Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin A1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0422 | 0.4508 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.037 | 0.3914 | 0.8664 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0422 | 0.4508 | 1 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.037 | 0.3914 | 0.3914 |
Trichomonas vaginalis | cyclin B, putative | 0.0051 | 0.0247 | 0.0421 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.037 | 0.3914 | 0.376 |
Trichomonas vaginalis | cyclins, putative | 0.0051 | 0.0247 | 0.0421 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.037 | 0.3914 | 0.376 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0899 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0247 | 0.0247 |
Echinococcus granulosus | Protein patched homolog 1 | 0.037 | 0.3914 | 0.376 |
Echinococcus multilocularis | protein patched | 0.037 | 0.3914 | 0.376 |
Trichomonas vaginalis | cyclin B, putative | 0.0051 | 0.0247 | 0.0421 |
Echinococcus multilocularis | protein dispatched 1 | 0.037 | 0.3914 | 0.376 |
Entamoeba histolytica | cyclin, putative | 0.0051 | 0.0247 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0247 | 0.0247 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0899 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0899 | 1 | 1 |
Trichomonas vaginalis | cyclin B, putative | 0.0051 | 0.0247 | 0.0421 |
Schistosoma mansoni | patched 1 | 0.037 | 0.3914 | 0.376 |
Trichomonas vaginalis | cyclins, putative | 0.0051 | 0.0247 | 0.0421 |
Trichomonas vaginalis | cyclins, putative | 0.0051 | 0.0247 | 0.0421 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0899 | 1 | 1 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.037 | 0.3914 | 0.376 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0899 | 1 | 1 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.037 | 0.3914 | 0.376 |
Loa Loa (eye worm) | hypothetical protein | 0.0899 | 1 | 1 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0899 | 1 | 1 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0899 | 1 | 1 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0422 | 0.4508 | 1 |
Onchocerca volvulus | 0.0051 | 0.0247 | 0.5 | |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.037 | 0.3914 | 0.376 |
Loa Loa (eye worm) | hypothetical protein | 0.037 | 0.3914 | 0.3914 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0899 | 1 | 1 |
Brugia malayi | CHE-14 protein | 0.037 | 0.3914 | 0.376 |
Trichomonas vaginalis | cyclin A, putative | 0.0051 | 0.0247 | 0.0421 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0422 | 0.4508 | 1 |
Trichomonas vaginalis | cyclins, putative | 0.0051 | 0.0247 | 0.0421 |
Trichomonas vaginalis | cyclin B, putative | 0.0051 | 0.0247 | 0.0421 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.