Detailed information for compound 314448

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 364.83 | Formula: C14H9ClN4O2S2
  • H donors: 2 H acceptors: 4 LogP: 3.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C(=O)Nc1scnc1C(=O)Nc1nccs1
  • InChi: 1S/C14H9ClN4O2S2/c15-9-3-1-2-8(6-9)11(20)18-13-10(17-7-23-13)12(21)19-14-16-4-5-22-14/h1-7H,(H,18,20)(H,16,19,21)
  • InChiKey: ISHUGZAGPIAKKD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Saccharomyces cerevisiae Map1p Starlite/ChEMBL References
Escherichia coli methionine aminopeptidase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Treponema pallidum methionine aminopeptidase (map) Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium yoelii methionine aminopeptidase, type I, putative Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) Get druggable targets OG5_126721 All targets in OG5_126721
Babesia bovis methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma brucei gambiense methionine aminopeptidase, putative,metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium yoelii methionine aminopeptidase, type I Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma japonicum Methionine aminopeptidase 1, putative Get druggable targets OG5_126721 All targets in OG5_126721
Leishmania mexicana methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium vivax methionine aminopeptidase 1a, putative Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma brucei methionine aminopeptidase, type I, putative Get druggable targets OG5_126721 All targets in OG5_126721
Cryptosporidium hominis methionine aminopeptidase 1 (MetAP 1) (MAP 1) (Peptidase M 1) Get druggable targets OG5_126721 All targets in OG5_126721
Theileria parva methionine aminopeptidase, type I, putative Get druggable targets OG5_126721 All targets in OG5_126721
Toxoplasma gondii methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Loa Loa (eye worm) methionine aminopeptidase type I Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium knowlesi methionine aminopeptidase 1b, putative Get druggable targets OG5_126721 All targets in OG5_126721
Candida albicans methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Chlamydia trachomatis methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium falciparum methionine aminopeptidase 1b, putative Get druggable targets OG5_126721 All targets in OG5_126721
Toxoplasma gondii methionine aminopeptidase, type i, putative Get druggable targets OG5_126721 All targets in OG5_126721
Leishmania donovani metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium knowlesi methionine aminopeptidase 1a, putative Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium ulcerans methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium ulcerans methionine aminopeptidase MapB Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium berghei methionine aminopeptidase 1b, putative Get druggable targets OG5_126721 All targets in OG5_126721
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium falciparum methionine aminopeptidase 1a, putative Get druggable targets OG5_126721 All targets in OG5_126721
Theileria parva methionine aminopeptidase, type I, putative Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma japonicum ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative Get druggable targets OG5_126721 All targets in OG5_126721
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma congolense metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Leishmania braziliensis methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Babesia bovis methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) Get druggable targets OG5_126721 All targets in OG5_126721
Schistosoma japonicum ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative Get druggable targets OG5_126721 All targets in OG5_126721
Neospora caninum methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Neospora caninum methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium berghei methionine aminopeptidase 1a, putative Get druggable targets OG5_126721 All targets in OG5_126721
Echinococcus granulosus methionyl aminopeptidase 1 M24 family Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma brucei methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Leishmania infantum methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Toxoplasma gondii methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 Get druggable targets OG5_126721 All targets in OG5_126721
Neospora caninum methionine aminopeptidase, putative Get druggable targets OG5_126721 All targets in OG5_126721
Brugia malayi Methionine aminopeptidase protein type I Get druggable targets OG5_126721 All targets in OG5_126721
Candida albicans methionine aminopeptidase Get druggable targets OG5_126721 All targets in OG5_126721
Cryptosporidium parvum methionine aminopeptidase with MYND finger at N-terminus Get druggable targets OG5_126721 All targets in OG5_126721
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) Get druggable targets OG5_126721 All targets in OG5_126721
Plasmodium vivax methionine aminopeptidase 1b, putative Get druggable targets OG5_126721 All targets in OG5_126721
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0292 0.3488 1
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0192 0.1743
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0161 0.0317
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0161 0.0317
Echinococcus multilocularis solute carrier family 5 0.0039 0.025 0.0524
Mycobacterium leprae putative cytochrome p450 0.0292 0.3488 1
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0086 0.0848 0.7688
Brugia malayi Sodium:solute symporter family protein 0.0039 0.025 0.0524
Onchocerca volvulus 0.0039 0.025 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0033 0.0161 0.0317
Loa Loa (eye worm) hypothetical protein 0.0039 0.025 0.0524
Brugia malayi Immunoglobulin I-set domain containing protein 0.0028 0.0103 0.0182
Brugia malayi photoreceptor-specific nuclear receptor 0.0033 0.0161 0.0317
Loa Loa (eye worm) hypothetical protein 0.0028 0.0103 0.0182
Echinococcus granulosus cytochrome P450 2K1 0.0026 0.0077 0.0122
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0292 0.3488 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0077 0.0701
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0106 0.1102 1
Chlamydia trachomatis methionine aminopeptidase 0.0086 0.0848 0.5
Brugia malayi Cytochrome P450 family protein 0.0026 0.0077 0.0122
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0292 0.3488 1
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0292 0.3488 1
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0086 0.0848 0.2258
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0033 0.0161 0.0317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0033 0.0161 0.0317
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0026 0.0077 0.0701
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0292 0.3488 1
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0106 0.1102 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0033 0.0161 0.0317
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0105 0.1089 0.2473
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0292 0.3488 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0033 0.0161 0.0317
Schistosoma mansoni inositol transporter 0.0039 0.025 0.0524
Entamoeba histolytica hypothetical protein 0.0105 0.1089 1
Schistosoma mansoni importin beta-1 0.003 0.0125 0.0233
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0026 0.0077 0.0701
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0025 0.0225
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0039 0.025 0.0524
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0161 0.0317
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0028 0.0103 0.0182
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0192 0.0389
Loa Loa (eye worm) hypothetical protein 0.0028 0.0106 0.0189
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0106 0.1102 0.2505
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0033 0.0161 0.0317
Leishmania major importin beta-1 subunit, putative 0.0024 0.0053 0.0483
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0317
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0033 0.0161 0.0317
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0033 0.0161 0.0317
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0192 0.0337
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0039 0.025 0.025
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0317
Schistosoma mansoni hypothetical protein 0.0028 0.0103 0.0182
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0292 0.3488 1
Echinococcus multilocularis FTZ F1 alpha 0.0033 0.0161 0.0317
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0039 0.025 0.0524
Loa Loa (eye worm) hypothetical protein 0.003 0.0125 0.0233
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0317
Echinococcus multilocularis 0.0026 0.0077 0.0122
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0033 0.0161 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0161 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0292 0.3488 1
Brugia malayi cytochrome P450 0.0026 0.0077 0.0122
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0033 0.0161 0.0317
Echinococcus granulosus sodium:glucose cotransporter 0.0039 0.025 0.0524
Brugia malayi Importin beta-1 subunit 0.003 0.0125 0.0233
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0086 0.0848 0.2258
Leishmania major cytochrome p450-like protein 0.0035 0.0192 0.1743
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0125 0.1135
Schistosoma mansoni hypothetical protein 0.0317 0.3802 0.8781
Schistosoma mansoni cytochrome P450 0.0026 0.0077 0.0122
Echinococcus multilocularis thyroid hormone receptor alpha 0.0033 0.0161 0.0317
Schistosoma mansoni transcription factor LCR-F1 0.0105 0.1089 0.2473
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0292 0.3488 1
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0161 0.0317
Onchocerca volvulus Bile acid receptor homolog 0.0033 0.0161 0.3959
Brugia malayi Steroid receptor seven-up type 2 0.0033 0.0161 0.0317
Onchocerca volvulus 0.0033 0.0161 0.3959
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0033 0.0161 0.0317
Toxoplasma gondii methionine aminopeptidase 0.0106 0.1102 0.1102
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0033 0.0161 0.0317
Echinococcus multilocularis ecdysone induced protein 78C 0.0033 0.0161 0.0317
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0292 0.3488 1
Echinococcus multilocularis importin subunit beta 1 0.003 0.0125 0.0233
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0086 0.0848 0.5
Echinococcus granulosus nuclear factor of activated T cells 5 0.0143 0.1579 0.3612
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0086 0.0848 0.1912
Schistosoma mansoni ankyrin 23/unc44 0.0028 0.0103 0.0182
Leishmania major cytochrome p450-like protein 0.0026 0.0077 0.0701
Schistosoma mansoni inositol transporter 0.0039 0.025 0.0524
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0292 0.3488 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0033 0.0161 0.0317
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0106 0.1102 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0033 0.0161 0.0317
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0025 0.0225
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0053 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0033 0.0161 0.0317
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0292 0.3488 1
Schistosoma mansoni RAR-like nuclear receptor 0.0033 0.0161 0.0317
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0161 0.0317
Entamoeba histolytica hypothetical protein 0.0105 0.1089 1
Echinococcus multilocularis Ankyrin 0.0028 0.0106 0.0189
Mycobacterium tuberculosis Probable oxidoreductase 0.0267 0.3156 0.9026
Brugia malayi Protein kinase domain containing protein 0.0028 0.0103 0.0182
Treponema pallidum methionine aminopeptidase (map) 0.0086 0.0848 0.5
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0033 0.0161 0.0317
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0292 0.3488 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0033 0.0161 0.0317
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0025 0.0225
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0025 0.5
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0086 0.0848 0.1912
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0033 0.0161 0.0317
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0105 0.1089 0.2473
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0053 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0161 0.0317
Brugia malayi Nuclear hormone receptor-like 1 0.0033 0.0161 0.0317
Schistosoma mansoni hypothetical protein 0.0026 0.0077 0.0122
Schistosoma mansoni hypothetical protein 0.0105 0.1089 0.2473
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0033 0.0161 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0292 0.3488 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0033 0.0161 0.3959
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0292 0.3488 1
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0106 0.1102 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0028 0.0103 0.0182
Brugia malayi RNA, U transporter 1 0.0084 0.0826 0.1862
Echinococcus granulosus sodium:myo inositol cotransporter 0.0039 0.025 0.0524
Leishmania major cytochrome p450-like protein 0.0026 0.0077 0.0701
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0106 0.1102 1
Echinococcus granulosus snurportin 1 0.0317 0.3802 0.8781
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0028 0.0106 0.0189
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0025 0.0025
Echinococcus granulosus Ankyrin 0.0028 0.0106 0.0189
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0192 0.0389
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0317
Brugia malayi steroid hormone receptor 0.0033 0.0161 0.0317
Brugia malayi Cytochrome P450 family protein 0.0046 0.0329 0.0707
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0028 0.0103 0.0182
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0106 0.1102 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0033 0.0161 0.0317
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0086 0.0848 0.0848
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0086 0.0848 0.2258
Echinococcus granulosus high affinity choline transporter 1 0.0358 0.4327 1
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0292 0.3488 1
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0161 0.0317
Trypanosoma brucei methionine aminopeptidase, putative 0.0106 0.1102 1
Echinococcus granulosus death domain containing protein 0.0028 0.0103 0.0182
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0125 0.1135
Entamoeba histolytica hypothetical protein 0.0105 0.1089 1
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0292 0.3488 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0192 0.0389
Brugia malayi Uncoordinated protein 44 0.0028 0.0103 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0033 0.0161 0.0317
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0025 0.0225
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0026 0.0077 0.0701
Brugia malayi nuclear hormone receptor 0.0033 0.0161 0.0317
Echinococcus multilocularis snurportin 1 0.0317 0.3802 0.8781
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0292 0.3488 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0033 0.0161 0.0317
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0317
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0053 0.0483
Loa Loa (eye worm) cytochrome P450 family protein 0.0046 0.0329 0.0707
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0033 0.0161 0.0317
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0125 0.0125
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0292 0.3488 1
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0039 0.025 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0033 0.0161 0.0317
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0317
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0161 0.0317
Entamoeba histolytica hypothetical protein 0.0105 0.1089 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0125 0.0233
Loa Loa (eye worm) methionine aminopeptidase type I 0.0106 0.1102 0.2505
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0292 0.3488 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0033 0.0161 0.3959
Schistosoma mansoni coup transcription factor 0.0033 0.0161 0.0317
Echinococcus granulosus solute carrier family 5 0.0039 0.025 0.0524
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0026 0.0077 0.0701
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0033 0.0161 0.0317
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0292 0.3488 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0025 0.0225
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0292 0.3488 1
Brugia malayi hypothetical protein 0.0105 0.1089 0.2473
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0086 0.0848 0.2258
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0292 0.3488 1
Schistosoma mansoni netrin receptor unc5 0.0028 0.0103 0.0182
Loa Loa (eye worm) cytochrome P450 0.0026 0.0077 0.0122
Echinococcus granulosus FTZ F1 alpha 0.0033 0.0161 0.0317
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0033 0.0161 0.0317
Brugia malayi GH02984p 0.0358 0.4327 1
Echinococcus granulosus netrin receptor unc 5 0.0028 0.0103 0.0182
Schistosoma mansoni thyroid hormone receptor 0.0033 0.0161 0.0317
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0292 0.3488 1
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0106 0.1102 0.2505
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0192 0.1743
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0143 0.1579 0.3612
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0292 0.3488 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0033 0.0161 0.0317
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0317 0.3802 0.8781
Loa Loa (eye worm) hypothetical protein 0.0358 0.4327 1
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0086 0.0848 0.7688
Echinococcus granulosus ecdysone induced protein 78C 0.0033 0.0161 0.0317
Echinococcus multilocularis high affinity choline transporter 1 0.0358 0.4327 1
Brugia malayi Cytochrome P450 family protein 0.0035 0.0192 0.0389
Schistosoma mansoni retinoic acid receptor RXR 0.0033 0.0161 0.0317
Brugia malayi Methionine aminopeptidase protein type I 0.0106 0.1102 0.2505
Leishmania major GTP-binding protein, putative 0.0022 0.0025 0.0225
Schistosoma mansoni sodium/solute symporter 0.0039 0.025 0.0524
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0033 0.0161 0.0317
Mycobacterium ulcerans methionine aminopeptidase 0.0086 0.0848 0.2258
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0033 0.0161 0.0317
Echinococcus multilocularis netrin receptor unc 5 0.0028 0.0103 0.0182
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0292 0.3488 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0033 0.0161 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0033 0.0161 0.0317
Brugia malayi Cytochrome P450 family protein 0.0035 0.0192 0.0389
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0053 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0033 0.0161 0.0317
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0033 0.0161 0.0317
Brugia malayi Death domain containing protein 0.0028 0.0103 0.0182
Plasmodium falciparum importin beta, putative 0.003 0.0125 0.1135
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0317
Brugia malayi nuclear receptor NHR-88 0.0033 0.0161 0.0317
Brugia malayi ecdysteroid receptor 0.0033 0.0161 0.0317
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0192 0.1743
Toxoplasma gondii methionine aminopeptidase 0.0086 0.0848 0.0848
Entamoeba histolytica hypothetical protein 0.0024 0.0053 0.0268
Schistosoma mansoni high-affinity choline transporter 0.0358 0.4327 1
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0039 0.025 0.0524
Echinococcus granulosus sodium:glucose cotransporter 2 0.0039 0.025 0.0524
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0086 0.0848 0.2258
Mycobacterium ulcerans oxidoreductase 0.0267 0.3156 0.9026
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0106 0.1102 1
Plasmodium vivax importin-beta 2, putative 0.003 0.0125 0.1135
Loa Loa (eye worm) steroid hormone receptor 0.0033 0.0161 0.0317
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0086 0.0848 0.1912

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.27 uM Inhibitory concentration required against Escherichia coli MetAP1 (150 nM) ChEMBL. 15993057
IC50 (binding) = 0.27 uM Inhibitory concentration required against Escherichia coli MetAP1 (150 nM) ChEMBL. 15993057
IC50 (binding) = 1.83 uM Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM) ChEMBL. 15993057
IC50 (binding) = 1.83 uM Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM) ChEMBL. 15993057

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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