Detailed information for compound 314984

Basic information

Technical information
  • TDR Targets ID: 314984
  • Name: 2-[(4-fluoro-3-phenoxybenzoyl)amino]benzoic a cid
  • MW: 351.328 | Formula: C20H14FNO4
  • H donors: 2 H acceptors: 3 LogP: 4.46 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(c(c1)Oc1ccccc1)F)Nc1ccccc1C(=O)O
  • InChi: 1S/C20H14FNO4/c21-16-11-10-13(12-18(16)26-14-6-2-1-3-7-14)19(23)22-17-9-5-4-8-15(17)20(24)25/h1-12H,(H,22,23)(H,24,25)
  • InChiKey: OPLSSBDEHIIFAG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[(4-fluoro-3-phenoxy-benzoyl)amino]benzoic acid
  • 2-[[(4-fluoro-3-phenoxyphenyl)-oxomethyl]amino]benzoic acid
  • 2-[(4-fluoro-3-phenoxy-phenyl)carbonylamino]benzoic acid
  • 2-[[4-fluoro-3-(phenoxy)benzoyl]amino]benzoic acid
  • 2-[[[4-fluoro-3-(phenoxy)phenyl]-oxomethyl]amino]benzoic acid
  • 2-[[4-fluoro-3-(phenoxy)phenyl]carbonylamino]benzoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Enterococcus faecalis (strain ATCC 700802 / V583) Beta-ketoacyl-ACP synthase III Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium falciparum beta-ketoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans beta-ketoacyl synthase-like protein Get druggable targets OG5_129509 All targets in OG5_129509
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium berghei apicoplast beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Chlamydia trachomatis oxoacyl-ACP synthase III Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium knowlesi beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Mycobacterium ulcerans 3-oxoacyl-ACP synthase Get druggable targets OG5_129509 All targets in OG5_129509
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative Get druggable targets OG5_129509 All targets in OG5_129509
Neospora caninum 3-oxoacyl-(acyl-carrier-protein) synthase III family protein, putative Get druggable targets OG5_129509 All targets in OG5_129509
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum ko:K01641 hydroxymethylglutaryl-CoA synthase [EC2.3.3.10], putative Beta-ketoacyl-ACP synthase III   321 aa 271 aa 22.1 %
Mycobacterium tuberculosis Conserved hypothetical protein Beta-ketoacyl-ACP synthase III   321 aa 310 aa 21.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0104 0.0921 0.1724
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0622 0.0622
Brugia malayi small heat shock protein 0.0566 0.5344 0.5344
Echinococcus granulosus neuropeptide FF receptor 2 0.003 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0383 0.359 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0125 0.0438
Echinococcus multilocularis expressed protein 0.039 0.3651 0.4547
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0223 0.3316
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0622 0.0902
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0116 0.0136
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0223 0.3316
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.189 0.3538
Loa Loa (eye worm) RGS-3 protein 0.002 0.0116 0.0217
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0036 0.0036
Brugia malayi Cytochrome P450 family protein 0.0031 0.0223 0.0223
Echinococcus granulosus bloom syndrome protein 0.0021 0.0125 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0207 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0036 0.0036
Schistosoma mansoni hypothetical protein 0.0067 0.0565 0.0819
Echinococcus granulosus tar DNA binding protein 0.0073 0.0622 0.0902
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0713 0.088
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0622 0.0902
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0371 0.0454
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus granulosus serotonin receptor 0.003 0.0215 0.0305
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.008 0.1982
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0116 0.0136
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Echinococcus granulosus microtubule associated protein 2 0.072 0.6814 1
Onchocerca volvulus 0.003 0.0215 0.0994
Schistosoma mansoni regulator of G protein signaling 0.002 0.0116 0.016
Echinococcus granulosus g protein coupled receptor 0.003 0.0215 0.0305
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0116 0.016
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0072 0.0609 0.0884
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0036 0.0067
Echinococcus granulosus neuropeptide receptor 0.003 0.0215 0.0305
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus multilocularis neuropeptide receptor A26 0.003 0.0215 0.0259
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.008 0.0224
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0116 0.0116
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.1057 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.008 0.0055
Schistosoma mansoni intermediate filament proteins 0.0053 0.0433 0.0624
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.002 0.0116 0.0217
Echinococcus granulosus axis inhibition protein axin 0.002 0.0116 0.016
Schistosoma mansoni hypothetical protein 0.0195 0.1789 0.2617
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.003 0.0215 0.0259
Brugia malayi Dopamine receptor 0.003 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus granulosus thyrotropin releasing hormone receptor 0.003 0.0215 0.0305
Echinococcus multilocularis dro:myosuppressin receptor 0.003 0.0215 0.0259
Brugia malayi Dopamine receptor protein 2 0.003 0.0215 0.0215
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0622 0.1164
Brugia malayi G-protein coupled receptor 0.003 0.0215 0.0215
Plasmodium falciparum thioredoxin reductase 0.0047 0.0371 0.1016
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0036 0.0036
Loa Loa (eye worm) voltage-dependent calcium channel 0.0022 0.0133 0.025
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0036 0.0036
Echinococcus multilocularis musashi 0.0053 0.0433 0.053
Schistosoma mansoni hypothetical protein 0.003 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0038 0.0038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0036 0.0042
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0215 0.0402
Echinococcus multilocularis muscleblind protein 1 0.0172 0.1568 0.1948
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.017 0.0239
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0116 0.0136
Loa Loa (eye worm) hypothetical protein 0.0052 0.0423 0.0792
Echinococcus multilocularis lamin 0.0053 0.0433 0.053
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0036 0.0036
Schistosoma mansoni neuropeptide f receptor 76f 0.003 0.0215 0.0305
Loa Loa (eye worm) TYRA-2 protein 0.003 0.0215 0.0402
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0059 0.1404
Schistosoma mansoni amine GPCR 0.003 0.0215 0.0305
Schistosoma mansoni neuropeptide receptor 0.003 0.0215 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.0828
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus granulosus dro:myosuppressin receptor 0.003 0.0215 0.0305
Echinococcus multilocularis lamin dm0 0.0053 0.0433 0.053
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0846 0.802 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.003 0.0215 0.0402
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Plasmodium falciparum glutathione reductase 0.0047 0.0371 0.1016
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus multilocularis neuropeptide FF receptor 2 0.003 0.0215 0.0259
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0223 0.0418
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0104 0.0921 0.0921
Entamoeba histolytica hypothetical protein 0.0038 0.0284 0.4368
Onchocerca volvulus Neuropeptide F receptor homolog 0.003 0.0215 0.0994
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0067
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0402 0.377 0.4696
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0028 0.0197 0.0368
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0036 0.0042
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0036 0.0067
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0215 0.0259
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.0072 0.0609 0.114
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Loa Loa (eye worm) hypothetical protein 0.0022 0.0133 0.025
Onchocerca volvulus 0.003 0.0215 0.0994
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0036 0.0036
Leishmania major trypanothione reductase 0.0047 0.0371 0.5882
Brugia malayi hypothetical protein 0.0065 0.0543 0.0543
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.359 1
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0116 0.016
Brugia malayi ORL1-like opioid receptor 0.003 0.0215 0.0215
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0116 0.0116
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0215 0.0305
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0116 0.0136
Echinococcus multilocularis alpha 1A adrenergic receptor 0.003 0.0215 0.0259
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0433 0.0809
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0104 0.0921 0.114
Onchocerca volvulus 0.003 0.0215 0.0994
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0058 0.0459
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.000000001034
Echinococcus multilocularis geminin 0.0195 0.1789 0.2223
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0215 0.0305
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.008 0.008
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0622 0.0902
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.003 0.0215 0.0402
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.0828
Onchocerca volvulus 0.003 0.0215 0.0994
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0036 0.0036
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Leishmania major cytochrome p450-like protein 0.0014 0.0058 0.0459
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0223 0.0418
Schistosoma mansoni amine GPCR 0.003 0.0215 0.0305
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0622 0.0902
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0067
Loa Loa (eye worm) follicle stimulating hormone receptor 0.003 0.0215 0.0402
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0609 1
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0215 0.0305
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.003 0.0215 0.0305
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0207 0.0293
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Mycobacterium tuberculosis Probable reductase 0.0106 0.0944 0.2507
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0713 0.1036
Brugia malayi abnormal cell lineage protein 10 (Protein lin-10), putative 0.0067 0.0562 0.0562
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0215 0.0259
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0215 0.0259
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0072 0.0609 0.0884
Loa Loa (eye worm) hypothetical protein 0.0025 0.0161 0.03
Echinococcus multilocularis serotonin receptor 0.003 0.0215 0.0259
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.0203
Schistosoma mansoni alpha-1 adrenergic receptor 0.003 0.0215 0.0305
Echinococcus granulosus 7tm_1 domain containing protein 0.003 0.0215 0.0305
Schistosoma mansoni coup transcription factor 0.0012 0.0036 0.0042
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0401 0.639
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0036 0.0067
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0215 0.0305
Brugia malayi neuropeptide F receptor 0.003 0.0215 0.0215
Entamoeba histolytica hypothetical protein 0.002 0.0116 0.1462
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.003 0.0215 0.0305
Brugia malayi bZIP transcription factor family protein 0.0082 0.0713 0.0713
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0622 0.1164
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.008 0.1982
Onchocerca volvulus 0.003 0.0215 0.0994
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0072 0.0609 0.0751
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0284 0.0406
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0116 0.016
Echinococcus granulosus neuropeptide receptor A26 0.003 0.0215 0.0305
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0215 0.0305
Echinococcus multilocularis g protein coupled receptor 0.003 0.0215 0.0259
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0116 0.0217
Brugia malayi hypothetical protein 0.0072 0.0609 0.0609
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0067
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus granulosus neuropeptide s receptor 0.003 0.0215 0.0305
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0072 0.0609 1
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0036 0.0036
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0036 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0215 0.0259
Schistosoma mansoni neuropeptide receptor 0.003 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.003 0.0215 0.0305
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.008 0.0828
Brugia malayi cytochrome P450 0.0014 0.0058 0.0058
Brugia malayi sulfakinin receptor protein 0.003 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.008 0.0828
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0215 0.0259
Brugia malayi nuclear receptor NHR-88 0.0012 0.0036 0.0036
Entamoeba histolytica hypothetical protein 0.0038 0.0284 0.4368
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0125 0.0125
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.017 0.0203
Schistosoma mansoni peptide (allatostatin)-like receptor 0.003 0.0215 0.0305
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0215 0.0305
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0383 0.359 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.0828
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0383 0.359 1
Echinococcus granulosus amyloid beta A4 protein 0.0074 0.0637 0.0925
Leishmania major cytochrome p450-like protein 0.0031 0.0223 0.3316
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0036 0.0067
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0433 0.0433
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0207 0.0249
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0067
Loa Loa (eye worm) hypothetical protein 0.002 0.0116 0.0217
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0383 0.359 1
Onchocerca volvulus 0.003 0.0215 0.0994
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0036 0.0036
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0944 0.2507
Echinococcus multilocularis 0.0014 0.0058 0.0063
Echinococcus granulosus 7TM GPCR rhodopsin 0.003 0.0215 0.0305
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0215 0.0305
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0116 0.0396
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0018 0.0101 0.026
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0622 0.0767
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0609 1
Schistosoma mansoni opsin-like receptor 0.003 0.0215 0.0305
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.008 0.0201
Echinococcus granulosus jun protein 0.0082 0.0713 0.1036
Schistosoma mansoni cytochrome P450 0.0014 0.0058 0.0075
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.003 0.0215 0.0305
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.002 0.0116 0.0116
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0215 0.0259
Schistosoma mansoni amine GPCR 0.003 0.0215 0.0305
Echinococcus granulosus lamin dm0 0.0053 0.0433 0.0624
Entamoeba histolytica hypothetical protein 0.0038 0.0284 0.4368
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0215 0.0305
Entamoeba histolytica hypothetical protein 0.002 0.0116 0.1462
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0036 0.0067
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0116 0.0116
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0116 0.0396
Schistosoma mansoni biogenic amine receptor 0.003 0.0215 0.0305
Loa Loa (eye worm) melatonin receptor type 1A 0.003 0.0215 0.0402
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0944 0.2507
Onchocerca volvulus 0.003 0.0215 0.0994
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0036 0.0167
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.1057 0.2829
Schistosoma mansoni biogenic amine receptor 0.003 0.0215 0.0305
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0116 0.016
Brugia malayi RE15519p 0.003 0.0215 0.0215
Echinococcus multilocularis serotonin receptor 0.003 0.0215 0.0259
Brugia malayi Dopamine receptor protein 1 0.003 0.0215 0.0215
Schistosoma mansoni hypothetical protein 0.003 0.0215 0.0305
Brugia malayi intermediate filament protein 0.0053 0.0433 0.0433
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.008 0.0055
Echinococcus granulosus peptide allatostatin:somatostatin 0.003 0.0215 0.0305
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0072 0.0609 0.0609
Echinococcus granulosus beta-adrenergic receptor kinase 0.002 0.0116 0.016
Schistosoma mansoni microtubule-associated protein tau 0.072 0.6814 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0207 0.0249
Onchocerca volvulus 0.0029 0.0207 0.0956
Echinococcus granulosus g-protein coupled receptor 0.003 0.0215 0.0305
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0036 0.0042
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.008 0.0828
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Schistosoma mansoni regulator of G protein signaling 0.002 0.0116 0.016
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.008 0.0201
Schistosoma mansoni neuropeptide receptor 0.003 0.0215 0.0305
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0036 0.0036
Brugia malayi RNA binding protein 0.0073 0.0622 0.0622
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0383 0.359 1
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.003 0.0215 0.0215
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0014 0.0058 0.0459
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0036 0.0036
Echinococcus multilocularis voltage dependent calcium channel 0.0104 0.0921 0.114
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.008 0.0691 0.1293
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0215 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0036 0.0036
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.008 0.0828
Echinococcus granulosus sex peptide receptor 0.003 0.0215 0.0305
Echinococcus granulosus tm gpcr rhodopsin 0.003 0.0215 0.0305
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.003 0.0215 0.0305
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0014 0.0058 0.0459
Schistosoma mansoni histamine h1 receptor 0.003 0.0215 0.0305
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0083 0.0111
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.003 0.0215 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.0828
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Schistosoma mansoni hypothetical protein 0.003 0.0215 0.0305
Loa Loa (eye worm) X11 protein 0.0074 0.0637 0.1192
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0215 0.0305
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.008 0.0828
Brugia malayi Pre-SET motif family protein 0.0205 0.189 0.189
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0401 0.639
Echinococcus granulosus expressed protein 0.039 0.3651 0.5353
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.008 0.0828
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0215 0.0305
Brugia malayi G protein-coupled receptor 0.003 0.0215 0.0215
Echinococcus multilocularis amyloid beta A4 protein 0.0074 0.0637 0.0786
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Toxoplasma gondii cytochrome p450 superfamily protein 0.0014 0.0058 0.1397
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus multilocularis g-protein coupled receptor 0.003 0.0215 0.0259
Loa Loa (eye worm) hypothetical protein 0.0025 0.0161 0.03
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0116 0.0136
Onchocerca volvulus 0.003 0.0215 0.0994
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0036 0.0042
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0072 0.0609 0.114
Plasmodium vivax SET domain protein, putative 0.0029 0.0207 0.0415
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Schistosoma mansoni lamin 0.0053 0.0433 0.0624
Onchocerca volvulus 0.003 0.0215 0.0994
Brugia malayi ecdysteroid receptor 0.0012 0.0036 0.0036
Echinococcus granulosus G protein coupled receptor 139 0.003 0.0215 0.0305
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0014 0.0058 0.0459
Onchocerca volvulus 0.0053 0.0433 0.2
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0401 0.639
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0036 0.0042
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0036 0.0036
Schistosoma mansoni voltage-gated cation channel 0.0104 0.0921 0.1342
Brugia malayi TAR-binding protein 0.0073 0.0622 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0116 0.0396
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Schistosoma mansoni regulator of G protein signaling 0.0023 0.0144 0.0201
Toxoplasma gondii thioredoxin reductase 0.0047 0.0371 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0108 0.0203
Onchocerca volvulus 0.003 0.0215 0.0994
Onchocerca volvulus 0.003 0.0215 0.0994
Echinococcus multilocularis sodium channel protein 0.0044 0.0347 0.0424
Echinococcus granulosus g protein coupled receptor 0.003 0.0215 0.0305
Schistosoma mansoni adenoreceptor 0.003 0.0215 0.0305
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0215 0.0305
Brugia malayi nuclear hormone receptor 0.0012 0.0036 0.0036
Brugia malayi Muscleblind-like protein 0.0172 0.1568 0.1568
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0067
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0215 0.0305
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0215 0.0305
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0215 0.0305
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0207 0.0293
Brugia malayi hypothetical protein 0.0038 0.0284 0.0284
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.003 0.0215 0.0402
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0196 0.0278
Echinococcus granulosus axis inhibition protein axin 0.002 0.0116 0.016
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0036 0.0042
Schistosoma mansoni hypothetical protein 0.003 0.0215 0.0305
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0072 0.0609 1
Schistosoma mansoni lamin 0.0053 0.0433 0.0624
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0371 0.0535
Echinococcus granulosus cytochrome P450 2K1 0.0014 0.0058 0.0075
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0007 0.0007
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0401 0.639
Schistosoma mansoni amine GPCR 0.003 0.0215 0.0305
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.003 0.0215 0.0259
Loa Loa (eye worm) hypothetical protein 0.0172 0.1568 0.2935
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0215 0.0259
Echinococcus multilocularis sex peptide receptor 0.003 0.0215 0.0259
Schistosoma mansoni biogenic amine (5HT) receptor 0.003 0.0215 0.0305
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0215 0.0305
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0622 0.0902
Echinococcus granulosus lamin 0.0053 0.0433 0.0624
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0215 0.0259
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.1057 0.2829
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0371 0.0695
Echinococcus granulosus muscleblind protein 0.0172 0.1568 0.2293
Plasmodium vivax glutathione reductase, putative 0.0047 0.0371 0.0882
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0215 0.0259
Schistosoma mansoni amyloid beta A4 protein related 0.0074 0.0637 0.0925
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.003 0.0215 0.0215
Toxoplasma gondii transporter, cation channel family protein 0.0022 0.0133 0.3461
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0116 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0223 0.0418
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0215 0.0259
Schistosoma mansoni axis inhibition protein axin 0.002 0.0116 0.016
Schistosoma mansoni regulator of G protein signaling 0.002 0.0116 0.016
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus multilocularis jun protein 0.0082 0.0713 0.088
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0116 0.016
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.008 0.0828
Onchocerca volvulus 0.003 0.0215 0.0994
Toxoplasma gondii hypothetical protein 0.0019 0.0108 0.277
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0215 0.0259
Loa Loa (eye worm) RecQ helicase 0.0021 0.0125 0.0234
Echinococcus granulosus voltage dependent calcium channel 0.0022 0.0133 0.0185
Echinococcus multilocularis fmrfamide receptor 0.003 0.0215 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus granulosus alpha 1A adrenergic receptor 0.003 0.0215 0.0305
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0036 0.0042
Echinococcus granulosus somatostatin receptor 0.003 0.0215 0.0305
Onchocerca volvulus 0.0234 0.2162 1
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0116 0.0116
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0036 0.0167
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0125 0.0438
Echinococcus granulosus fmrfamide receptor 0.003 0.0215 0.0305
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.0828
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0371 0.0887
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.008 0.006
Schistosoma mansoni axis inhibition protein axin 0.002 0.0116 0.016
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0036 0.0067
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0383 0.359 1
Brugia malayi G-protein coupled receptor 0.003 0.0215 0.0215
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.008 0.006
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.003 0.0215 0.0259
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0116 0.016
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0116 0.0396
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0371 0.5882
Brugia malayi hypothetical protein 0.002 0.0116 0.0116
Echinococcus granulosus intermediate filament protein 0.0053 0.0433 0.0624
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.003 0.0215 0.0305
Brugia malayi Tachykinin-like peptides receptor 99D 0.003 0.0215 0.0215
Plasmodium falciparum thioredoxin reductase 0.0016 0.008 0.0201
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2162 1
Brugia malayi hypothetical protein 0.002 0.0116 0.0116
Loa Loa (eye worm) calcium channel 0.0104 0.0921 0.1724
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.008 0.0828
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0116 0.016
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0116 0.0396
Echinococcus multilocularis beta adrenergic receptor kinase 0.002 0.0116 0.0136
Plasmodium falciparum glutathione reductase 0.0016 0.008 0.0201
Schistosoma mansoni regulator of G protein signaling 0.002 0.0116 0.016
Brugia malayi larval opioid receptor 0.003 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Loa Loa (eye worm) cytochrome P450 0.0014 0.0058 0.0109
Loa Loa (eye worm) hypothetical protein 0.0009 0.0007 0.0014
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0036 0.0067
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0036 0.0042
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0284 0.0345
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0036 0.0042
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0215 0.0305
Onchocerca volvulus 0.0012 0.0036 0.0167
Brugia malayi G protein-coupled receptor F59B2.13 0.003 0.0215 0.0215
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0104 0.0921 0.114
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Schistosoma mansoni growth hormone secretagogue receptor 0.003 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.0017 0.009 0.0168
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.008 0.0106
Onchocerca volvulus 0.003 0.0215 0.0994
Schistosoma mansoni biogenic amine (5HT) receptor 0.0402 0.377 0.5528
Echinococcus granulosus g protein coupled receptor 0.003 0.0215 0.0305
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0104 0.0921 0.1342
Loa Loa (eye worm) hypothetical protein 0.002 0.0116 0.0217
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.003 0.0215 0.0305
Echinococcus multilocularis G protein coupled receptor 139 0.003 0.0215 0.0259
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.008 0.0224
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0215 0.0305
Echinococcus multilocularis microtubule associated protein 2 0.072 0.6814 0.8495
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0067
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0116 0.0396
Loa Loa (eye worm) hypothetical protein 0.0017 0.0084 0.0158
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.002 0.0116 0.0217
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0104 0.0921 0.1342
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.003 0.0215 0.0259
Brugia malayi neuropeptide F receptor 0.003 0.0215 0.0215
Loa Loa (eye worm) hypothetical protein 0.0172 0.1568 0.2935
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0116 0.0136
Brugia malayi PXA domain containing protein 0.002 0.0116 0.0116
Onchocerca volvulus 0.003 0.0215 0.0994
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.003 0.0215 0.0259
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0116 0.0136
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0223 0.0467
Brugia malayi AKH receptor 0.003 0.0215 0.0215
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0036 0.0067
Entamoeba histolytica hypothetical protein 0.002 0.0116 0.1462
Schistosoma mansoni hypothetical protein 0.0038 0.0284 0.0406
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.003 0.0215 0.0402
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.002 0.0116 0.0217
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0207 0.5476
Echinococcus multilocularis fmrfamide receptor 0.003 0.0215 0.0259
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0215 0.0305
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0116 0.0217
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0063 0.0531 0.8644
Echinococcus granulosus rhodopsin orphan GPCR 0.003 0.0215 0.0305
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.1057 0.2829
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.003 0.0215 0.0215
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0944 0.2507
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0044 0.0347 0.05
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.003 0.0215 0.0259
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.0828
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.008 0.0828
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.003 0.0215 0.0994
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0104 0.0921 0.114
Brugia malayi gonadotropin-releasing hormone receptor 2 0.003 0.0215 0.0215
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0036 0.0042
Entamoeba histolytica hypothetical protein 0.0038 0.0284 0.4368
Schistosoma mansoni opsin-like receptor 0.003 0.0215 0.0305
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.0828
Loa Loa (eye worm) hypothetical protein 0.0053 0.0433 0.0809
Echinococcus granulosus allatostatin A receptor 0.003 0.0215 0.0305
Echinococcus granulosus geminin 0.0195 0.1789 0.2617
Brugia malayi cytoplasmic intermediate filament protein 0.0028 0.0197 0.0197
Echinococcus multilocularis muscleblind protein 0.0172 0.1568 0.1948
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0036 0.0042
Echinococcus granulosus neuropeptides capa receptor 0.003 0.0215 0.0305
Echinococcus granulosus neuropeptide receptor 0.003 0.0215 0.0305
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0036 0.0036
Loa Loa (eye worm) neuropeptide F receptor 0.003 0.0215 0.0402
Onchocerca volvulus 0.003 0.0215 0.0994
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0116 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0215 0.0305
Loa Loa (eye worm) glutathione reductase 0.0047 0.0371 0.0695
Loa Loa (eye worm) hypothetical protein 0.002 0.0116 0.0217
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0036 0.0036
Echinococcus multilocularis neuropeptide receptor 0.003 0.0215 0.0259
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0104 0.0921 0.1342
Brugia malayi GnHR receptor homolog 0.003 0.0215 0.0215
Onchocerca volvulus 0.003 0.0215 0.0994
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.008 0.009
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0116 0.016
Loa Loa (eye worm) hypothetical protein 0.0566 0.5344 1
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0036 0.0042
Echinococcus granulosus biogenic amine 5HT receptor 0.003 0.0215 0.0305
Brugia malayi Cytochrome P450 family protein 0.0031 0.0223 0.0223
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0944 0.2507
Brugia malayi steroid hormone receptor 0.0012 0.0036 0.0036
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.003 0.0215 0.0259
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0104 0.0921 0.1342
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Treponema pallidum NADH oxidase 0.0016 0.008 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0215 0.0259
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0036 0.0042
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0036 0.0036
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.008 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Schistosoma mansoni hypothetical protein 0.0014 0.0058 0.0075
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.003 0.0215 0.0305
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0036 0.0036
Onchocerca volvulus 0.0065 0.0543 0.2514
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0036 0.0042
Trypanosoma brucei trypanothione reductase 0.0047 0.0371 0.5882
Brugia malayi Thioredoxin reductase 0.0047 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0026 0.017 0.0318
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0036 0.0036
Brugia malayi Serotonin/octopamine receptor family protein 7 0.003 0.0215 0.0215
Loa Loa (eye worm) G-protein coupled receptor 0.003 0.0215 0.0402
Brugia malayi putative neuropeptide receptor NPR1 0.003 0.0215 0.0215
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.003 0.0215 0.0305
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.008 0.0106
Echinococcus multilocularis somatostatin receptor 0.003 0.0215 0.0259
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0036 0.0036
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0036 0.0042
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0036 0.0042
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0223 0.3316
Schistosoma mansoni myosin xvIII 0.003 0.0215 0.0305
Echinococcus multilocularis rhodopsin orphan GPCR 0.003 0.0215 0.0259
Entamoeba histolytica fatty acid elongase, putative 0.005 0.0401 0.639
Onchocerca volvulus 0.0053 0.0433 0.2
Echinococcus granulosus tachykinin peptides receptor 99D 0.003 0.0215 0.0305
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0036 0.0042
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0104 0.0921 0.114
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Brugia malayi Cytochrome P450 family protein 0.0014 0.0058 0.0058
Echinococcus granulosus neuropeptide Y receptor 0.003 0.0215 0.0305
Echinococcus granulosus voltage dependent calcium channel 0.0104 0.0921 0.1342
Brugia malayi hypothetical protein 0.003 0.0215 0.0215
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0116 0.016
Echinococcus multilocularis neuropeptides capa receptor 0.003 0.0215 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.008 0.0828
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus multilocularis transcription factor Dp 1 0.0041 0.0321 0.0391
Echinococcus granulosus orexin receptor type 2 0.003 0.0215 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0116 0.0396
Schistosoma mansoni opsin-like receptor 0.003 0.0215 0.0305
Onchocerca volvulus 0.003 0.0215 0.0994
Echinococcus multilocularis allatostatin A receptor 0.003 0.0215 0.0259
Brugia malayi Cytochrome P450 family protein 0.0033 0.0238 0.0238
Echinococcus multilocularis orexin receptor type 2 0.003 0.0215 0.0259
Schistosoma mansoni biogenic amine receptor 0.003 0.0215 0.0305
Schistosoma mansoni hypothetical protein 0.0195 0.1789 0.2617
Loa Loa (eye worm) hypothetical protein 0.002 0.0116 0.0217
Echinococcus multilocularis g protein coupled receptor 0.003 0.0215 0.0259
Schistosoma mansoni neuropeptide receptor 0.003 0.0215 0.0305
Brugia malayi Melatonin receptor type 1A 0.003 0.0215 0.0215
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0036 0.0167
Echinococcus multilocularis G-protein coupled receptor, putative 0.003 0.0215 0.0259
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.003 0.0215 0.0305
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0944 0.2507
Brugia malayi PXA domain containing protein 0.002 0.0116 0.0116
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0383 0.359 1
Brugia malayi glutathione reductase 0.0047 0.0371 0.0371
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.003 0.0215 0.0305
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0433 0.0809
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0125 0.0147
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0116 0.0136
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.003 0.0215 0.0259
Leishmania major cytochrome p450-like protein 0.0014 0.0058 0.0459
Loa Loa (eye worm) hypothetical protein 0.0012 0.0036 0.0067
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0007 0.0014
Echinococcus multilocularis voltage dependent calcium channel 0.0104 0.0921 0.114
Echinococcus multilocularis tachykinin peptides receptor 99D 0.003 0.0215 0.0259
Echinococcus multilocularis neuropeptide Y receptor 0.003 0.0215 0.0259
Echinococcus multilocularis neuropeptide s receptor 0.003 0.0215 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Echinococcus granulosus hypothetical protein 0.003 0.0215 0.0305
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0944 0.8862
Brugia malayi putative neuropeptide receptor 0.003 0.0215 0.0215
Schistosoma mansoni jun-related protein 0.0067 0.0565 0.0819
Loa Loa (eye worm) RNA binding protein 0.0073 0.0622 0.1164
Echinococcus granulosus transcription factor Dp 1 0.0041 0.0321 0.0461
Echinococcus multilocularis neuropeptide receptor 0.003 0.0215 0.0259
Loa Loa (eye worm) hypothetical protein 0.003 0.0215 0.0402
Brugia malayi Pre-SET motif family protein 0.0029 0.0207 0.0207
Schistosoma mansoni neuropeptide F-like receptor 0.003 0.0215 0.0305
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0116 0.0136
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0116 0.016
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0238 0.0446
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0284 0.0406
Schistosoma mansoni biogenic amine (dopamine) receptor 0.003 0.0215 0.0305
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0072 0.0609 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0036 0.0042
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.008 0.006
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.003 0.0215 0.0305
Echinococcus granulosus biogenic amine 5HT receptor 0.0402 0.377 0.5528
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0036 0.0042
Brugia malayi follicle stimulating hormone receptor 0.003 0.0215 0.0215
Echinococcus multilocularis g protein coupled receptor 0.003 0.0215 0.0259
Loa Loa (eye worm) hypothetical protein 0.0029 0.0207 0.0387
Schistosoma mansoni amine GPCR 0.003 0.0215 0.0305
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0063 0.0531 0.8644
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0036 0.0036
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0371 0.0882
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0014 0.0058 0.0459
Brugia malayi Serotonin receptor 0.003 0.0215 0.0215
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0104 0.0921 0.1342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0207 0.0293
Loa Loa (eye worm) hypothetical protein 0.002 0.0116 0.0217
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0116 0.016
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.008 0.006
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0207 0.0293

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 5.42 Inhibition of Enterococcus faecalis FabH by FabD/FabH coupled assay ChEMBL. 17707951
IC50 (binding) = 3.8 uM Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III ChEMBL. 15743201
IC50 (binding) = 3.8 uM Inhibitory concentration against Enterococcus faecalis beta-Ketoacyl-acyl carrier protein synthase III ChEMBL. 15743201

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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