TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 308.379 | Formula: C12H12N4O2S2
H donors: 2 H acceptors: 4 LogP: 2.86 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: C=CC(C(=O)Nc1scnc1C(=O)Nc1nccs1)C
InChi: 1S/C12H12N4O2S2/c1-3-7(2)9(17)15-11-8(14-6-20-11)10(18)16-12-13-4-5-19-12/h3-7H,1H2,2H3,(H,15,17)(H,13,16,18)
InChiKey: NTZQHHLLIHUMMD-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	methionine aminopeptidase	Starlite/ChEMBL	References
Saccharomyces cerevisiae	Map1p	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Treponema pallidum	methionine aminopeptidase (map)	Get druggable targets OG5_126721	All targets in OG5_126721
Cryptosporidium parvum	methionine aminopeptidase with MYND finger at N-terminus	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium falciparum	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium knowlesi	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Loa Loa (eye worm)	methionine aminopeptidase type I	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	Get druggable targets OG5_126721	All targets in OG5_126721
Cryptosporidium hominis	methionine aminopeptidase 1 (MetAP 1) (MAP 1) (Peptidase M 1)	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium berghei	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Theileria parva	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium berghei	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium ulcerans	methionine aminopeptidase MapB	Get druggable targets OG5_126721	All targets in OG5_126721
Toxoplasma gondii	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Neospora caninum	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Chlamydia trachomatis	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Toxoplasma gondii	methionine aminopeptidase, type i, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Candida albicans	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium vivax	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei gambiense	methionine aminopeptidase, putative,metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania infantum	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Babesia bovis	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania donovani	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium yoelii	methionine aminopeptidase, type I	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania mexicana	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium ulcerans	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma japonicum	ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative	Get druggable targets OG5_126721	All targets in OG5_126721
Brugia malayi	Methionine aminopeptidase protein type I	Get druggable targets OG5_126721	All targets in OG5_126721
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma japonicum	Methionine aminopeptidase 1, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Babesia bovis	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Neospora caninum	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Neospora caninum	methionine aminopeptidase, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	Get druggable targets OG5_126721	All targets in OG5_126721
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	Get druggable targets OG5_126721	All targets in OG5_126721
Candida albicans	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium yoelii	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Leishmania braziliensis	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721
Theileria parva	methionine aminopeptidase, type I, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium vivax	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium knowlesi	methionine aminopeptidase 1a, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Schistosoma japonicum	ko:K01265 methionyl aminopeptidase [EC3.4.11.18], putative	Get druggable targets OG5_126721	All targets in OG5_126721
Toxoplasma gondii	methionine aminopeptidase	Get druggable targets OG5_126721	All targets in OG5_126721
Plasmodium falciparum	methionine aminopeptidase 1b, putative	Get druggable targets OG5_126721	All targets in OG5_126721
Trypanosoma congolense	metallo- peptidase, Clan MG, Family M24	Get druggable targets OG5_126721	All targets in OG5_126721

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	cysteine peptidase A (CPA)	0.0017	0.0505	0.0673
Echinococcus granulosus	Jumonji AT rich interactive domain 1B	0.0036	0.1621	0.1621
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0011	0.0119	0.0204
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0512	0.0512
Echinococcus granulosus	lysine specific demethylase 5A	0.0124	0.6953	0.6953
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0161	0.0217
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1967	0.2819
Mycobacterium ulcerans	methionine aminopeptidase	0.0086	0.4653	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.343	0.5861
Schistosoma mansoni	cpg binding protein	0.0033	0.1447	0.1447
Brugia malayi	Cathepsin L-like cysteine proteinase	0.0012	0.0161	0.0231
Onchocerca volvulus		0.0012	0.0161	0.0374
Brugia malayi	jmjC domain containing protein	0.0032	0.1403	0.2017
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.4877	0.4877
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0086	0.4653	0.4653
Brugia malayi	metallopeptidase family M24 containing protein	0.0011	0.0119	0.0171
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0011	0.0119	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0444	0.0626
Echinococcus granulosus	methionine aminopeptidase type I	0.0011	0.0119	0.0119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0505	1
Entamoeba histolytica	cysteine protease, putative	0.0017	0.0505	1
Plasmodium vivax	FACT complex subunit SPT16, putative	0.0011	0.0119	0.0204
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Onchocerca volvulus		0.0017	0.0505	0.3475
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0058	0.2953	0.4943
Trypanosoma brucei	hypothetical protein, conserved	0.002	0.0663	0.1134
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Trypanosoma brucei	JmjC domain, hydroxylase, putative	0.0032	0.1403	0.2397
Loa Loa (eye worm)	hypothetical protein	0.0039	0.1822	0.261
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.055	0.055
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0505	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0016	0.0444	0.0444
Echinococcus granulosus	GPCR family 2	0.0016	0.0444	0.0444
Plasmodium vivax	methionine aminopeptidase 1a, putative	0.0086	0.4653	0.795
Echinococcus granulosus	zinc finger protein	0.0022	0.0767	0.0767
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.4877	0.4877
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0505	0.0726
Plasmodium falciparum	methionine aminopeptidase 2	0.0011	0.0119	0.0204
Schistosoma mansoni	cpg binding protein	0.0033	0.1447	0.1447
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Plasmodium vivax	methionine aminopeptidase 1c, putative	0.0011	0.0119	0.0204
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0505	1
Echinococcus multilocularis	FACT complex subunit SPT16	0.0011	0.0119	0.0119
Plasmodium falciparum	methionine aminopeptidase 1a, putative	0.0086	0.4653	0.795
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.0663	0.1134
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.343	0.5861
Echinococcus granulosus	cathepsin l1	0.0012	0.0161	0.0161
Brugia malayi	Methionine aminopeptidase protein type I	0.0106	0.5853	0.8417
Loa Loa (eye worm)	jmjC domain-containing protein	0.0124	0.6953	1
Onchocerca volvulus		0.0017	0.0505	0.3475
Toxoplasma gondii	cathepsin CPL	0.0017	0.0505	0.0673
Schistosoma mansoni	hypothetical protein	0.0035	0.1583	0.1583
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0011	0.0119	0.0204
Schistosoma mansoni	hypothetical protein	0.0016	0.0444	0.0444
Plasmodium vivax	hypothetical protein, conserved	0.002	0.0663	0.1134
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0025	0.095	0.095
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0032	0.1403	0.2397
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0106	0.5853	0.5853
Loa Loa (eye worm)	ctsf protein	0.0017	0.0505	0.0713
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.0009	0.001	0.001
Brugia malayi	Bromodomain containing protein	0.0078	0.4174	0.6003
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0505	0.0726
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0505	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0161	0.0231
Loa Loa (eye worm)	jmjC domain-containing protein	0.0032	0.1403	0.2006
Chlamydia trachomatis	methionine aminopeptidase	0.0086	0.4653	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0505	1
Echinococcus granulosus	FACT complex subunit SPT16	0.0011	0.0119	0.0119
Leishmania major	methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24	0.0106	0.5853	1
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0011	0.0119	0.0204
Brugia malayi	F/Y-rich N-terminus family protein	0.0011	0.012	0.0173
Trypanosoma cruzi	cysteine peptidase, putative	0.0017	0.0505	0.0863
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0063	0.3234	0.3234
Echinococcus multilocularis	Transcription factor, JmjC domain containing protein	0.0121	0.6735	0.6735
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0512	0.0512
Brugia malayi	metallopeptidase family M24 containing protein	0.0011	0.0119	0.0171
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0404	0.069
Loa Loa (eye worm)	hypothetical protein	0.0045	0.2185	0.3133
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0018	0.055	0.055
Plasmodium falciparum	JmjC domain-containing protein, putative	0.0032	0.1403	0.2397
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.009	0.4877	0.4877
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0505	0.3475
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0505	0.0505
Entamoeba histolytica	cysteine proteinase, putative	0.0012	0.0161	0.3182
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0011	0.0119	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0161	0.0217
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.009	0.4877	0.7009
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0505	0.0505
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Brugia malayi	Cytochrome P450 family protein	0.0026	0.1	0.1438
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0011	0.0119	0.0204
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Schistosoma mansoni	zinc finger protein	0.0016	0.0404	0.0404
Leishmania major	hypothetical protein, conserved	0.0032	0.1403	0.2239
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0505	0.0505
Echinococcus multilocularis	methionine aminopeptidase, type I	0.0011	0.0119	0.0119
Schistosoma mansoni	hypothetical protein	0.0016	0.0444	0.0444
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0505	0.0726
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0011	0.0119	0.0204
Echinococcus granulosus	xaa pro aminopeptidase	0.0011	0.0119	0.0119
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.4877	0.4877
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0029	0.1229	0.1756
Loa Loa (eye worm)	jmjC domain-containing protein	0.0032	0.1403	0.2006
Echinococcus multilocularis	phd:f box containing protein	0.0032	0.1403	0.1403
Trypanosoma brucei	metallo- peptidase, Clan MG, Family M24	0.0106	0.5853	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Plasmodium falciparum	FACT complex subunit SPT16, putative	0.0011	0.0119	0.0204
Schistosoma mansoni	hypothetical protein	0.0016	0.0404	0.0404
Schistosoma mansoni	peptidase	0.0011	0.0119	0.0119
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0017	0.0505	0.0505
Schistosoma mansoni	hypothetical protein	0.0175	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0016	0.0444	0.0444
Toxoplasma gondii	histone lysine demethylase JMJD6a	0.0032	0.1403	0.2239
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0016	0.0444	0.0639
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0106	0.5853	1
Brugia malayi	CXXC zinc finger family protein	0.0029	0.1229	0.1767
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0011	0.0119	0.0119
Trypanosoma cruzi	aminopeptidase P1, putative	0.0011	0.0119	0.0204
Schistosoma mansoni	protein phosphatase 2C	0.0032	0.1403	0.1403
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Entamoeba histolytica	aminopeptidase, putative	0.0011	0.0119	0.2361
Trypanosoma cruzi	ISWI complex protein	0.0016	0.0404	0.069
Schistosoma mansoni	zinc finger protein	0.0022	0.0767	0.0767
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0505	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Trypanosoma brucei	methionine aminopeptidase, putative	0.0106	0.5853	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Treponema pallidum	methionine aminopeptidase (map)	0.0086	0.4653	1
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0505	1
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0124	0.6953	0.6953
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0063	0.3234	0.3234
Plasmodium vivax	vivapain-2	0.0017	0.0505	0.0863
Echinococcus multilocularis	zinc finger protein	0.0022	0.0767	0.0767
Echinococcus multilocularis	cysteine protease	0.0017	0.0505	0.0505
Onchocerca volvulus	Cathepsin L homolog	0.0017	0.0505	0.3475
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0017	0.0505	0.0505
Plasmodium falciparum	methionine aminopeptidase 1b, putative	0.0106	0.5853	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.009	0.4877	0.4877
Brugia malayi	jmjC domain containing protein	0.0121	0.6735	0.9686
Onchocerca volvulus		0.0017	0.0505	0.3475
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0062	0.3208	0.3208
Leishmania major	hypothetical protein, conserved	0.002	0.0663	0.0949
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0161	0.0217
Schistosoma mansoni	proliferation-associated protein 2G4 38kDa (M24 family)	0.0011	0.0119	0.0119
Echinococcus multilocularis	cpg binding protein	0.0033	0.1447	0.1447
Brugia malayi	latrophilin 2 splice variant baaae	0.0035	0.1583	0.2276
Schistosoma mansoni	phosphatidylserine receptor	0.0032	0.1403	0.1403
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0011	0.0119	0.0204
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24, putative	0.0011	0.0119	0.0204
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0051	0.2563	0.3678
Loa Loa (eye worm)	hypothetical protein	0.0051	0.2563	0.3678
Giardia lamblia	Xaa-Pro dipeptidase	0.0011	0.0119	0.5
Brugia malayi	jmjC domain containing protein	0.0032	0.1403	0.2017
Schistosoma mansoni	cpg binding protein	0.0029	0.1229	0.1229
Brugia malayi	jmjC domain containing protein	0.0032	0.1403	0.2017
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Trypanosoma brucei	Xaa-Pro aminopeptidase, putative	0.0011	0.0119	0.0204
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.4877	0.4877
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1403	0.2006
Onchocerca volvulus		0.0017	0.0505	0.3475
Trypanosoma brucei	ISWI complex protein	0.0016	0.0404	0.069
Mycobacterium tuberculosis	Methionine aminopeptidase MapB (map) (peptidase M)	0.0086	0.4653	1
Echinococcus granulosus	phd:f box containing protein	0.0032	0.1403	0.1403
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.009	0.4877	0.7014
Plasmodium falciparum	aminopeptidase P	0.0011	0.0119	0.0204
Echinococcus multilocularis	xaa pro aminopeptidase	0.0011	0.0119	0.0119
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0051	0.2563	0.3687
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Echinococcus granulosus	cpg binding protein	0.0033	0.1447	0.1447
Schistosoma mansoni	Xaa-Pro dipeptidase (M24 family)	0.0011	0.0119	0.0119
Onchocerca volvulus		0.0029	0.1229	1
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0505	1
Schistosoma mansoni	hypothetical protein	0.0175	1	1
Leishmania major	cathepsin L-like protease	0.0066	0.343	0.5775
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0017	0.0505	0.0713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0505	0.0713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Trypanosoma cruzi	metallo-peptidase, Clan MG, Family M24	0.0011	0.0119	0.0204
Loa Loa (eye worm)	fibroinase	0.0017	0.0505	0.0713
Trypanosoma cruzi	aminopeptidase P, putative	0.0011	0.0119	0.0204
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0161	0.3182
Schistosoma mansoni	jumonji domain containing protein	0.0121	0.6735	0.6735
Mycobacterium ulcerans	methionine aminopeptidase MapB	0.0086	0.4653	1
Leishmania major	cathepsin L-like protease	0.0017	0.0505	0.0673
Wolbachia endosymbiont of Brugia malayi	methionine aminopeptidase	0.0086	0.4653	1
Leishmania major	cathepsin L-like protease	0.0066	0.343	0.5775
Loa Loa (eye worm)	jmjC domain-containing protein	0.0032	0.1403	0.2006
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.3086	0.5273
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0017	0.0505	0.0863
Echinococcus multilocularis	GPCR, family 2	0.0016	0.0444	0.0444
Echinococcus multilocularis	xaa Pro dipeptidase	0.0011	0.0119	0.0119
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0011	0.0119	0.0119
Loa Loa (eye worm)	PHD-finger family protein	0.0021	0.0732	0.104
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0017	0.0505	1
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Echinococcus granulosus	histone lysine methyltransferase setb	0.0018	0.055	0.055
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0018	0.055	0.055
Plasmodium vivax	methionine aminopeptidase 2, putative	0.0011	0.0119	0.0204
Loa Loa (eye worm)	hypothetical protein	0.0035	0.1583	0.2265
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Brugia malayi	jmjC domain containing protein	0.0124	0.6953	1
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0119	0.0158
Onchocerca volvulus		0.0017	0.0505	0.3475
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0016	0.0444	0.0444
Echinococcus multilocularis	lysine specific demethylase 6a	0.0032	0.1403	0.1403
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0037	0.1672	0.1672
Giardia lamblia	Methionine aminopeptidase	0.0011	0.0119	0.5
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0505	0.0726
Schistosoma mansoni	jumonji domain containing protein	0.0032	0.1403	0.1403
Echinococcus granulosus	lysine specific demethylase 6a	0.0032	0.1403	0.1403
Schistosoma mansoni	aminopeptidase P homologue (M24 family)	0.0011	0.0119	0.0119
Brugia malayi	Papain family cysteine protease containing protein	0.0017	0.0505	0.0726
Echinococcus multilocularis	jumonji domain containing 1A	0.0032	0.1403	0.1403
Echinococcus granulosus	fetal alzheimer antigen falz	0.0025	0.095	0.095
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Onchocerca volvulus		0.0017	0.0505	0.3475
Loa Loa (eye worm)	hypothetical protein	0.0072	0.381	0.5473
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.2581	0.4411
Echinococcus granulosus	methionyl aminopeptidase 2	0.0011	0.0119	0.0119
Echinococcus multilocularis	JmjC domain containing protein 4	0.0032	0.1403	0.1403
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0505	0.0726
Echinococcus multilocularis	geminin	0.0175	1	1
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.343	0.5861
Echinococcus multilocularis	Jumonji, AT rich interactive domain 1B	0.0036	0.1621	0.1621
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Trypanosoma cruzi	metallo- peptidase, Clan MG, Family M24	0.0106	0.5853	1
Schistosoma mansoni	hypothetical protein	0.0016	0.0444	0.0444
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0051	0.2563	0.3687
Echinococcus granulosus	Xaa Pro aminopeptidase 3	0.0011	0.0119	0.0119
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0505	1
Schistosoma mansoni	hypothetical protein	0.0021	0.0732	0.0732
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0017	0.0505	0.0713
Schistosoma mansoni	methionyl aminopeptidase 1 (M24 family)	0.0086	0.4653	0.4653
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.343	0.5861
Trypanosoma cruzi	Metallopeptidase family M24/FACT complex subunit (SPT16/CDC68)/Histone chaperone Rttp106-like, putative	0.0011	0.0119	0.0204
Loa Loa (eye worm)	bromodomain containing protein	0.0018	0.0549	0.0777
Brugia malayi	Latrophilin receptor protein 2	0.0016	0.0444	0.0639
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0512	0.0512
Plasmodium vivax	peptidase, putative	0.0011	0.0119	0.0204
Entamoeba histolytica	Xaa-Pro dipeptidase, putative	0.0011	0.0119	0.2361
Echinococcus granulosus	cathepsin l1	0.0017	0.0505	0.0505
Echinococcus granulosus	Proliferation associated protein 2G4	0.0011	0.0119	0.0119
Trypanosoma brucei	methionine aminopeptidase, type I, putative	0.0106	0.5853	1
Echinococcus granulosus	xaa Pro dipeptidase	0.0011	0.0119	0.0119
Leishmania major	cathepsin L-like protease	0.0017	0.0505	0.0673
Schistosoma mansoni	bromodomain containing protein	0.0066	0.3454	0.3454
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0119	0.0158
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP)	0.0086	0.4653	1
Trypanosoma brucei	Metallopeptidase family M24, putative	0.0011	0.0119	0.0204
Echinococcus multilocularis	xaa Pro dipeptidase	0.0011	0.0119	0.0119
Schistosoma mansoni	ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related	0.0032	0.1403	0.1403
Echinococcus granulosus	methionyl aminopeptidase 1 M24 family	0.0106	0.5853	0.5853
Echinococcus granulosus	jumonji domain containing 1A	0.0032	0.1403	0.1403
Trypanosoma brucei	Facilitates chromatin transcription complex subunit spt16	0.0011	0.0119	0.0204
Echinococcus multilocularis	lysine specific demethylase 5A	0.0121	0.6735	0.6735
Onchocerca volvulus		0.0017	0.0505	0.3475
Loa Loa (eye worm)	cytochrome P450 family protein	0.0026	0.1	0.1426
Schistosoma mansoni	aminopeptidase P1 (M24 family)	0.0011	0.0119	0.0119
Schistosoma mansoni	chromatin-specific transcription elongation factor 140 kDa subunit (M24 family)	0.0011	0.0119	0.0119
Entamoeba histolytica	hypothetical protein, conserved	0.0011	0.0119	0.2361
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Plasmodium falciparum	methionine aminopeptidase 1c, putative	0.0011	0.0119	0.0204
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0037	0.1672	0.1672
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0011	0.0119	0.0204
Trypanosoma cruzi	Metallopeptidase family M24, putative	0.0011	0.0119	0.0204
Trypanosoma cruzi	JmjC domain, hydroxylase, putative	0.0032	0.1403	0.2397
Leishmania major	cathepsin L-like protease	0.0017	0.0505	0.0673
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0025	0.095	0.095
Schistosoma mansoni	hypothetical protein	0.0016	0.0444	0.0444
Brugia malayi	PHD-finger family protein	0.0027	0.1095	0.1575
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Schistosoma mansoni	cathepsin F (C01 family)	0.0017	0.0505	0.0505
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.0009	0.001	0.001
Leishmania major	cathepsin L-like protease	0.0017	0.0505	0.0673
Plasmodium vivax	proliferation-associated protein 2g4, putative	0.0011	0.0119	0.0204
Toxoplasma gondii	histone lysine demethylase JMJC1/KDM5D/JARID1D	0.0032	0.1403	0.2239
Trypanosoma cruzi	hypothetical protein, conserved	0.002	0.0663	0.1134
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Loa Loa (eye worm)	metallopeptidase family M24 containing protein	0.0011	0.0119	0.0158
Schistosoma mansoni	cathepsin F (C01 family)	0.0012	0.0161	0.0161
Entamoeba histolytica	cysteine proteinase, putative	0.0017	0.0505	1
Onchocerca volvulus	Cathepsin F homolog	0.0017	0.0505	0.3475
Mycobacterium leprae	PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M)	0.0086	0.4653	1
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0017	0.0505	0.0863
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Echinococcus multilocularis	Xaa Pro aminopeptidase 3	0.0011	0.0119	0.0119
Echinococcus granulosus	JmjC domain containing protein 4	0.0032	0.1403	0.1403
Echinococcus multilocularis	methionyl aminopeptidase 1 (M24 family)	0.0086	0.4653	0.4653
Plasmodium vivax	vivapain-2	0.0017	0.0505	0.0863
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0011	0.0119	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1403	0.2006
Mycobacterium tuberculosis	Methionine aminopeptidase MapA (map) (peptidase M) (MetAP)	0.0086	0.4653	1
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0017	0.0505	0.0863
Schistosoma mansoni	phd/f-box containing protein	0.0032	0.1403	0.1403
Loa Loa (eye worm)	DNA-binding protein	0.0011	0.0119	0.0158
Entamoeba histolytica	methionine aminopeptidase, putative	0.0011	0.0119	0.2361
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0011	0.0119	0.0158
Plasmodium falciparum	HP12 protein homolog, putative	0.002	0.0663	0.1134
Brugia malayi	Cathepsin L-like precursor	0.0017	0.0505	0.0726
Leishmania major	cathepsin L-like protease	0.0066	0.343	0.5775
Brugia malayi	metallopeptidase family M24 containing protein	0.0011	0.0119	0.0171
Leishmania major	hypothetical protein, conserved	0.0016	0.0404	0.0497
Brugia malayi	Bromodomain containing protein	0.0039	0.1818	0.2614
Plasmodium vivax	methionine aminopeptidase 1b, putative	0.0106	0.5853	1
Echinococcus multilocularis	cathepsin L cysteine protease	0.0017	0.0505	0.0505
Brugia malayi	initiation factor 2-associated protein.	0.0011	0.0119	0.0171
Loa Loa (eye worm)	hypothetical protein	0.0032	0.1403	0.2006
Leishmania major	cathepsin L-like protease	0.0017	0.0505	0.0673
Trichomonas vaginalis	Clan MG, familly M24, aminopeptidase P-like metallopeptidase	0.0011	0.0119	0.2361
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0505	1
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0017	0.0505	1
Brugia malayi	DNA-binding protein, 42 kDa containing protein	0.0011	0.0119	0.0171
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.009	0.4877	0.4877
Echinococcus granulosus	xaa Pro dipeptidase	0.0011	0.0119	0.0119
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0016	0.0444	0.0444
Brugia malayi	Cathepsin L-like precursor	0.0012	0.0161	0.0231
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0012	0.0161	0.3182
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Brugia malayi	cathepsin L-like precursor	0.0012	0.0161	0.0231
Toxoplasma gondii	hypothetical protein	0.002	0.0663	0.0949
Brugia malayi	jmjC domain containing protein	0.0032	0.1403	0.2017
Echinococcus multilocularis	cysteine protease	0.0017	0.0505	0.0505
Schistosoma mansoni	jumonji/arid domain-containing protein	0.0124	0.6953	0.6953
Toxoplasma gondii	methionine aminopeptidase	0.0106	0.5853	1
Toxoplasma gondii	methionine aminopeptidase, type i, putative	0.0086	0.4653	0.7907
Echinococcus granulosus	Transcription factor JmjC domain containing protein	0.0121	0.6735	0.6735
Loa Loa (eye worm)	cysteine protease	0.0017	0.0505	0.0713
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0017	0.0505	1
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0512	0.0512
Entamoeba histolytica	peptidase, putative	0.0011	0.0119	0.2361
Loa Loa (eye worm)	hypothetical protein	0.0011	0.0119	0.0158
Plasmodium vivax	JmjC domain containing protein	0.0032	0.1403	0.2397
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.343	0.5861
Loa Loa (eye worm)	hypothetical protein	0.0018	0.055	0.0779
Plasmodium falciparum	proliferation-associated protein 2g4, putative	0.0011	0.0119	0.0204
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0016	0.0444	0.0626
Toxoplasma gondii	methionine aminopeptidase	0.0086	0.4653	0.7907
Loa Loa (eye worm)	methionine aminopeptidase type I	0.0106	0.5853	0.8414
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0017	0.0505	0.0505
Giardia lamblia	Xaa-Pro dipeptidase	0.0011	0.0119	0.5
Echinococcus multilocularis	Proliferation associated protein 2G4	0.0011	0.0119	0.0119

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.044 uM	Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)	ChEMBL.	15993057
IC50 (binding)	= 0.044 uM	Inhibitory concentration required against Escherichia coli MetAP1 (150 nM)	ChEMBL.	15993057
IC50 (binding)	= 0.37 uM	Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)	ChEMBL.	15993057
IC50 (binding)	= 0.37 uM	Inhibitory concentration required against Saccharomyces cerevisiae MetAP1 (330 nM)	ChEMBL.	15993057

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL359851

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 314542