Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Lactobacillus casei | Thymidylate synthase | Starlite/ChEMBL | References |
Escherichia coli | thymidylate synthetase | Starlite/ChEMBL | References |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0453 | 0.0453 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0283 | 0.0283 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0453 | 0.0453 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.0351 | 0.5 |
Onchocerca volvulus | 0.0584 | 1 | 0.5 | |
Loa Loa (eye worm) | inositol-1 | 0.0039 | 0.0351 | 0.0333 |
Brugia malayi | hypothetical protein | 0.0278 | 0.458 | 0.4529 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0039 | 0.0351 | 0.0261 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0399 | 0.0381 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.0885 | 0.0868 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0453 | 0.0453 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0351 | 0.0351 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 1 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.0351 | 0.5 |
Echinococcus multilocularis | thymidylate synthase | 0.0584 | 1 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0584 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0073 | 0.0958 | 0.0874 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.0351 | 0.0351 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0051 | 0.0051 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0694 | 0.0694 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.0351 | 0.0351 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0278 | 0.458 | 0.4424 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.0351 | 0.0351 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0584 | 1 | 1 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0584 | 1 | 1 |
Echinococcus granulosus | thymidylate synthase | 0.0584 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0366 | 0.0348 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0584 | 1 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0584 | 1 | 1 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0051 | 0.0051 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.0283 | 0.0283 |
Loa Loa (eye worm) | thymidylate synthase | 0.0584 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0325 | 0.0307 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0453 | 0.0453 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.0694 | 0.0694 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0453 | 0.0364 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.0324 | 0.0234 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0584 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0453 | 0.0453 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.0756 | 0.0756 |
Mycobacterium ulcerans | thymidylate synthase | 0.0584 | 1 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase, putative | 0.0278 | 0.458 | 0.4383 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0453 | 0.0453 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0453 | 0.0435 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0051 | 0.0051 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0584 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0018 | 0.0018 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0278 | 0.458 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.3 nM | Inhibitory constant against thymidylate synthase from Escherichia coli | ChEMBL. | 15715461 |
Ki (binding) | = 0.3 nM | Inhibitory constant against thymidylate synthase from Escherichia coli | ChEMBL. | 15715461 |
Ki (binding) | = 0.5 nM | Inhibitory constant against thymidylate synthase from Lactobacillus casei | ChEMBL. | 15715461 |
Ki (binding) | = 0.5 nM | Inhibitory constant against thymidylate synthase from Lactobacillus casei | ChEMBL. | 15715461 |
Ki (binding) | = 8.5 nM | Inhibitory constant against human thymidylate synthase | ChEMBL. | 15715461 |
Ki (binding) | = 8.5 nM | Inhibitory constant against human thymidylate synthase | ChEMBL. | 15715461 |
SI (binding) | = 17 | Ratio of inhibitory constant against human and Lactobacillus casei thymidylate synthases | ChEMBL. | 15715461 |
SI (binding) | = 28 | Ratio of inhibitory constant against human and Escherichia coli thymidylate synthases | ChEMBL. | 15715461 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.