Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphorylase, glycogen, liver | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Glycogen phosphorylase | 0.013 | 0.0522 | 0.5 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.013 | 0.0522 | 0.0522 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.013 | 0.0522 | 0.0522 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0507 | 0.2504 | 0.2504 |
Echinococcus granulosus | twitchin | 0.0039 | 0.0042 | 0.0042 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.0522 | 0.5 |
Echinococcus multilocularis | roundabout 2 | 0.0049 | 0.0095 | 0.0095 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1931 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0779 | 0.3938 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.1931 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.0522 | 1 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0041 | 0.0054 | 0.0054 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1931 | 1 | 1 |
Echinococcus granulosus | roundabout 2 | 0.0049 | 0.0095 | 0.0095 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.013 | 0.0522 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.0522 | 0.0522 |
Brugia malayi | Dihydrofolate reductase | 0.1931 | 1 | 1 |
Brugia malayi | carbohydrate phosphorylase | 0.013 | 0.0522 | 0.0522 |
Echinococcus multilocularis | glycogen phosphorylase | 0.013 | 0.0522 | 0.0522 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0779 | 0.3938 | 0.5 |
Onchocerca volvulus | 0.0463 | 0.2271 | 0.9685 | |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1931 | 1 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0779 | 0.3938 | 0.5 |
Schistosoma mansoni | nephrin | 0.0039 | 0.0042 | 0.0042 |
Echinococcus granulosus | neuroglian | 0.0039 | 0.0042 | 0.0042 |
Schistosoma mansoni | glycogen phosphorylase | 0.0056 | 0.0133 | 0.0133 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0507 | 0.2504 | 0.2504 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1931 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0054 | 0.0054 |
Schistosoma mansoni | dihydrofolate reductase | 0.1931 | 1 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.013 | 0.0522 | 1 |
Schistosoma mansoni | cell adhesion molecule | 0.0041 | 0.0054 | 0.0054 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.0522 | 0.0522 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0779 | 0.3938 | 0.5 |
Echinococcus multilocularis | neuroglian | 0.0039 | 0.0042 | 0.0042 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.0522 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0095 | 0.0095 |
Schistosoma mansoni | glycogen phosphorylase | 0.013 | 0.0522 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0095 | 0.0095 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.013 | 0.0522 | 0.0522 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1931 | 1 | 1 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1931 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.013 | 0.0522 | 0.0522 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0779 | 0.3938 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0779 | 0.3938 | 0.5 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0474 | 0.2328 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 uM | Inhibitory concentration against human SK-Hep-1 cells (hepatoma cell line); ND=Not determined | ChEMBL. | 15603973 |
IC50 (binding) | = 0.34 uM | Inhibitory concentration against glycogen phosphorylase | ChEMBL. | 15603973 |
IC50 (binding) | = 0.34 uM | Inhibitory concentration against glycogen phosphorylase | ChEMBL. | 15603973 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.