Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A2b receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.1144 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1144 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.1144 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.1144 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1144 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.1144 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.1144 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.1144 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.1144 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1144 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.1144 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.1144 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | > 2000 nM | Binding affinity for adenosine A2b receptor by using as [3H]-ZM-241,385 (14 nM) radioligand in membranes from HEK-A2B cells | ChEMBL. | 15664822 |
Ki (binding) | > 2000 nM | Binding affinity for adenosine A2b receptor by using as [3H]-ZM-241,385 (14 nM) radioligand in membranes from HEK-A2B cells | ChEMBL. | 15664822 |
Ki (binding) | > 5000 nM | Binding affinity for adenosine A2a receptor by using as [3H]-ZM-241,385 (2 nM) radioligand in membranes from HEK-A2A cells | ChEMBL. | 15664822 |
Ki (binding) | > 5000 nM | Binding affinity for adenosine A2a receptor by using as [3H]-ZM-241,385 (2 nM) radioligand in membranes from HEK-A2A cells | ChEMBL. | 15664822 |
Ki (binding) | > 6000 nM | Binding affinity for adenosine A1 receptor by using as [3H]-CPX (0.5 nM) radioligand in membranes from Chinese hamster ovary cells | ChEMBL. | 15664822 |
Ki (binding) | > 6000 nM | Binding affinity for adenosine A1 receptor by using as [3H]-CPX (0.5 nM) radioligand in membranes from Chinese hamster ovary cells | ChEMBL. | 15664822 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.