024
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0715 0.0715
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0715 0.0715
Schistosoma mansoni Smad4 0.0008 0.0039 0.0039
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0231 0.0231
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0068 0.0093
Loa Loa (eye worm) hypothetical protein 0.0006 0.0008 0.0011
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0381 0.0381
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0231 0.0316
Echinococcus granulosus GPCR family 2 0.0031 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0031 0.0381 0.0522
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0262 1
Leishmania major DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0115 0.1998
Echinococcus granulosus smad 0.0008 0.0039 0.0039
Echinococcus granulosus dna polymerase eta 0.0044 0.0575 0.0575
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0068 0.0093
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.0039 0.0039
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0048 0.0066
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0231 0.0316
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0203 0.3432
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0068 0.0068
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0024 0.0024
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0068 0.0068
Echinococcus multilocularis GPCR, family 2 0.0031 0.0381 0.0381
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0068 0.0068
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0618 0.0618
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.0039 0.0039
Echinococcus multilocularis muscleblind protein 0.0146 0.2106 0.2106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0015 0.0582
Giardia lamblia DINP protein human, muc B family 0.0019 0.0203 0.8738
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0575 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0262 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0151 0.0151
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0231 0.3928
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0381 0.0522
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0151 0.0207
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0715 0.0715
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0068 0.0068
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.1667 0.2281
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0068 0.0068
Brugia malayi latrophilin 2 splice variant baaae 0.0067 0.0917 0.1254
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0068 0.0093
Schistosoma mansoni hypothetical protein 0.0031 0.0381 0.0381
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0151 0.0151
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0068 0.0093
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0203 0.3432
Leishmania major GTP-binding protein, putative 0.0021 0.0231 0.401
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0203 0.3521
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.0039 0.0054
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0381 0.0522
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0024 0.0024
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0203 0.0203
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0151 0.0207
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0151 0.0207
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0231 1
Brugia malayi MH2 domain containing protein 0.0117 0.1667 0.2281
Brugia malayi RNA, U transporter 1 0.008 0.112 0.1532
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0068 0.0068
Brugia malayi mbt repeat family protein 0.0047 0.0618 0.0846
Loa Loa (eye worm) hypothetical protein 0.0495 0.7309 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0715 0.0978
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0068 0.0068
Schistosoma mansoni cpg binding protein 0.003 0.0364 0.0364
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0068 0.0068
Mycobacterium ulcerans manganese transport protein MntH 0.0495 0.7309 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0068 0.0068
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0203 0.0277
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0618 0.0618
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0068 0.0093
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0203 0.0277
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0381 0.0522
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0006 0.0015 0.0582
Schistosoma mansoni smad 0.0008 0.0039 0.0039
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0715 0.0715
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0068 0.0093
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0146 0.2106 0.2881
Echinococcus granulosus Smad4 0.0008 0.0039 0.0039
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0151 0.0151
Loa Loa (eye worm) hypothetical protein 0.001 0.0068 0.0093
Loa Loa (eye worm) hypothetical protein 0.0044 0.0575 0.0787
Trypanosoma brucei hypothetical protein, conserved 0.0006 0.0008 0.0136
Echinococcus multilocularis microtubule associated protein 2 0.0675 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0589 0.0589
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0068 0.0093
Plasmodium vivax DNA repair protein REV1, putative 0.0006 0.0008 0.0011
Leishmania major DNA polymerase eta, putative 0.0044 0.0575 1
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0231 0.0231
Leishmania major importin beta-1 subunit, putative 0.0023 0.0262 0.456
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0203 0.7723
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0006 0.0015 0.0582
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521
Echinococcus granulosus importin subunit beta 1 0.0028 0.0342 0.0342
Brugia malayi NRAMP-like transporter K11G12.4 0.0495 0.7309 1
Schistosoma mansoni smad1 5 8 and 0.0008 0.0039 0.0039
Schistosoma mansoni smad1 5 8 and 0.0008 0.0039 0.0039
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0342 0.0342
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0151 0.0207
Plasmodium falciparum DNA repair protein REV1, putative 0.0006 0.0008 0.0011
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0068 0.0068
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.0039 0.0039
Schistosoma mansoni thyroid hormone receptor 0.001 0.0068 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0068 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0203 0.3521

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) = 14.8 uM Cytostatic concentration required to inhibit HEL cell proliferation ChEMBL. 15715482
CC50 (functional) = 20 uM Cytostatic concentration of the compound required to inhibit MT-4 cell proliferation ChEMBL. 15715482
CC50 (functional) = 21 uM Cytostatic concentration of the cell proliferation ChEMBL. 15715482
EC50 (functional) = 5 uM Effective concentration of the compound required to inhibit HIV-1 IIIB in CEM cell culture ChEMBL. 15715482
EC50 (functional) > 10 uM Effective concentration of the compound required to inhibit HIV-1 IIIB in MT-4 cell culture ChEMBL. 15715482
EC50 (functional) > 10 uM Effective concentration of the compound required to inhibit HIV-2 ROD in MT-4 cell culture ChEMBL. 15715482
EC50 (functional) > 10 uM Effective concentration of the compound required to inhibit HIV-2 ROD in CEM cell culture ChEMBL. 15715482
EC50 (functional) > 16 uM Effective concentration of the compound required to inhibit HCMV AD-169 in HEL Cells ChEMBL. 15715482
EC50 (functional) = 29 uM Effective concentration of the compound required to inhibit HCMV Davis in HEL Cells ChEMBL. 15715482
MCC (functional) >= 80 uM Minimal cytotoxic concentration required to cause microscopically visible alteration of cell morphology in HEL Cells ChEMBL. 15715482

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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