Detailed information for compound 315235

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 355.454 | Formula: C19H21N3O2S
  • H donors: 1 H acceptors: 3 LogP: 3.76 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NC(=O)C(S1)Cc1ccc(cc1)CCCN(c1ccccn1)C
  • InChi: 1S/C19H21N3O2S/c1-22(17-6-2-3-11-20-17)12-4-5-14-7-9-15(10-8-14)13-16-18(23)21-19(24)25-16/h2-3,6-11,16H,4-5,12-13H2,1H3,(H,21,23,24)
  • InChiKey: HWZRVMPTVKDNDX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Loa Loa (eye worm) hypothetical protein 0.0029 0.0049 0.0049
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.2622 0.7306 1
Schistosoma mansoni thyroid hormone receptor 0.015 0.0388 0.0378
Brugia malayi hypothetical protein 0.0071 0.0166 0.0159
Echinococcus multilocularis nuclear receptor nhr 48 0.0071 0.0166 0.0163
Brugia malayi nuclear hormone receptor family member nhr-6 0.0071 0.0166 0.0159
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0076 0.0079
Brugia malayi Nuclear hormone receptor family member nhr-3 0.015 0.0388 0.0381
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0019 0.0011
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0028
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.015 0.0388 0.0385
Echinococcus granulosus thymidylate synthase 0.0864 0.2386 0.2383
Echinococcus multilocularis dihydrofolate reductase 0.3585 1 1
Echinococcus multilocularis Smad4 0.0016 0.0013 0.001
Schistosoma mansoni cytochrome P450 0.0039 0.0076 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.015 0.0388 0.0388
Echinococcus granulosus Nuclear hormone receptor HR96 0.0071 0.0166 0.0163
Loa Loa (eye worm) DR-78 0.0071 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.015 0.0388 0.0385
Echinococcus multilocularis smad 0.0016 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0041 0.0041
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0071 0.0166 0.0163
Echinococcus granulosus ecdysone induced protein 78C 0.015 0.0388 0.0385
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0039 0.0076 0.0104
Brugia malayi nuclear receptor NHR-67 0.0071 0.0166 0.0159
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.015 0.0388 0.0385
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.3585 1 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0011 0.0011
Schistosoma mansoni nuclear hormone receptor 0.0071 0.0166 0.0155
Mycobacterium tuberculosis Hypothetical protein 0.0411 0.1118 0.105
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.015 0.0388 0.0385
Entamoeba histolytica hypothetical protein 0.0035 0.0066 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0038 0.003
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.0087 0.0211 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.015 0.0388 0.0381
Loa Loa (eye worm) cytochrome P450 0.0039 0.0076 0.0076
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0013 0.0013
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0079 0.019 0.019
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Schistosoma mansoni retinoic acid receptor RXR 0.015 0.0388 0.0378
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0013 0.001
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0041 0.0041
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0038 0.0034
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.015 0.0388 0.0385
Brugia malayi Nuclear hormone receptor family member nhr-1 0.015 0.0388 0.0381
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0038 0.0337
Loa Loa (eye worm) hypothetical protein 0.015 0.0388 0.0388
Schistosoma mansoni RAR-like nuclear receptor 0.015 0.0388 0.0378
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.0073 0.0073
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.3585 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0049 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Echinococcus multilocularis ecdysone induced protein 78C 0.015 0.0388 0.0385
Schistosoma mansoni intermediate filament proteins 0.0026 0.0041 0.003
Schistosoma mansoni steroid hormone receptor ad4bp 0.015 0.0388 0.0378
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0166 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Onchocerca volvulus Bile acid receptor homolog 0.015 0.0388 0.1479
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0202 0.0532 0.0532
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0066 0.0062
Loa Loa (eye worm) nuclear receptor NHR-67 0.0071 0.0166 0.0166
Schistosoma mansoni smad1 5 8 and 0.0016 0.0013 0.0002
Loa Loa (eye worm) hypothetical protein 0.015 0.0388 0.0388
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.015 0.0388 0.0385
Brugia malayi cytochrome P450 0.0039 0.0076 0.0069
Echinococcus multilocularis lamin dm0 0.0026 0.0041 0.0038
Brugia malayi nuclear receptor RXR 0.0071 0.0166 0.0159
Echinococcus granulosus nuclear receptor nhr 48 0.0071 0.0166 0.0163
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.015 0.0388 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0041 0.0034
Brugia malayi Smad1 0.0016 0.0013 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.015 0.0388 0.0388
Brugia malayi Nuclear hormone receptor E75 0.0071 0.0166 0.0159
Onchocerca volvulus 0.015 0.0388 0.1479
Trypanosoma cruzi cytochrome P450, putative 0.0125 0.0319 0.0412
Brugia malayi photoreceptor-specific nuclear receptor 0.015 0.0388 0.0381
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0013 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0166 0.0163
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0071 0.0166 0.0163
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0038 0.0052
Loa Loa (eye worm) nuclear hormone receptor 0.0071 0.0166 0.0166
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0066 0.0589
Brugia malayi thymidylate synthase 0.0864 0.2386 0.238
Onchocerca volvulus 0.0071 0.0166 0.0533
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0082 0.0071
Brugia malayi nuclear hormone receptor 0.015 0.0388 0.0381
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0411 0.1118 0.1509
Leishmania major dihydrofolate reductase-thymidylate synthase 0.2622 0.7306 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.2622 0.7306 1
Brugia malayi ecdysone receptor 0.0071 0.0166 0.0159
Giardia lamblia GTOR 0.0018 0.0019 0.5
Entamoeba histolytica hypothetical protein 0.0035 0.0066 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.015 0.0388 0.0385
Loa Loa (eye worm) dihydrofolate reductase 0.3585 1 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0071 0.0166 0.0166
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0103 0.0103
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.015 0.0388 0.0378
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0039 0.0076 0.0079
Brugia malayi hypothetical protein 0.0071 0.0166 0.0159
Schistosoma mansoni zinc finger protein 0.0071 0.0166 0.0155
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0071 0.0166 0.0155
Loa Loa (eye worm) hypothetical protein 0.015 0.0388 0.0388
Loa Loa (eye worm) hypothetical protein 0.015 0.0388 0.0388
Schistosoma mansoni nuclear receptor 0.0071 0.0166 0.0155
Brugia malayi Nuclear hormone receptor E75 0.0071 0.0166 0.0159
Brugia malayi MH2 domain containing protein 0.0016 0.0013 0.0006
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0079 0.019 0.0179
Brugia malayi nuclear receptor NHR-88 0.0071 0.0166 0.0159
Echinococcus granulosus dihydrofolate reductase 0.3585 1 1
Brugia malayi Steroid receptor seven-up type 2 0.015 0.0388 0.0381
Onchocerca volvulus 0.0229 0.061 0.2427
Brugia malayi nuclear receptor RXR 0.0079 0.019 0.0183
Loa Loa (eye worm) cytochrome P450 family protein 0.0125 0.0319 0.0319
Brugia malayi hypothetical protein 0.0035 0.0066 0.0058
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0049 0.0046
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0013 0.001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.015 0.0388 0.0381
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0019 0.0026
Echinococcus granulosus GPCR family 2 0.0015 0.0011 0.0007
Brugia malayi hypothetical protein 0.0079 0.019 0.0183
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.015 0.0388 0.0388
Brugia malayi Nuclear hormone receptor family member nhr-41 0.015 0.0388 0.0381
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0019 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.015 0.0388 0.0381
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0007
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0019 0.0008
Brugia malayi MH2 domain containing protein 0.0235 0.0626 0.0619
Loa Loa (eye worm) hypothetical protein 0.0079 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0079 0.019 0.019
Trypanosoma brucei cytochrome P450, putative 0.0125 0.0319 0.0436
Echinococcus multilocularis lamin 0.0026 0.0041 0.0038
Schistosoma mansoni nuclear receptor nhr-48 0.0071 0.0166 0.0155
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0019 0.0019
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0071 0.0166 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Loa Loa (eye worm) steroid hormone receptor 0.015 0.0388 0.0388
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.015 0.0388 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Entamoeba histolytica hypothetical protein 0.0035 0.0066 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0038 0.0027
Schistosoma mansoni nuclear hormone receptor 0.0071 0.0166 0.0155
Brugia malayi intermediate filament protein 0.0026 0.0041 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0411 0.1118 1
Brugia malayi conserved hypotetical protein 0.0071 0.0166 0.0159
Loa Loa (eye worm) cytochrome P450 family protein 0.0125 0.0319 0.0319
Brugia malayi Pre-SET motif family protein 0.0202 0.0532 0.0525
Schistosoma mansoni nuclear receptor 0.0071 0.0166 0.0155
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0019 0.0019
Brugia malayi Cytochrome P450 family protein 0.0125 0.0319 0.0312
Brugia malayi tailless protein 0.0071 0.0166 0.0159
Brugia malayi hypothetical protein 0.0079 0.019 0.0183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Echinococcus granulosus intermediate filament protein 0.0026 0.0041 0.0038
Brugia malayi MH1 domain containing protein 0.0016 0.0013 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0038
Loa Loa (eye worm) cytochrome P450 family protein 0.0039 0.0076 0.0076
Schistosoma mansoni dihydrofolate reductase 0.3585 1 1
Leishmania major cytochrome p450-like protein 0.0125 0.0319 0.0412
Echinococcus multilocularis musashi 0.0026 0.0041 0.0038
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0864 0.2386 0.2377
Echinococcus granulosus lamin dm0 0.0026 0.0041 0.0038
Echinococcus granulosus smad 0.0016 0.0013 0.001
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0079 0.019 0.0187
Loa Loa (eye worm) CYP4Cod1 0.0125 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0079 0.019 0.019
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.0626 0.0626
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0864 0.2386 0.2327
Schistosoma mansoni voltage-gated potassium channel 0.0041 0.0082 0.0071
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0049 0.0046
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.0073 0.0069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Loa Loa (eye worm) hypothetical protein 0.0015 0.0011 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.015 0.0388 0.0388
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.015 0.0388 0.0378
Brugia malayi orphan nuclear receptor NR2E1 0.0071 0.0166 0.0159
Leishmania major cytochrome p450-like protein 0.0039 0.0076 0.0079
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Brugia malayi Pre-SET motif family protein 0.0029 0.0049 0.0042
Echinococcus multilocularis thymidylate synthase 0.0864 0.2386 0.2383
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0019 0.0026
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0007 0.0007
Brugia malayi ecdysteroid receptor 0.015 0.0388 0.0381
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.3585 1 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0035 0.0066 0.0589
Echinococcus granulosus FTZ F1 alpha 0.015 0.0388 0.0385
Leishmania major cytochrome p450-like protein 0.0039 0.0076 0.0079
Brugia malayi nuclear receptor NHR-88 0.015 0.0388 0.0381
Onchocerca volvulus 0.0864 0.2386 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.019 0.0183
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.015 0.0388 0.1479
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.2622 0.7306 1
Echinococcus multilocularis 0.0039 0.0076 0.0073
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.015 0.0388 0.0388
Schistosoma mansoni Tr4/Tr2 (homologue) 0.015 0.0388 0.0378
Schistosoma mansoni smad1 5 8 and 0.0016 0.0013 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Brugia malayi MH1 domain containing protein 0.0016 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0003
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0049 0.0038
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0864 0.2386 0.2327
Schistosoma mansoni lamin 0.0026 0.0041 0.003
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0019 0.0026
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0061 0.0053
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0013 0.0013
Toxoplasma gondii cytochrome p450 superfamily protein 0.0039 0.0076 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.015 0.0388 0.0381
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0011 0.0007
Brugia malayi Dihydrofolate reductase 0.3585 1 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0071 0.0166 0.0163
Schistosoma mansoni smad1 5 8 and 0.0016 0.0013 0.0002
Echinococcus granulosus cytochrome P450 2K1 0.0039 0.0076 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Echinococcus granulosus Nuclear hormone receptor HR96 0.0071 0.0166 0.0163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Loa Loa (eye worm) hypothetical protein 0.0048 0.0103 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-31 0.015 0.0388 0.0381
Echinococcus multilocularis FTZ F1 alpha 0.015 0.0388 0.0385
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0066 0.0062
Schistosoma mansoni thyroid hormone receptor 0.015 0.0388 0.0378
Brugia malayi Nuclear hormone receptor-like 1 0.015 0.0388 0.0381
Loa Loa (eye worm) hypothetical protein 0.0026 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0033 0.0061 0.005
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0038 0.0034
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0019 0.0015
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.2622 0.7306 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.015 0.0388 0.0381
Loa Loa (eye worm) hypothetical protein 0.0079 0.019 0.019
Echinococcus multilocularis thyroid hormone receptor alpha 0.015 0.0388 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.015 0.0388 0.0378
Echinococcus granulosus nuclear receptor 2DBD gamma 0.015 0.0388 0.0385
Brugia malayi nuclear hormone receptor 0.0071 0.0166 0.0159
Loa Loa (eye worm) hypothetical protein 0.0079 0.019 0.019
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.0073 0.0065
Onchocerca volvulus Protein ultraspiracle homolog 0.015 0.0388 0.1479
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0071 0.0166 0.0533
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0013 0.001
Schistosoma mansoni hypothetical protein 0.0035 0.0066 0.0055
Brugia malayi steroid hormone receptor 0.015 0.0388 0.0381
Brugia malayi Cytochrome P450 family protein 0.0125 0.0319 0.0312
Schistosoma mansoni lamin 0.0026 0.0041 0.003
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0019 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.015 0.0388 0.0381
Echinococcus granulosus lamin 0.0026 0.0041 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0011 0.0007
Brugia malayi nuclear hormone receptor family member odr-7 0.0071 0.0166 0.0159
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0038 0.0052
Entamoeba histolytica hypothetical protein 0.0025 0.0038 0.4029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0103 0.0096
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0103 0.0096
Trichomonas vaginalis set domain proteins, putative 0.0229 0.061 0.5457
Brugia malayi Cytochrome P450 family protein 0.0039 0.0076 0.0069
Brugia malayi hypothetical protein 0.0411 0.1118 0.1112
Onchocerca volvulus 0.0029 0.0049 0.0033
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.015 0.0388 0.0385
Brugia malayi MH2 domain containing protein 0.0016 0.0013 0.0006
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Echinococcus multilocularis GPCR, family 2 0.0015 0.0011 0.0007
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0019 0.0015
Brugia malayi Nuclear hormone receptor family member nhr-25 0.015 0.0388 0.0381
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0041 0.0041
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.0073 0.0069
Schistosoma mansoni coup transcription factor 0.015 0.0388 0.0378
Schistosoma mansoni nuclear hormone receptor 0.015 0.0388 0.0378
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0019 0.0026
Loa Loa (eye worm) thymidylate synthase 0.0864 0.2386 0.2386
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0071 0.0166 0.0155
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0019 0.0026
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.015 0.0388 0.0385
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.015 0.0388 0.0385
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0046 0.0043
Loa Loa (eye worm) hypothetical protein 0.015 0.0388 0.0388
Mycobacterium ulcerans thymidylate synthase 0.0864 0.2386 0.2327
Chlamydia trachomatis dihydrofolate reductase 0.3585 1 0.5
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.2622 0.7306 0.5
Loa Loa (eye worm) hypothetical protein 0.015 0.0388 0.0388
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0071 0.0166 0.0163
Schistosoma mansoni hypothetical protein 0.0039 0.0076 0.0065
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0039 0.0076 0.0079
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0019 0.0015
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0011 0.0004
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0066 0.0055
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0038 0.0026
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.015 0.0388 0.0385
Onchocerca volvulus 0.0071 0.0166 0.0533
Brugia malayi Nuclear hormone receptor-like 1 0.0079 0.019 0.0183
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0013 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0038
Brugia malayi Cytochrome P450 family protein 0.0039 0.0076 0.0069
Trypanosoma cruzi cytochrome P450, putative 0.0125 0.0319 0.0412
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Echinococcus granulosus thyroid hormone receptor alpha 0.0071 0.0166 0.0163
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0071 0.0166 0.0533
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0049 0.0038
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0039 0.0076 0.0079
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.015 0.0388 0.0388
Schistosoma mansoni Smad4 0.0016 0.0013 0.0002
Loa Loa (eye worm) hypothetical protein 0.015 0.0388 0.0388
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-19 0.015 0.0388 0.0381
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.015 0.0388 0.0388
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0049 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Echinococcus granulosus Smad4 0.0016 0.0013 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.015 0.0388 0.0378
Loa Loa (eye worm) hypothetical protein 0.0033 0.0061 0.0061
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0079 0.019 0.0187
Schistosoma mansoni smad 0.0016 0.0013 0.0002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0125 0.0319 0.0245
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0079 0.019 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0019 0.0168
Loa Loa (eye worm) hypothetical protein 0.0032 0.0059 0.0059
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0011 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-49 0.015 0.0388 0.0381
Entamoeba histolytica hypothetical protein 0.0035 0.0066 1
Loa Loa (eye worm) Smad1 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0071 0.0166 0.0166
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0071 0.0166 0.0159
Schistosoma mansoni retinoid-x-receptor (RXR) 0.015 0.0388 0.0378
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0028 0.0013
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0019 0.0008

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) 0 Activation of peroxisome proliferator-activated receptor gamma in reporter gene assay: most active ChEMBL. 15745794

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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