Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.1222 | 1 | 0.5 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0692 | 0.1131 | 0.5 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.1222 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0692 | 0.1131 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.1222 | 1 | 0.5 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0692 | 0.1131 | 0.5 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.1222 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1222 | 1 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.1222 | 1 | 0.5 |
Leishmania major | dihydroorotate dehydrogenase | 0.1222 | 1 | 0.5 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1222 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.1222 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.1222 | 1 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.1222 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.1222 | 1 | 0.5 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.1222 | 1 | 0.5 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.1222 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 53.5 % | Percent inhibition of tartrate resistant acid phosphatase positive osteoclast like multinucleated cells formation by 1alpha, 25-dihydroxy vitamin D3 in mouse bone marrow cells | ChEMBL. | 15745811 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.