TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.309 | Formula: C22H17Cl2N5O2
H donors: 2 H acceptors: 4 LogP: 4.07 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1cc(Cl)c(c(c1)Cl)c1cc2cnc(nc2n(c1=O)C)Nc1ccccc1
InChi: 1S/C22H17Cl2N5O2/c1-12(30)26-15-9-17(23)19(18(24)10-15)16-8-13-11-25-22(27-14-6-4-3-5-7-14)28-20(13)29(2)21(16)31/h3-11H,1-2H3,(H,26,30)(H,25,27,28)
InChiKey: LHOFZGGWCFMZNR-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	WEE1 G2 checkpoint kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma brucei	wee1-like protein kinase	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania braziliensis	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania infantum	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania mexicana	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma congolense	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania donovani	protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania donovani	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0172	0.288	0.3782
Brugia malayi	Guanylyl cyclase protein 23	0.0041	0.0195	0.0135
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0172	0.2877	0.3013
Loa Loa (eye worm)	hypothetical protein	0.0365	0.682	0.9351
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0049	0.5
Brugia malayi	hypothetical protein	0.0172	0.288	0.3866
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0344	0.6399	0.6363
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0365	0.682	0.9342
Echinococcus multilocularis	survival motor neuron protein 1	0.0231	0.4076	0.4018
Brugia malayi	nuclear receptor RXR	0.0193	0.3302	0.4453
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0344	0.6399	0.6363
Echinococcus multilocularis	NMDA receptor	0.0344	0.6399	0.6363
Echinococcus granulosus	atrial natriuretic peptide receptor	0.0041	0.0195	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0172	0.288	0.281
Brugia malayi	hypothetical protein	0.0172	0.288	0.3866
Schistosoma mansoni	nuclear hormone receptor	0.0172	0.288	0.3016
Echinococcus granulosus	neutral amino acid transporter	0.0388	0.7294	0.7268
Schistosoma mansoni	glutamate receptor NMDA	0.0256	0.4588	0.4914
Echinococcus granulosus	neutral amino acid transporter A	0.0388	0.7294	0.7268
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0365	0.682	0.9342
Loa Loa (eye worm)	hypothetical protein	0.0365	0.682	0.9351
Echinococcus multilocularis	metabotropic glutamate receptor 5	0.0041	0.0195	0.0098
Echinococcus granulosus	Excitatory amino acid transporter	0.0388	0.7294	0.7268
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0041	0.0195	0.0267
Schistosoma mansoni	nuclear receptor	0.0172	0.288	0.3016
Brugia malayi	hypothetical protein	0.0041	0.0195	0.0135
Echinococcus granulosus	excitatory amino acid transporter 2	0.0388	0.7294	0.7268
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0172	0.288	0.3016
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0344	0.6399	0.6363
Echinococcus granulosus	ecdysone induced protein 78C	0.0365	0.682	0.6789
Schistosoma mansoni	nuclear receptor nhr-48	0.0172	0.288	0.3016
Echinococcus granulosus	cytochrome P450 2K1	0.0052	0.0418	0.0324
Echinococcus multilocularis	neutral amino acid transporter A	0.0388	0.7294	0.7268
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3302	0.4527
Brugia malayi	Nuclear hormone receptor-like 1	0.0193	0.3302	0.4453
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0572	0.0587
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Onchocerca volvulus		0.0365	0.682	0.9333
Onchocerca volvulus	Excitatory amino acid transporter homolog	0.0388	0.7294	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0041	0.0195	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0572	0.0587
Echinococcus granulosus	nmda type glutamate receptor	0.008	0.0987	0.0898
Trypanosoma cruzi	Wee1-like protein kinase, putative	0.0069	0.0767	0.2015
Loa Loa (eye worm)	hypothetical protein	0.0365	0.682	0.9351
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.008	0.0987	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Onchocerca volvulus		0.0172	0.288	0.3782
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0365	0.682	0.6789
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0365	0.682	0.9351
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.008	0.0987	0.0898
Brugia malayi	nuclear receptor NHR-88	0.0172	0.288	0.3866
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.008	0.0987	0.0898
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0059	0.0572	0.0587
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0388	0.7294	0.7268
Echinococcus multilocularis	receptor type guanylyl cyclase	0.0041	0.0195	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3302	0.4527
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0365	0.682	0.9342
Brugia malayi	photoreceptor-specific nuclear receptor	0.0365	0.682	0.9342
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0365	0.682	0.7394
Echinococcus multilocularis	excitatory amino acid transporter 2	0.0388	0.7294	0.7268
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0172	0.288	0.281
Schistosoma mansoni	glutamate receptor kainate	0.048	0.9166	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0195	0.0267
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0215	0.3755	0.3693
Loa Loa (eye worm)	hypothetical protein	0.0231	0.4076	0.5588
Brugia malayi	Steroid receptor seven-up type 2	0.0365	0.682	0.9342
Schistosoma mansoni	coup transcription factor	0.0365	0.682	0.7394
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0172	0.2877	0.2807
Loa Loa (eye worm)	glutamate receptor 2	0.0215	0.3755	0.5148
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0195	0.0267
Wolbachia endosymbiont of Brugia malayi	Na+/H+-dicarboxylate symporter	0.0388	0.7294	0.5
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0365	0.682	0.9342
Treponema pallidum	glutamate transporter	0.0172	0.2877	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0172	0.288	0.281
Schistosoma mansoni	solute carrier family 1 (glial high affinity glutamate transporter	0.0388	0.7294	0.792
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0195	0.0267
Trypanosoma brucei	wee1-like protein kinase	0.0069	0.0767	0.1333
Echinococcus multilocularis	neutral amino acid transporter A	0.0388	0.7294	0.7268
Echinococcus multilocularis	Excitatory amino acid transporter	0.0388	0.7294	0.7268
Echinococcus multilocularis	Excitatory amino acid transporter	0.0388	0.7294	0.7268
Brugia malayi	steroid hormone receptor	0.0365	0.682	0.9342
Brugia malayi	metabotropic GABA-B receptor subtype 2	0.0041	0.0195	0.0135
Brugia malayi	Cytochrome P450 family protein	0.018	0.3035	0.4083
Loa Loa (eye worm)	receptor family ligand binding region containing protein	0.0041	0.0195	0.0267
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0172	0.288	0.281
Echinococcus multilocularis	nmda type glutamate receptor	0.008	0.0987	0.0898
Onchocerca volvulus	Protein ultraspiracle homolog	0.0365	0.682	0.9333
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0365	0.682	0.7394
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0365	0.682	0.6789
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0256	0.4588	0.4535
Schistosoma mansoni	protein kinase	0.0041	0.0195	0.0033
Brugia malayi	cytochrome P450	0.0052	0.0418	0.0446
Echinococcus multilocularis	sodium:dicarboxylate symporter	0.0388	0.7294	0.7268
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0365	0.682	0.6789
Echinococcus multilocularis		0.0052	0.0418	0.0324
Echinococcus multilocularis	excitatory amino acid transporter 3	0.0388	0.7294	0.7268
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0365	0.682	0.6789
Schistosoma mansoni	tyrosine kinase	0.0041	0.0195	0.0033
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0172	0.2877	0.2807
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0172	0.288	0.281
Loa Loa (eye worm)	cytochrome P450	0.0052	0.0418	0.0573
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0069	0.0767	0.2015
Brugia malayi	conserved hypotetical protein	0.0172	0.288	0.3866
Brugia malayi	hypothetical protein	0.0193	0.3302	0.4453
Schistosoma mansoni	glutamate receptor kainate	0.048	0.9166	1
Trypanosoma cruzi	cytochrome P450, putative	0.018	0.3035	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0365	0.682	0.7394
Treponema pallidum	glutamate/aspartate transporter	0.0172	0.2877	0.5
Schistosoma mansoni	RAR-like nuclear receptor	0.0365	0.682	0.7394
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0172	0.288	0.281
Schistosoma mansoni	retinoic acid receptor RXR	0.0365	0.682	0.7394
Brugia malayi	hypothetical protein	0.0231	0.4076	0.5529
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0365	0.682	0.9342
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3302	0.4527
Trypanosoma cruzi	cytochrome p450-like protein, putative	0.0052	0.0418	0.0787
Loa Loa (eye worm)	excitatory amino acid transporter	0.0388	0.7294	1
Schistosoma mansoni	thyroid hormone receptor	0.0365	0.682	0.7394
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0172	0.288	0.3866
Echinococcus granulosus	expressed protein	0.0364	0.6804	0.6773
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0052	0.0418	0.0787
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0365	0.682	0.9342
Schistosoma mansoni	glutamate receptor NMDA	0.0215	0.3755	0.3988
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0172	0.288	0.3866
Echinococcus granulosus	excitatory amino acid transporter 2	0.0388	0.7294	0.7268
Echinococcus granulosus	glutamate receptor 2	0.0256	0.4588	0.4535
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0344	0.6399	0.6363
Brugia malayi	Cytochrome P450 family protein	0.018	0.3035	0.4083
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0172	0.288	0.281
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0195	0.0267
Onchocerca volvulus		0.0047	0.0323	0.0181
Echinococcus multilocularis	ecdysone induced protein 78C	0.0365	0.682	0.6789
Brugia malayi	nuclear hormone receptor	0.0365	0.682	0.9342
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.052	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0365	0.682	0.9351
Brugia malayi	ecdysteroid receptor	0.0365	0.682	0.9342
Mycobacterium tuberculosis	Probable C4-dicarboxylate-transport transmembrane protein DctA	0.0388	0.7294	1
Trypanosoma cruzi	Wee1-like protein kinase, putative	0.0069	0.0767	0.2015
Echinococcus multilocularis	neutral amino acid transporter A	0.0388	0.7294	0.7268
Echinococcus granulosus	excitatory amino acid transporter 3	0.0388	0.7294	0.7268
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0365	0.682	0.9342
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0365	0.682	0.7394
Brugia malayi	Nuclear hormone receptor E75	0.0172	0.288	0.3866
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0365	0.682	0.6789
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.052	1	1
Echinococcus granulosus	nuclear receptor nhr 48	0.0172	0.288	0.281
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.018	0.3035	1
Brugia malayi	Excitatory amino acid transporter	0.0388	0.7294	1
Loa Loa (eye worm)	RGC/RGC protein kinase	0.0041	0.0195	0.0267
Leishmania major	cytochrome p450-like protein	0.0052	0.0418	0.0787
Schistosoma mansoni	nuclear receptor	0.0172	0.288	0.3016
Loa Loa (eye worm)	hypothetical protein	0.0365	0.682	0.9351
Echinococcus multilocularis	atrial natriuretic peptide receptor	0.0041	0.0195	0.0098
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0572	0.0452
Entamoeba histolytica	hypothetical protein	0.0041	0.0195	0.5
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0365	0.682	0.7394
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0069	0.0767	0.2015
Echinococcus granulosus	receptor type guanylyl cyclase	0.0041	0.0195	0.0098
Echinococcus multilocularis	neutral amino acid transporter excitatory amino acid transporter	0.0388	0.7294	0.7268
Echinococcus multilocularis	FTZ F1 alpha	0.0365	0.682	0.6789
Loa Loa (eye worm)	cytochrome P450 family protein	0.018	0.3035	0.4161
Echinococcus multilocularis	glutamate receptor 2	0.0215	0.3755	0.3693
Brugia malayi	nuclear receptor NHR-67	0.0172	0.288	0.3866
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0365	0.682	0.9351
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0193	0.3302	0.3485
Onchocerca volvulus		0.0172	0.288	0.3782
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0365	0.682	0.7394
Leishmania major	cytochrome p450-like protein	0.0052	0.0418	0.0787
Echinococcus granulosus	metabotropic glutamate receptor 2	0.0041	0.0195	0.0098
Brugia malayi	Metabotropic glutamate receptor precursor.	0.0041	0.0195	0.0135
Brugia malayi	hypothetical protein	0.0193	0.3302	0.4453
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3302	0.4527
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0059	0.0572	0.1328
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0059	0.0572	0.0479
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0195	0.0267
Loa Loa (eye worm)	hypothetical protein	0.0365	0.682	0.9351
Loa Loa (eye worm)	hypothetical protein	0.0365	0.682	0.9351
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0365	0.682	0.9342
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0193	0.3302	0.4527
Schistosoma mansoni	glutamate receptor AMPA	0.0215	0.3755	0.3988
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0365	0.682	0.9342
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Schistosoma mansoni	sodium/dicarboxylate symporter-related	0.0172	0.2877	0.3013
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0365	0.682	0.6789
Schistosoma mansoni	tyrosine kinase	0.0041	0.0195	0.0033
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0365	0.682	0.9342
Schistosoma mansoni	cytochrome P450	0.0052	0.0418	0.0281
Loa Loa (eye worm)	cytochrome P450 family protein	0.0052	0.0418	0.0573
Chlamydia trachomatis	glutamate symporter	0.0388	0.7294	1
Trypanosoma cruzi	Wee1-like protein kinase, putative	0.0069	0.0767	0.2015
Echinococcus granulosus	thyroid hormone receptor alpha	0.0172	0.288	0.281
Loa Loa (eye worm)	hypothetical protein	0.0365	0.682	0.9351
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0365	0.682	0.9342
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0365	0.682	0.6789
Schistosoma mansoni	thyroid hormone receptor	0.0365	0.682	0.7394
Echinococcus granulosus	tyrosine kinase	0.0041	0.0195	0.0098
Echinococcus multilocularis	tyrosine kinase	0.0041	0.0195	0.0098
Schistosoma mansoni	glutamate receptor AMPA	0.0215	0.3755	0.3988
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0323	0.0175
Schistosoma mansoni	nuclear hormone receptor	0.0172	0.288	0.3016
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0195	0.0267
Schistosoma mansoni	glutamate receptor kainate	0.0215	0.3755	0.3988
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0365	0.682	0.9351
Echinococcus multilocularis	glutamate receptor 2	0.0176	0.2962	0.2893
Schistosoma mansoni	ATP-binding cassette transporter	0.0215	0.3755	0.3988
Trichomonas vaginalis	voltage and ligand gated potassium channel, putative	0.0034	0.0049	0.5
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Loa Loa (eye worm)	DR-78	0.0172	0.288	0.3948
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0215	0.3755	0.3693
Echinococcus granulosus	Excitatory amino acid transporter	0.0388	0.7294	0.7268
Brugia malayi	Glutamate receptor 1 precursor	0.0215	0.3755	0.5082
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0365	0.682	0.7394
Echinococcus granulosus	sodium:dicarboxylate symporter	0.0388	0.7294	0.7268
Loa Loa (eye worm)	metabotropic GABA-B receptor subtype 2	0.0041	0.0195	0.0267
Loa Loa (eye worm)	cytochrome P450 family protein	0.018	0.3035	0.4161
Schistosoma mansoni	hypothetical protein	0.0052	0.0418	0.0281
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0365	0.682	0.6789
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0365	0.682	0.6789
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0256	0.4588	0.4535
Brugia malayi	Nuclear hormone receptor-like 1	0.0365	0.682	0.9342
Brugia malayi	ecdysone receptor	0.0172	0.288	0.3866
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0172	0.288	0.3782
Brugia malayi	tailless protein	0.0172	0.288	0.3866
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0193	0.3302	0.3236
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0418	0.0446
Loa Loa (eye worm)	glutamate receptor	0.0041	0.0195	0.0267
Brugia malayi	Nuclear hormone receptor-like 1	0.0193	0.3302	0.4453
Echinococcus multilocularis	nmda type glutamate receptor	0.0041	0.0195	0.0098
Trypanosoma brucei	cytochrome P450, putative	0.018	0.3035	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0172	0.288	0.281
Brugia malayi	nuclear receptor NHR-88	0.0365	0.682	0.9342
Loa Loa (eye worm)	hypothetical protein	0.0365	0.682	0.9351
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0172	0.288	0.3948
Schistosoma mansoni	hypothetical protein	0.0047	0.0323	0.0175
Schistosoma mansoni	aldehyde dehydrogenase	0.0059	0.0572	0.0452
Echinococcus granulosus	metabotropic glutamate receptor 5	0.0041	0.0195	0.0098
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0059	0.0572	0.0479
Toxoplasma gondii	aldehyde dehydrogenase	0.0059	0.0572	1
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0195	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0172	0.288	0.3948
Loa Loa (eye worm)	CYP4Cod1	0.018	0.3035	0.4161
Loa Loa (eye worm)	glutamate receptor 1	0.0215	0.3755	0.5148
Brugia malayi	Glutamate receptor 2 precursor	0.0215	0.3755	0.5082
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0195	0.0267
Echinococcus granulosus	survival motor neuron protein 1	0.0231	0.4076	0.4018
Echinococcus granulosus	glutamate receptor 2	0.0176	0.2962	0.2893
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0195	0.0267
Loa Loa (eye worm)	metabotropic glutamate receptor 8	0.0041	0.0195	0.0267
Echinococcus granulosus	neutral amino acid transporter A	0.0388	0.7294	0.7268
Echinococcus multilocularis	glutamate receptor 2	0.0256	0.4588	0.4535
Echinococcus multilocularis	nuclear receptor nhr 48	0.0172	0.288	0.281
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0323	0.0313
Echinococcus granulosus	nmda type glutamate receptor	0.0041	0.0195	0.0098
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0365	0.682	0.6789
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0059	0.0572	0.0223
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0365	0.682	0.6789
Leishmania major	cytochrome p450-like protein	0.018	0.3035	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0195	0.0267
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0172	0.288	0.3016
Echinococcus granulosus	FTZ F1 alpha	0.0365	0.682	0.6789
Schistosoma mansoni	nuclear hormone receptor	0.0365	0.682	0.7394
Trypanosoma cruzi	Lanosterol 14-alpha demethylase	0.0052	0.0418	0.0787
Brugia malayi	Nuclear hormone receptor E75	0.0172	0.288	0.3866
Brugia malayi	Receptor family ligand binding region containing protein	0.0041	0.0195	0.0135
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0365	0.682	0.9333
Brugia malayi	Receptor family ligand binding region containing protein	0.0041	0.0195	0.0135
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0365	0.682	0.6789
Loa Loa (eye worm)	voltage and ligand gated potassium channel	0.0036	0.0097	0.0133
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.052	1	1
Loa Loa (eye worm)	nuclear hormone receptor	0.0172	0.288	0.3948
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.052	1	1
Echinococcus multilocularis	expressed protein	0.0364	0.6804	0.6773
Schistosoma mansoni	hypothetical protein	0.008	0.0987	0.0913
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0365	0.682	0.6789
Mycobacterium leprae	Conserved hypothetical protein	0.0052	0.0418	0.5
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.052	1	1
Echinococcus granulosus	glutamate receptor subunit protein glur	0.008	0.0987	0.0898
Onchocerca volvulus	Bile acid receptor homolog	0.0365	0.682	0.9333
Loa Loa (eye worm)	hypothetical protein	0.0193	0.3302	0.4527
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0172	0.288	0.281
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0365	0.682	0.9351
Trypanosoma cruzi	cytochrome P450, putative	0.018	0.3035	1
Echinococcus multilocularis	metabotropic glutamate receptor 2	0.0041	0.0195	0.0098
Brugia malayi	orphan nuclear receptor NR2E1	0.0172	0.288	0.3866
Brugia malayi	nuclear receptor RXR	0.0172	0.288	0.3866
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0365	0.682	0.9342
Loa Loa (eye worm)	steroid hormone receptor	0.0365	0.682	0.9351
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0193	0.3302	0.3485
Brugia malayi	nuclear hormone receptor family member odr-7	0.0172	0.288	0.3866
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0365	0.682	0.6789
Loa Loa (eye worm)	hypothetical protein	0.0128	0.1978	0.2712
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Schistosoma mansoni	zinc finger protein	0.0172	0.288	0.3016
Brugia malayi	nuclear hormone receptor	0.0172	0.288	0.3866
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0193	0.3302	0.3236
Brugia malayi	metabotropic glutamate receptor type 2	0.0041	0.0195	0.0135
Schistosoma mansoni	metabotropic glutamate receptor	0.0041	0.0195	0.0033
Mycobacterium leprae	putative cytochrome p450	0.0052	0.0418	0.5
Leishmania major	lanosterol 14-alpha-demethylase, putative	0.0052	0.0418	0.0787
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0365	0.682	0.9351
Brugia malayi	Cytochrome P450 family protein	0.0052	0.0418	0.0446
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0365	0.682	0.9351
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0365	0.682	0.9342
Loa Loa (eye worm)	hypothetical protein	0.0172	0.288	0.3948

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.5 uM	Inhibition of c-Src tyrosine kinase	ChEMBL.	15780636
IC50 (binding)	= 3.6 uM	Inhibition of checkpoint kinase Wee1	ChEMBL.	15780636
IC50 (binding)	= 3.6 uM	Inhibition of checkpoint kinase Wee1	ChEMBL.	15780636

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL178122

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 315233