Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.9658 | 0.9658 |
Echinococcus granulosus | lamin | 0.0028 | 1 | 1 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 0.5 |
Schistosoma mansoni | lamin | 0.0028 | 1 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0028 | 1 | 1 |
Echinococcus multilocularis | musashi | 0.0028 | 1 | 1 |
Echinococcus granulosus | lamin dm0 | 0.0028 | 1 | 1 |
Echinococcus multilocularis | lamin dm0 | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0013 | 0.0342 | 0.0342 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0015 | 0.1333 | 0.1333 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 1 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0028 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 1 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0028 | 1 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0028 | 1 | 1 |
Onchocerca volvulus | 0.0028 | 1 | 0.5 | |
Onchocerca volvulus | 0.0028 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 1.4 uM | Inhibitory concentration was measured against growth hormone secretagogue receptor | ChEMBL. | 15780615 |
IC50 (binding) | = 5.6 uM | Inhibitory concentration was measured against growth hormone secretagogue receptor using cellular function assay with fluorescent calcium indicator | ChEMBL. | 15780615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.