Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | melanin-concentrating hormone receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0265 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1569 | 1 | 1 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0265 | 0.0595 | 0.0595 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0265 | 0.0595 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0265 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0595 | 0.0595 |
Brugia malayi | Carboxylesterase family protein | 0.0265 | 0.0595 | 0.0595 |
Onchocerca volvulus | 0.0265 | 0.0595 | 1 | |
Brugia malayi | Carboxylesterase family protein | 0.1569 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.1569 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0265 | 0.0595 | 0.0595 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0265 | 0.0595 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0265 | 0.0595 | 0.0595 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1569 | 1 | 1 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0265 | 0.0595 | 0.0595 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0265 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0595 | 0.0595 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0265 | 0.0595 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0265 | 0.0595 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0265 | 0.0595 | 0.0595 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0265 | 0.0595 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0595 | 0.0595 |
Echinococcus granulosus | neuroligin | 0.0265 | 0.0595 | 0.0595 |
Schistosoma mansoni | acetylcholinesterase | 0.0265 | 0.0595 | 0.0595 |
Echinococcus granulosus | acetylcholinesterase | 0.1569 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.1569 | 1 | 1 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0265 | 0.0595 | 0.0595 |
Brugia malayi | Carboxylesterase family protein | 0.0265 | 0.0595 | 0.0595 |
Schistosoma mansoni | gliotactin | 0.0265 | 0.0595 | 0.0595 |
Onchocerca volvulus | 0.0265 | 0.0595 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.1569 | 1 | 1 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0265 | 0.0595 | 0.0595 |
Echinococcus multilocularis | neuroligin | 0.0265 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | carboxylesterase | 0.1569 | 1 | 1 |
Onchocerca volvulus | 0.0265 | 0.0595 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.1569 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.1569 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1569 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0595 | 0.0595 |
Brugia malayi | hypothetical protein | 0.0265 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | hypothetical protein | 0.1569 | 1 | 1 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0265 | 0.0595 | 0.0595 |
Brugia malayi | Carboxylesterase family protein | 0.0265 | 0.0595 | 0.0595 |
Giardia lamblia | Kinase, CDC7 | 0.0183 | 0 | 0.5 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0265 | 0.0595 | 0.0595 |
Onchocerca volvulus | 0.0265 | 0.0595 | 1 | |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0265 | 0.0595 | 0.0595 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.0595 | 0.0595 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0265 | 0.0595 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0265 | 0.0595 | 0.0595 |
Onchocerca volvulus | 0.0265 | 0.0595 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 22 nM | Displacement of [125I]-MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells | ChEMBL. | 15686900 |
Ki (binding) | = 22 nM | Displacement of [125I]-MCH from human Melanin-concentrating hormone 1 (MCH1) receptor modified for optimal expression in HEK293 cells | ChEMBL. | 15686900 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.