Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Enterococcus faecalis (strain ATCC 700802 / V583) | Beta-ketoacyl-ACP synthase III | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Mycobacterium tuberculosis | Conserved hypothetical protein | Beta-ketoacyl-ACP synthase III | 321 aa | 310 aa | 21.9 % |
Schistosoma japonicum | ko:K01641 hydroxymethylglutaryl-CoA synthase [EC2.3.3.10], putative | Beta-ketoacyl-ACP synthase III | 321 aa | 271 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.1487 | 0.1487 |
Schistosoma mansoni | dihydrofolate reductase | 0.1958 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1958 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1958 | 1 | 1 |
Mycobacterium ulcerans | 3-oxoacyl-ACP synthase | 0.0383 | 0.1487 | 0.1487 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1958 | 1 | 1 |
Mycobacterium tuberculosis | 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) | 0.0383 | 0.1487 | 0.1487 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1853 | 0.9431 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1853 | 0.9431 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1853 | 0.9431 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1958 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1958 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1853 | 0.9431 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1958 | 1 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1958 | 1 | 1 |
Mycobacterium ulcerans | beta-ketoacyl synthase-like protein | 0.0383 | 0.1487 | 0.1487 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1853 | 0.9431 | 0.5 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1853 | 0.9431 | 1 |
Wolbachia endosymbiont of Brugia malayi | 3-oxoacyl-ACP synthase | 0.0383 | 0.1487 | 0.5 |
Onchocerca volvulus | 0.0108 | 0 | 0.5 | |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1958 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.569 | Inhibition of Enterococcus faecalis FabH by FabD/FabH coupled assay | ChEMBL. | 17707951 |
IC50 (binding) | = 2.7 uM | Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III | ChEMBL. | 15743201 |
IC50 (binding) | = 2.7 uM | Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III | ChEMBL. | 15743201 |
MIC (functional) | = 9 ug ml-1 | Antibacterial activity against Escherichia coli expressing TolC mutant | ChEMBL. | 24112046 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.