Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0121 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0002 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.3179 | 0.3179 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | TAR-binding protein | 0.0121 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0121 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0121 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0121 | 1 | 1 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0121 | 1 | 1 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Schistosoma mansoni | tar DNA-binding protein | 0.0121 | 1 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0033 | 0.1708 | 0.1708 |
Schistosoma mansoni | ATP-citrate synthase | 0.0077 | 0.584 | 0.584 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1885 | 0.1885 |
Brugia malayi | ATP-citrate synthase | 0.0086 | 0.6672 | 0.6672 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0121 | 1 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.1885 | 0.1885 |
Schistosoma mansoni | tar DNA-binding protein | 0.0121 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0121 | 1 | 1 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Brugia malayi | Isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Loa Loa (eye worm) | RNA binding protein | 0.0121 | 1 | 1 |
Brugia malayi | isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.3179 | 0.3179 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.3179 | 0.3179 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1885 | 0.5 |
Brugia malayi | hypothetical protein | 0.0035 | 0.1885 | 0.1885 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1885 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.3179 | 0.3179 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0016 | 0.0002 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0121 | 1 | 1 |
Toxoplasma gondii | ATP-citrate lyase, putative | 0.0086 | 0.6672 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0016 | 0.0002 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0016 | 0.0002 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.1885 | 0.1885 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0016 | 0.0002 | 0.0002 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.1885 | 0.1885 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0016 | 0.0002 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0016 | 0.0002 | 0.0002 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0016 | 0.0002 | 0.5 |
Loa Loa (eye worm) | ATP-citrate synthase | 0.0086 | 0.6672 | 0.6672 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1885 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0002 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0033 | 0.1708 | 0.1708 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.1708 | 0.1708 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0016 | 0.0002 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.1885 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3.23 uM | Inhibitory concentration towards human colon adenocarcinoma cell line (HCT-15) was determined | ChEMBL. | 15686901 |
IC50 (functional) | = 3.23 uM | Inhibitory concentration towards human colon adenocarcinoma cell line (HCT-15) was determined | ChEMBL. | 15686901 |
IC50 (functional) | = 4.34 uM | Inhibitory concentration towards chronic myelogenous leukemic cell line (K562) was determined | ChEMBL. | 15686901 |
IC50 (functional) | = 4.34 uM | Inhibitory concentration towards chronic myelogenous leukemic cell line (K562) was determined | ChEMBL. | 15686901 |
IC50 (functional) | = 11.06 uM | Inhibitory concentration of the compound against human prostatic adenocarcenoma cell line (PC-3) was determined | ChEMBL. | 15686901 |
IC50 (functional) | = 11.06 uM | Inhibitory concentration of the compound against human prostatic adenocarcenoma cell line (PC-3) was determined | ChEMBL. | 15686901 |
IC50 (functional) | = 13.89 uM | Inhibitory concentration towards human central nervous system glioblastoma cell line (U251) was determined | ChEMBL. | 15686901 |
IC50 (functional) | = 13.89 uM | Inhibitory concentration towards human central nervous system glioblastoma cell line (U251) was determined | ChEMBL. | 15686901 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15686901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.