TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 431.702 | Formula: C20H13Cl3N4O
H donors: 1 H acceptors: 3 LogP: 5.53 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc(Cl)c(c(c1)Cl)c1cc2cnc(nc2n(c1=O)C)Nc1ccccc1
InChi: 1S/C20H13Cl3N4O/c1-27-18-11(10-24-20(26-18)25-13-5-3-2-4-6-13)7-14(19(27)28)17-15(22)8-12(21)9-16(17)23/h2-10H,1H3,(H,24,25,26)
InChiKey: XBKDBULVPUEAHW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	WEE1 G2 checkpoint kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania braziliensis	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma brucei	wee1-like protein kinase	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania mexicana	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania infantum	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania donovani	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania donovani	protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma congolense	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0799	0.082
Onchocerca volvulus		0.0091	0.0817	0.0599
Schistosoma mansoni	coup transcription factor	0.0089	0.0799	0.123
Toxoplasma gondii	histone lysine methyltransferase SET1	0.006	0.0508	1
Trypanosoma brucei	wee1-like protein kinase	0.0069	0.0599	1
Onchocerca volvulus	Protein ultraspiracle homolog	0.0089	0.0799	0.0581
Schistosoma mansoni	transcription factor LCR-F1	0.0039	0.031	0.0478
Onchocerca volvulus		0.0042	0.0336	0.0107
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0037	0.0021
Entamoeba histolytica	hypothetical protein	0.0026	0.0175	0.2666
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0042	0.0336	0.0518
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0089	0.0799	0.082
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0021	0.0126	0.1569
Brugia malayi	nuclear receptor NHR-67	0.0042	0.0336	0.0335
Wolbachia endosymbiont of Brugia malayi	4'-phosphopantetheinyl transferase	0.0026	0.0175	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0089	0.0799	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0047	0.0386	0.0594
Schistosoma mansoni	cpg binding protein	0.0031	0.0232	0.0357
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0979	0.9537	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0042	0.0336	0.0107
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0037	0.0021
Brugia malayi	ecdysone receptor	0.0042	0.0336	0.0335
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0021	0.0126	0.0208
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0386	0.0386
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0089	0.0799	0.082
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0042	0.0336	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0937	0.9124	0.9566
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0042	0.0336	0.0518
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0047	0.0386	0.0594
Leishmania major	phosphopantetheinyl transferase-like protein	0.0026	0.0175	0.2445
Brugia malayi	nuclear hormone receptor	0.0979	0.9537	1
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0089	0.0799	0.1325
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0232	0.0225
Brugia malayi	Nuclear hormone receptor-like 1	0.0089	0.0799	0.0821
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	0.0069	0.0599	1
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Brugia malayi	exodeoxyribonuclease III family protein	0.0021	0.0126	0.0113
Schistosoma mansoni	zinc finger protein	0.0042	0.0336	0.0518
Brugia malayi	cytochrome P450	0.0012	0.0037	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0386	0.0386
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0042	0.0336	0.0558
Brugia malayi	steroid hormone receptor	0.0089	0.0799	0.0821
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0126	0.5
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0039	0.031	0.0478
Leishmania major	hypothetical protein, conserved	0.0028	0.0194	0.2794
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0047	0.0386	0.0386
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0799	0.082
Echinococcus granulosus	cpg binding protein	0.0033	0.025	0.0385
Loa Loa (eye worm)	CYP4Cod1	0.0012	0.0037	0.002
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Echinococcus multilocularis		0.0012	0.0037	0.0062
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0021	0.0126	0.5
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0021	0.0126	0.0112
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0021	0.0126	0.0193
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0091	0.0817	0.1355
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0126	0.1569
Trichomonas vaginalis	ap endonuclease, putative	0.0021	0.0126	0.5
Treponema pallidum	4'-phosphopantetheinyl transferase	0.0026	0.0175	1
Schistosoma mansoni	nuclear receptor	0.0042	0.0336	0.0518
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0089	0.0799	0.123
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0089	0.0799	0.0821
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0089	0.0799	0.082
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0089	0.0799	0.123
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0042	0.0336	0.0334
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0089	0.0799	0.1325
Brugia malayi	Nuclear hormone receptor-like 1	0.0047	0.0386	0.0387
Schistosoma mansoni	thyroid hormone receptor	0.0089	0.0799	0.123
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0089	0.0799	0.1325
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0039	0.031	0.0514
Chlamydia trachomatis	holo [acyl-carrier protein] synthase	0.0026	0.0175	0.5
Brugia malayi	conserved hypotetical protein	0.0042	0.0336	0.0335
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0817	0.0839
Schistosoma mansoni	hypothetical protein	0.0012	0.0045	0.0069
Schistosoma mansoni	ap endonuclease	0.0021	0.0126	0.0193
Toxoplasma gondii	exonuclease III APE	0.0021	0.0126	0.187
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0089	0.0799	0.0821
Toxoplasma gondii	4'-phosphopantetheinyl transferase superfamily protein	0.0026	0.0175	0.2915
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0089	0.0799	0.1325
Brugia malayi	Steroid receptor seven-up type 2	0.0089	0.0799	0.0821
Schistosoma mansoni	hypothetical protein	0.0039	0.031	0.0478
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0194	0.2794
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0089	0.0799	0.0821
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0089	0.0799	0.0821
Brugia malayi	Nuclear hormone receptor E75	0.0042	0.0336	0.0335
Echinococcus multilocularis	nuclear receptor nhr 48	0.0042	0.0336	0.0558
Trypanosoma brucei	hypothetical protein, conserved	0.0026	0.0175	0.2445
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0089	0.0799	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Brugia malayi	nuclear hormone receptor	0.0089	0.0799	0.0821
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0042	0.0336	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0194	1
Brugia malayi	ecdysteroid receptor	0.0089	0.0799	0.0821
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0089	0.0799	0.123
Brugia malayi	photoreceptor-specific nuclear receptor	0.0089	0.0799	0.0821
Brugia malayi	hypothetical protein	0.0039	0.031	0.0307
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0042	0.0336	0.0107
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0336	0.0518
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0089	0.0799	0.123
Brugia malayi	nuclear receptor RXR	0.0047	0.0386	0.0387
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.0194	0.3331
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0021	0.0126	0.1569
Echinococcus granulosus	histone lysine N methyltransferase MLL3	0.001	0.0019	0.0029
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.0194	0.2794
Schistosoma mansoni	retinoic acid receptor RXR	0.0669	0.6495	1
Echinococcus multilocularis	cpg binding protein	0.0033	0.025	0.0414
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0021	0.0126	0.1569
Echinococcus multilocularis	Ataxin 2, N terminal,domain containing protein	0.0012	0.0045	0.0074
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0089	0.0799	0.0821
Trypanosoma cruzi	Wee1-like protein kinase, putative	0.0069	0.0599	1
Echinococcus multilocularis	histone lysine N methyltransferase MLL3	0.001	0.0019	0.0031
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0799	0.082
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0042	0.0336	0.0518
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0089	0.0799	0.123
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0037	0.0021
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Brugia malayi	hypothetical protein	0.0047	0.0386	0.0387
Brugia malayi	tailless protein	0.0042	0.0336	0.0335
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0089	0.0799	0.123
Echinococcus granulosus	nuclear receptor nhr 48	0.0042	0.0336	0.0518
Loa Loa (eye worm)	nuclear hormone receptor	0.0042	0.0336	0.0334
Echinococcus granulosus	thyroid hormone receptor alpha	0.0042	0.0336	0.0518
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0194	0.0184
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0089	0.0799	0.123
Entamoeba histolytica	hypothetical protein	0.0039	0.031	1
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0089	0.0799	0.123
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0042	0.0336	0.0558
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0021	0.0126	0.6415
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0386	0.0386
Brugia malayi	hypothetical protein	0.0018	0.0098	0.0085
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0037	0.002
Schistosoma mansoni	hypothetical protein	0.0012	0.0037	0.0058
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0622	0.6032	1
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0021	0.0126	0.6415
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Echinococcus granulosus	Ataxin 2 N terminaldomain containing protein	0.0012	0.0045	0.0069
Schistosoma mansoni	nuclear receptor nhr-48	0.0042	0.0336	0.0518
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0067	0.0578	0.0891
Schistosoma mansoni	nuclear hormone receptor	0.0089	0.0799	0.123
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0089	0.0799	0.082
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0042	0.0336	0.0335
Schistosoma mansoni	cpg binding protein	0.0033	0.025	0.0385
Schistosoma mansoni	ap endonuclease	0.0021	0.0126	0.0193
Brugia malayi	nuclear receptor NHR-88	0.0089	0.0799	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0799	0.082
Brugia malayi	nuclear receptor NHR-88	0.0042	0.0336	0.0335
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0091	0.0817	0.084
Loa Loa (eye worm)	cytochrome P450 family protein	0.0053	0.0448	0.0451
Onchocerca volvulus	Bile acid receptor homolog	0.0089	0.0799	0.0581
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0089	0.0799	0.0821
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0047	0.0386	0.064
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0799	0.082
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0089	0.0799	0.123
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0386	0.0386
Brugia malayi	hypothetical protein	0.0042	0.0336	0.0335
Trypanosoma cruzi	Wee1-like protein kinase, putative	0.0069	0.0599	1
Schistosoma mansoni	cpg binding protein	0.0033	0.025	0.0385
Onchocerca volvulus		0.0089	0.0799	0.0581
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.0194	0.2794
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0089	0.0799	0.0821
Toxoplasma gondii	4'-phosphopantetheinyl transferase domain-containing protein	0.0026	0.0175	0.2915
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0089	0.0799	0.0821
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Schistosoma mansoni	nuclear hormone receptor	0.0042	0.0336	0.0518
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0089	0.0799	0.123
Entamoeba histolytica	hypothetical protein	0.0039	0.031	1
Entamoeba histolytica	hypothetical protein	0.0039	0.031	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0042	0.0336	0.0558
Brugia malayi	Nuclear hormone receptor-like 1	0.0047	0.0386	0.0387
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Echinococcus granulosus	L aminoadipate semialdehyde	0.0091	0.0817	0.1259
Mycobacterium leprae	conserved hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	thyroid hormone receptor	0.0089	0.0799	0.123
Schistosoma mansoni	nuclear receptor	0.0042	0.0336	0.0518
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0089	0.0799	0.1325
Loa Loa (eye worm)	cytochrome P450 family protein	0.0012	0.0037	0.002
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0089	0.0799	0.1325
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0089	0.0799	0.123
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0799	0.082
Entamoeba histolytica	hypothetical protein	0.0039	0.031	1
Mycobacterium ulcerans	phosphopantetheinyl transferase, PptII	0.0026	0.0175	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0089	0.0799	0.123
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0669	0.6495	1
Onchocerca volvulus		0.0042	0.0336	0.0107
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0089	0.0799	0.082
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0089	0.0799	0.0821
Brugia malayi	hypothetical protein	0.0028	0.0194	0.0186
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0091	0.0817	0.1259
Mycobacterium ulcerans	4'-phosphopantetheinyl transferase	0.0026	0.0175	1
Plasmodium vivax	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0175	0.7152
Echinococcus granulosus	cytochrome P450 2K1	0.0012	0.0037	0.0058
Brugia malayi	orphan nuclear receptor NR2E1	0.0042	0.0336	0.0335
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0042	0.0336	0.0558
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0089	0.0799	0.123
Plasmodium falciparum	holo-[acyl-carrier-protein] synthase, putative	0.0026	0.0175	0.7152
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0089	0.0799	0.0821
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0232	0.0224
Echinococcus granulosus	FTZ F1 alpha	0.0089	0.0799	0.123
Loa Loa (eye worm)	steroid hormone receptor	0.0089	0.0799	0.082
Brugia malayi	nuclear receptor RXR	0.0042	0.0336	0.0335
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0089	0.0799	0.082
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0089	0.0799	0.123
Loa Loa (eye worm)	hypothetical protein	0.0042	0.0336	0.0334
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0042	0.0336	0.0518
Brugia malayi	hypothetical protein	0.0042	0.0336	0.0335
Mycobacterium tuberculosis	holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie	0.0026	0.0175	1
Schistosoma mansoni	cytochrome P450	0.0012	0.0037	0.0058
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0799	0.082
Brugia malayi	Nuclear hormone receptor E75	0.0042	0.0336	0.0335
Trypanosoma cruzi	Wee1-like protein kinase, putative	0.0069	0.0599	1
Echinococcus granulosus	ecdysone induced protein 78C	0.0089	0.0799	0.123
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0089	0.0799	0.082
Loa Loa (eye worm)	cytochrome P450	0.0012	0.0037	0.002
Brugia malayi	nuclear hormone receptor family member odr-7	0.0042	0.0336	0.0335
Brugia malayi	Cytochrome P450 family protein	0.0053	0.0448	0.0452
Loa Loa (eye worm)	DR-78	0.0042	0.0336	0.0334
Echinococcus multilocularis	FTZ F1 alpha	0.0089	0.0799	0.1325
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	0.0069	0.0599	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.0089	0.0799	0.1325
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0386	0.0386
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0042	0.0336	0.0335
Brugia malayi	hypothetical protein	0.0047	0.0386	0.0387
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0089	0.0799	0.0821
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.0194	1
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0047	0.0386	0.0594
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.0194	1
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0089	0.0799	0.1325
Loa Loa (eye worm)	hypothetical protein	0.0089	0.0799	0.082

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.33 uM	Inhibition of c-Src tyrosine kinase	ChEMBL.	15780636
IC50 (binding)	= 8.6 uM	Inhibition of checkpoint kinase Wee1	ChEMBL.	15780636
IC50 (binding)	= 8.6 uM	Inhibition of checkpoint kinase Wee1	ChEMBL.	15780636

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL362005

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 315688