TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 518.571 | Formula: C27H33F3N4O3
H donors: 1 H acceptors: 3 LogP: 3.15 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: OCCN1CCC(C1)N(C(=O)N1CCC(C1)N(C(=O)c1ccc(cc1)c1ccc(cc1)C(F)(F)F)C)C
InChi: 1S/C27H33F3N4O3/c1-31(24-12-14-34(18-24)26(37)32(2)23-11-13-33(17-23)15-16-35)25(36)21-5-3-19(4-6-21)20-7-9-22(10-8-20)27(28,29)30/h3-10,23-24,35H,11-18H2,1-2H3
InChiKey: UFQHJBUUPWHGOJ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanin-concentrating hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Death domain containing protein	0.0015	0.0004	0.0004
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0079	0.0079
Brugia malayi	Associated with TFs and helicases family protein	0.0012	0.0000000000049098	0.0000000000049098
Loa Loa (eye worm)	RecQ helicase	0.0022	0.0013	0.0013
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.7743	1	1
Schistosoma mansoni	hypothetical protein	0.0012	0.0000000000049098	0.0000000000049098
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0063	0.0066	0.0066
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Loa Loa (eye worm)	CHromoDomain protein family member	0.0012	0.0000000000049098	0.0000000000049098
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004
Brugia malayi	follicle stimulating hormone receptor	0.025	0.0308	0.0308
Leishmania major	oxidoreductase-like protein	0.0015	0.0005	0.0004
Schistosoma mansoni	hypothetical protein	0.0345	0.043	0.043
Brugia malayi	GMP synthase	0.0034	0.0029	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0031	0.0025	0.0025
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0037	0.0253
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0022	0.0149
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0066	0.0064
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.025	0.0308	0.0308
Trichomonas vaginalis	conserved hypothetical protein	0.0041	0.0037	0.0253
Mycobacterium ulcerans	thymidylate synthase	0.2422	0.3117	0.3116
Plasmodium falciparum	GMP synthase [glutamine-hydrolyzing]	0.0034	0.0029	0.0033
Echinococcus granulosus	bloom syndrome protein	0.0022	0.0013	0.0013
Trypanosoma brucei	oxidoreductase-like protein	0.0015	0.0005	0.0004
Echinococcus multilocularis	p2X purinoceptor 4	0.0409	0.0514	0.0514
Brugia malayi	SET domain containing protein	0.0013	0.0001	0.0001
Echinococcus granulosus	chromobox protein 1	0.0073	0.0079	0.0079
Trichomonas vaginalis	conserved hypothetical protein	0.0029	0.0022	0.0149
Schistosoma mansoni	ankyrin 23/unc44	0.0015	0.0004	0.0004
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0077	0.0084	0.0084
Trypanosoma brucei	pteridine reductase 1	0.0203	0.0247	0.028
Toxoplasma gondii	2,4-dienoyl CoA reductase 2, peroxisomal family protein	0.0015	0.0005	0.0005
Onchocerca volvulus		0.2422	0.3117	1
Schistosoma mansoni	hypothetical protein	0.0048	0.0046	0.0046
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0044	0.0041	0.0133
Schistosoma mansoni	glutamine-dependent NAD(+) synthetase	0.0086	0.0096	0.0096
Mycobacterium tuberculosis	Hypothetical protein	0.1152	0.1475	0.1471
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0031	0.0025	0.0025
Echinococcus multilocularis	geminin	0.0345	0.043	0.043
Echinococcus multilocularis	dihydrofolate reductase	0.7743	1	1
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0079	0.0534
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0217	0.0266	0.0266
Echinococcus granulosus	p2X purinoceptor 4	0.0409	0.0514	0.0514
Trichomonas vaginalis	conserved hypothetical protein	0.1152	0.1475	1
Plasmodium falciparum	apurinic/apyrimidinic endonuclease Apn1, putative	0.008	0.0088	0.01
Echinococcus multilocularis	netrin receptor unc 5	0.0015	0.0004	0.0004
Leishmania major	GMP synthase, putative,glutamine amidotransferase, putative	0.0034	0.0029	0.0032
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049098	0.00000000051351
Schistosoma mansoni	P2X receptor subunit	0.0409	0.0514	0.0514
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0015	0.0004	0.0004
Plasmodium vivax	apurinic/apyrimidinic endonuclease Apn1, putative	0.008	0.0088	0.01
Onchocerca volvulus		0.0032	0.0026	0.0083
Mycobacterium leprae	PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)	0.2422	0.3117	0.3109
Echinococcus granulosus	p2X purinoceptor 4	0.0409	0.0514	0.0514
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0015	0.0004	0.0004
Mycobacterium tuberculosis	Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase)	0.008	0.0088	0.0084
Brugia malayi	Dihydrofolate reductase	0.7743	1	1
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0015	0.0004	0.0004
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0001	0.0001
Brugia malayi	Cytochrome P450 family protein	0.0013	0.0001	0.0001
Schistosoma mansoni	blooms syndrome DNA helicase	0.0018	0.0007	0.0007
Mycobacterium tuberculosis	Conserved hypothetical protein	0.0021	0.0012	0.0007
Echinococcus granulosus	dihydrofolate reductase	0.7743	1	1
Mycobacterium ulcerans	3-alpha-hydroxysteroid dehydrogenase	0.0015	0.0005	0.0003
Brugia malayi	DNA-(Apurinic or apyrimidinic site) lyase	0.008	0.0088	0.0088
Mycobacterium leprae	PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE)	0.008	0.0088	0.0076
Echinococcus multilocularis	Ankyrin	0.0015	0.0004	0.0004
Treponema pallidum	NAD synthetase	0.0086	0.0096	0.5
Entamoeba histolytica	hypothetical protein	0.0012	0.0000000000049098	0.00000000051351
Trichomonas vaginalis	set domain proteins, putative	0.0248	0.0305	0.2067
Brugia malayi	hypothetical protein	0.0234	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0012	0.0012
Plasmodium vivax	glutamine-dependent NAD(+) synthetase, putative	0.0086	0.0096	0.0109
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Plasmodium falciparum	glutamine-dependent NAD(+) synthetase, putative	0.0086	0.0096	0.0109
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0005	0.0003
Plasmodium vivax	SET domain protein, putative	0.0031	0.0025	0.0028
Schistosoma mansoni	survival motor neuron protein	0.0048	0.0046	0.0046
Echinococcus multilocularis	chromodomain helicase DNA binding protein 1	0.0012	0.0000000000049098	0.0000000000049098
Onchocerca volvulus	Putative hydroxypyruvate isomerase	0.0021	0.0012	0.0038
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.6813	0.8797	1
Schistosoma mansoni	P2X receptor subunit	0.0409	0.0514	0.0514
Schistosoma mansoni	glutamine-dependent NAD(+) synthetase	0.0052	0.0051	0.0051
Plasmodium vivax	ADP-dependent DNA helicase RecQ, putative	0.0015	0.0004	0.0005
Leishmania major	pteridine reductase 1	0.021	0.0256	0.029
Mycobacterium leprae	PROBABLE GLUTAMINE-DEPENDENT NAD(+) SYNTHETASE NADE (NAD(+) SYNTHASE [GLUTAMINE-HYDROLYSING])	0.0086	0.0096	0.0084
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0048	0.0046	0.0046
Schistosoma mansoni	bifunctional dihydrofolate reductase-thymidylate synthase	0.2422	0.3117	0.3117
Brugia malayi	Protein kinase domain containing protein	0.0015	0.0004	0.0004
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0065	0.0068	0.0068
Plasmodium falciparum	ADP-dependent DNA helicase RecQ	0.002	0.001	0.0011
Echinococcus granulosus	chromobox protein 1	0.0073	0.0079	0.0079
Mycobacterium tuberculosis	Glutamine-dependent NAD(+) synthetase NadE (NAD(+) synthase [glutamine-hydrolysing])	0.0086	0.0096	0.0091
Brugia malayi	hypothetical protein	0.1152	0.1475	0.1475
Echinococcus granulosus	GMP synthase glutamine hydrolyzing	0.0034	0.0029	0.0029
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0041	0.0281
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Schistosoma mansoni	hypothetical protein	0.0345	0.043	0.043
Trypanosoma brucei	GMP synthase [glutamine-hydrolysing]	0.0034	0.0029	0.0032
Trichomonas vaginalis	chromobox protein, putative	0.0073	0.0079	0.0534
Loa Loa (eye worm)	hypothetical protein	0.0234	0.0287	0.0287
Echinococcus granulosus	histone lysine methyltransferase setb	0.0031	0.0025	0.0025
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.6813	0.8797	1
Brugia malayi	Bloom's syndrome protein homolog	0.0022	0.0013	0.0013
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Echinococcus multilocularis	chromodomain helicase DNA binding protein 4	0.0012	0.0000000000049098	0.0000000000049098
Echinococcus granulosus	survival motor neuron protein 1	0.0234	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0037	0.0037
Mycobacterium ulcerans	epimerase	0.0021	0.0012	0.0011
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0063	0.0066	0.0061
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049098	0.00000000051351
Trichomonas vaginalis	nh(3)-dependent NAD(+) synthetase, putative	0.0086	0.0096	0.0648
Plasmodium vivax	GMP synthetase, putative	0.0034	0.0029	0.0033
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.7743	1	1
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.003	0.0023	0.0023
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0025	0.0025
Toxoplasma gondii	ATP-dependent DNA helicase, RecQ family protein	0.0015	0.0004	0.0004
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.7743	1	1
Schistosoma mansoni	GMP synthetase	0.0034	0.0029	0.0029
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0066	0.0066
Loa Loa (eye worm)	thymidylate synthase	0.2422	0.3117	0.3117
Onchocerca volvulus		0.0043	0.004	0.0129
Trichomonas vaginalis	DNA helicase recq, putative	0.0022	0.0013	0.0091
Trypanosoma cruzi	NAD+ synthase, putative	0.0086	0.0096	0.0107
Echinococcus granulosus	Chromo domain	0.0012	0.0000000000049098	0.0000000000049098
Onchocerca volvulus		0.0012	0.0000000028171	0.0000000090379
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0031	0.0025	0.0028
Loa Loa (eye worm)	heterochromatin protein 1	0.0073	0.0079	0.0079
Giardia lamblia	NH3-dependent NAD+ synthetase	0.0086	0.0096	0.5
Mycobacterium ulcerans	short chain dehydrogenase	0.0015	0.0005	0.0003
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0031	0.0025	0.0025
Brugia malayi	Type III restriction enzyme, res subunit family protein	0.0012	0.0000000000049098	0.0000000000049098
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.6813	0.8797	1
Schistosoma mansoni	dihydrofolate reductase	0.7743	1	1
Schistosoma mansoni	P2X receptor subunit	0.0409	0.0514	0.0514
Brugia malayi	Heterochromatin protein 1	0.0073	0.0079	0.0079
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase, putative	0.1152	0.1475	0.1675
Echinococcus granulosus	p2X purinoceptor 4	0.0409	0.0514	0.0514
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.6813	0.8797	1
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0043	0.004	0.004
Echinococcus granulosus	chromodomain helicase DNA binding protein 4	0.0012	0.0000000000049098	0.0000000000049098
Echinococcus granulosus	Chromobox protein 3	0.0012	0.0000000028171	0.0000000028171
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0001	0.0001
Echinococcus granulosus	geminin	0.0345	0.043	0.043
Mycobacterium ulcerans	sugar phosphate isomerases/epimerases	0.0021	0.0012	0.0011
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0000000000049098	0.0000000000049098
Echinococcus granulosus	chromodomain helicase DNA binding protein 1	0.0012	0.0000000000049098	0.0000000000049098
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Mycobacterium ulcerans	NAD synthetase	0.0086	0.0096	0.0094
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Echinococcus granulosus	death domain containing protein	0.0015	0.0004	0.0004
Mycobacterium ulcerans	hypothetical protein	0.0021	0.0012	0.0011
Plasmodium falciparum	chromodomain-helicase-DNA-binding protein 1 homolog, putative	0.0012	0.0000000000049098	0.000000000005581
Trypanosoma cruzi	oxidoreductase-like protein, putative	0.0015	0.0005	0.0004
Onchocerca volvulus	Netrin receptor homolog	0.0015	0.0004	0.0013
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.0066	0.0064
Onchocerca volvulus		0.0048	0.0046	0.0148
Echinococcus multilocularis	bloom syndrome protein	0.0022	0.0013	0.0013
Brugia malayi	CHD4 protein	0.0012	0.0000000000049098	0.0000000000049098
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0025	0.0025
Toxoplasma gondii	chromodomain helicase DNA binding protein CHD1/SWI2/SNF2	0.0012	0.0000000000049098	0.000000000005581
Echinococcus multilocularis	thymidylate synthase	0.2422	0.3117	0.3117
Echinococcus granulosus	Ankyrin	0.0015	0.0004	0.0004
Brugia malayi	thymidylate synthase	0.2422	0.3117	0.3117
Trichomonas vaginalis	DNA helicase recq1, putative	0.0022	0.0013	0.0091
Schistosoma mansoni	chromobox protein	0.0073	0.0079	0.0079
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0063	0.0066	0.0073
Trichomonas vaginalis	chromobox protein, putative	0.0044	0.0041	0.0281
Echinococcus multilocularis	Chromobox protein 3	0.0012	0.0000000028171	0.0000000028171
Toxoplasma gondii	glutamine-dependent NAD(+) synthetase protein, putative	0.0086	0.0096	0.0109
Loa Loa (eye worm)	dihydrofolate reductase	0.7743	1	1
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0029	0.0029
Schistosoma mansoni	chromobox protein	0.0073	0.0079	0.0079
Loa Loa (eye worm)	hypothetical protein	0.008	0.0088	0.0088
Brugia malayi	chromobox protein homolog 3	0.0041	0.0037	0.0037
Echinococcus multilocularis	Chromo domain	0.0012	0.0000000000049098	0.0000000000049098
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0015	0.0004	0.0004
Echinococcus granulosus	thymidylate synthase	0.2422	0.3117	0.3117
Brugia malayi	Uncoordinated protein 44	0.0015	0.0004	0.0004
Toxoplasma gondii	endonuclease IV APN	0.008	0.0088	0.01
Leishmania major	NAD synthase, putative	0.0086	0.0096	0.0107
Brugia malayi	Pre-SET motif family protein	0.0031	0.0025	0.0025
Brugia malayi	Hypothetical 29.7 kDa protein C05D11.5 in chromosome III	0.0021	0.0012	0.0012
Plasmodium vivax	hypothetical protein, conserved	0.0012	0.0000000000049098	0.000000000005581
Loa Loa (eye worm)	CYP4Cod1	0.0013	0.0001	0.0001
Mycobacterium ulcerans	endonuclease IV	0.008	0.0088	0.0087
Mycobacterium tuberculosis	Probable thymidylate synthase ThyA (ts) (TSASE)	0.2422	0.3117	0.3114
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.6813	0.8797	1
Trichomonas vaginalis	chromodomain helicase DNA binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Loa Loa (eye worm)	hypothetical protein	0.0012	0.0000000000049098	0.0000000000049098
Echinococcus multilocularis	survival motor neuron protein 1	0.0234	0.0287	0.0287
Trypanosoma brucei	NAD+ synthase, putative	0.0086	0.0096	0.0107
Echinococcus granulosus	netrin receptor unc 5	0.0015	0.0004	0.0004
Loa Loa (eye worm)	cytochrome P450 family protein	0.0013	0.0001	0.0001
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0026	0.0026
Schistosoma mansoni	P2X receptor subunit	0.0409	0.0514	0.0514
Trypanosoma cruzi	NAD+ synthase, putative	0.0086	0.0096	0.0107
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0037	0.012
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.0066	0.0066
Echinococcus multilocularis	GMP synthase (glutamine hydrolyzing)	0.0034	0.0029	0.0029
Trichomonas vaginalis	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049098	0.000000000033293
Onchocerca volvulus		0.0248	0.0305	0.0978
Toxoplasma gondii	bifunctional GMP synthase/glutamine amidotransferase protein	0.0034	0.0029	0.0033
Echinococcus multilocularis	chromobox protein 1	0.0073	0.0079	0.0079
Brugia malayi	Pre-SET motif family protein	0.0217	0.0266	0.0266
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.6813	0.8797	1
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0015	0.0004	0.0004
Mycobacterium ulcerans	GMP synthase	0.0034	0.0029	0.0028
Schistosoma mansoni	chromodomain helicase DNA binding protein	0.0012	0.0000000000049098	0.0000000000049098
Schistosoma mansoni	hypothetical protein	0.0015	0.0004	0.0004
Chlamydia trachomatis	dihydrofolate reductase	0.7743	1	1
Entamoeba histolytica	chromodomain-helicase-DNA-binding protein, putative	0.0012	0.0000000000049098	0.00000000051351
Echinococcus multilocularis	p2X purinoceptor 4	0.0409	0.0514	0.0514
Schistosoma mansoni	netrin receptor unc5	0.0015	0.0004	0.0004
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0063	0.0066	0.0066
Onchocerca volvulus		0.0015	0.0005	0.0015
Entamoeba histolytica	NAD synthetase, putative	0.0086	0.0096	1
Echinococcus multilocularis	p2X purinoceptor 4	0.0409	0.0514	0.0514
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0077	0.0084	0.0084
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0015	0.0005	0.0003
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0031	0.0025	0.0025
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0004	0.0004

Activities

Activity type	Activity value	Assay description	Source	Reference
Ki (binding)	= 96 nM	Displacement of [125I]-MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells	ChEMBL.	15686900
Ki (binding)	= 96 nM	Displacement of [125I]-MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells	ChEMBL.	15686900

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 314918