Detailed information for compound 314946

Basic information

Technical information
  • TDR Targets ID: 314946
  • Name: 1-(4-chlorobenzoyl)-3-ethyl-2-methylindole-5- sulfonic acid
  • MW: 377.842 | Formula: C18H16ClNO4S
  • H donors: 1 H acceptors: 4 LogP: 4.11 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCc1c(C)n(c2c1cc(cc2)S(=O)(=O)O)C(=O)c1ccc(cc1)Cl
  • InChi: 1S/C18H16ClNO4S/c1-3-15-11(2)20(18(21)12-4-6-13(19)7-5-12)17-9-8-14(10-16(15)17)25(22,23)24/h4-10H,3H2,1-2H3,(H,22,23,24)
  • InChiKey: JBQAXYBGLYQQKA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-chlorobenzoyl)-3-ethyl-2-methyl-indole-5-sulfonic acid
  • 1-[(4-chlorophenyl)-oxomethyl]-3-ethyl-2-methyl-5-indolesulfonic acid
  • 1-(4-chlorophenyl)carbonyl-3-ethyl-2-methyl-indole-5-sulfonic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0655 0.0643
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0024 0.039 0.0387
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.1875 0.4367
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0436 0.0306
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0306 0.7465 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0655 0.0643
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.039 0.0387
Schistosoma mansoni chromobox protein 0.0023 0.0349 0.0347
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0023 0.0365 0.0362
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0512 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0349 0.2674
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0655 0.0653
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.1303 0.13
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2099 0.2096
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.1159 0.1418
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0145 0.3417 0.44
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0655 0.0643
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0655 0.0814
Echinococcus multilocularis chromobox protein 1 0.0138 0.3254 0.3252
Loa Loa (eye worm) heterochromatin protein 1 0.0138 0.3254 0.4828
Onchocerca volvulus 0.0035 0.0655 0.1521
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0655 0.0578
Loa Loa (eye worm) helicase 0.0023 0.0349 0.0515
Loa Loa (eye worm) hypothetical protein 0.0023 0.0349 0.0515
Loa Loa (eye worm) hypothetical protein 0.0061 0.1307 0.1937
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0574 0.0849
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0498 0.0736
Loa Loa (eye worm) hypothetical protein 0.0035 0.0655 0.0969
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0655 0.0814
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0655 0.0643
Schistosoma mansoni P2X receptor subunit 0.023 0.5571 0.5569
Echinococcus multilocularis Chromo domain 0.0023 0.0349 0.0347
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0349 0.0172
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.7465 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0077 0.1728 0.4022
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0574 0.0853
Onchocerca volvulus 0.0023 0.0349 0.0808
Loa Loa (eye worm) RNA binding protein 0.0124 0.2901 0.4304
Brugia malayi Protein cec-1. 0.0023 0.0349 0.0519
Loa Loa (eye worm) hypothetical protein 0.0179 0.4291 0.6369
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0512 0.0422
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0349 0.0172
Onchocerca volvulus 0.0029 0.0498 0.1156
Schistosoma mansoni P2X receptor subunit 0.0076 0.169 0.1687
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0349 0.0519
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.3417 0.44
Loa Loa (eye worm) glutaminase 0.0277 0.6736 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0349 0.0515
Brugia malayi beta-lactamase family protein 0.0035 0.0655 0.0973
Toxoplasma gondii exonuclease III APE 0.0018 0.0238 0.2064
Schistosoma mansoni hypothetical protein 0.0407 1 1
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0349 0.0347
Echinococcus granulosus p2X purinoceptor 4 0.023 0.5571 0.5569
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0238 0.5
Mycobacterium ulcerans beta-lactamase 0.0035 0.0655 0.0643
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0349 0.0347
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0655 0.0814
Schistosoma mansoni hypothetical protein 0.0032 0.0574 0.0572
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0238 0.0349
Entamoeba histolytica hypothetical protein 0.0023 0.0349 1
Trichomonas vaginalis chromobox protein, putative 0.0023 0.0349 0.0172
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0655 0.0653
Leishmania major hypothetical protein, conserved 0.0035 0.0655 0.0578
Echinococcus granulosus chromobox protein 1 0.0138 0.3254 0.3252
Mycobacterium tuberculosis Conserved protein 0.0035 0.0655 0.0814
Onchocerca volvulus 0.0023 0.0349 0.0808
Echinococcus granulosus p2X purinoceptor 4 0.023 0.5571 0.5569
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0655 0.0814
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2099 0.2096
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1728 0.2293
Onchocerca volvulus 0.0035 0.0655 0.1521
Brugia malayi DIX domain containing protein 0.0009 0.0003 0.0004
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0425 0.0288
Brugia malayi beta-lactamase 0.0035 0.0655 0.0973
Brugia malayi Heterochromatin protein 1 0.0138 0.3254 0.4831
Loa Loa (eye worm) CHromoDomain protein family member 0.0024 0.039 0.0575
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0349 0.0172
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0349 0.0347
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0349 0.0347
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0145 0.3417 0.44
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0003 0.0004
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2099 0.2096
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0349 0.2674
Loa Loa (eye worm) hypothetical protein 0.0023 0.0349 0.0515
Schistosoma mansoni P2X receptor subunit 0.0076 0.169 0.1687
Mycobacterium ulcerans glutaminase 0.0277 0.6736 1
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.1159 0.1418
Schistosoma mansoni ap endonuclease 0.0018 0.0238 0.0235
Echinococcus granulosus cpg binding protein 0.003 0.0539 0.0537
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0349 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2901 0.2899
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0003 0.0000014151
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0655 0.0973
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2901 0.2899
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0349 1
Brugia malayi CXXC zinc finger family protein 0.0029 0.0498 0.074
Mycobacterium tuberculosis Conserved hypothetical protein 0.0161 0.3828 0.7
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0349 0.0172
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0512 0.0422
Loa Loa (eye worm) hypothetical protein 0.0035 0.0655 0.0969
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0574 0.0572
Entamoeba histolytica hypothetical protein 0.0023 0.0349 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0655 0.0578
Echinococcus granulosus Chromo domain 0.0023 0.0349 0.0347
Echinococcus multilocularis p2X purinoceptor 4 0.023 0.5571 0.5569
Mycobacterium tuberculosis Conserved protein 0.0035 0.0655 0.0814
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0023 0.0349 0.3046
Loa Loa (eye worm) TAR-binding protein 0.0124 0.2901 0.4304
Echinococcus multilocularis GPCR, family 2 0.0032 0.0574 0.0572
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0512 0.0422
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.01 0.2289 0.3398
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.5367 1
Brugia malayi glutaminase DH11.1 0.0277 0.6736 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0574 0.0849
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0655 0.0653
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.1098 0.119
Brugia malayi hypothetical protein 0.0023 0.0349 0.0519
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0003 0.00000095306
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0238 0.0235
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0574 0.0853
Brugia malayi TAR-binding protein 0.0124 0.2901 0.4306
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0655 0.0969
Trichomonas vaginalis chromobox protein, putative 0.0138 0.3254 0.4642
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0349 0.0172
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0512 0.0422
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0003 0.0004
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2099 0.2096
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0436 0.0306
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0024 0.039 0.0387
Schistosoma mansoni hypothetical protein 0.0032 0.0574 0.0572
Schistosoma mansoni hypothetical protein 0.0068 0.1495 0.1493
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0003 0.00000095306
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0655 0.0578
Echinococcus multilocularis chromobox protein 1 0.0138 0.3254 0.3252
Brugia malayi RNA binding protein 0.0124 0.2901 0.4306
Trichomonas vaginalis hypothetical protein 0.0023 0.0349 0.0172
Leishmania major mitochondrial DNA polymerase beta 0.0306 0.7465 1
Echinococcus granulosus Chromobox protein 3 0.0023 0.0349 0.0347
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0861 0.0863
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0003 0.0004
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.114 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0655 0.0969
Echinococcus multilocularis tar DNA binding protein 0.0124 0.2901 0.2899
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.2099 0.2096
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0655 0.0643
Loa Loa (eye worm) hypothetical protein 0.01 0.2289 0.3395
Echinococcus multilocularis cpg binding protein 0.003 0.0539 0.0537
Schistosoma mansoni ap endonuclease 0.0018 0.0238 0.0235
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.1728 0.2293
Brugia malayi RNA recognition motif domain containing protein 0.0124 0.2901 0.4306
Echinococcus multilocularis p2X purinoceptor 4 0.023 0.5571 0.5569
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0029 0.0512 0.0422
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.2099 0.2096
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0574 0.0572
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0655 0.0814
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0306 0.7465 1
Echinococcus granulosus p2X purinoceptor 4 0.023 0.5571 0.5569
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0512 0.0422
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0124 0.2901 0.4304
Loa Loa (eye worm) glutaminase 2 0.0277 0.6736 1
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0349 0.0519
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0349 0.0347
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0349 0.0172
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0349 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0349 0.3046
Trichomonas vaginalis chromobox protein, putative 0.0138 0.3254 0.4642
Brugia malayi hypothetical protein 0.0009 0.0003 0.0004
Schistosoma mansoni cpg binding protein 0.0029 0.0498 0.0496
Echinococcus granulosus GPCR family 2 0.0032 0.0574 0.0572
Toxoplasma gondii hypothetical protein 0.0049 0.102 0.8945
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0238 0.5
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0023 0.0349 0.0172
Brugia malayi Calcitonin receptor-like protein seb-1 0.01 0.2289 0.3398
Brugia malayi SET domain containing protein 0.0023 0.0365 0.0542
Mycobacterium ulcerans hypothetical protein 0.0161 0.3828 0.5526
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0349 0.0347
Loa Loa (eye worm) hypothetical protein 0.0035 0.0655 0.0969
Mycobacterium ulcerans hypothetical protein 0.0035 0.0655 0.0643
Loa Loa (eye worm) hypothetical protein 0.0023 0.0349 0.0515
Echinococcus granulosus chromobox protein 1 0.0138 0.3254 0.3252
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2901 0.2899
Loa Loa (eye worm) hypothetical protein 0.0023 0.0349 0.0515
Brugia malayi beta-lactamase family protein 0.0035 0.0655 0.0973
Toxoplasma gondii ABC1 family protein 0.0035 0.0655 0.5736
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0349 0.0172
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0512 0.0422
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0349 0.2674
Schistosoma mansoni chromobox protein 0.0138 0.3254 0.3252
Mycobacterium leprae Probable lipase LipE 0.0035 0.0655 0.5
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0238 0.5
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0655 0.0643
Echinococcus granulosus chromobox protein 2 0.0023 0.0349 0.0347
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.2099 0.3116
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0349 1
Onchocerca volvulus 0.0023 0.0365 0.0844
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0655 0.5
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0574 0.0572
Brugia malayi chromobox protein homolog 3 0.0077 0.1728 0.2565
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0861 0.0863
Loa Loa (eye worm) beta-lactamase 0.0035 0.0655 0.0969
Loa Loa (eye worm) hypothetical protein 0.0023 0.0349 0.0515
Schistosoma mansoni chromobox protein 0.0138 0.3254 0.3252
Loa Loa (eye worm) hypothetical protein 0.0077 0.1728 0.2562
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0179 0.4291 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0655 0.0814
Loa Loa (eye worm) hypothetical protein 0.0035 0.0655 0.0969
Schistosoma mansoni P2X receptor subunit 0.023 0.5571 0.5569
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0349 0.0519
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0655 0.0653
Schistosoma mansoni cpg binding protein 0.003 0.0539 0.0537
Brugia malayi hypothetical protein 0.0009 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.0023 0.0349 0.0515
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0349 0.0172
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0349 1
Brugia malayi N-terminal motif family protein 0.0179 0.4291 0.6371
Entamoeba histolytica hypothetical protein 0.0023 0.0349 1
Echinococcus multilocularis p2X purinoceptor 4 0.023 0.5571 0.5569
Onchocerca volvulus 0.0061 0.1307 0.3041
Echinococcus granulosus tar DNA binding protein 0.0124 0.2901 0.2899
Trichomonas vaginalis chromobox protein, putative 0.0083 0.1875 0.252
Schistosoma mansoni chromobox protein 0.0023 0.0349 0.0347
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0023 0.0349 0.3046
Schistosoma mansoni hypothetical protein 0.0032 0.0574 0.0572
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0349 0.0172
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.2099 0.3113
Echinococcus multilocularis dnaJ subfamily B 0.0407 1 1
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0349 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0861 0.0863
Loa Loa (eye worm) pigment dispersing factor receptor c 0.01 0.2289 0.3395
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.2099 0.2096
Brugia malayi CHD4 protein 0.0024 0.039 0.0579
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0655 0.0814
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.1495 0.222
Onchocerca volvulus 0.0035 0.0655 0.1521
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0238 0.0235
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0861 0.0863
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0655 1
Trichomonas vaginalis Heterochromatin protein, putative 0.0023 0.0349 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0655 0.0643
Mycobacterium tuberculosis Conserved protein 0.0035 0.0655 0.0814
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0655 0.0643
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0349 0.0172
Schistosoma mansoni hypothetical protein 0.0023 0.0349 0.0347
Schistosoma mansoni hypothetical protein 0.0032 0.0574 0.0572
Echinococcus multilocularis chromobox protein 2 0.0023 0.0349 0.0347
Loa Loa (eye worm) hypothetical protein 0.0035 0.0655 0.0969
Trichomonas vaginalis glutaminase, putative 0.0277 0.6736 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0574 0.0572
Schistosoma mansoni cpg binding protein 0.003 0.0539 0.0537
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0349 0.0519
Schistosoma mansoni glutaminase 0.0277 0.6736 0.6735
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2901 0.2899
Trichomonas vaginalis esterase, putative 0.0035 0.0655 0.0643
Loa Loa (eye worm) hypothetical protein 0.0068 0.1495 0.2216
Trichomonas vaginalis conserved hypothetical protein 0.0023 0.0349 0.0172
Schistosoma mansoni tar DNA-binding protein 0.0124 0.2901 0.2899
Trichomonas vaginalis chromobox protein, putative 0.0083 0.1875 0.252
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0238 0.0353
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0023 0.0349 1

Activities

Activity type Activity value Assay description Source Reference
Effect (functional) 0 Effect of compound (10 uM) on doxorubicin-induced cytotoxicity towards T98G cell line expressing multidrug resistance associated protein 1 (MRP-1); Inactive ChEMBL. 15715484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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