Detailed information for compound 316098

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 412.479 | Formula: C23H28N2O5
  • H donors: 2 H acceptors: 3 LogP: 3.63 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC1OC(CC1O)n1cc2cc(oc2nc1=O)c1ccc(cc1)CCC(C)(C)C
  • InChi: 1S/C23H28N2O5/c1-23(2,3)9-8-14-4-6-15(7-5-14)18-10-16-12-25(22(28)24-21(16)30-18)20-11-17(27)19(13-26)29-20/h4-7,10,12,17,19-20,26-27H,8-9,11,13H2,1-3H3
  • InChiKey: VVFZGODVTVEORJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Echinococcus multilocularis peroxidasin 0.0078 0.0516 0.0567
Echinococcus multilocularis nuclear receptor nhr 48 0.0152 0.1478 0.1626
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0169 0.1695 0.1624
Brugia malayi nuclear hormone receptor family member nhr-6 0.0152 0.1478 0.1406
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0366 0.424 0.4445
Loa Loa (eye worm) carbonic anhydrase 3 0.0742 0.9093 0.9085
Schistosoma mansoni thyroid hormone receptor 0.0323 0.3683 0.3994
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0516 0.0435
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0516 0.0435
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0254 0.0188
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0742 0.9093 0.9085
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0323 0.3683 0.405
Brugia malayi Steroid receptor seven-up type 2 0.0323 0.3683 0.3629
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Brugia malayi hypothetical protein 0.0171 0.1714 0.1644
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0152 0.1478 0.1626
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0516 0.0435
Echinococcus multilocularis carbonic anhydrase 0.0169 0.1695 0.1864
Loa Loa (eye worm) hypothetical protein 0.0323 0.3683 0.3629
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0366 0.424 0.4445
Loa Loa (eye worm) hypothetical protein 0.0323 0.3683 0.3629
Loa Loa (eye worm) raf kinase 0.0209 0.2206 0.2139
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Loa Loa (eye worm) hypothetical protein 0.0066 0.0367 0.0285
Brugia malayi jmjC domain containing protein 0.0058 0.0254 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0323 0.3683 0.3629
Brugia malayi tailless protein 0.0152 0.1478 0.1406
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Loa Loa (eye worm) hypothetical protein 0.0169 0.1695 0.1624
Loa Loa (eye worm) hypothetical protein 0.0812 1 1
Schistosoma mansoni serine/threonine protein kinase 0.021 0.2219 0.2369
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0742 0.9093 0.9085
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0323 0.3683 0.405
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0323 0.3683 0.405
Brugia malayi P38 map kinase family protein 2 0.0366 0.424 0.4191
Loa Loa (eye worm) hypothetical protein 0.0323 0.3683 0.3629
Echinococcus multilocularis carbonic anhydrase 0.0169 0.1695 0.1864
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0152 0.1478 0.1015
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0323 0.3683 0.3629
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0152 0.1478 0.1547
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0058 0.0254 0.0279
Schistosoma mansoni carbonic anhydrase-related 0.0169 0.1695 0.1787
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0085 0.0093
Schistosoma mansoni nuclear hormone receptor 0.0323 0.3683 0.3994
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0366 0.424 0.4191
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0152 0.1478 0.1626
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0742 0.9093 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0742 0.9093 1
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0169 0.1695 0.1624
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0516 0.0435
Toxoplasma gondii hypothetical protein 0.0169 0.1695 0.5
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0323 0.3683 0.405
Echinococcus multilocularis raf serine:threonine protein kinase 0.021 0.2219 0.244
Plasmodium falciparum carbonic anhydrase 0.0169 0.1695 0.5
Echinococcus multilocularis mitogen activated protein kinase 11 0.0366 0.424 0.4663
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0323 0.3683 0.3629
Brugia malayi nuclear receptor NHR-88 0.0152 0.1478 0.1406
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0323 0.3683 0.334
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Echinococcus multilocularis FTZ F1 alpha 0.0323 0.3683 0.405
Brugia malayi Calcitonin receptor-like protein seb-1 0.0097 0.0764 0.0685
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0152 0.1478 0.1626
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.101 0.0934
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0152 0.1478 0.1626
Brugia malayi hypothetical protein 0.0152 0.1478 0.1406
Brugia malayi nuclear hormone receptor 0.0323 0.3683 0.3629
Schistosoma mansoni hypothetical protein 0.0169 0.1695 0.1787
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0169 0.1695 0.1624
Echinococcus multilocularis thyroid hormone receptor alpha 0.0323 0.3683 0.405
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0097 0.0764 0.0685
Schistosoma mansoni nuclear receptor nhr-48 0.0152 0.1478 0.1547
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0357 0.0392
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0323 0.3683 0.3994
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0742 0.9093 1
Brugia malayi hypothetical protein 0.0078 0.0516 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0323 0.3683 0.3629
Brugia malayi Nuclear hormone receptor-like 1 0.0323 0.3683 0.3629
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Loa Loa (eye worm) hypothetical protein 0.0171 0.1714 0.1644
Brugia malayi photoreceptor-specific nuclear receptor 0.0323 0.3683 0.3629
Brugia malayi Nuclear hormone receptor-like 1 0.0171 0.1714 0.1644
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0323 0.3683 0.3629
Brugia malayi latrophilin 2 splice variant baaae 0.0066 0.0367 0.0285
Brugia malayi Nuclear hormone receptor E75 0.0152 0.1478 0.1406
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0516 0.0435
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0152 0.1478 0.1626
Loa Loa (eye worm) hypothetical protein 0.0171 0.1714 0.1644
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0357 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Echinococcus granulosus FTZ F1 alpha 0.0323 0.3683 0.405
Loa Loa (eye worm) hypothetical protein 0.0323 0.3683 0.3629
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0323 0.3683 0.3629
Schistosoma mansoni peroxidasin 0.0078 0.0516 0.0478
Brugia malayi nuclear receptor NHR-88 0.0323 0.3683 0.3629
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.101 0.0934
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0323 0.3683 0.3629
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0171 0.1714 0.1809
Brugia malayi Raf kinase 0.0203 0.2125 0.2057
Schistosoma mansoni retinoic acid receptor RXR 0.0323 0.3683 0.3994
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0323 0.3683 0.3629
Onchocerca volvulus 0.0152 0.1478 0.1015
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0323 0.3683 0.3994
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0152 0.1478 0.1015
Loa Loa (eye worm) hypothetical protein 0.0169 0.1695 0.1624
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Brugia malayi nuclear receptor RXR 0.0171 0.1714 0.1644
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0323 0.3683 0.3994
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0742 0.9093 0.9085
Loa Loa (eye worm) blistered cuticle protein 3 0.0078 0.0516 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0323 0.3683 0.3629
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Echinococcus granulosus carbonic anhydrase 0.0169 0.1695 0.1864
Schistosoma mansoni hypothetical protein 0.0166 0.1654 0.1743
Echinococcus granulosus thyroid hormone receptor alpha 0.0152 0.1478 0.1626
Loa Loa (eye worm) hypothetical protein 0.0171 0.1714 0.1644
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0323 0.3683 0.3994
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0169 0.1695 0.1624
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0516 0.0435
Onchocerca volvulus Bile acid receptor homolog 0.0323 0.3683 0.334
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0254 0.0171
Brugia malayi Nuclear hormone receptor-like 1 0.0171 0.1714 0.1644
Loa Loa (eye worm) hypothetical protein 0.0323 0.3683 0.3629
Brugia malayi nuclear hormone receptor 0.0152 0.1478 0.1406
Schistosoma mansoni nuclear receptor 0.0152 0.1478 0.1547
Brugia malayi nuclear receptor RXR 0.0152 0.1478 0.1406
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0323 0.3683 0.3994
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0171 0.1714 0.1809
Onchocerca volvulus 0.0152 0.1478 0.1015
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0058 0.0254 0.0279
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0323 0.3683 0.405
Brugia malayi hypothetical protein 0.0152 0.1478 0.1406
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0085 0.0093
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0152 0.1478 0.1406
Echinococcus multilocularis lysine specific demethylase 5A 0.0058 0.0254 0.0279
Schistosoma mansoni carbonic anhydrase-related 0.0169 0.1695 0.1787
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0097 0.0764 0.0685
Loa Loa (eye worm) steroid hormone receptor 0.0323 0.3683 0.3629
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0323 0.3683 0.405
Loa Loa (eye worm) hypothetical protein 0.0097 0.0764 0.0685
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0119 0.1046 0.0969
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0323 0.3683 0.405
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Onchocerca volvulus 0.0323 0.3683 0.334
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0323 0.3683 0.3629
Schistosoma mansoni zinc finger protein 0.0152 0.1478 0.1547
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0152 0.1478 0.1406
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0323 0.3683 0.3629
Echinococcus multilocularis mitogen activated protein kinase 14 0.0366 0.424 0.4663
Echinococcus granulosus Nuclear hormone receptor HR96 0.0152 0.1478 0.1626
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0742 0.9093 1
Brugia malayi Blistered cuticle protein 3 0.0078 0.0516 0.0435
Schistosoma mansoni nuclear receptor 0.0152 0.1478 0.1547
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Echinococcus granulosus geminin 0.0166 0.1654 0.1819
Schistosoma mansoni nuclear hormone receptor 0.0152 0.1478 0.1547
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0085 0.0093
Loa Loa (eye worm) hypothetical protein 0.0323 0.3683 0.3629
Brugia malayi ecdysone receptor 0.0152 0.1478 0.1406
Leishmania major carbonic anhydrase-like protein 0.0742 0.9093 1
Brugia malayi orphan nuclear receptor NR2E1 0.0152 0.1478 0.1406
Loa Loa (eye worm) hypothetical protein 0.0171 0.1714 0.1644
Brugia malayi nuclear receptor NHR-67 0.0152 0.1478 0.1406
Brugia malayi jmjC domain containing protein 0.0058 0.0254 0.0171
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Echinococcus granulosus ecdysone induced protein 78C 0.0323 0.3683 0.405
Echinococcus granulosus raf serine:threonine protein kinase 0.021 0.2219 0.244
Schistosoma mansoni hypothetical protein 0.0066 0.0367 0.0314
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0323 0.3683 0.3629
Brugia malayi Animal haem peroxidase family protein 0.0078 0.0516 0.0435
Schistosoma mansoni nuclear hormone receptor 0.0152 0.1478 0.1547
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0357 0.0302
Echinococcus granulosus mitogen activated protein kinase 14 0.0366 0.424 0.4663
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0152 0.1478 0.1626
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0366 0.424 0.4445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0323 0.3683 0.3629
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0323 0.3683 0.405
Echinococcus granulosus carbonic anhydrase 0.0169 0.1695 0.1864
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0323 0.3683 0.3629
Echinococcus multilocularis mitogen activated protein kinase 14 0.0366 0.424 0.4663
Loa Loa (eye worm) hypothetical protein 0.0323 0.3683 0.3629
Schistosoma mansoni thyroid hormone receptor 0.0323 0.3683 0.3994
Loa Loa (eye worm) hypothetical protein 0.0171 0.1714 0.1644
Echinococcus granulosus nuclear receptor nhr 48 0.0152 0.1478 0.1626
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0323 0.3683 0.405
Echinococcus multilocularis geminin 0.0166 0.1654 0.1819
Schistosoma mansoni carbonic anhydrase 0.0169 0.1695 0.1787
Echinococcus multilocularis mitogen activated protein kinase 11 0.0366 0.424 0.4663
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0323 0.3683 0.405
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0171 0.1714 0.1885
Echinococcus multilocularis carbonic anhydrase II 0.0742 0.9093 1
Brugia malayi ecdysteroid receptor 0.0323 0.3683 0.3629
Echinococcus granulosus mitogen activated protein kinase 11 0.0366 0.424 0.4663
Schistosoma mansoni jumonji/arid domain-containing protein 0.0058 0.0254 0.0188
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0152 0.1478 0.1547
Echinococcus granulosus peroxidasin 0.0078 0.0516 0.0567
Echinococcus granulosus Nuclear hormone receptor HR96 0.0152 0.1478 0.1626
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0516 0.0435
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0323 0.3683 0.3629
Loa Loa (eye worm) hypothetical protein 0.0323 0.3683 0.3629
Loa Loa (eye worm) nuclear receptor NHR-67 0.0152 0.1478 0.1406
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0323 0.3683 0.3994
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0323 0.3683 0.3629
Echinococcus granulosus carbonic anhydrase II 0.0742 0.9093 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0357 0.0274
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0357 0.0274
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0323 0.3683 0.405
Onchocerca volvulus 0.0812 1 1
Schistosoma mansoni RAR-like nuclear receptor 0.0323 0.3683 0.3994
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0171 0.1714 0.1885
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0152 0.1478 0.1626
Schistosoma mansoni carbonic anhydrase-related 0.0169 0.1695 0.1787
Loa Loa (eye worm) hypothetical protein 0.0078 0.0516 0.0435
Schistosoma mansoni steroid hormone receptor ad4bp 0.0323 0.3683 0.3994
Echinococcus multilocularis carbonic anhydrase 0.0169 0.1695 0.1864
Loa Loa (eye worm) nuclear hormone receptor 0.0152 0.1478 0.1406
Schistosoma mansoni jumonji domain containing protein 0.0058 0.0254 0.0188
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0171 0.1714 0.1644
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0169 0.1695 0.1624
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0169 0.1695 0.1624
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0323 0.3683 0.3629
Onchocerca volvulus Protein ultraspiracle homolog 0.0323 0.3683 0.334
Loa Loa (eye worm) hypothetical protein 0.0152 0.1478 0.1406
Trypanosoma brucei carbonic anhydrase-like protein 0.0742 0.9093 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0323 0.3683 0.3629
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0323 0.3683 0.405
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0085 0.0093
Brugia malayi Nuclear hormone receptor E75 0.0152 0.1478 0.1406
Schistosoma mansoni peroxidasin 0.0078 0.0516 0.0478
Loa Loa (eye worm) hypothetical protein 0.0169 0.1695 0.1624
Loa Loa (eye worm) animal heme peroxidase 0.0078 0.0516 0.0435
Echinococcus granulosus lysine specific demethylase 5A 0.0058 0.0254 0.0279
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0323 0.3683 0.3629
Loa Loa (eye worm) DR-78 0.0152 0.1478 0.1406
Brugia malayi conserved hypotetical protein 0.0152 0.1478 0.1406
Brugia malayi nuclear hormone receptor family member odr-7 0.0152 0.1478 0.1406
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0357 0.0392
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0323 0.3683 0.405
Brugia malayi MH2 domain containing protein 0.0116 0.101 0.0934
Brugia malayi hypothetical protein 0.0171 0.1714 0.1644
Echinococcus granulosus carbonic anhydrase 0.0169 0.1695 0.1864
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0366 0.424 0.4445
Schistosoma mansoni hypothetical protein 0.0166 0.1654 0.1743
Echinococcus multilocularis ecdysone induced protein 78C 0.0323 0.3683 0.405
Brugia malayi Peroxidasin 0.0078 0.0516 0.0435
Brugia malayi steroid hormone receptor 0.0323 0.3683 0.3629
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0323 0.3683 0.3629
Schistosoma mansoni coup transcription factor 0.0323 0.3683 0.3994

Activities

Activity type Activity value Assay description Source Reference
CC50 (functional) >= 200 uM Cytotoxic concentration required to inhibit Hel cell growth by using DMSO as solvent ChEMBL. 15993062
clogP = 3.37 Calculated partition coefficient (clogP) ChEMBL. 15993062
EC50 (functional) ND 0 uM Effective concentration required to reduce thymidine kinase-Varicella ChEMBL. 15993062
EC50 (functional) = 0.31 uM Effective concentration required to reduce Varicella ChEMBL. 15993062
EC50 (functional) = 0.33 uM Effective concentration required to reduce Varicella ChEMBL. 15993062
EC50 (functional) >= 80 uM Effective concentration required to reduce thymidine kinase-Varicella ChEMBL. 15993062
MCC (functional) = 80 uM Minimal cytotoxic concentration required to alter microscopically detectable cell morphology ChEMBL. 15993062

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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