Detailed information for compound 316469

Basic information

Technical information
  • TDR Targets ID: 316469
  • Name: (2S)-2-[benzenesulfonyl(2-methylpropyl)amino] -6-(9H-fluoren-9-ylmethoxycarbonylamino)hexan oic acid
  • MW: 564.692 | Formula: C31H36N2O6S
  • H donors: 2 H acceptors: 5 LogP: 5.93 Rotable bonds: 15
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(OCC1c2ccccc2c2c1cccc2)NCCCC[C@H](N(S(=O)(=O)c1ccccc1)CC(C)C)C(=O)O
  • InChi: 1S/C31H36N2O6S/c1-22(2)20-33(40(37,38)23-12-4-3-5-13-23)29(30(34)35)18-10-11-19-32-31(36)39-21-28-26-16-8-6-14-24(26)25-15-7-9-17-27(25)28/h3-9,12-17,22,28-29H,10-11,18-21H2,1-2H3,(H,32,36)(H,34,35)/t29-/m0/s1
  • InChiKey: WFVLXAJTZZDGIZ-LJAQVGFWSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (2S)-2-[benzenesulfonyl(isobutyl)amino]-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
  • (2S)-2-[benzenesulfonyl(isobutyl)amino]-6-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]hexanoic acid
  • (2S)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-methylpropyl(phenylsulfonyl)amino]hexanoic acid
  • (2S)-2-[besyl(isobutyl)amino]-6-(9H-fluoren-9-ylmethoxycarbonylamino)hexanoic acid
  • (2S)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(2-methylpropyl-phenylsulfonylamino)hexanoic acid
  • (2S)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(isobutyl-phenylsulfonyl-amino)hexanoic acid
  • (2S)-6-[(9H-fluoren-9-ylmethoxy-oxomethyl)amino]-2-(isobutyl-phenylsulfonylamino)hexanoic acid
  • (2S)-6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-(2-methylpropyl-phenylsulfonyl-amino)hexanoic acid
  • AIDS225369
  • L-Lysine, N6-[(9H-fluoren-9-ylmethoxy)carbonyl]-N2-(phenylsulfonyl)-N2-(2-methylpropyl)-
  • AIDS-225369

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0112 0.0567 0.0851
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.015 0.0212
Loa Loa (eye worm) hypothetical protein 0.0112 0.0567 0.0851
Echinococcus multilocularis tar DNA binding protein 0.0066 0.0268 0.0262
Echinococcus granulosus FTZ F1 alpha 0.0112 0.0567 0.0551
Loa Loa (eye worm) hypothetical protein 0.0047 0.0143 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0268 0.0268
Onchocerca volvulus Bile acid receptor homolog 0.0112 0.0567 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Loa Loa (eye worm) hypothetical protein 0.0059 0.0224 0.0327
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0112 0.0567 0.0851
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0183 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0112 0.0567 0.0851
Loa Loa (eye worm) RNA binding protein 0.0066 0.0268 0.0394
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Echinococcus multilocularis thyroid hormone receptor alpha 0.0112 0.0567 0.0573
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0183 0.0173
Brugia malayi Nuclear hormone receptor-like 1 0.0112 0.0567 0.0851
Loa Loa (eye worm) hypothetical protein 0.0112 0.0567 0.0851
Echinococcus multilocularis transcription factor Dp 1 0.0599 0.3719 0.3856
Loa Loa (eye worm) DR-78 0.0053 0.0183 0.0264
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0053 1
Schistosoma mansoni zinc finger protein 0.0053 0.0183 0.0183
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.0224 0.0327
Echinococcus multilocularis FTZ F1 alpha 0.0112 0.0567 0.0573
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0112 0.0567 0.0551
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Brugia malayi photoreceptor-specific nuclear receptor 0.0112 0.0567 0.0851
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0112 0.0567 0.0567
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.015 0.0212
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0112 0.0567 0.0851
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0143 0.0202
Schistosoma mansoni thyroid hormone receptor 0.0112 0.0567 0.0567
Brugia malayi tailless protein 0.0053 0.0183 0.0264
Schistosoma mansoni nuclear receptor 0.0053 0.0183 0.0183
Entamoeba histolytica hypothetical protein 0.0037 0.0084 0.0103
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0084 0.0067
Echinococcus multilocularis dna polymerase eta 0.0047 0.0143 0.0132
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1035 0.654 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0112 0.0567 0.0851
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0112 0.0567 0.0851
Brugia malayi nuclear hormone receptor family member nhr-6 0.0053 0.0183 0.0264
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.1035 0.654 0.6795
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0112 0.0567 0.0573
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0112 0.0567 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0112 0.0567 0.0573
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0112 0.0567 0.0851
Loa Loa (eye worm) hypothetical protein 0.0112 0.0567 0.0851
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0053 0.0183 0.0264
Schistosoma mansoni steroid hormone receptor ad4bp 0.0112 0.0567 0.0567
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0084 0.0084
Brugia malayi hypothetical protein 0.0053 0.0183 0.0264
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.1035 0.654 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0268 0.0268
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0053 0.0183 0.0167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0112 0.0567 0.0567
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0183 0.0167
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0183 0.0264
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0059 0.0224 0.0216
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.164 0.164
Entamoeba histolytica hypothetical protein 0.0037 0.0084 0.0103
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0112 0.0567 0.0851
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.015 0.015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0112 0.0567 0.0851
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0112 0.0567 0.0851
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.015 0.0138
Schistosoma mansoni hypothetical protein 0.0176 0.0984 0.0984
Loa Loa (eye worm) TAR-binding protein 0.0066 0.0268 0.0394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0112 0.0567 0.0851
Loa Loa (eye worm) hypothetical protein 0.0059 0.0224 0.0327
Echinococcus granulosus ecdysone induced protein 78C 0.0112 0.0567 0.0551
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0112 0.0567 0.0573
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.1035 0.654 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0112 0.0567 0.0851
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0112 0.0567 0.0551
Brugia malayi nuclear receptor NHR-67 0.0053 0.0183 0.0264
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0183 0.0167
Brugia malayi Steroid receptor seven-up type 2 0.0112 0.0567 0.0851
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0112 0.0567 0.0551
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0112 0.0567 0.0567
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0112 0.0567 0.0851
Schistosoma mansoni nuclear receptor 0.0053 0.0183 0.0183
Loa Loa (eye worm) nuclear receptor NHR-67 0.0053 0.0183 0.0264
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.1035 0.654 0.6534
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0017 0.5
Brugia malayi RNA binding protein 0.0066 0.0268 0.0394
Schistosoma mansoni RAR-like nuclear receptor 0.0112 0.0567 0.0567
Brugia malayi nuclear hormone receptor family member odr-7 0.0053 0.0183 0.0264
Brugia malayi conserved hypotetical protein 0.0053 0.0183 0.0264
Onchocerca volvulus Protein ultraspiracle homolog 0.0112 0.0567 1
Echinococcus granulosus dna polymerase eta 0.0047 0.0143 0.0127
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0059 0.0224 0.0208
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Loa Loa (eye worm) hypothetical protein 0.0059 0.0224 0.0327
Echinococcus multilocularis ecdysone induced protein 78C 0.0112 0.0567 0.0573
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.0268 0.0394
Brugia malayi nuclear receptor NHR-88 0.0053 0.0183 0.0264
Echinococcus multilocularis nuclear receptor nhr 48 0.0053 0.0183 0.0173
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0112 0.0567 0.0573
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0059 0.0224 0.0224
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.1035 0.654 0.654
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0112 0.0567 0.0851
Onchocerca volvulus 0.0112 0.0567 1
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0017 0.1335
Loa Loa (eye worm) hypothetical protein 0.0059 0.0224 0.0327
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.015 0.015
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.1035 0.654 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.015 0.0133
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0017 0.0009
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0143 0.0202
Brugia malayi hypothetical protein 0.0053 0.0183 0.0264
Schistosoma mansoni thyroid hormone receptor 0.0112 0.0567 0.0567
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0268 0.0268
Loa Loa (eye worm) nuclear hormone receptor 0.0053 0.0183 0.0264
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0112 0.0567 0.0851
Echinococcus granulosus thyroid hormone receptor alpha 0.0053 0.0183 0.0167
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0112 0.0567 0.0567
Loa Loa (eye worm) hypothetical protein 0.0112 0.0567 0.0851
Trypanosoma brucei DNA polymerase eta, putative 0.0047 0.0143 0.0202
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0053 0.0183 0.0183
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0059 0.0224 0.0224
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0112 0.0567 0.0851
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0059 0.0224 0.0327
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0112 0.0567 0.0851
Trypanosoma cruzi DNA polymerase eta, putative 0.0033 0.0053 0.0065
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0053 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Loa Loa (eye worm) hypothetical protein 0.0112 0.0567 0.0851
Brugia malayi nuclear receptor NHR-88 0.0112 0.0567 0.0851
Brugia malayi ecdysone receptor 0.0053 0.0183 0.0264
Schistosoma mansoni DNA polymerase eta 0.0047 0.0143 0.0143
Echinococcus multilocularis geminin 0.0176 0.0984 0.1007
Echinococcus granulosus geminin 0.0176 0.0984 0.0969
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0084 0.007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0112 0.0567 0.0851
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1035 0.654 1
Brugia malayi Nuclear hormone receptor E75 0.0053 0.0183 0.0264
Entamoeba histolytica hypothetical protein 0.0037 0.0084 0.0103
Echinococcus granulosus nuclear receptor nhr 48 0.0053 0.0183 0.0167
Loa Loa (eye worm) hypothetical protein 0.0112 0.0567 0.0851
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0112 0.0567 0.0573
Brugia malayi TAR-binding protein 0.0066 0.0268 0.0394
Brugia malayi hypothetical protein 0.0059 0.0224 0.0327
Schistosoma mansoni nuclear hormone receptor 0.0112 0.0567 0.0567
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0112 0.0567 0.0567
Schistosoma mansoni coup transcription factor 0.0112 0.0567 0.0567
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0112 0.0567 0.0551
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0183 0.0183
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0112 0.0567 0.0573
Brugia malayi hypothetical protein 0.0037 0.0084 0.0111
Brugia malayi Flap endonuclease-1 0.0027 0.0017 0.0009
Brugia malayi Nuclear hormone receptor-like 1 0.0059 0.0224 0.0327
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0017 0.0009
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.1035 0.654 1
Plasmodium falciparum flap endonuclease 1 0.0027 0.0017 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0017 0.5
Brugia malayi orphan nuclear receptor NR2E1 0.0053 0.0183 0.0264
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.015 0.015
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0112 0.0567 0.0851
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0268 0.0268
Leishmania major DNA polymerase eta, putative 0.0047 0.0143 0.0202
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0053 0.0183 0.0264
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0112 0.0567 0.0551
Schistosoma mansoni nuclear receptor nhr-48 0.0053 0.0183 0.0183
Brugia malayi hypothetical protein 0.0059 0.0224 0.0327
Brugia malayi nuclear hormone receptor 0.0112 0.0567 0.0851
Echinococcus granulosus Nuclear hormone receptor HR96 0.0053 0.0183 0.0167
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0112 0.0567 0.0551
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.015 0.0138
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.9733 0.9733
Loa Loa (eye worm) hypothetical protein 0.0112 0.0567 0.0851
Schistosoma mansoni tar DNA-binding protein 0.0066 0.0268 0.0268
Schistosoma mansoni hypothetical protein 0.0037 0.0084 0.0084
Brugia malayi nuclear receptor RXR 0.0059 0.0224 0.0327
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0183 0.0173
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.151 0.9617 1
Loa Loa (eye worm) hypothetical protein 0.0112 0.0567 0.0851
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0017 0.0009
Echinococcus granulosus tar DNA binding protein 0.0066 0.0268 0.0252
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0053 0.0183 0.0173
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Schistosoma mansoni retinoic acid receptor RXR 0.1569 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.015 0.0133
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.0268 0.0394
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0053 0.0183 0.0173
Loa Loa (eye worm) hypothetical protein 0.0059 0.0224 0.0327
Schistosoma mansoni hypothetical protein 0.0176 0.0984 0.0984
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Leishmania major DNA polymerase eta, putative 0.0033 0.0053 0.0065
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0017 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0112 0.0567 0.0851
Brugia malayi nuclear hormone receptor 0.0053 0.0183 0.0264
Entamoeba histolytica hypothetical protein 0.0037 0.0084 0.0103
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0264
Loa Loa (eye worm) steroid hormone receptor 0.0112 0.0567 0.0851
Brugia malayi nuclear receptor RXR 0.0053 0.0183 0.0264
Brugia malayi ecdysteroid receptor 0.0112 0.0567 0.0851
Brugia malayi steroid hormone receptor 0.0112 0.0567 0.0851
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0112 0.0567 0.0567
Echinococcus granulosus transcription factor Dp 1 0.0599 0.3719 0.3708
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.1035 0.654 1

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 18.7 nM Binding affinfity against human immunodeficiency virus (HIV) protease ChEMBL. 15713418
Ki (binding) = 18.7 nM Binding affinfity against human immunodeficiency virus (HIV) protease ChEMBL. 15713418

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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