Detailed information for compound 316699

Basic information

Technical information
  • TDR Targets ID: 316699
  • Name: methyl 4-(3-hydroxyanilino)-5-methylpyrrolo[2 ,1-f][1,2,4]triazine-6-carboxylate
  • MW: 298.297 | Formula: C15H14N4O3
  • H donors: 2 H acceptors: 4 LogP: 2.15 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cn2c(c1C)c(ncn2)Nc1cccc(c1)O
  • InChi: 1S/C15H14N4O3/c1-9-12(15(21)22-2)7-19-13(9)14(16-8-17-19)18-10-4-3-5-11(20)6-10/h3-8,20H,1-2H3,(H,16,17,18)
  • InChiKey: HDUYYHXMLYTCAI-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl 4-(3-hydroxyanilino)-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
  • 4-(3-hydroxyanilino)-5-methyl-6-pyrrolo[2,1-f][1,2,4]triazinecarboxylic acid methyl ester
  • methyl 4-[(3-hydroxyphenyl)amino]-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
  • 4-(3-hydroxyanilino)-5-methyl-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester
  • methyl 4-[(3-hydroxyphenyl)amino]-5-methylpyrrolo[5,1-f][1,2,4]triazine-6-carboxylate
  • methyl 4-[(3-hydroxyphenyl)amino]-5-methyl-pyrrolo[5,1-f][1,2,4]triazine-6-carboxylate
  • 4-[(3-hydroxyphenyl)amino]-5-methyl-6-pyrrolo[5,1-f][1,2,4]triazinecarboxylic acid methyl ester
  • 4-[(3-hydroxyphenyl)amino]-5-methyl-pyrrolo[5,1-f][1,2,4]triazine-6-carboxylic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens kinase insert domain receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Immunoglobulin I-set domain containing protein Get druggable targets OG5_130320 All targets in OG5_130320
Loa Loa (eye worm) TK/KIN16 protein kinase Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Get druggable targets OG5_130320 All targets in OG5_130320
Onchocerca volvulus Tyrosine kinase homolog Get druggable targets OG5_130320 All targets in OG5_130320
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0033 0.0204 0.0182
Echinococcus multilocularis FTZ F1 alpha 0.0069 0.0586 0.06
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0927 0.9552 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0069 0.0586 0.0577
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0586 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0069 0.0586 0.0583
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0132 0.0074
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0188 1
Echinococcus multilocularis transcription factor Dp 1 0.0537 0.5471 0.5684
Brugia malayi hypothetical protein 0.0037 0.0245 0.0225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Onchocerca volvulus 0.0167 0.1604 0.9718
Echinococcus multilocularis dna polymerase eta 0.0044 0.0326 0.0329
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0586 0.0583
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0336 0.034
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0132 0.0074
Loa Loa (eye worm) hypothetical protein 0.0069 0.0586 0.0596
Leishmania major DNA polymerase eta, putative 0.0044 0.0326 0.0278
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0132 0.0119
Loa Loa (eye worm) nuclear receptor NHR-67 0.0033 0.0204 0.0195
Leishmania major hypothetical protein, conserved 0.0025 0.0123 0.0064
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0069 0.0586 0.0577
Loa Loa (eye worm) hypothetical protein 0.0069 0.0586 0.0596
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.0065
Schistosoma mansoni RAR-like nuclear receptor 0.0069 0.0586 0.0577
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0033 0.0204 0.0195
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0069 0.0586 0.06
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0586 0.06
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0062 0.0055
Plasmodium falciparum flap endonuclease 1 0.0026 0.0132 1
Brugia malayi conserved hypotetical protein 0.0033 0.0204 0.0182
Onchocerca volvulus Tyrosine kinase homolog 0.0171 0.1645 1
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0183 0.1771 0.1838
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0509
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0033 0.0204 0.0182
Entamoeba histolytica hypothetical protein 0.0036 0.0235 0.0182
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0069 0.0586 0.0596
Onchocerca volvulus 0.0069 0.0586 0.2653
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Brugia malayi nuclear receptor RXR 0.0033 0.0204 0.0182
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0062 0.0033
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0235 0.0225
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0132 0.0127
Loa Loa (eye worm) hypothetical protein 0.0069 0.0586 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0069 0.0586 0.0583
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0132 0.1335
Loa Loa (eye worm) DR-78 0.0033 0.0204 0.0195
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0933 0.9618 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0586 0.0596
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0132 0.0074
Schistosoma mansoni hypothetical protein 0.0168 0.1617 0.1609
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0927 0.9552 0.9932
Schistosoma mansoni thyroid hormone receptor 0.0069 0.0586 0.0577
Leishmania major DNA polymerase eta, putative 0.0031 0.0188 0.0133
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0069 0.0586 0.0577
Schistosoma mansoni cell adhesion molecule 0.0015 0.0018 0.0008
Schistosoma mansoni coup transcription factor 0.0069 0.0586 0.0577
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0204 0.0182
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0509
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0069 0.0586 0.0583
Loa Loa (eye worm) RNA binding protein 0.0063 0.0518 0.0525
Schistosoma mansoni nuclear hormone receptor 0.0069 0.0586 0.0577
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0055
Loa Loa (eye worm) hypothetical protein 0.0069 0.0586 0.0596
Brugia malayi hypothetical protein 0.0037 0.0245 0.0225
Entamoeba histolytica hypothetical protein 0.0036 0.0235 0.0182
Echinococcus multilocularis roundabout 2 0.0018 0.0048 0.004
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0069 0.0586 0.06
Echinococcus multilocularis thyroid hormone receptor alpha 0.0069 0.0586 0.06
Onchocerca volvulus Protein ultraspiracle homolog 0.0069 0.0586 0.2653
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0033 0.0204 0.0194
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0336 0.0327
Loa Loa (eye worm) nuclear hormone receptor 0.0033 0.0204 0.0195
Echinococcus granulosus roundabout 2 0.0018 0.0048 0.0038
Entamoeba histolytica hypothetical protein 0.0036 0.0235 0.0182
Entamoeba histolytica hypothetical protein 0.0036 0.0235 0.0182
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0069 0.0586 0.06
Echinococcus granulosus tar DNA binding protein 0.0063 0.0518 0.0509
Loa Loa (eye worm) hypothetical protein 0.0025 0.0123 0.011
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0033 0.0204 0.0194
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0245 0.0225
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0132 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0518 0.0529
Schistosoma mansoni hypothetical protein 0.0036 0.0235 0.0225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Brugia malayi ecdysone receptor 0.0033 0.0204 0.0182
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0132 1
Loa Loa (eye worm) hypothetical protein 0.0069 0.0586 0.0596
Brugia malayi TAR-binding protein 0.0063 0.0518 0.0512
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0927 0.9552 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Brugia malayi nuclear receptor RXR 0.0037 0.0245 0.0225
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0069 0.0586 0.0596
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0123 0.0064
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0927 0.9552 1
Loa Loa (eye worm) steroid hormone receptor 0.0069 0.0586 0.0596
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0927 0.9552 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Loa Loa (eye worm) hypothetical protein 0.0069 0.0586 0.0596
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0509
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0062 0.0046
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0069 0.0586 0.0577
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0062 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0069 0.0586 0.06
Brugia malayi RNA binding protein 0.0063 0.0518 0.0512
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0586 0.0583
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0069 0.0586 0.0596
Brugia malayi photoreceptor-specific nuclear receptor 0.0069 0.0586 0.0583
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.0065
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0069 0.0586 0.0596
Brugia malayi nuclear receptor NHR-88 0.0033 0.0204 0.0182
Brugia malayi nuclear hormone receptor 0.0069 0.0586 0.0583
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0062 0.5
Schistosoma mansoni nuclear receptor 0.0033 0.0204 0.0194
Brugia malayi nuclear receptor NHR-88 0.0069 0.0586 0.0583
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0204 0.0194
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0927 0.9552 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0037 0.0245 0.0238
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0518 0.0525
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0518 0.0512
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0069 0.0586 0.0577
Brugia malayi nuclear hormone receptor family member nhr-6 0.0033 0.0204 0.0182
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Brugia malayi Immunoglobulin I-set domain containing protein 0.0183 0.1771 0.1828
Brugia malayi nuclear hormone receptor family member odr-7 0.0033 0.0204 0.0182
Brugia malayi nuclear receptor NHR-67 0.0033 0.0204 0.0182
Schistosoma mansoni zinc finger protein 0.0033 0.0204 0.0194
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0069 0.0586 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0069 0.0586 0.0583
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0037 0.0245 0.0235
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0037 0.0245 0.0235
Brugia malayi hypothetical protein 0.0036 0.0235 0.0214
Schistosoma mansoni DNA polymerase eta 0.0044 0.0326 0.0316
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0069 0.0586 0.0577
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0069 0.0586 0.0596
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0069 0.0586 0.0583
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0069 0.0586 0.0577
Brugia malayi ecdysteroid receptor 0.0069 0.0586 0.0583
Brugia malayi hypothetical protein 0.0025 0.0123 0.0097
Schistosoma mansoni steroid hormone receptor ad4bp 0.0069 0.0586 0.0577
Echinococcus granulosus geminin 0.0168 0.1617 0.1609
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0927 0.9552 0.9552
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0037 0.0245 0.0235
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0188 0.0133
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0069 0.0586 0.0596
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0927 0.9552 0.9552
Brugia malayi Nuclear hormone receptor-like 1 0.0069 0.0586 0.0583
Schistosoma mansoni flap endonuclease-1 0.0023 0.0106 0.0096
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0336 0.032
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0132 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0586 0.0583
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Echinococcus multilocularis nuclear receptor nhr 48 0.0033 0.0204 0.0202
Echinococcus granulosus thyroid hormone receptor alpha 0.0033 0.0204 0.0194
Schistosoma mansoni nuclear hormone receptor 0.0033 0.0204 0.0194
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0518 0.0525
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0509
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0336 0.0333
Loa Loa (eye worm) hypothetical protein 0.0018 0.0048 0.0031
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0927 0.9552 1
Onchocerca volvulus Bile acid receptor homolog 0.0069 0.0586 0.2653
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0069 0.0586 0.0583
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0235 0.0234
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0204 0.0194
Echinococcus granulosus ecdysone induced protein 78C 0.0069 0.0586 0.0577
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0123 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0069 0.0586 0.0596
Brugia malayi Flap endonuclease-1 0.0026 0.0132 0.0106
Loa Loa (eye worm) hypothetical protein 0.0033 0.0204 0.0195
Echinococcus granulosus transcription factor Dp 1 0.0537 0.5471 0.5467
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0033 0.0204 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0033 0.0204 0.0202
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0336 0.0327
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0069 0.0586 0.06
Echinococcus granulosus Nuclear hormone receptor HR96 0.0033 0.0204 0.0194
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0069 0.0586 0.0583
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0927 0.9552 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0204 0.0202
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0069 0.0586 0.0577
Echinococcus granulosus nuclear receptor nhr 48 0.0033 0.0204 0.0194
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0069 0.0586 0.0577
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0062 0.0065
Echinococcus multilocularis geminin 0.0168 0.1617 0.1673
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0069 0.0586 0.0583
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0062 0.5
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0062 0.0052
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0037 0.0245 0.0245
Schistosoma mansoni retinoic acid receptor RXR 0.097 1 1
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0132 1
Echinococcus granulosus dna polymerase eta 0.0044 0.0326 0.0316
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0018 0.0008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0235 0.0225
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0336 0.0327
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0062 0.0052
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0069 0.0586 0.0577
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0336 0.0327
Brugia malayi hypothetical protein 0.0033 0.0204 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0326 0.0341
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0238
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0062 0.0052
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0123 0.0129
Schistosoma mansoni hypothetical protein 0.0168 0.1617 0.1609
Brugia malayi orphan nuclear receptor NR2E1 0.0033 0.0204 0.0182
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Loa Loa (eye worm) hypothetical protein 0.0044 0.0326 0.0323
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0336 0.034
Brugia malayi Steroid receptor seven-up type 2 0.0069 0.0586 0.0583
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0238
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0033 0.0204 0.0202
Loa Loa (eye worm) hypothetical protein 0.0069 0.0586 0.0596
Brugia malayi Nuclear hormone receptor E75 0.0033 0.0204 0.0182
Echinococcus granulosus flap endonuclease 1 0.0026 0.0132 0.0122
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0069 0.0586 0.0583
Echinococcus granulosus FTZ F1 alpha 0.0069 0.0586 0.0577
Echinococcus multilocularis ecdysone induced protein 78C 0.0069 0.0586 0.06
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0238
Loa Loa (eye worm) hypothetical protein 0.0037 0.0245 0.0238
Echinococcus granulosus dna polymerase kappa 0.0019 0.0062 0.0052
Brugia malayi Nuclear hormone receptor-like 1 0.0037 0.0245 0.0225
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0033 0.0204 0.0194
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0326 0.031
Schistosoma mansoni nuclear receptor 0.0033 0.0204 0.0194
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0033 0.0204 0.0202
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0336 0.0327
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0062 0.0065
Brugia malayi steroid hormone receptor 0.0069 0.0586 0.0583
Schistosoma mansoni nuclear receptor nhr-48 0.0033 0.0204 0.0194
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0326 0.0278
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0518 0.0509
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0062 0.5
Brugia malayi nuclear hormone receptor 0.0033 0.0204 0.0182
Schistosoma mansoni thyroid hormone receptor 0.0069 0.0586 0.0577
Brugia malayi tailless protein 0.0033 0.0204 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0069 0.0586 0.0583
Trypanosoma brucei unspecified product 0.0019 0.0062 0.0065
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0069 0.0586 0.2653

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 61 nM Inhibitory concentration against Vascular endothelial growth factor receptor 2 ChEMBL. 15713401
IC50 (binding) = 61 nM Inhibitory concentration against Vascular endothelial growth factor receptor 2 ChEMBL. 15713401

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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