Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dopamine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Norepinephrine transporter | Starlite/ChEMBL | References |
Rattus norvegicus | Serotonin transporter | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin transporter | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0292 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0133 | 0.3087 | 0.5 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0133 | 0.3087 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0133 | 0.3087 | 0.5 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0292 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0292 | 1 | 1 |
Onchocerca volvulus | 0.0292 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0292 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0133 | 0.3087 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.0292 | 1 | 1 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0292 | 1 | 1 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0292 | 1 | 0.5 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0133 | 0.3087 | 0.5 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0063 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0 | 0.5 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0063 | 0 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.0292 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 4.02 nM | Displacement of [3H]-paroxetine from serotonin transporter of rat cerebral cortex | ChEMBL. | 15686927 |
Ki (binding) | = 4.02 nM | Displacement of [3H]-paroxetine from serotonin transporter of rat cerebral cortex | ChEMBL. | 15686927 |
Ki (binding) | = 183 nM | Displacement of [3H]-GBR-12,935 from dopamine transporter of rat caudate-putamen | ChEMBL. | 15686927 |
Ki (binding) | = 183 nM | Displacement of [3H]-GBR-12,935 from dopamine transporter of rat caudate-putamen | ChEMBL. | 15686927 |
Ki (binding) | > 10000 nM | Displacement of [3H]-nisoxetine from norepinephrine transporter of rat cerebral cortex | ChEMBL. | 15686927 |
Ki (binding) | > 10000 nM | Displacement of [3H]-nisoxetine from norepinephrine transporter of rat cerebral cortex | ChEMBL. | 15686927 |
Ratio (binding) | = 46 | Selectivity for inhibition of serotinin and dopamine transporters | ChEMBL. | 15686927 |
Ratio (binding) | > 2488 | Selectivity for inhibition of serotinin and norepinephrin transporters | ChEMBL. | 15686927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.