Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dipeptidyl peptidase IV | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 789 aa | 30.2 % | |
Onchocerca volvulus | Dipeptidyl peptidase IV | 767 aa | 637 aa | 27.0 % | |
Candida albicans | dipeptidyl aminopeptidase similar to S. cerevisiae STE13 (YOR219C) involved in maturation of alpha-factor | Dipeptidyl peptidase IV | 767 aa | 814 aa | 25.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.2296 | 1 | 0.5 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0209 | 0.0624 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.2296 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.2296 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.2296 | 1 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.2191 | 0.9528 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.2296 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.2296 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.2296 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.0624 | 0.0624 |
Brugia malayi | thymidylate synthase | 0.0108 | 0.0168 | 0.0168 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.0624 | 0.0624 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.2296 | 1 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.0624 | 0.0624 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.0624 | 0.0624 |
Echinococcus granulosus | thymidylate synthase | 0.0108 | 0.0168 | 0.0168 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2191 | 0.9528 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0108 | 0.0168 | 0.0168 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.2191 | 0.9528 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.2296 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.2191 | 0.9528 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.2191 | 0.9528 | 1 |
Echinococcus multilocularis | thymidylate synthase | 0.0108 | 0.0168 | 0.0168 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.2191 | 0.9528 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.0624 | 0.0464 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.