TDR Targets

Basic information

Technical information

TDR Targets ID: 314601
Name: 5-(4-chloro-2-methoxyphenyl)-1-methyl-N-(1-ph enylbutyl)-N-propyl-1,2,4-triazol-3-amine
MW: 412.956 | Formula: C23H29ClN4O
H donors: 0 H acceptors: 2 LogP: 6.39 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCCN(C(c1ccccc1)CCC)c1nn(c(n1)c1ccc(cc1OC)Cl)C
InChi: 1S/C23H29ClN4O/c1-5-10-20(17-11-8-7-9-12-17)28(15-6-2)23-25-22(27(3)26-23)19-14-13-18(24)16-21(19)29-4/h7-9,11-14,16,20H,5-6,10,15H2,1-4H3
InChiKey: GUXOKTNDTLBAEY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

5-(4-chloro-2-methoxy-phenyl)-1-methyl-N-(1-phenylbutyl)-N-propyl-1,2,4-triazol-3-amine
[5-(4-chloro-2-methoxy-phenyl)-1-methyl-1,2,4-triazol-3-yl]-(1-phenylbutyl)-propyl-amine

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	corticotropin releasing hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	Get druggable targets OG5_130760	All targets in OG5_130760
Schistosoma japonicum	IPR001879,Hormone receptor, extracellular,domain-containing	Get druggable targets OG5_130760	All targets in OG5_130760
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130760	All targets in OG5_130760
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	Get druggable targets OG5_130760	All targets in OG5_130760

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Loa Loa (eye worm)	pigment dispersing factor receptor c	corticotropin releasing hormone receptor 1	444 aa	445 aa	25.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	tailless protein	0.0045	0.015	0.0143
Echinococcus granulosus	transcription factor Dp 1	0.0743	0.5471	0.5462
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0182	0.0168
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0095	0.0535	0.0535
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Entamoeba histolytica	hypothetical protein	0.0039	0.0102	0.0085
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0095	0.0535	0.0535
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.005	0.0191	0.0178
Schistosoma mansoni	nuclear receptor nhr-48	0.0045	0.015	0.015
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0095	0.0535	0.0544
Trypanosoma brucei	flap endonuclease-1 (FEN-1), putative	0.0028	0.0021	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0095	0.0535	0.0544
Brugia malayi	Tyrosyl-DNA phosphodiesterase family protein	0.1284	0.9592	1
Brugia malayi	ecdysone receptor	0.0045	0.015	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0379	0.2692	0.2797
Trypanosoma brucei	DNA polymerase eta, putative	0.0048	0.0174	0.0168
Echinococcus multilocularis	protein tyrosine kinase	0.0529	0.3835	0.3976
Giardia lamblia	Flap structure-specific endonuclease	0.0028	0.0021	0.5
Leishmania major	tyrosyl-DNA phosphodiesterase 1	0.1284	0.9592	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.036	0.2554	0.264
Schistosoma mansoni	nuclear receptor	0.0045	0.015	0.015
Onchocerca volvulus	Bile acid receptor homolog	0.0095	0.0535	1
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0095	0.0535	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Schistosoma mansoni	zinc finger protein	0.0045	0.015	0.015
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0045	0.015	0.015
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0045	0.015	0.0135
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.0182	0.0168
Echinococcus granulosus	geminin	0.0182	0.1197	0.1178
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0095	0.0535	0.0544
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0095	0.0535	0.0544
Brugia malayi	nuclear hormone receptor	0.0095	0.0535	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0535	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0535	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0535	0.0544
Schistosoma mansoni	RAR-like nuclear receptor	0.0095	0.0535	0.0535
Loa Loa (eye worm)	hypothetical protein	0.005	0.0191	0.0186
Brugia malayi	nuclear receptor RXR	0.005	0.0191	0.0186
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0068	0.0326	0.0327
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0182	0.0162
Loa Loa (eye worm)	hypothetical protein	0.005	0.0191	0.0186
Echinococcus multilocularis	geminin	0.0182	0.1197	0.1226
Brugia malayi	nuclear hormone receptor	0.0045	0.015	0.0143
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0095	0.0535	0.0535
Trypanosoma cruzi	DNA polymerase eta, putative	0.0034	0.0065	0.0054
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0175	0.1143	0.1179
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0326	0.0326
Entamoeba histolytica	tyrosyl-DNA phosphodiesterase, putative	0.1284	0.9592	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0175	0.1143	0.1179
Loa Loa (eye worm)	tyrosyl-DNA phosphodiesterase	0.1284	0.9592	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0554	0.4028	0.4191
Schistosoma mansoni	hypothetical protein	0.0175	0.1143	0.1143
Entamoeba histolytica	hypothetical protein	0.0039	0.0102	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0535	0.0544
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0095	0.0535	0.0515
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0095	0.0535	0.0544
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0095	0.0535	0.0544
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1284	0.9592	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Loa Loa (eye worm)	hypothetical protein	0.005	0.0191	0.0186
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0095	0.0535	0.0536
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0045	0.015	0.0143
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0095	0.0535	0.0536
Leishmania major	DNA polymerase eta, putative	0.0048	0.0174	0.0168
Loa Loa (eye worm)	nuclear hormone receptor	0.0045	0.015	0.0143
Schistosoma mansoni	hypothetical protein	0.0175	0.1143	0.1143
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0045	0.015	0.013
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0045	0.015	0.0135
Brugia malayi	nuclear receptor NHR-67	0.0045	0.015	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0739	0.5439	0.5665
Schistosoma mansoni	nuclear receptor	0.0045	0.015	0.015
Brugia malayi	nuclear receptor NHR-88	0.0045	0.015	0.0143
Brugia malayi	RNA recognition motif domain containing protein	0.0068	0.0326	0.0327
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0045	0.015	0.0135
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0175	0.1143	0.1124
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0095	0.0535	1
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0095	0.0535	0.0536
Loa Loa (eye worm)	flap endonuclease-1	0.0028	0.0021	0.0007
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0045	0.015	0.015
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.036	0.2554	0.2539
Brugia malayi	hypothetical protein	0.0045	0.015	0.0143
Brugia malayi	steroid hormone receptor	0.0095	0.0535	0.0544
Loa Loa (eye worm)	hypothetical protein	0.005	0.0191	0.0186
Brugia malayi	hypothetical protein	0.005	0.0191	0.0186
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.005	0.0191	0.0191
Onchocerca volvulus		0.0095	0.0535	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0535	0.0544
Echinococcus multilocularis	ecdysone induced protein 78C	0.0095	0.0535	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0095	0.0535	0.0535
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0182	0.0182
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Echinococcus granulosus	tar DNA binding protein	0.0068	0.0326	0.0307
Brugia malayi	orphan nuclear receptor NR2E1	0.0045	0.015	0.0143
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.0102	0.0102
Brugia malayi	hypothetical protein	0.0045	0.015	0.0143
Schistosoma mansoni	hypothetical protein	0.0175	0.1143	0.1143
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0174	0.0168
Schistosoma mansoni	hypothetical protein	0.0182	0.1197	0.1197
Brugia malayi	Nuclear hormone receptor-like 1	0.005	0.0191	0.0186
Brugia malayi	ecdysteroid receptor	0.0095	0.0535	0.0544
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0326	0.0326
Trichomonas vaginalis	flap endonuclease-1, putative	0.0028	0.0021	0.5
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.015	0.015
Brugia malayi	Protein kinase domain containing protein	0.0535	0.3883	0.4039
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0326	0.0326
Schistosoma mansoni	retinoic acid receptor RXR	0.1337	1	1
Loa Loa (eye worm)	RNA binding protein	0.0068	0.0326	0.0327
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Schistosoma mansoni	hypothetical protein	0.0175	0.1143	0.1143
Loa Loa (eye worm)	TK/FAK protein kinase	0.0535	0.3883	0.4039
Toxoplasma gondii	flap structure-specific endonuclease 1, putative	0.0028	0.0021	0.1335
Loa Loa (eye worm)	TAR-binding protein	0.0068	0.0326	0.0327
Loa Loa (eye worm)	hypothetical protein	0.005	0.0191	0.0186
Plasmodium falciparum	flap endonuclease 1	0.0028	0.0021	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0045	0.015	0.013
Schistosoma mansoni	thyroid hormone receptor	0.0095	0.0535	0.0535
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0095	0.0535	0.0535
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0095	0.0535	0.0515
Brugia malayi	hypothetical protein	0.005	0.0191	0.0186
Brugia malayi	Nuclear hormone receptor E75	0.0045	0.015	0.0143
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.1287	0.9616	1
Toxoplasma gondii	ImpB/MucB/SamB family protein	0.0034	0.0065	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0095	0.0535	0.0515
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0045	0.015	0.0135
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.0182	0.0176
Echinococcus granulosus	FTZ F1 alpha	0.0095	0.0535	0.0515
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0095	0.0535	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Schistosoma mansoni	coup transcription factor	0.0095	0.0535	0.0535
Trypanosoma brucei	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1284	0.9592	1
Schistosoma mansoni	tyrosine kinase	0.0529	0.3835	0.3835
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0554	0.4028	0.4191
Loa Loa (eye worm)	DR-78	0.0045	0.015	0.0143
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0095	0.0535	0.0544
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0095	0.0535	0.0544
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0045	0.015	0.0143
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.0182	0.0162
Echinococcus granulosus	nuclear receptor nhr 48	0.0045	0.015	0.013
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0182	0.0182
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0095	0.0535	0.0536
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0095	0.0535	0.0535
Brugia malayi	Nuclear hormone receptor-like 1	0.005	0.0191	0.0186
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0095	0.0535	0.0544
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0045	0.015	0.013
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0739	0.5439	0.5665
Brugia malayi	Flap endonuclease-1	0.0028	0.0021	0.0007
Entamoeba histolytica	hypothetical protein	0.0039	0.0102	0.0085
Schistosoma mansoni	thyroid hormone receptor	0.0095	0.0535	0.0535
Echinococcus granulosus	dna polymerase eta	0.0048	0.0174	0.0154
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0045	0.015	0.0143
Echinococcus granulosus	ecdysone induced protein 78C	0.0095	0.0535	0.0515
Brugia malayi	RNA binding protein	0.0068	0.0326	0.0327
Entamoeba histolytica	hypothetical protein	0.0039	0.0102	0.0085
Echinococcus multilocularis	nuclear receptor nhr 48	0.0045	0.015	0.0135
Schistosoma mansoni	hypothetical protein	0.0379	0.2692	0.2692
Plasmodium vivax	flap endonuclease 1, putative	0.0028	0.0021	1
Brugia malayi	latrophilin 2 splice variant baaae	0.0379	0.2692	0.2797
Schistosoma mansoni	hypothetical protein	0.0039	0.0102	0.0102
Echinococcus multilocularis	FTZ F1 alpha	0.0095	0.0535	0.0536
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0535	0.0544
Brugia malayi	Latrophilin receptor protein 2	0.0175	0.1143	0.1179
Trypanosoma cruzi	tyrosyl-DNA Phosphodiesterase (Tdp1), putative	0.1284	0.9592	1
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0535	0.0544
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0045	0.015	0.013
Schistosoma mansoni	nuclear hormone receptor	0.0095	0.0535	0.0535
Loa Loa (eye worm)	steroid hormone receptor	0.0095	0.0535	0.0544
Brugia malayi	TAR-binding protein	0.0068	0.0326	0.0327
Echinococcus granulosus	protein tyrosine kinase	0.0529	0.3835	0.3823
Trypanosoma cruzi	DNA polymerase eta, putative	0.0048	0.0174	0.0168
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.005	0.0191	0.0186
Echinococcus multilocularis	transcription factor Dp 1	0.0743	0.5471	0.5681
Brugia malayi	conserved hypotetical protein	0.0045	0.015	0.0143
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0095	0.0535	0.0544
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0095	0.0535	0.0515
Echinococcus multilocularis	tyrosyl DNA phosphodiesterase 1	0.1284	0.9592	0.9976
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.0102	0.0082
Echinococcus granulosus	tyrosyl DNA phosphodiesterase 1	0.1284	0.9592	0.9591
Leishmania major	flap endonuclease-1 (FEN-1), putative	0.0028	0.0021	0.0007
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0175	0.1143	0.1169
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0095	0.0535	0.0536
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0095	0.0535	0.0515
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0095	0.0535	0.0544
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0095	0.0535	0.0544
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0095	0.0535	0.0536
Echinococcus granulosus	GPCR family 2	0.0175	0.1143	0.1124
Trypanosoma cruzi	flap endonuclease-1 (FEN-1), putative	0.0028	0.0021	0.0007
Brugia malayi	Steroid receptor seven-up type 2	0.0095	0.0535	0.0544
Echinococcus granulosus	thyroid hormone receptor alpha	0.0045	0.015	0.013
Schistosoma mansoni	nuclear hormone receptor	0.0045	0.015	0.015
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.0182	0.0176
Schistosoma mansoni	hypothetical protein	0.0182	0.1197	0.1197
Echinococcus multilocularis	dna polymerase eta	0.0048	0.0174	0.016
Schistosoma mansoni	DNA polymerase eta	0.0048	0.0174	0.0174
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0326	0.0326
Schistosoma mansoni	tyrosyl-DNA phosphodiesterase	0.1284	0.9592	0.9592
Brugia malayi	nuclear receptor NHR-88	0.0095	0.0535	0.0544
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0095	0.0535	0.0515
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0045	0.015	0.0143
Brugia malayi	Nuclear hormone receptor-like 1	0.0095	0.0535	0.0544
Brugia malayi	Nuclear hormone receptor E75	0.0045	0.015	0.0143
Brugia malayi	nuclear hormone receptor family member odr-7	0.0045	0.015	0.0143
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0095	0.0535	0.0544
Onchocerca volvulus	Protein ultraspiracle homolog	0.0095	0.0535	1
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0095	0.0535	0.0544
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.0102	0.0085
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Schistosoma mansoni	tar DNA-binding protein	0.0068	0.0326	0.0326
Brugia malayi	hypothetical protein	0.0039	0.0102	0.0092
Brugia malayi	photoreceptor-specific nuclear receptor	0.0095	0.0535	0.0544
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0095	0.0535	0.0544
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.0182	0.0182
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.005	0.0191	0.0171
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0095	0.0535	0.0544
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0095	0.0535	0.0544
Brugia malayi	ImpB/MucB/SamB family protein	0.0048	0.0174	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0045	0.015	0.0143
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0095	0.0535	0.0536
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0095	0.0535	0.0535
Brugia malayi	nuclear receptor RXR	0.0045	0.015	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0095	0.0535	0.0544
Loa Loa (eye worm)	hypothetical protein	0.0175	0.1143	0.1179
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.005	0.0191	0.0191
Echinococcus multilocularis	tar DNA binding protein	0.0068	0.0326	0.0319
Leishmania major	DNA polymerase eta, putative	0.0034	0.0065	0.0054
Echinococcus multilocularis	GPCR, family 2	0.0175	0.1143	0.1169
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0095	0.0535	0.0544

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 14 nM	Inhibition of [125I]-[Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells	ChEMBL.	15743196
Ki (binding)	= 14 nM	Inhibition of [125I]-[Tyr0]-sauvagine binding to human Corticotropin releasing factor receptor 1 expressed in mouse fibroblast Ltk- cells	ChEMBL.	15743196

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 11212115

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 314601