TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 936.843 | Formula: C36H51F3N10O16
H donors: 16 H acceptors: 16 LogP: -5.6 Rotable bonds: 14
Rule of 5 violations (Lipinski): 4
SMILES: OCC1NC(=O)C(CNC(=O)C(NCc2cc(F)c(c(c2)F)F)C)NC(=O)C(NC(=O)C(O)CNC(=O)C(NC(=O)C(NC(=O)C(NC1=O)C(C)C)C(C(C(=O)N)O)O)C(O)C)C(=O)O
InChi: 1S/C36H51F3N10O16/c1-11(2)21-33(61)48-23(25(53)26(54)27(40)55)34(62)47-22(13(4)51)32(60)43-9-19(52)31(59)49-24(36(64)65)35(63)44-17(29(57)45-18(10-50)30(58)46-21)8-42-28(56)12(3)41-7-14-5-15(37)20(39)16(38)6-14/h5-6,11-13,17-19,21-26,41,50-54H,7-10H2,1-4H3,(H2,40,55)(H,42,56)(H,43,60)(H,44,63)(H,45,57)(H,46,58)(H,47,62)(H,48,61)(H,49,59)(H,64,65)
InChiKey: DQMRJUAVWZYUSS-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	TKL/MLK/TAK1 protein kinase	0.1368	0.5735	0.5735
Mycobacterium leprae	ATP-dependent Clp protease proteolytic subunit 1	0.006	0.0182	0.1871
Brugia malayi	Pre-SET motif family protein	0.0066	0.0206	0.0205
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Mycobacterium tuberculosis	Peptide synthetase MbtF (peptide synthase)	0.0034	0.007	0.0546
Schistosoma mansoni	serine/threonine protein kinase	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.2372	1	1
Loa Loa (eye worm)	TKL/STKR/TYPE1 protein kinase	0.1368	0.5735	0.5735
Echinococcus multilocularis	SHC transforming protein 3	0.1004	0.4191	0.419
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0018	0.0001	0.0001
Onchocerca volvulus		0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Echinococcus granulosus	suppressor of cytokine signaling 6	0.1004	0.4191	0.419
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0115	0.0414	0.0412
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.1004	0.4191	0.419
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.013	0.0476	0.0474
Entamoeba histolytica	acyl-coA synthetase, putative	0.0116	0.0417	0.035
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Trypanosoma brucei	Flagellum attachment zone protein 20	0.1368	0.5735	1
Trichomonas vaginalis	conserved hypothetical protein	0.1368	0.5735	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.1004	0.4191	0.419
Loa Loa (eye worm)	SH2 domain-containing protein	0.1004	0.4191	0.4191
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus multilocularis	NCK adaptor protein	0.1004	0.4191	0.419
Echinococcus multilocularis	GA binding protein alpha chain	0.0048	0.013	0.0128
Loa Loa (eye worm)	TK/FAK protein kinase	0.1368	0.5735	0.5735
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TKL/MLK/ILK protein kinase	0.1368	0.5735	0.5735
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Loa Loa (eye worm)	TK/EPH protein kinase	0.1368	0.5735	0.5735
Brugia malayi	AMP-binding enzyme family protein	0.0116	0.0417	0.0415
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.1368	0.5735	1
Schistosoma mansoni	suppressor of cytokine signaling	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1004	0.4191	0.419
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0293	0.0293
Schistosoma mansoni	transcription factor LCR-F1	0.013	0.0476	0.0474
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0116	0.0417	0.5778
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.2372	1	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.1368	0.5735	0.5735
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1004	0.4191	0.419
Onchocerca volvulus		0.1004	0.4191	0.419
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.1004	0.4191	0.415
Echinococcus multilocularis	integrin linked protein kinase	0.1368	0.5735	0.5734
Echinococcus granulosus	tensin	0.1004	0.4191	0.419
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0175	0.067	1
Brugia malayi	SH2 domain containing protein	0.1004	0.4191	0.419
Echinococcus granulosus	tyrosine kinase	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Onchocerca volvulus		0.0034	0.007	0.0068
Onchocerca volvulus		0.2372	1	1
Echinococcus multilocularis	FL cytokine receptor	0.1368	0.5735	0.5734
Leishmania major	4-coumarate:coa ligase-like protein	0.0116	0.0417	0.0613
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Brugia malayi	cytokine inducible SH2-containing protein 5	0.1004	0.4191	0.419
Toxoplasma gondii	protein kinase domain-containing protein	0.1368	0.5735	1
Echinococcus multilocularis	natriuretic peptide receptor 1	0.1368	0.5735	0.5734
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.2372	1	1
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Schistosoma mansoni	hypothetical protein	0.1004	0.4191	0.419
Brugia malayi	SH2 domain containing protein	0.2372	1	1
Echinococcus granulosus	retinal guanylyl cyclase 2	0.1368	0.5735	0.5734
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.1004	0.4191	0.419
Loa Loa (eye worm)	intermediate filament protein	0.0018	0.0001	0.0001
Mycobacterium tuberculosis	Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase	0.0034	0.007	0.0546
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Schistosoma mansoni	GTPase activating protein	0.1004	0.4191	0.419
Schistosoma mansoni	hypothetical protein	0.0046	0.0122	0.0121
Schistosoma mansoni	hypothetical protein	0.0021	0.0016	0.0015
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Brugia malayi	C-terminal src kinase protein 1	0.1368	0.5735	0.5734
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Echinococcus multilocularis	epidermal growth factor receptor	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Loa Loa (eye worm)	TK protein kinase	0.1368	0.5735	0.5735
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1004	0.4191	0.4191
Echinococcus multilocularis	protein kinase	0.1368	0.5735	0.5734
Brugia malayi	SH2 domain containing protein	0.1004	0.4191	0.419
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0175	0.067	0.0669
Echinococcus multilocularis	tyrosine protein kinase Abl	0.2372	1	1
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Schistosoma mansoni	adapter molecule crk	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.1004	0.4191	0.419
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.2372	1	1
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.1368	0.5735	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2372	1	1
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Mycobacterium tuberculosis	Peptide synthetase MbtE (peptide synthase)	0.0034	0.007	0.0546
Echinococcus granulosus	retinal guanylyl cyclase 2	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0175	0.067	1
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Brugia malayi	Tensin	0.1004	0.4191	0.419
Echinococcus multilocularis	activin receptor type	0.1368	0.5735	0.5734
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.1368	0.5735	0.5734
Entamoeba histolytica	SH2 domain containing protein	0.1004	0.4191	0.415
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0034	0.007	0.007
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Onchocerca volvulus		0.1004	0.4191	0.419
Loa Loa (eye worm)	D-ets-4 DNA binding domain-containing protein	0.0048	0.013	0.013
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Onchocerca volvulus		0.0034	0.007	0.0068
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0066	0.0206	0.0205
Echinococcus granulosus	tyrosine protein kinase	0.1368	0.5735	0.5734
Brugia malayi	Ets-domain containing protein	0.0048	0.013	0.0128
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Leishmania major	protein kinase, putative	0.1368	0.5735	1
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	TK/ABL protein kinase	0.2372	1	1
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	serine/threonine kinase, putative	0.1368	0.5735	0.5705
Loa Loa (eye worm)	TK/FER protein kinase	0.1368	0.5735	0.5735
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.1004	0.4191	0.419
Brugia malayi	Protein kinase domain containing protein	0.2372	1	1
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.1368	0.5735	0.5734
Echinococcus multilocularis	tyrosine protein kinase pr2	0.1368	0.5735	0.5734
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TK/ALK protein kinase	0.1368	0.5735	0.5735
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Schistosoma mansoni	microtubule-associated protein tau	0.153	0.6422	0.6422
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.1368	0.5735	0.5734
Brugia malayi	Protein kinase domain containing protein	0.2372	1	1
Mycobacterium tuberculosis	Probable peptide synthetase Nrp (peptide synthase)	0.0034	0.007	0.0546
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	protein kinase, putative	0.1004	0.4191	0.415
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0082	0.0272	0.6071
Trichomonas vaginalis	conserved hypothetical protein	0.1368	0.5735	1
Loa Loa (eye worm)	hypothetical protein	0.2372	1	1
Schistosoma mansoni	peptidase Clp (S14 family)	0.0175	0.067	0.0669
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.1368	0.5735	0.5734
Echinococcus granulosus	tumor protein p63	0.0729	0.3021	0.302
Loa Loa (eye worm)	TK protein kinase	0.1368	0.5735	0.5735
Brugia malayi	SH2 domain containing protein	0.2372	1	1
Plasmodium falciparum	tyrosine kinase-like protein	0.1368	0.5735	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Schistosoma mansoni	tensin-related	0.1004	0.4191	0.419
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.1368	0.5735	0.5734
Brugia malayi	integrin-linked kinase	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Echinococcus multilocularis	SH2 motif	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	protein kinase domain-containing protein	0.1368	0.5735	0.5735
Brugia malayi	oxidoreductase, short chain dehydrogenase/reductase family protein	0.0034	0.007	0.0068
Echinococcus multilocularis	raf serine:threonine protein kinase	0.1368	0.5735	0.5734
Onchocerca volvulus		0.1368	0.5735	0.5734
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Loa Loa (eye worm)	TK/FER protein kinase	0.1368	0.5735	0.5735
Loa Loa (eye worm)	TK protein kinase	0.1368	0.5735	0.5735
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TKL/MLK/HH498 protein kinase	0.1368	0.5735	0.5735
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.1368	0.5735	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0068	0.0213	0.0212
Loa Loa (eye worm)	TK/ROR protein kinase	0.1368	0.5735	0.5735
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0082	0.0272	0.6071
Brugia malayi	Latrophilin receptor protein 2	0.0021	0.0016	0.0015
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Brugia malayi	Probable ClpP-like protease	0.0175	0.067	0.0669
Echinococcus granulosus	signal transduction protein lnk realted	0.1004	0.4191	0.419
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.1368	0.5735	0.5734
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Entamoeba histolytica	protein kinase with ankyrin repeats, putative	0.1368	0.5735	0.5705
Mycobacterium tuberculosis	Phenyloxazoline synthase MbtB (phenyloxazoline synthetase)	0.0034	0.007	0.0546
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.1004	0.4191	0.419
Echinococcus multilocularis	atrial natriuretic peptide receptor 1	0.1368	0.5735	0.5734
Onchocerca volvulus		0.2372	1	1
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0175	0.067	1
Brugia malayi	Protein kinase domain containing protein	0.2372	1	1
Echinococcus granulosus	N chimaerin	0.1004	0.4191	0.419
Echinococcus granulosus	growth factor receptor bound protein 2	0.1004	0.4191	0.419
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0066	0.0206	0.0241
Brugia malayi	Ets-domain containing protein	0.0048	0.013	0.0128
Echinococcus multilocularis	tyrosine protein kinase HCK	0.1368	0.5735	0.5734
Schistosoma mansoni	serine/threonine protein kinase	0.1368	0.5735	0.5734
Echinococcus granulosus	activated cdc42 kinase 1	0.1368	0.5735	0.5734
Brugia malayi	Guanylyl cyclase protein 23	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus multilocularis	tyrosine protein kinase csk	0.1368	0.5735	0.5734
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.007	0.0068
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0115	0.0414	0.9917
Echinococcus multilocularis	protein tyrosine kinase	0.1368	0.5735	0.5734
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.1004	0.4191	0.419
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Brugia malayi	Tyrosine-protein kinase PR2	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Schistosoma mansoni	thyroid hormone receptor	0.0197	0.0763	0.0761
Echinococcus multilocularis	tyrosine protein kinase Srms	0.2372	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0115	0.0414	0.9917
Loa Loa (eye worm)	SH2 domain-containing protein	0.1004	0.4191	0.4191
Onchocerca volvulus		0.0116	0.0417	0.0415
Echinococcus granulosus	receptor type guanylyl cyclase	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.2372	1	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0082	0.0272	0.6071
Schistosoma mansoni	hypothetical protein	0.0182	0.07	0.0699
Echinococcus granulosus	epidermal growth factor receptor	0.1368	0.5735	0.5734
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	hypothetical protein	0.013	0.0476	0.0409
Brugia malayi	Raf kinase	0.1368	0.5735	0.5734
Mycobacterium tuberculosis	P-hydroxybenzoyl-AMP ligase FadD22	0.0034	0.007	0.0546
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0115	0.0414	0.5727
Echinococcus multilocularis	tyrosine protein kinase	0.1368	0.5735	0.5734
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.1368	0.5735	1
Echinococcus multilocularis	GPCR, family 2	0.0021	0.0016	0.0015
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0066	0.0206	0.0205
Brugia malayi	Tyrosine-protein kinase F09A5.2 in chromosome X, putative	0.1368	0.5735	0.5734
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Echinococcus granulosus	protein kinase	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.2372	1	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0116	0.0417	1
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Brugia malayi	Fli-1 protein	0.0146	0.0546	0.0545
Brugia malayi	bone morphogenetic protein type 1 receptor	0.1368	0.5735	0.5734
Leishmania major	hypothetical protein, conserved	0.1368	0.5735	1
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Loa Loa (eye worm)	TK/FER protein kinase	0.1368	0.5735	0.5735
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0082	0.0272	0.6071
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus multilocularis	tensin	0.1004	0.4191	0.419
Brugia malayi	STAT protein, DNA binding domain containing protein	0.1004	0.4191	0.419
Echinococcus multilocularis	kinase suppressor of Ras 1	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Echinococcus multilocularis	protein kinase	0.1368	0.5735	0.5734
Trichomonas vaginalis	conserved hypothetical protein	0.1368	0.5735	1
Schistosoma mansoni	tyrosine kinase	0.2372	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.2372	1	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	TK protein kinase	0.1368	0.5735	0.5735
Loa Loa (eye worm)	hypothetical protein	0.0041	0.01	0.01
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Onchocerca volvulus		0.1368	0.5735	0.5734
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0086	0.0293	0.371
Plasmodium falciparum	protein kinase, putative	0.1368	0.5735	1
Echinococcus multilocularis	N chimaerin	0.1004	0.4191	0.419
Trypanosoma cruzi	protein kinase, putative	0.1368	0.5735	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0066	0.0206	0.0205
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus multilocularis	transfer RNA-Thr	0.1368	0.5735	0.5734
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0021	0.0016	0.0016
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Brugia malayi	MH2 domain containing protein	0.0083	0.0279	0.0278
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Brugia malayi	Variant SH3 domain containing protein	0.1004	0.4191	0.419
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.1368	0.5735	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Schistosoma mansoni	tyrosine kinase	0.2372	1	1
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Echinococcus multilocularis	SH2 motif	0.1004	0.4191	0.419
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0066	0.0206	0.0205
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Mycobacterium ulcerans	acyl-CoA synthetase	0.0116	0.0417	0.5778
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.1368	0.5735	0.5734
Brugia malayi	Immunoglobulin I-set domain containing protein	0.1368	0.5735	0.5734
Echinococcus multilocularis	protein KINase family member (kin 25)	0.1368	0.5735	0.5734
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0068	0.0213	0.0212
Echinococcus granulosus	ephrin type A receptor 4 A	0.1368	0.5735	0.5734
Schistosoma mansoni	ephrin receptor	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Trichomonas vaginalis	conserved hypothetical protein	0.1368	0.5735	1
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.1368	0.5735	0.5734
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0461	0.1885	0.1885
Schistosoma mansoni	tyrosine kinase	0.2372	1	1
Echinococcus multilocularis	tyrosine kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0116	0.0417	0.5778
Brugia malayi	Receptor family ligand binding region containing protein	0.1368	0.5735	0.5734
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Trichomonas vaginalis	set domain proteins, putative	0.0525	0.2155	0.3682
Schistosoma mansoni	thyroid hormone receptor	0.0197	0.0763	0.0761
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Toxoplasma gondii	protein kinase	0.1368	0.5735	1
Onchocerca volvulus		0.1368	0.5735	0.5734
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0021	0.0016	0.0015
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0116	0.0417	0.5778
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.1004	0.4191	0.4191
Echinococcus granulosus	tyrosine protein kinase csk	0.1368	0.5735	0.5734
Entamoeba histolytica	tyrosin kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Brugia malayi	Pre-SET motif family protein	0.0461	0.1885	0.1884
Schistosoma mansoni	suppressor of cytokine signaling	0.1004	0.4191	0.419
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0116	0.0417	0.5778
Onchocerca volvulus		0.1368	0.5735	0.5734
Brugia malayi	proto-oncogene tyrosine-protein kinase FER	0.1368	0.5735	0.5734
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0175	0.067	0.1061
Brugia malayi	protein-tyrosine kinase	0.2372	1	1
Plasmodium vivax	acyl-CoA synthetase, putative	0.0086	0.0293	0.0394
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Echinococcus granulosus	tyrosine protein kinase Srms	0.2372	1	1
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.2372	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Brugia malayi	ephrin receptor 1 precursor	0.1368	0.5735	0.5734
Loa Loa (eye worm)	STAT protein	0.1004	0.4191	0.4191
Brugia malayi	AMP-binding enzyme family protein	0.0116	0.0417	0.0415
Echinococcus granulosus	kinase suppressor of Ras 1	0.1368	0.5735	0.5734
Brugia malayi	SH2 domain containing protein	0.1004	0.4191	0.419
Loa Loa (eye worm)	fli-1 protein	0.0146	0.0546	0.0546
Loa Loa (eye worm)	SRC-1	0.2372	1	1
Onchocerca volvulus		0.2372	1	1
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Echinococcus granulosus	3'partial\|retinal guanylyl cyclase 2	0.1368	0.5735	0.5734
Schistosoma mansoni	hypothetical protein	0.013	0.0476	0.0474
Onchocerca volvulus		0.0107	0.0378	0.0377
Echinococcus multilocularis	activated cdc42 kinase 1	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus multilocularis	tensin	0.1004	0.4191	0.419
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.013	0.0476	0.0474
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2372	1	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.1368	0.5735	0.5735
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.1004	0.4191	0.419
Mycobacterium ulcerans	acyl-CoA synthetase	0.0116	0.0417	0.5778
Echinococcus multilocularis	ephrin type A receptor 4 A	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0175	0.067	0.1061
Schistosoma mansoni	ephrin receptor	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Echinococcus granulosus	mitogen-activated protein kinase kinase kinase 9	0.1368	0.5735	0.5734
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.1004	0.4191	0.419
Schistosoma mansoni	serine/threonine protein kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Echinococcus granulosus	NCK adaptor protein	0.1004	0.4191	0.419
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Loa Loa (eye worm)	transcription factor SMAD2	0.0083	0.0279	0.0279
Echinococcus granulosus	acetyl coenzyme A synthetase cytoplasmic	0.0034	0.007	0.0068
Schistosoma mansoni	growth factor receptor-bound protein	0.1004	0.4191	0.419
Loa Loa (eye worm)	hypothetical protein	0.0175	0.067	0.067
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0021	0.0016	0.0015
Loa Loa (eye worm)	TK protein kinase	0.1368	0.5735	0.5735
Schistosoma mansoni	serine/threonine RGC	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TK/FER protein kinase	0.1368	0.5735	0.5735
Echinococcus granulosus	tyrosine protein kinase Blk	0.2372	1	1
Echinococcus granulosus	integrin linked protein kinase	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine protein kinase	0.1368	0.5735	0.5734
Plasmodium vivax	protein kinase, putative	0.1368	0.5735	1
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Brugia malayi	Protein kinase domain containing protein	0.2372	1	1
Echinococcus granulosus	insulin receptor	0.1368	0.5735	0.5734
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Echinococcus granulosus	natriuretic peptide receptor 1	0.1368	0.5735	0.5734
Brugia malayi	Probable tyrosine-protein kinase kin-31	0.1368	0.5735	0.5734
Echinococcus granulosus	epidermal growth factor receptor	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Trichomonas vaginalis	conserved hypothetical protein	0.1368	0.5735	1
Loa Loa (eye worm)	TK/Met protein kinase	0.1368	0.5735	0.5735
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0066	0.0206	0.0205
Toxoplasma gondii	Tyrosine kinase-like (TKL) protein	0.1368	0.5735	1
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0116	0.0417	1
Onchocerca volvulus		0.1004	0.4191	0.419
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.1368	0.5735	1
Echinococcus granulosus	tyrosine protein kinase HCK	0.1368	0.5735	0.5734
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.1004	0.4191	0.4191
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Schistosoma mansoni	gabp alpha	0.0048	0.013	0.0128
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0122	0.0122
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.1368	0.5735	1
Loa Loa (eye worm)	TK protein kinase	0.1368	0.5735	0.5735
Echinococcus multilocularis	growth factor receptor bound protein 2	0.1004	0.4191	0.419
Echinococcus granulosus	tyrosine protein kinase Src42A	0.2372	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Loa Loa (eye worm)	TK protein kinase	0.1368	0.5735	0.5735
Echinococcus multilocularis	SH2 motif	0.1004	0.4191	0.419
Echinococcus multilocularis	tumor protein p63	0.0729	0.3021	0.302
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0001	0.0001
Echinococcus multilocularis	tyrosine protein kinase shark	0.2372	1	1
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Loa Loa (eye worm)	TK/FER protein kinase	0.1368	0.5735	0.5735
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0066	0.0206	0.0205
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Plasmodium falciparum	acyl-CoA synthetase	0.0086	0.0293	0.0394
Echinococcus granulosus	tyrosine protein kinase csk	0.1368	0.5735	0.5734
Trichomonas vaginalis	protein kinase atn1, putative	0.1368	0.5735	1
Brugia malayi	Adenylate and Guanylate cyclase catalytic domain containing protein	0.1368	0.5735	0.5734
Entamoeba histolytica	hypothetical protein	0.013	0.0476	0.0409
Loa Loa (eye worm)	TK/DDR protein kinase	0.1368	0.5735	0.5735
Echinococcus granulosus	raf serine:threonine protein kinase	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TK protein kinase	0.1368	0.5735	0.5735
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.2372	1	1
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	receptor protein kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Schistosoma mansoni	tensin-related	0.1004	0.4191	0.419
Loa Loa (eye worm)	TKL/RAF/KSR protein kinase	0.1368	0.5735	0.5735
Echinococcus granulosus	c src tyrosine kinase	0.2372	1	1
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0021	0.0016	0.0015
Echinococcus granulosus	tyrosine protein kinase pr2	0.1368	0.5735	0.5734
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.1004	0.4191	0.4191
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Brugia malayi	Sex muscle abnormal protein 5	0.1004	0.4191	0.419
Echinococcus granulosus	SH2 motif	0.1004	0.4191	0.419
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.2372	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0116	0.0417	0.035
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.1004	0.4191	0.4191
Brugia malayi	SRC-1	0.2372	1	1
Trypanosoma cruzi	protein kinase, putative	0.1368	0.5735	1
Echinococcus granulosus	expressed conserved protein	0.1004	0.4191	0.419
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Mycobacterium ulcerans	acyl-CoA synthetase	0.0116	0.0417	0.5778
Trichomonas vaginalis	CAMK family protein kinase	0.1368	0.5735	1
Plasmodium falciparum	protein kinase, putative	0.1368	0.5735	1
Brugia malayi	hypothetical protein	0.2372	1	1
Onchocerca volvulus		0.1004	0.4191	0.419
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2372	1	1
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Brugia malayi	SH2 domain containing protein	0.1004	0.4191	0.419
Loa Loa (eye worm)	TK protein kinase	0.1368	0.5735	0.5735
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Onchocerca volvulus		0.1368	0.5735	0.5734
Brugia malayi	Variant SH3 domain containing protein	0.1004	0.4191	0.419
Onchocerca volvulus	Atrial natriuretic peptide receptor 3 homolog	0.1368	0.5735	0.5734
Entamoeba histolytica	hypothetical protein	0.013	0.0476	0.0409
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus multilocularis	insulin receptor	0.1368	0.5735	0.5734
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.1004	0.4191	0.419
Echinococcus granulosus	SHC transforming protein 3	0.1004	0.4191	0.419
Schistosoma mansoni	ets-related	0.0146	0.0546	0.0545
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Schistosoma mansoni	cellular tumor antigen P53	0.0107	0.0378	0.0377
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0086	0.0293	0.6617
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.1368	0.5735	0.5735
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Schistosoma mansoni	acetyl-CoA synthetase	0.0034	0.007	0.0068
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0182	0.07	0.0699
Schistosoma mansoni	vav2	0.1004	0.4191	0.419
Echinococcus granulosus	tyrosine protein kinase Lyn	0.2372	1	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Brugia malayi	latrophilin 2 splice variant baaae	0.0046	0.0122	0.0121
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Trichomonas vaginalis	STE family protein kinase	0.1368	0.5735	1
Echinococcus granulosus	protein tyrosine kinase	0.1368	0.5735	0.5734
Echinococcus granulosus	microtubule associated protein 2	0.153	0.6422	0.6422
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.1368	0.5735	1
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0175	0.067	0.0669
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0378	0.0378
Entamoeba histolytica	hypothetical protein	0.013	0.0476	0.0409
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Brugia malayi	Variant SH3 domain containing protein	0.1004	0.4191	0.419
Echinococcus multilocularis	tyrosine protein kinase csk	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.1004	0.4191	0.4191
Echinococcus multilocularis	tyrosine protein kinase csk	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Brugia malayi	SH2 domain containing protein	0.1004	0.4191	0.419
Mycobacterium ulcerans	hypothetical protein	0.0116	0.0417	0.5778
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0417	0.0417
Onchocerca volvulus		0.0525	0.2155	0.2154
Trypanosoma brucei	Pseudokinase, putative	0.1368	0.5735	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Brugia malayi	hypothetical protein	0.1368	0.5735	0.5734
Schistosoma mansoni	SH2A	0.1004	0.4191	0.419
Echinococcus granulosus	tyrosine kinase	0.2372	1	1
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Echinococcus granulosus	histone lysine methyltransferase setb	0.0066	0.0206	0.0205
Onchocerca volvulus		0.0034	0.007	0.0068
Loa Loa (eye worm)	hypothetical protein	0.0066	0.0206	0.0206
Toxoplasma gondii	calcium dependent protein kinase CDPK8	0.1368	0.5735	1
Brugia malayi	SH2 domain containing protein	0.1004	0.4191	0.419
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0021	0.0016	0.0015
Echinococcus multilocularis	tyrosine protein kinase Blk	0.2372	1	1
Schistosoma mansoni	protein tyrosine kinase	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.2372	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Mycobacterium tuberculosis	Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase)	0.0034	0.007	0.0546
Onchocerca volvulus		0.0034	0.007	0.0068
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.2372	1	1
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0175	0.067	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0175	0.067	0.1061
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Brugia malayi	tRNA modification GTPase TrmE family protein	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.007	0.0068
Schistosoma mansoni	hypothetical protein	0.0021	0.0016	0.0015
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.007	0.0546
Loa Loa (eye worm)	TK/FER protein kinase	0.1368	0.5735	0.5735
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.007	0.0068
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Brugia malayi	AMP-binding enzyme family protein	0.0116	0.0417	0.0415
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0182	0.07	0.0699
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0417	0.0417
Loa Loa (eye worm)	RGC/RGC protein kinase	0.1368	0.5735	0.5735
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Brugia malayi	hypothetical protein	0.1004	0.4191	0.419
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0293	0.0293
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Loa Loa (eye worm)	hypothetical protein	0.0068	0.0213	0.0213
Echinococcus granulosus	SH2 domain containing adapter protein F	0.1004	0.4191	0.419
Loa Loa (eye worm)	TKL/RAF/RAF protein kinase	0.1368	0.5735	0.5735
Entamoeba histolytica	serine/threonine kinase, putative	0.1368	0.5735	0.5705
Schistosoma mansoni	hypothetical protein	0.0021	0.0016	0.0015
Echinococcus granulosus	tyrosine protein kinase ABL1	0.2372	1	1
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Echinococcus multilocularis		0.1004	0.4191	0.419
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Plasmodium vivax	tyrosine kinase-like protein, putative	0.1368	0.5735	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.2372	1	1
Schistosoma mansoni	hypothetical protein	0.0021	0.0016	0.0015
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0021	0.0016	0.0015
Entamoeba histolytica	ankyrin repeat protein	0.1368	0.5735	0.5705
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.1368	0.5735	0.5734
Brugia malayi	Tyrosine-protein kinase abl-1	0.2372	1	1
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0116	0.0417	0.5778
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Brugia malayi	Furin-like cysteine rich region family protein	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Schistosoma mansoni	hypothetical protein	0.1368	0.5735	0.5734
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.1004	0.4191	0.419
Schistosoma mansoni	src-type protein tyrosine kinase-related	0.1368	0.5735	0.5734
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.1004	0.4191	0.419
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0068	0.0213	0.0213
Loa Loa (eye worm)	serine/threonine protein kinase	0.1368	0.5735	0.5735
Trichomonas vaginalis	conserved hypothetical protein	0.1368	0.5735	1
Loa Loa (eye worm)	TK/INSR protein kinase	0.1368	0.5735	0.5735
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Echinococcus granulosus	tyrosine protein kinase Src42A	0.1004	0.4191	0.419
Echinococcus granulosus	tyrosine kinase	0.2372	1	1
Trichomonas vaginalis	protein tyrosine kinase, putative	0.1368	0.5735	1
Entamoeba histolytica	ankyrin repeat protein	0.1368	0.5735	0.5705
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	serine/threonine kinase, putative	0.1368	0.5735	0.5705
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0116	0.0417	0.5778
Echinococcus multilocularis	dual specificity testis specific protein kinase	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0293	0.0293
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	acyl-CoA synthetase, putative	0.0116	0.0417	0.035
Loa Loa (eye worm)	RGC/RGC protein kinase	0.1368	0.5735	0.5735
Echinococcus multilocularis	acetyl coenzyme A synthetase, cytoplasmic	0.0034	0.007	0.0068
Schistosoma mansoni	tensin	0.1004	0.4191	0.419
Loa Loa (eye worm)	RGC/RGC protein kinase	0.1368	0.5735	0.5735
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Schistosoma mansoni	tensin	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.1004	0.4191	0.419
Trichomonas vaginalis	conserved hypothetical protein	0.1368	0.5735	1
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.006	0.0182	0.0198
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.007	0.0546
Plasmodium falciparum	tyrosine kinase-like protein	0.1368	0.5735	1
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Onchocerca volvulus		0.2372	1	1
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Leishmania major	protein kinase, putative	0.1368	0.5735	1
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus multilocularis	SH2 domain containing protein 7	0.1004	0.4191	0.419
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.2372	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Brugia malayi	Variant SH3 domain containing protein	0.1004	0.4191	0.419
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0293	0.0293
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Echinococcus granulosus	activated cdc42 kinase 1	0.1368	0.5735	0.5734
Echinococcus granulosus	retinal guanylyl cyclase 2	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TK protein kinase	0.2372	1	1
Onchocerca volvulus		0.1368	0.5735	0.5734
Plasmodium vivax	tyrosine kinase-like protein, putative	0.1368	0.5735	1
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.1368	0.5735	0.5734
Echinococcus multilocularis	tyrosine protein kinase Fes:Fps	0.1368	0.5735	0.5734
Echinococcus granulosus	dual specificity testis-specific protein kinase	0.1368	0.5735	0.5734
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.006	0.0182	0.0198
Echinococcus granulosus	atrial natriuretic peptide receptor 1	0.1368	0.5735	0.5734
Entamoeba histolytica	tyrosin kinase, putative	0.1368	0.5735	0.5705
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TK/ACK protein kinase	0.1368	0.5735	0.5735
Echinococcus multilocularis	c src tyrosine kinase	0.2372	1	1
Entamoeba histolytica	serine/threonine kinase, putative	0.1368	0.5735	0.5705
Schistosoma mansoni	shc transforming protein	0.1004	0.4191	0.419
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	serine/threonine kinase, putative	0.1368	0.5735	0.5705
Trichomonas vaginalis	AGC family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0016	0.0016
Brugia malayi	hypothetical protein	0.013	0.0476	0.0474
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Echinococcus multilocularis	mitogen activated protein kinase kinase kinase	0.1368	0.5735	0.5734
Onchocerca volvulus		0.2372	1	1
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.1004	0.4191	0.419
Onchocerca volvulus		0.1004	0.4191	0.419
Echinococcus multilocularis	heat shock protein 70	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Echinococcus granulosus	peptidase Clp S14 family	0.0115	0.0414	0.0412
Entamoeba histolytica	tyrosin kinase, putative	0.1368	0.5735	0.5705
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Echinococcus granulosus	suppressor of cytokine signaling 7	0.1004	0.4191	0.419
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0417	0.0417
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Onchocerca volvulus		0.0066	0.0206	0.0205
Schistosoma mansoni	growth factor receptor-bound protein	0.1004	0.4191	0.419
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0064	0.0196	0.0195
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2372	1	1
Mycobacterium tuberculosis	Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.007	0.0546
Plasmodium vivax	SET domain protein, putative	0.0066	0.0206	0.0241
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Echinococcus granulosus	GA binding protein alpha chain	0.0048	0.013	0.0128
Brugia malayi	Protein kinase domain containing protein	0.2372	1	1
Echinococcus multilocularis	tyrosine kinase	0.2372	1	1
Leishmania major	4-coumarate:coa ligase-like protein	0.0116	0.0417	0.0613
Entamoeba histolytica	protein kinase domain containing protein	0.1368	0.5735	0.5705
Leishmania major	4-coumarate:coa ligase-like protein	0.0116	0.0417	0.0613
Entamoeba histolytica	cysteine surface protein, putative	0.1368	0.5735	0.5705
Onchocerca volvulus		0.2372	1	1
Echinococcus granulosus	GPCR family 2	0.0021	0.0016	0.0015
Loa Loa (eye worm)	hypothetical protein	0.0034	0.007	0.007
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0175	0.067	1
Echinococcus granulosus	tyrosine protein kinase Src64B	0.2372	1	1
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.2372	1	1
Echinococcus granulosus	mitogen activated protein kinase kinase kinase	0.1368	0.5735	0.5734
Echinococcus granulosus	fibroblast growth factor receptor 4	0.1368	0.5735	0.5734
Entamoeba histolytica	receptor protein kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	tyrosine- protein kinase 2, putative	0.1368	0.5735	0.5705
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus granulosus	macrophage colony stimulating factor 1 receptor	0.1368	0.5735	0.5734
Entamoeba histolytica	protein tyrosine kinase domain-containing protein	0.1368	0.5735	0.5705
Echinococcus granulosus	tyrosine protein kinase Fes:Fps	0.1368	0.5735	0.5734
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Echinococcus multilocularis	macrophage colony stimulating factor 1 receptor	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0293	0.0293
Echinococcus granulosus	SH2 domain containing protein 7	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.2372	1	1
Echinococcus granulosus	tyrosine protein kinase csk	0.1368	0.5735	0.5734
Echinococcus multilocularis	retinal guanylyl cyclase 2	0.1368	0.5735	0.5734
Toxoplasma gondii	STE kinase	0.1368	0.5735	1
Loa Loa (eye worm)	SH2 domain-containing protein	0.1004	0.4191	0.4191
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0197	0.0763	0.0761
Echinococcus multilocularis	microtubule associated protein 2	0.153	0.6422	0.6422
Brugia malayi	AMP-binding enzyme family protein	0.0034	0.007	0.0068
Entamoeba histolytica	serine/threonine kinase, putative	0.1368	0.5735	0.5705
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.1368	0.5735	1
Onchocerca volvulus	Tyrosine kinase receptor Cad96Ca homolog	0.1368	0.5735	0.5734
Echinococcus multilocularis	signal transduction protein lnk realted	0.1004	0.4191	0.419
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TK/KIN6 protein kinase	0.1368	0.5735	0.5735
Brugia malayi	RhoGAP domain containing protein	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus granulosus	SH2 motif	0.1004	0.4191	0.419
Toxoplasma gondii	hypothetical protein	0.006	0.0182	0.0198
Echinococcus multilocularis	tyrosine protein kinase csk	0.1368	0.5735	0.5734
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Trichomonas vaginalis	TK family protein kinase	0.1368	0.5735	1
Brugia malayi	hypothetical protein	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Entamoeba histolytica	tyrosin kinase, putative	0.1368	0.5735	0.5705
Onchocerca volvulus		0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine-protein kinase fps85d	0.1368	0.5735	0.5734
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2372	1	1
Mycobacterium tuberculosis	Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0034	0.007	0.0546
Echinococcus granulosus	tyrosine protein kinase Fyn	0.2372	1	1
Onchocerca volvulus	Tyrosine kinase homolog	0.1368	0.5735	0.5734
Loa Loa (eye worm)	MH2 domain-containing protein	0.0083	0.0279	0.0279
Giardia lamblia	Protein 21.1	0.1368	0.5735	1
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0175	0.067	0.5
Onchocerca volvulus		0.1004	0.4191	0.419
Entamoeba histolytica	hypothetical protein, conserved	0.1368	0.5735	0.5705
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.2372	1	1
Schistosoma mansoni	protein kinase	0.1368	0.5735	0.5734
Brugia malayi	SH2 domain containing protein	0.1004	0.4191	0.419
Loa Loa (eye worm)	hypothetical protein	0.0034	0.007	0.007
Schistosoma mansoni	serine/threonine protein kinase	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TK/FER protein kinase	0.1368	0.5735	0.5735
Echinococcus granulosus	hypothetical protein	0.1004	0.4191	0.419
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.1004	0.4191	0.419
Giardia lamblia	Kinase, NEK	0.1368	0.5735	1
Loa Loa (eye worm)	TK/RYK protein kinase	0.1368	0.5735	0.5735
Onchocerca volvulus		0.1368	0.5735	0.5734
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Loa Loa (eye worm)	AMP-binding enzyme family protein	0.0034	0.007	0.007
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.1368	0.5735	0.5734
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.1004	0.4191	0.419
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.1368	0.5735	0.5734
Loa Loa (eye worm)	TK/FER protein kinase	0.2372	1	1
Loa Loa (eye worm)	oxidoreductase	0.0034	0.007	0.007
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0175	0.067	1
Schistosoma mansoni	signal transduction protein lnk-related	0.1004	0.4191	0.419
Loa Loa (eye worm)	TK/CSK protein kinase	0.1368	0.5735	0.5735
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0175	0.067	0.1061
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.1368	0.5735	0.5705
Schistosoma mansoni	tyrosine protein kinase fes (fps) (ptk group IV)	0.1368	0.5735	0.5734
Echinococcus multilocularis	epidermal growth factor receptor	0.1368	0.5735	0.5734
Trypanosoma brucei	protein kinase, putative	0.1368	0.5735	1
Loa Loa (eye worm)	hypothetical protein	0.1368	0.5735	0.5735
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.2372	1	1
Brugia malayi	Protein kinase domain containing protein	0.1368	0.5735	0.5734
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Schistosoma mansoni	tensin	0.1004	0.4191	0.419
Schistosoma mansoni	nck2/grb4	0.1004	0.4191	0.419
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Echinococcus granulosus	activin receptor type	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.1368	0.5735	0.5734
Schistosoma mansoni	tyrosine kinase	0.2372	1	1
Entamoeba histolytica	tyrosine kinase, putative	0.1368	0.5735	0.5705
Entamoeba histolytica	hypothetical protein	0.1368	0.5735	0.5705
Trichomonas vaginalis	TKL family protein kinase	0.1368	0.5735	1
Entamoeba histolytica	protein kinase, putative	0.1368	0.5735	0.5705
Schistosoma mansoni	hypothetical protein	0.1004	0.4191	0.419
Plasmodium falciparum	protein kinase, putative	0.1368	0.5735	1
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.2372	1	1
Echinococcus multilocularis	receptor type guanylyl cyclase	0.1368	0.5735	0.5734
Brugia malayi	acetyl-Coenzyme A synthetase 2	0.0034	0.007	0.0068
Loa Loa (eye worm)	hypothetical protein	0.1004	0.4191	0.4191
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.1004	0.4191	0.419

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 0.06 mg l-1	Inhibitory concentration against RNA polymerase from E. coli using cellfreetranscription assay	ChEMBL.	15990299
MIC (functional)	= 64 mg l-1	Minimum inhibitory concentration against Moraxella catarrhalis using broth microdilution method	ChEMBL.	15990299

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: 399890

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 315061