Detailed information for compound 314703

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 149.532 | Formula: C4H4ClNO3
  • H donors: 2 H acceptors: 2 LogP: 0.28 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC1OC(=C(C1=N)Cl)O
  • InChi: 1S/C4H4ClNO3/c5-1-2(6)4(8)9-3(1)7/h4,6-8H
  • InChiKey: DVXWWTQSCMWHFK-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus glycine receptor subunit alpha 1 0.0302 0.4286 0.5447
Loa Loa (eye worm) hypothetical protein 0.0162 0.2017 0.2299
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Loa Loa (eye worm) fli-1 protein 0.0218 0.2925 0.3334
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0272 0.3798 0.4755
Onchocerca volvulus 0.0162 0.2017 0.2097
Mycobacterium ulcerans Type I modular polyketide synthase 0.034 0.4909 0.5939
Echinococcus granulosus glycine receptor subunit beta 0.0302 0.4286 0.5447
Brugia malayi WGR domain containing protein 0.0285 0.4017 0.4017
Onchocerca volvulus Fatty acid synthase homolog 0.0628 0.9618 1
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0088 0.0795 0.5302
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0048 0.0444
Echinococcus granulosus GA binding protein alpha chain 0.0072 0.054 0.0635
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0302 0.4286 0.4286
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Onchocerca volvulus 0.0139 0.1636 0.1701
Trypanosoma brucei poly(adp-ribose) polymerase 0.0285 0.4017 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0048 0.005
Echinococcus granulosus glycine receptor subunit beta 0.0302 0.4286 0.5447
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0198 0.2601 0.3155
Schistosoma mansoni nAChR subunit 0.0302 0.4286 0.4936
Giardia lamblia Methyltransferase like 2 0.0105 0.1081 1
Onchocerca volvulus 0.0302 0.4286 0.4456
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0302 0.4286 0.5447
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0285 0.4017 0.4621
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0361 0.5262 0.6713
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0302 0.4286 0.4936
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0088 0.0795 0.0795
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0427 0.3945
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Schistosoma mansoni acetylcholine receptor subunit beta 0.0139 0.1636 0.1826
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0361 0.5262 0.6713
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0302 0.4286 0.5447
Onchocerca volvulus 0.0302 0.4286 0.4456
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0302 0.4286 0.4884
Echinococcus multilocularis nAChR subunit 0.0162 0.2017 0.2533
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0222 0.2983 0.3666
Brugia malayi Methyltransferase-like protein 4 0.0105 0.1081 0.1081
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0088 0.0795 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0302 0.4286 0.4286
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0139 0.1636 0.2044
Schistosoma mansoni nAChR subunit 0.0139 0.1636 0.1826
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0302 0.4286 0.4286
Loa Loa (eye worm) hypothetical protein 0.0285 0.4017 0.4578
Brugia malayi hypothetical protein 0.0139 0.1636 0.1636
Onchocerca volvulus 0.0302 0.4286 0.4456
Onchocerca volvulus 0.0607 0.9265 0.9633
Echinococcus multilocularis chromobox protein 1 0.0069 0.0495 0.0577
Loa Loa (eye worm) ACC-1 protein 0.0302 0.4286 0.4884
Echinococcus granulosus poly (ADP ribose) polymerase 0.0161 0.1996 0.2506
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0326 0.4681 0.5334
Loa Loa (eye worm) hypothetical protein 0.0162 0.2017 0.2299
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0302 0.4286 0.4286
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0302 0.4286 0.4286
Echinococcus granulosus serine/threonine protein kinase 0.0044 0.0081 0.0045
Brugia malayi Ets-domain containing protein 0.0072 0.054 0.054
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.011 0.1154 0.1222
Brugia malayi Heterochromatin protein 1 0.0069 0.0495 0.0495
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0226 0.3057 0.3556
Onchocerca volvulus 0.0302 0.4286 0.4456
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0326 0.4681 0.5936
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0068 0.0473 0.0129
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0139 0.1636 0.2044
Schistosoma mansoni methyltransferase-related 0.0105 0.1081 0.1174
Brugia malayi Cation transporter family protein 0.0302 0.4286 0.4286
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0276 0.3872 0.4855
Trichomonas vaginalis conserved hypothetical protein 0.0105 0.1081 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0361 0.5262 0.6449
Onchocerca volvulus 0.0326 0.4681 0.4867
Schistosoma mansoni gabp alpha 0.0072 0.054 0.0539
Brugia malayi AMP-binding enzyme family protein 0.0107 0.1116 0.1116
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Brugia malayi Cation transporter family protein 0.0302 0.4286 0.4286
Loa Loa (eye worm) fatty acid synthase 0.0344 0.4979 0.5674
Schistosoma mansoni nAChR subunit 0.0302 0.4286 0.4936
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0119 0.131 0.1624
Entamoeba histolytica PH domain containing protein kinase, putative 0.0044 0.0081 0.0028
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0302 0.4286 0.5447
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0088 0.0795 0.0701
Mycobacterium leprae Polyketide synthase Pks13 0.0512 0.7721 1
Echinococcus granulosus nAChR subunit 0.0162 0.2017 0.2533
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0088 0.0795 0.0906
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Entamoeba histolytica protein kinase, putative 0.0065 0.0427 0.0473
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0291 0.4106 0.5168
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.034 0.4909 0.6241
Mycobacterium ulcerans polyketide synthase MbtD 0.0107 0.1116 0.0464
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0302 0.4286 0.5447
Echinococcus granulosus poly (ADP ribose) polymerase 0.0081 0.0682 0.0818
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0088 0.0795 0.0963
Loa Loa (eye worm) hypothetical protein 0.0053 0.024 0.0274
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0247 0.3389 0.3884
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.025 0.3453 0.4294
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0302 0.4286 0.5447
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0361 0.5262 0.6713
Onchocerca volvulus 0.0162 0.2017 0.2097
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0302 0.4286 0.4936
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0302 0.4286 0.5447
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0302 0.4286 0.5447
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.034 0.4909 0.6241
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0048 0.0444
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0302 0.4286 0.5447
Brugia malayi hypothetical protein 0.0139 0.1636 0.1636
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0495 0.4582
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0427 0.3945
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0427 0.3945
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0139 0.1636 0.2044
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0064 0.0405 0.0461
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Echinococcus granulosus poly ADP ribose polymerase 1 0.0519 0.7829 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0302 0.4286 0.4884
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0302 0.4286 0.4286
Schistosoma mansoni ets-related 0.0218 0.2925 0.3339
Echinococcus granulosus poly adp ribose polymerase 2 0.0285 0.4017 0.5102
Schistosoma mansoni microsomal glutathione s-transferase 0.013 0.1483 0.1647
Echinococcus multilocularis glycine receptor subunit beta 0.0302 0.4286 0.5447
Loa Loa (eye worm) hypothetical protein 0.0162 0.2017 0.2299
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0088 0.0795 0.0963
Loa Loa (eye worm) LGC-31 protein 0.0302 0.4286 0.4884
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0302 0.4286 0.5447
Onchocerca volvulus 0.0139 0.1636 0.1701
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0302 0.4286 0.4286
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0107 0.1116 0.1171
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Mycobacterium tuberculosis Hypothetical protein 0.0105 0.1081 0.1124
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0302 0.4286 0.5447
Echinococcus granulosus glycine receptor subunit alpha 1 0.0302 0.4286 0.5447
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0302 0.4286 0.4286
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0302 0.4286 0.4884
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0302 0.4286 0.4936
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0139 0.1636 0.1636
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Trypanosoma cruzi Protein kinase B 0.0044 0.0081 0.0055
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0285 0.4017 0.5102
Loa Loa (eye worm) GABA receptor subunit 0.0162 0.2017 0.2299
Onchocerca volvulus Putative nachr subunit 0.0302 0.4286 0.4456
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Leishmania major hypothetical protein, conserved 0.0105 0.1081 1
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0285 0.4017 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0222 0.2983 0.3158
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0162 0.2017 0.2017
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0139 0.1636 0.1865
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0302 0.4286 0.4286
Mycobacterium ulcerans polyketide synthase Pks9 0.0222 0.2983 0.3158
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0539 0.8161 1
Mycobacterium ulcerans polyketide synthase Pks13 0.0512 0.7721 1
Entamoeba histolytica hypothetical protein 0.0162 0.2017 0.252
Echinococcus granulosus tyrosine protein kinase shark 0.0074 0.0567 0.067
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.011 0.1154 0.1222
Echinococcus granulosus glycine receptor subunit alpha 1 0.0302 0.4286 0.5447
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0302 0.4286 0.5447
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0042 0.0059 0.0017
Mycobacterium ulcerans Type I modular polyketide synthase 0.034 0.4909 0.5939
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0302 0.4286 0.5447
Echinococcus granulosus poly (ADP ribose) polymerase 0.0081 0.0682 0.0818
Loa Loa (eye worm) hypothetical protein 0.0162 0.2017 0.2299
Echinococcus multilocularis microsomal glutathione S transferase 3 0.013 0.1483 0.1847
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0088 0.0795 0.0839
Schistosoma mansoni nAChR subunit 0.0302 0.4286 0.4936
Mycobacterium tuberculosis Probable thioesterase TesA 0.0291 0.4106 0.5168
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0042 0.0059 0.0017
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0088 0.0795 0.1861
Brugia malayi WGR domain containing protein 0.0519 0.7829 0.7829
Loa Loa (eye worm) hypothetical protein 0.0162 0.2017 0.2299
Schistosoma mansoni nAChR subunit 0.0302 0.4286 0.4936
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0361 0.5262 0.6449
Loa Loa (eye worm) acyl carrier protein 0.016 0.1983 0.226
Brugia malayi AMP-binding enzyme family protein 0.0326 0.4681 0.4681
Loa Loa (eye worm) hypothetical protein 0.0162 0.2017 0.2299
Schistosoma mansoni tyrosine kinase 0.0074 0.0567 0.0571
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.034 0.4909 0.6241
Loa Loa (eye worm) hypothetical protein 0.0186 0.2408 0.2745
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0272 0.3798 0.4335
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Echinococcus multilocularis GA binding protein alpha chain 0.0072 0.054 0.0635
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Mycobacterium ulcerans thioesterase 0.0291 0.4106 0.4781
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0088 0.0795 1
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.034 0.4909 0.6241
Echinococcus multilocularis rac serine:threonine kinase 0.0044 0.0081 0.0045
Schistosoma mansoni chromobox protein 0.0069 0.0495 0.0487
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0139 0.1636 0.2044
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0302 0.4286 0.4884
Mycobacterium leprae Probable polyketide synthase Pks1 0.0361 0.5262 0.6713
Entamoeba histolytica protein kinase, putative 0.0064 0.0405 0.0445
Trypanosoma cruzi DNA repair protein, putative 0.0068 0.0473 0.1046
Schistosoma mansoni neurotransmitter gated ion channel 0.0139 0.1636 0.1826
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0361 0.5262 0.6713
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0361 0.5262 0.6713
Brugia malayi Protein kinase domain containing protein 0.0065 0.0427 0.0427
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0302 0.4286 0.4936
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0302 0.4286 0.5447
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Brugia malayi hypothetical protein 0.0139 0.1636 0.1636
Mycobacterium ulcerans Type I modular polyketide synthase 0.034 0.4909 0.5939
Loa Loa (eye worm) hypothetical protein 0.0061 0.037 0.0421
Schistosoma mansoni neurotransmitter gated ion channel 0.0162 0.2017 0.2273
Onchocerca volvulus 0.0139 0.1636 0.1701
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0044 0.0081 0.0055
Echinococcus multilocularis glycine receptor subunit beta 0.0302 0.4286 0.5447
Mycobacterium ulcerans polyketide synthase 0.0361 0.5262 0.6449
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0519 0.7829 1
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0302 0.4286 0.5447
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0302 0.4286 0.5447
Brugia malayi hypothetical protein 0.0139 0.1636 0.1636
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0427 0.3945
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0302 0.4286 0.4936
Loa Loa (eye worm) ACC-1 protein 0.0302 0.4286 0.4884
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0338 0.488 0.6202
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0302 0.4286 0.5447
Trypanosoma brucei DNA repair protein, putative 0.0068 0.0473 0.0129
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1636 0.1636
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0512 0.7721 1
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0088 0.0795 0.1861
Mycobacterium ulcerans polyketide synthase 0.034 0.4909 0.5939
Loa Loa (eye worm) hypothetical protein 0.0162 0.2017 0.2299
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0302 0.4286 0.5447
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0088 0.0795 0.5
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0204 0.2703 0.308
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0495 0.0564
Loa Loa (eye worm) hypothetical protein 0.0577 0.8775 1
Echinococcus granulosus chromobox protein 1 0.0069 0.0495 0.0577
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0072 0.054 0.0615
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0427 0.3945
Brugia malayi Ets-domain containing protein 0.0072 0.054 0.054
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Brugia malayi Fli-1 protein 0.0218 0.2925 0.2925
Toxoplasma gondii type I fatty acid synthase, putative 0.0248 0.3416 0.4009
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Schistosoma mansoni chromobox protein 0.0069 0.0495 0.0487
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0519 0.7829 0.9097
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0139 0.1636 0.1636
Echinococcus granulosus nAChR subunit 0.0302 0.4286 0.5447
Entamoeba histolytica hypothetical protein 0.0081 0.0682 0.0802
Toxoplasma gondii MAPEG family protein 0.013 0.1483 0.157
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0162 0.2017 0.2017
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0338 0.488 0.6202
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.005 0.0183 0.1686
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0519 0.7829 1
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.034 0.4909 0.5939
Toxoplasma gondii AGC kinase 0.0064 0.0405 0.0207
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0088 0.0795 0.1027
Brugia malayi Cation transporter family protein 0.0302 0.4286 0.4286
Mycobacterium ulcerans thioesterase TesA 0.0291 0.4106 0.4781
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0427 0.3945
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0302 0.4286 0.4286
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Schistosoma mansoni nAChR subunit 0.0139 0.1636 0.1826
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0302 0.4286 0.4884
Trichomonas vaginalis AGC family protein kinase 0.0065 0.0427 0.3945
Loa Loa (eye worm) hypothetical protein 0.0395 0.5809 0.662
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1636 0.1636
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0302 0.4286 0.4286
Echinococcus multilocularis tyrosine protein kinase shark 0.0074 0.0567 0.067
Brugia malayi GnHR receptor homolog 0.0325 0.4668 0.4668
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0068 0.0473 0.1046
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0302 0.4286 0.4286
Onchocerca volvulus 0.0302 0.4286 0.4456
Schistosoma mansoni tyrosine kinase 0.0072 0.054 0.0539
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0176 0.2242 0.2527
Mycobacterium tuberculosis Conserved protein 0.0105 0.1081 0.1124
Brugia malayi hypothetical protein 0.0139 0.1636 0.1636
Loa Loa (eye worm) hypothetical protein 0.0162 0.2017 0.2299
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0272 0.3798 0.4335
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0302 0.4286 0.5447
Onchocerca volvulus DNA ligase 3 homolog 0.0068 0.0473 0.0492
Onchocerca volvulus 0.0302 0.4286 0.4456
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0139 0.1636 0.1636
Echinococcus granulosus serine threonine protein kinase nrc 0.0042 0.0059 0.0017
Loa Loa (eye worm) AGC/AKT protein kinase 0.0065 0.0427 0.0486
Plasmodium vivax hypothetical protein, conserved 0.005 0.0183 0.1686
Echinococcus granulosus poly (ADP ribose) polymerase 0.0081 0.0682 0.0818
Echinococcus multilocularis nAChR subunit 0.0302 0.4286 0.5447
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0162 0.2017 0.2273
Loa Loa (eye worm) hypothetical protein 0.0162 0.2017 0.2299
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0111 0.1177 0.1252
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0512 0.7721 1
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0302 0.4286 0.4936
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0139 0.1636 0.1865
Echinococcus granulosus WGR domain containing protein 0.0161 0.1996 0.2506
Mycobacterium ulcerans fatty acid synthase Fas 0.011 0.1154 0.0518
Schistosoma mansoni neurotransmitter gated ion channel 0.0139 0.1636 0.1826
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0139 0.1636 0.2044
Schistosoma mansoni nAChR subunit 0.0302 0.4286 0.4936
Loa Loa (eye worm) hypothetical protein 0.0053 0.024 0.0274
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0085 0.0757 0.0691
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0302 0.4286 0.4286
Loa Loa (eye worm) hypothetical protein 0.0139 0.1636 0.1865
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0302 0.4286 0.4884
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.034 0.4909 0.4909
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0285 0.4017 1
Entamoeba histolytica PH domain containing protein kinase, putative 0.0044 0.0081 0.0028
Toxoplasma gondii type I fatty acid synthase, putative 0.0361 0.5262 0.634
Loa Loa (eye worm) hypothetical protein 0.0068 0.0473 0.0539
Brugia malayi excitatory GABA receptor EXP-1A 0.0302 0.4286 0.4286
Schistosoma mansoni nAChR subunit 0.0302 0.4286 0.4936
Brugia malayi p70 ribosomal S6 kinase beta 0.0064 0.0405 0.0405
Schistosoma mansoni nAChR subunit 0.0302 0.4286 0.4936
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0302 0.4286 0.4286
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884
Entamoeba histolytica protein kinase, putative 0.0065 0.0427 0.0473
Echinococcus granulosus chromobox protein 1 0.0069 0.0495 0.0577
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0302 0.4286 0.4286
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0162 0.2017 0.2017
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0495 0.4582
Loa Loa (eye worm) acetylcholine receptor protein 0.0139 0.1636 0.1865
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0141 0.1668 0.1908
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0302 0.4286 0.4286
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0139 0.1636 0.1636
Echinococcus multilocularis chromobox protein 1 0.0069 0.0495 0.0577
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.034 0.4909 0.6241
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0088 0.0795 0.5
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0162 0.2017 0.2017
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0162 0.2017 0.2273
Schistosoma mansoni acetylcholine receptor-related 0.0139 0.1636 0.1826
Echinococcus granulosus microsomal glutathione S transferase 3 0.013 0.1483 0.1847
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0566 0.8599 1
Loa Loa (eye worm) hypothetical protein 0.0302 0.4286 0.4884

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 8 mm Zone of inhibition of Pseudomonas aeruginosa after treatment with the compound ChEMBL. 15686887
Inhibition (functional) = 8 mm Zone of inhibition of Escherichia coli after treatment with the compound ChEMBL. 15686887
Inhibition (functional) = 8 mm Zone of inhibition of Escherichia coli after treatment with the compound ChEMBL. 15686887
Inhibition (functional) = 16 mm Zone of inhibition of Staphylococcus aureus after treatment with compound ChEMBL. 15686887
MBC (functional) = 8 ug ml-1 Minimum bacteriostatic concentration of the compound in Staphylococcus aureus S2 strain was determined ChEMBL. 15686887
MBC (functional) = 16 ug ml-1 Minimum bacteriostatic concentration of the compound in Staphylococcus aureus S1 strain was determined ChEMBL. 15686887
MBC (functional) = 32 ug ml-1 Minimum bacteriostatic concentration of the compound in Staphylococcus aureus ATCC 25923 strain was determined ChEMBL. 15686887
MBC (functional) = 32 ug ml-1 Minimum bacteriostatic concentration of the compound in Acinetobacter species A1 strain was determined ChEMBL. 15686887
MBC (functional) = 64 ug ml-1 Minimum bacteriostatic concentration of the compound in Acinetobacter species A2 strain was determined ChEMBL. 15686887
MBC (functional) = 64 ug ml-1 Minimum bacteriostatic concentration of the compound in Escherichia coli E1 strain was determined ChEMBL. 15686887
MBC (functional) = 64 ug ml-1 Minimum bacteriostatic concentration of the compound in Enterobacter En1 strain was determined ChEMBL. 15686887
MBC (functional) = 64 ug ml-1 Minimum bacteriostatic concentration of the compound in Enterobacter En3 strain was determined ChEMBL. 15686887
MBC (functional) = 64 ug ml-1 Minimum bacteriostatic concentration of the compound in Klebsiella pneumoniae K1 strain was determined ChEMBL. 15686887
MBC (functional) = 64 ug ml-1 Minimum bacteriostatic concentration of the compound in Pseudomonas aeruginosa P7 strain was determined ChEMBL. 15686887
MBC (functional) = 64 ug ml-1 Minimum bacteriostatic concentration of the compound in Pseudomonas aeruginosa ATCC 27853 was determined ChEMBL. 15686887
MBC (functional) = 64 ug ml-1 Minimum bacteriostatic concentration of the compound in Escherichia coli E1 strain was determined ChEMBL. 15686887
MBC (functional) = 128 ug ml-1 Minimum bacteriostatic concentration of the compound in Escherichia coli E3 strain was determined ChEMBL. 15686887
MBC (functional) = 128 ug ml-1 Minimum bacteriostatic concentration of the compound Escherichia coli ATCC 25922 strain was determined ChEMBL. 15686887
MBC (functional) = 128 ug ml-1 Minimum bacteriostatic concentration of the compound in Klebsiella pneumoniae K2 strain was determined ChEMBL. 15686887
MBC (functional) = 128 ug ml-1 Minimum bacteriostatic concentration of the compound in Pseudomonas aeruginosa P12 strain was determined ChEMBL. 15686887
MBC (functional) = 128 ug ml-1 Minimum bacteriostatic concentration of the compound in Escherichia coli E3 strain was determined ChEMBL. 15686887
MBC (functional) = 128 ug ml-1 Minimum bacteriostatic concentration of the compound Escherichia coli ATCC 25922 strain was determined ChEMBL. 15686887
MIC (functional) = 4 ug ml-1 Minimum inhibitory concentration of the compound in Staphylococcus aureus S2 strain was determined ChEMBL. 15686887
MIC (functional) = 16 ug ml-1 Minimum inhibitory concentration of the compound in Staphylococcus aureus S1 strain was determined ChEMBL. 15686887
MIC (functional) = 16 ug ml-1 Minimum inhibitory concentration of the compound in Staphylococcus aureus ATCC 25923 strian was determined ChEMBL. 15686887
MIC (functional) = 16 ug ml-1 Minimum inhibitory concentration of the compound in Acinetobacter species A1 strain was determined ChEMBL. 15686887
MIC (functional) = 32 ug ml-1 Minimum inhibitory concentration of the compound in Escherichia coli E1 strain was determined ChEMBL. 15686887
MIC (functional) = 32 ug ml-1 Minimum inhibitory concentration of the compound in Klebsiella pneumoniae K1 strain was determined ChEMBL. 15686887
MIC (functional) = 32 ug ml-1 Minimum inhibitory concentration of the compound in Pseudomonas aeruginosa P7 strain was determined ChEMBL. 15686887
MIC (functional) = 32 ug ml-1 Minimum inhibitory concentration of the compound in Pseudomonas aeruginosa ATCC 27853 strain was determined ChEMBL. 15686887
MIC (functional) = 32 ug ml-1 Minimum inhibitory concentration of the compound in Acinetobacter species A2 strain was determined ChEMBL. 15686887
MIC (functional) = 32 ug ml-1 Minimum inhibitory concentration of the compound in Escherichia coli E1 strain was determined ChEMBL. 15686887
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration of the compound in Escherichia coli ATCC 25922 strain was determined ChEMBL. 15686887
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration of the compound in Escherichia coli E3 strain was determined ChEMBL. 15686887
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration of the compound in Enterobacter En1 strain was determined ChEMBL. 15686887
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration of the compound in Enterobacter En3 strain was determined ChEMBL. 15686887
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration of the compound in Pseudomonas aeruginosa P12 strain was determined ChEMBL. 15686887
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration of the compound in Escherichia coli ATCC 25922 strain was determined ChEMBL. 15686887
MIC (functional) = 64 ug ml-1 Minimum inhibitory concentration of the compound in Escherichia coli E3 strain was determined ChEMBL. 15686887
MIC (functional) = 128 ug ml-1 Minimum inhibitory concentration of the compound in Klebsiella pneumoniae K2 strain was determined ChEMBL. 15686887

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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