Detailed information for compound 314526

Basic information

Technical information
  • TDR Targets ID: 314526
  • Name: 1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxy phenyl]-3-(2,4-difluorophenyl)urea
  • MW: 485.867 | Formula: C24H18ClF2N3O4
  • H donors: 2 H acceptors: 2 LogP: 5.05 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc2nccc(c2cc1OC)Oc1ccc(cc1Cl)NC(=O)Nc1ccc(cc1F)F
  • InChi: 1S/C24H18ClF2N3O4/c1-32-22-11-15-19(12-23(22)33-2)28-8-7-20(15)34-21-6-4-14(10-16(21)25)29-24(31)30-18-5-3-13(26)9-17(18)27/h3-12H,1-2H3,(H2,29,30,31)
  • InChiKey: ZJIOFIWKIMJTMZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[3-chloro-4-[(6,7-dimethoxy-4-quinolyl)oxy]phenyl]-3-(2,4-difluorophenyl)urea
  • 1-[3-chloro-4-(6,7-dimethoxyquinolin-4-yl)oxy-phenyl]-3-(2,4-difluorophenyl)urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References
Homo sapiens platelet-derived growth factor receptor, alpha polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0109 0.0181
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0364 1
Echinococcus granulosus hypothetical protein 0.0016 0.0057 0.0094
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0109 0.1261
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0057 0.0094
Brugia malayi ImpB/MucB/SamB family protein 0.0021 0.0109 0.0181
Echinococcus granulosus snurportin 1 0.0351 0.4055 0.6714
Echinococcus granulosus dna polymerase kappa 0.0021 0.0109 0.0181
Brugia malayi steroid hormone receptor 0.0022 0.0125 0.0206
Onchocerca volvulus 0.0167 0.1853 0.3835
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0571 1
Schistosoma mansoni hypothetical protein 0.0105 0.1121 0.1568
Schistosoma mansoni hypothetical protein 0.0022 0.0126 0.0177
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0677 0.0947
Giardia lamblia DINP protein human, muc B family 0.0021 0.0109 0.5
Echinococcus multilocularis somatostatin receptor 0.0016 0.0057 0.0057
Schistosoma mansoni bromodomain containing protein 0.007 0.0696 0.0974
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0125 0.0174
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0057 0.0079
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0042 0.0364 0.601
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0057 0.0079
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0125 0.0206
Brugia malayi RNA binding protein 0.0068 0.0677 0.1121
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0057 0.0094
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.051 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0346 0.0573
Onchocerca volvulus Tyrosine kinase homolog 0.0177 0.1977 0.4099
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0677 0.1121
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.0171 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0057 0.0057
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0054 0.051 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0179 0.409
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0057 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0125 0.0206
Trypanosoma brucei ISWI complex protein 0.0016 0.0058 0.0773
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi PHD-finger family protein 0.0029 0.0202 0.0334
Echinococcus granulosus serotonin receptor 0.0016 0.0057 0.0094
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0057 0.0079
Brugia malayi CXXC zinc finger family protein 0.003 0.022 0.0364
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0057 0.0094
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0125 0.0174
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0041 0.0346 0.6421
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0109 0.2326
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0253 0.3887
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0057 0.0057
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0565 0.0936
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0125 0.0206
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Onchocerca volvulus 0.0016 0.0057 0.0011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0057 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0125 0.0125
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0051 0.0546
Schistosoma mansoni neuropeptide receptor 0.0016 0.0057 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi Importin beta-1 subunit 0.0033 0.0253 0.042
Loa Loa (eye worm) hypothetical protein 0.0044 0.0385 0.0638
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0109 0.1852
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0057 0.0094
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0038 0.0311 0.5896
Onchocerca volvulus 0.0016 0.0057 0.0011
Schistosoma mansoni inositol monophosphatase 0.0042 0.0364 0.0509
Schistosoma mansoni hypothetical protein 0.0052 0.0488 0.0682
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Echinococcus granulosus orexin receptor type 2 0.0016 0.0057 0.0094
Schistosoma mansoni terminal deoxycytidyl transferase 0.0021 0.0109 0.0153
Entamoeba histolytica hypothetical protein 0.0188 0.2112 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0057 0.0094
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0057 0.0057
Plasmodium vivax acyl-CoA synthetase, putative 0.0041 0.0346 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0125 0.0206
Loa Loa (eye worm) hypothetical protein 0.0052 0.0488 0.0807
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0016 0.0051 0.0546
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0677 0.1121
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0206
Brugia malayi neuropeptide F receptor 0.0016 0.0057 0.0094
Echinococcus multilocularis serotonin receptor 0.0016 0.0057 0.0057
Schistosoma mansoni acetyl-CoA synthetase 0.0016 0.0051 0.0072
Plasmodium falciparum acyl-CoA synthetase 0.0041 0.0346 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0019 0.0088 0.0146
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Echinococcus granulosus g protein coupled receptor 0.0016 0.0057 0.0094
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0125 0.0206
Loa Loa (eye worm) hypothetical protein 0.0076 0.0772 0.1278
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0125 0.0206
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0057 0.0057
Trypanosoma brucei unspecified product 0.0021 0.0109 0.2326
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0057 0.0057
Onchocerca volvulus 0.003 0.022 0.0358
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.061 0.715 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0016 0.0051 0.0085
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0206
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0057 0.0057
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0057 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0057 0.0094
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0057 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0057 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0057 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0125 0.0206
Schistosoma mansoni coup transcription factor 0.0022 0.0125 0.0174
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0364 1
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi RE15519p 0.0016 0.0057 0.0094
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0051 0.0546
Leishmania major DNA polymerase kappa, putative 0.0021 0.0109 0.1261
Schistosoma mansoni hypothetical protein 0.0052 0.0488 0.0682
Brugia malayi ORL1-like opioid receptor 0.0016 0.0057 0.0094
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0125 0.0206
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0206
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0057 0.0094
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0057 0.0079
Plasmodium vivax importin-beta 2, putative 0.0033 0.0253 0.6858
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0057 0.0079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0109 0.0181
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0166 0.1843 0.3051
Brugia malayi Dopamine receptor protein 1 0.0016 0.0057 0.0094
Schistosoma mansoni opsin-like receptor 0.0016 0.0057 0.0079
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0016 0.0051 0.0546
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0057 0.0094
Trypanosoma cruzi ISWI complex protein 0.0016 0.0058 0.0203
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0057 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0125 0.0206
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0051 0.0085
Brugia malayi G-protein coupled receptor 0.0016 0.0057 0.0094
Echinococcus granulosus neuropeptide receptor 0.0016 0.0057 0.0094
Echinococcus multilocularis lamin 0.0059 0.0565 0.0565
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Onchocerca volvulus 0.0016 0.0057 0.0011
Loa Loa (eye worm) hypothetical protein 0.0054 0.051 0.0845
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0057 0.0079
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0238 0.0394
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0179 0.409
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0109 0.1852
Schistosoma mansoni cpg binding protein 0.0034 0.0265 0.037
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0238 0.0394
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0166 0.1843 0.3051
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0206
Echinococcus granulosus lamin 0.0059 0.0565 0.0936
Schistosoma mansoni transcription factor LCR-F1 0.0188 0.2112 0.2955
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0088 0.0123
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0188 0.2112 0.2112
Schistosoma mansoni hypothetical protein 0.0351 0.4055 0.5672
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0125 0.0174
Onchocerca volvulus 0.0016 0.0057 0.0011
Echinococcus granulosus zinc finger protein 0.0023 0.0133 0.0221
Schistosoma mansoni neuropeptide receptor 0.0016 0.0057 0.0079
Echinococcus granulosus g protein coupled receptor 0.0016 0.0057 0.0094
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.0079
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.065 0.1077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0125 0.0206
Echinococcus granulosus sex peptide receptor 0.0016 0.0057 0.0094
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0125 0.0206
Loa Loa (eye worm) bromodomain containing protein 0.0019 0.0088 0.0146
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0125 0.0206
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0364 1
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi Serotonin receptor 0.0016 0.0057 0.0094
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.051 0.2227
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0109 0.1261
Echinococcus granulosus allatostatin A receptor 0.0016 0.0057 0.0094
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0016 0.0051 0.0546
Loa Loa (eye worm) hypothetical protein 0.0019 0.0088 0.0146
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0057 0.0057
Schistosoma mansoni cellular tumor antigen P53 0.0053 0.0498 0.0696
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.0079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0057 0.0079
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0057 0.0094
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.051 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Brugia malayi larval opioid receptor 0.0016 0.0057 0.0094
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0051 0.0085
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0125 0.0125
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0057 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0057 0.0057
Brugia malayi hypothetical protein 0.0409 0.4751 0.7865
Schistosoma mansoni zinc finger protein 0.0023 0.0133 0.0186
Schistosoma mansoni biogenic amine receptor 0.0016 0.0057 0.0079
Schistosoma mansoni intermediate filament proteins 0.0059 0.0565 0.079
Onchocerca volvulus Huntingtin homolog 0.0409 0.4751 1
Brugia malayi TAR-binding protein 0.0068 0.0677 0.1121
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0057 0.0094
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0057 0.0094
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) latrophilin receptor protein 2 0.0052 0.0488 0.0807
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0057 0.0094
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0057 0.0057
Brugia malayi putative neuropeptide receptor 0.0016 0.0057 0.0094
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0057 0.0094
Echinococcus multilocularis lamin dm0 0.0059 0.0565 0.0565
Schistosoma mansoni hypothetical protein 0.0113 0.1215 0.17
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0125 0.0206
Brugia malayi follicle stimulating hormone receptor 0.0257 0.2933 0.4856
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0253 0.6673
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0057 0.0094
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Schistosoma mansoni lamin 0.0059 0.0565 0.079
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0057 0.0094
Echinococcus granulosus roundabout 2 0.0023 0.013 0.0215
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0057 0.0094
Brugia malayi nuclear hormone receptor 0.0022 0.0125 0.0206
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0109 0.1738
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0057 0.0079
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0125 0.0206
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0019 0.0088 0.0123
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0057 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0125 0.0206
Echinococcus granulosus importin subunit beta 1 0.0033 0.0253 0.042
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0677 0.0947
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0057 0.0094
Schistosoma mansoni histamine h1 receptor 0.0016 0.0057 0.0079
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0109 0.1738
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.008 0.0112
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0057 0.0079
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0057 0.0079
Schistosoma mansoni cell adhesion molecule 0.0015 0.0039 0.0054
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0125 0.0206
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.051 1
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi RNA, U transporter 1 0.0093 0.0978 0.1619
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0057 0.0094
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0188 0.2112 0.3498
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0311
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0206
Echinococcus multilocularis roundabout 2 0.0023 0.013 0.013
Echinococcus multilocularis dnaJ subfamily B 0.0428 0.4975 0.4975
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0015 0.0039 0.0064
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0016 0.0051 0.0051
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0023 0.013 0.0215
Loa Loa (eye worm) hypothetical protein 0.0041 0.0346 0.0573
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0052 0.0488 0.0488
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0027 0.0188 0.0311
Schistosoma mansoni importin beta-1 0.0033 0.0253 0.0354
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0057 0.0094
Mycobacterium ulcerans hypothetical protein 0.0054 0.051 1
Onchocerca volvulus 0.0016 0.0057 0.0011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.2933 0.4856
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0057 0.0094
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0057 0.0094
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0057 0.0079
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0057 0.0094
Onchocerca volvulus Huntingtin homolog 0.0409 0.4751 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0057 0.0094
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0057 0.0094
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0057 0.0079
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0125 0.0156
Entamoeba histolytica hypothetical protein 0.0188 0.2112 1
Onchocerca volvulus 0.0059 0.0565 0.1094
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0039 0.0324 0.0324
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0051 0.0546
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0016 0.0051 0.0546
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0057 0.0079
Echinococcus granulosus tar DNA binding protein 0.0068 0.0677 0.1121
Loa Loa (eye worm) RNA binding protein 0.0068 0.0677 0.1121
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.008 0.0112
Loa Loa (eye worm) hypothetical protein 0.0409 0.4751 0.7865
Schistosoma mansoni hypothetical protein 0.0188 0.2112 0.2955
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Onchocerca volvulus 0.0054 0.051 0.0977
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0057 0.0057
Brugia malayi Immunoglobulin I-set domain containing protein 0.0184 0.2064 0.3417
Loa Loa (eye worm) hypothetical protein 0.0041 0.0346 0.0573
Loa Loa (eye worm) hypothetical protein 0.0517 0.604 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0057 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0125 0.0174
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0057 0.0094
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0057 0.0079
Brugia malayi latrophilin 2 splice variant baaae 0.0113 0.1215 0.2012
Schistosoma mansoni zinc finger protein 0.0016 0.0058 0.0081
Echinococcus granulosus neuroglian 0.0019 0.0086 0.0143
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0057 0.0094
Brugia malayi Serotonin receptor 0.0016 0.0057 0.0094
Schistosoma mansoni opsin-like receptor 0.0016 0.0057 0.0079
Echinococcus multilocularis dna polymerase eta 0.0021 0.0109 0.0109
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0016 0.0057 0.0079
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0364 0.6808
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0057 0.0057
Schistosoma mansoni DNA polymerase eta 0.0021 0.0109 0.0153
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0057 0.0079
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0057 0.0011
Brugia malayi Dopamine receptor 0.0016 0.0057 0.0094
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0125 0.0125
Echinococcus granulosus dnaJ subfamily B 0.0428 0.4975 0.8237
Leishmania major hypothetical protein, conserved 0.0016 0.0058 0.0138
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0057 0.0079
Echinococcus granulosus g protein coupled receptor 0.0016 0.0057 0.0094
Entamoeba histolytica acyl-CoA synthetase, putative 0.0054 0.051 0.2227
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0038 0.0311 0.5659
Entamoeba histolytica hypothetical protein 0.0027 0.0179 0.062
Echinococcus granulosus tumor protein p63 0.0364 0.4215 0.6978
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0057 0.0057
Schistosoma mansoni inositol monophosphatase 0.0042 0.0364 0.0509
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Schistosoma mansoni amine GPCR 0.0016 0.0057 0.0079
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0021 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0057 0.0094
Schistosoma mansoni cpg binding protein 0.0034 0.0265 0.037
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0021 0.0109 0.1852
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0051 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi G protein-coupled receptor 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Onchocerca volvulus 0.0059 0.0565 0.1094
Onchocerca volvulus 0.0016 0.0057 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0057 0.0057
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0054 0.051 0.0845
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0057 0.0057
Brugia malayi AMP-binding enzyme family protein 0.0054 0.051 0.0845
Loa Loa (eye worm) hypothetical protein 0.0048 0.0431 0.0713
Entamoeba histolytica acyl-coA synthetase, putative 0.0054 0.051 0.2227
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.0171 0.0171
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0058 0.0552 0.0914
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0051 0.0085
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0125 0.0174
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0057 0.0057
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0125 0.0206
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0021 0.0109 0.0153
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) PHD-finger family protein 0.0022 0.0126 0.0209
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0057 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0057 0.0079
Leishmania major DNA polymerase eta, putative 0.0021 0.0109 0.1261
Schistosoma mansoni nephrin 0.0019 0.0086 0.0121
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0016 0.0051 0.0085
Schistosoma mansoni hypothetical protein 0.0052 0.0488 0.0682
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0057 0.0057
Brugia malayi Inositol-1 0.0042 0.0364 0.0602
Mycobacterium ulcerans DNA polymerase IV 0.0021 0.0109 0.1261
Echinococcus granulosus somatostatin receptor 0.0016 0.0057 0.0094
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0125 0.0125
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0057 0.0079
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0042 0.0364 0.5
Onchocerca volvulus 0.0016 0.0057 0.0011
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0057 0.0057
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0042 0.0364 0.1516
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.051 1
Schistosoma mansoni tyrosine kinase 0.0014 0.0028 0.004
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0125 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0125 0.0206
Loa Loa (eye worm) hypothetical protein 0.0054 0.051 0.0845
Schistosoma mansoni biogenic amine receptor 0.0016 0.0057 0.0079
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0057 0.0094
Echinococcus granulosus inositol monophosphatase 1 0.0042 0.0364 0.0602
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0206
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0125 0.0125
Echinococcus granulosus neuropeptide receptor 0.0016 0.0057 0.0094
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0125 0.0206
Brugia malayi GnHR receptor homolog 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0041 0.0346 0.0573
Onchocerca volvulus 0.0016 0.0057 0.0011
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0125 0.0174
Loa Loa (eye worm) hypothetical protein 0.0113 0.1215 0.2012
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0057 0.0079
Brugia malayi Melatonin receptor type 1A 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi AKH receptor 0.0016 0.0057 0.0094
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0042 0.0364 0.6808
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0109 0.1852
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0057 0.0057
Onchocerca volvulus 0.0105 0.1121 0.2276
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.065 0.065
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0351 0.4055 0.6714
Leishmania major importin beta-1 subunit, putative 0.0027 0.0179 0.2785
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0057 0.0057
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0677 0.0947
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0125 0.0174
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0057 0.0057
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0057 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Schistosoma mansoni myosin xvIII 0.0016 0.0057 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0016 0.0051 0.0582
Onchocerca volvulus 0.0016 0.0057 0.0011
Loa Loa (eye worm) hypothetical protein 0.0059 0.0565 0.0936
Onchocerca volvulus 0.0016 0.0057 0.0011
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0057 0.0079
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0054 0.051 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Schistosoma mansoni opsin-like receptor 0.0016 0.0057 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0125 0.0206
Brugia malayi Calcitonin receptor-like protein seb-1 0.0166 0.1843 0.3051
Trypanosoma brucei DNA polymerase eta, putative 0.0021 0.0109 0.2326
Echinococcus granulosus lamin dm0 0.0059 0.0565 0.0936
Brugia malayi intermediate filament protein 0.0059 0.0565 0.0936
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0057 0.0057
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0057 0.0011
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0125 0.0206
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.032 0.6071
Echinococcus multilocularis GPCR, family 2 0.0052 0.0488 0.0488
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0041 0.0346 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0039 0.0324 0.0536
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0052 0.0488 0.0807
Loa Loa (eye worm) hypothetical protein 0.0409 0.4751 0.7865
Loa Loa (eye worm) hypothetical protein 0.0022 0.0125 0.0206
Brugia malayi AMP-binding enzyme family protein 0.0016 0.0051 0.0085
Loa Loa (eye worm) hypothetical protein 0.0028 0.0201 0.0332
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.0171 0.0284
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0057 0.0094
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0042 0.0364 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0253 0.6673
Entamoeba histolytica deoxycytidyl transferase, putative 0.0021 0.0109 0.0281
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi Dopamine receptor protein 2 0.0016 0.0057 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0125 0.0206
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0125 0.0174
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.051 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0125 0.0206
Schistosoma mansoni survival motor neuron protein 0.0105 0.1121 0.1568
Loa Loa (eye worm) hypothetical protein 0.0016 0.0051 0.0085
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0057 0.0057
Echinococcus multilocularis cpg binding protein 0.0034 0.0265 0.0265
Schistosoma mansoni amine GPCR 0.0016 0.0057 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0677 0.0947
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0125 0.0174
Leishmania major 4-coumarate:coa ligase-like protein 0.0054 0.051 1
Echinococcus granulosus survival motor neuron protein 1 0.0517 0.604 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.032 0.6071
Brugia malayi hypothetical protein 0.0517 0.604 1
Onchocerca volvulus 0.0016 0.0057 0.0011
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0125 0.0156
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi Bromodomain containing protein 0.0041 0.0354 0.0586
Brugia malayi G-protein coupled receptor 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Echinococcus multilocularis sex peptide receptor 0.0016 0.0057 0.0057
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0057 0.0057
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0041 0.0346 0.6617
Trichomonas vaginalis inositol monophosphatase, putative 0.0042 0.0364 1
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0057 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0105 0.1121 0.1856
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Onchocerca volvulus 0.0016 0.0057 0.0011
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0057 0.0094
Echinococcus multilocularis musashi 0.0059 0.0565 0.0565
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0016 0.0051 0.0582
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.051 1
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0057 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Trichomonas vaginalis DNA polymerase eta, putative 0.0021 0.0109 0.1852
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.051 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0057 0.0094
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0057 0.0094
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.008 0.008
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0057 0.0057
Echinococcus multilocularis inositol monophosphatase 1 0.0042 0.0364 0.0364
Loa Loa (eye worm) oxidoreductase 0.0016 0.0051 0.0085
Echinococcus multilocularis snurportin 1 0.0351 0.4055 0.4055
Echinococcus granulosus dna polymerase eta 0.0021 0.0109 0.0181
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0057 0.0094
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0125 0.0125
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0057 0.0079
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0125 0.0206
Onchocerca volvulus 0.0016 0.0057 0.0011
Trypanosoma cruzi DNA polymerase kappa, putative 0.0021 0.0109 0.1852
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.022 0.0364
Echinococcus granulosus fmrfamide receptor 0.0016 0.0057 0.0094
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0125 0.0174
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0052 0.0488 0.0488
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0054 0.051 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0016 0.0051 0.0085
Onchocerca volvulus 0.0053 0.0498 0.095
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0041 0.0346 0.0573
Plasmodium falciparum importin beta, putative 0.0033 0.0253 0.6858
Brugia malayi neuropeptide F receptor 0.0016 0.0057 0.0094
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0201 0.0332
Echinococcus granulosus GPCR family 2 0.0052 0.0488 0.0807
Onchocerca volvulus 0.0016 0.0057 0.0011
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0057 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0057 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0125 0.0206
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0042 0.0364 1
Brugia malayi AMP-binding enzyme family protein 0.0054 0.051 0.0845
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Schistosoma mansoni neuropeptide receptor 0.0016 0.0057 0.0079
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0057 0.0094
Echinococcus multilocularis tumor protein p63 0.0364 0.4215 0.4215
Schistosoma mansoni adenoreceptor 0.0016 0.0057 0.0079
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0125 0.0206
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0057 0.0057
Schistosoma mansoni hypothetical protein 0.0428 0.4975 0.6958
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0125 0.0206
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.008 0.0133
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0052 0.0488 0.0807
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0057 0.0057
Brugia malayi Latrophilin receptor protein 2 0.0052 0.0488 0.0807
Brugia malayi hypothetical protein 0.0188 0.2112 0.3498
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0057 0.0079
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0057 0.0094
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0057 0.0057
Onchocerca volvulus 0.0016 0.0057 0.0011
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0125 0.0206
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0166 0.1843 0.3051
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0057 0.0094
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0179 0.409
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.032 0.6071
Echinococcus granulosus cpg binding protein 0.0034 0.0265 0.0438
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0125 0.0206
Loa Loa (eye worm) hypothetical protein 0.0033 0.0253 0.042
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0057 0.0057
Echinococcus granulosus intermediate filament protein 0.0059 0.0565 0.0936
Brugia malayi nuclear receptor NHR-88 0.0022 0.0125 0.0206
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0016 0.0051 0.0546
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0052 0.0488 0.0807
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0051 0.0546
Schistosoma mansoni amine GPCR 0.0016 0.0057 0.0079
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0016 0.0051 0.0546
Entamoeba histolytica hypothetical protein 0.0188 0.2112 1
Echinococcus multilocularis neuroglian 0.0019 0.0086 0.0086
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0125 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0125 0.0206
Brugia malayi sulfakinin receptor protein 0.0016 0.0057 0.0094
Schistosoma mansoni biogenic amine receptor 0.0016 0.0057 0.0079
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0179 0.409
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0021 0.0109 0.0181
Loa Loa (eye worm) inositol-1 0.0042 0.0364 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0125 0.0206
Schistosoma mansoni hypothetical protein 0.0016 0.0058 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0677 0.0947
Brugia malayi Bromodomain containing protein 0.0083 0.0847 0.1403
Echinococcus granulosus twitchin 0.0019 0.0086 0.0143
Trypanosoma cruzi ISWI complex protein 0.0016 0.0058 0.0203
Schistosoma mansoni lamin 0.0059 0.0565 0.079
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0677 0.1121
Echinococcus multilocularis zinc finger protein 0.0023 0.0133 0.0133
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0057 0.0057
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0016 0.0051 0.0085
Entamoeba histolytica hypothetical protein 0.0188 0.2112 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0021 0.0109 0.0181
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0125 0.0125
Mycobacterium ulcerans acyl-CoA synthetase 0.0054 0.051 1
Schistosoma mansoni amine GPCR 0.0016 0.0057 0.0079
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0125 0.0125
Schistosoma mansoni cpg binding protein 0.003 0.022 0.0307
Trypanosoma cruzi DNA polymerase eta, putative 0.0021 0.0109 0.1852
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0057 0.0057
Schistosoma mansoni amine GPCR 0.0016 0.0057 0.0079
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0057 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0057 0.0094
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0184 0.2064 0.3417
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0677 0.0677
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0565 0.0936
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0109 0.2326
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0125 0.0206
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0038 0.032 0.6071
Onchocerca volvulus 0.0016 0.0057 0.0011
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0057 0.0079
Loa Loa (eye worm) hypothetical protein 0.0023 0.013 0.0215
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0125 0.0174
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0125 0.0174
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Onchocerca volvulus 0.0016 0.0057 0.0011
Echinococcus multilocularis dna polymerase kappa 0.0021 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0019 0.0088 0.0088
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0039 0.0064
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0057 0.0094
Onchocerca volvulus 0.0022 0.0125 0.0156
Schistosoma mansoni neuropeptide receptor 0.0016 0.0057 0.0079
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0109 0.2326
Brugia malayi hypothetical protein 0.0016 0.0057 0.0094
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0622 0.087
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0057 0.0057
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0094
Schistosoma mansoni hypothetical protein 0.0052 0.0488 0.0682
Trypanosoma brucei DNA polymerase IV, putative 0.0021 0.0109 0.2326
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0054 0.051 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0355 0.0588
Loa Loa (eye worm) hypothetical protein 0.0053 0.0498 0.0824
Brugia malayi ecdysteroid receptor 0.0022 0.0125 0.0206
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0016 0.0051 0.0546
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0565 0.0936
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0057 0.0094
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0054 0.051 1
Brugia malayi AMP-binding enzyme family protein 0.0054 0.051 0.0845
Echinococcus multilocularis survival motor neuron protein 1 0.0517 0.604 0.604
Echinococcus multilocularis serotonin receptor 0.0016 0.0057 0.0057

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 2.6 nM Inhibition of vascular endothelial growth factor receptor 2 ChEMBL. 15743179
IC50 (binding) = 2.6 nM Inhibition of vascular endothelial growth factor receptor 2 ChEMBL. 15743179
IC50 (binding) = 13 nM Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay ChEMBL. 15743179
IC50 (binding) = 13 nM Inhibition of platelet-derived growth factor receptor alpha in cell-intact assay ChEMBL. 15743179

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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