Detailed information for compound 317020

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 694.851 | Formula: C40H54O10
  • H donors: 1 H acceptors: 5 LogP: 5.09 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(=O)O[C@@H]1C=C(C)C(C2[C@@]1(C)C1[C@H](OC(=O)C)[C@H](OC(=O)C)[C@@]3(C([C@]1(C)CC2)C=CCOC3)[C@H](OC(=O)C)C)(O)CCCc1ccccc1
  • InChi: 1S/C40H54O10/c1-24-22-33(48-27(4)42)38(8)32(40(24,45)19-12-16-30-14-10-9-11-15-30)18-20-37(7)31-17-13-21-46-23-39(31,25(2)47-26(3)41)36(50-29(6)44)34(35(37)38)49-28(5)43/h9-11,13-15,17,22,25,31-36,45H,12,16,18-21,23H2,1-8H3/t25-,31?,32?,33-,34+,35?,36+,37+,38-,39-,40?/m1/s1
  • InChiKey: AFEGSFWAVVEGCD-CMZXHQBKSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens potassium voltage-gated channel, shaker-related subfamily, member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Potassium voltage-gated channel subfamily A member 5, putative Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum Potassium voltage-gated channel protein Shaker, putative Get druggable targets OG5_127659 All targets in OG5_127659
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma japonicum ko:K04876 potassium voltage-gated channel, Shaker-related subfamily A, member, putative Get druggable targets OG5_127659 All targets in OG5_127659
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus multilocularis potassium voltage gated channel protein Get druggable targets OG5_127659 All targets in OG5_127659
Echinococcus granulosus potassium voltage gated channel subfamily A Get druggable targets OG5_127659 All targets in OG5_127659
Schistosoma mansoni voltage-gated potassium channel Get druggable targets OG5_127659 All targets in OG5_127659
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus shaker cognate potassium voltage-gated channel, shaker-related subfamily, member 3 575 aa 465 aa 34.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0055 0.0379 0.0413
Loa Loa (eye worm) hypothetical protein 0.0153 0.1318 0.189
Brugia malayi glutathione reductase 0.0024 0.0087 0.008
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0766 0.7154 1
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0104 0.0847 0.0817
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0109 0.0305
Leishmania major trypanothione reductase 0.0024 0.0087 0.0345
Mycobacterium tuberculosis Probable hydrolase 0.0029 0.014 0.0074
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0299 0.2705 0.2681
Brugia malayi Receptor family ligand binding region containing protein 0.0153 0.1318 0.189
Mycobacterium tuberculosis Conserved protein 0.0029 0.014 0.0074
Schistosoma mansoni ATP-binding cassette transporter 0.0299 0.2705 0.3929
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0157
Echinococcus multilocularis nmda type glutamate receptor 0.0153 0.1318 0.1289
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0109 0.0305
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0109 0.0431
Entamoeba histolytica hypothetical protein 0.0153 0.1318 0.7648
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.0847 0.1197
Brugia malayi Metabotropic glutamate receptor precursor. 0.0153 0.1318 0.189
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0299 0.2705 0.2681
Loa Loa (eye worm) hypothetical protein 0.0115 0.095 0.1349
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0153 0.1318 0.189
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.014 1
Chlamydia trachomatis dihydrofolate reductase 0.0732 0.6833 0.9545
Trypanosoma cruzi extracellular receptor, putative 0.0153 0.1318 0.5219
Echinococcus multilocularis geminin 0.0393 0.3606 0.3585
Toxoplasma gondii ABC1 family protein 0.0029 0.014 0.0429
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0093 0.0747 0.1051
Loa Loa (eye worm) hypothetical protein 0.0153 0.1318 0.189
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0663 0.6179 0.6166
Schistosoma mansoni survival motor neuron protein 0.0023 0.0082 0.0072
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0153 0.1318 0.189
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.014 1
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0104 0.0847 0.1197
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0029 0.014 0.0074
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0299 0.2705 0.2681
Loa Loa (eye worm) glutamate receptor 0.0153 0.1318 0.189
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0452 0.4164 0.4145
Entamoeba histolytica hypothetical protein 0.0196 0.1723 1
Loa Loa (eye worm) RGC/RGC protein kinase 0.0153 0.1318 0.189
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0452 0.4164 0.4145
Brugia malayi hypothetical protein 0.0196 0.1723 0.2486
Entamoeba histolytica hypothetical protein 0.0026 0.0109 0.0632
Leishmania major hypothetical protein, conserved 0.0029 0.014 0.0553
Brugia malayi Guanylyl cyclase protein 23 0.0153 0.1318 0.189
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0452 0.4164 0.4145
Echinococcus multilocularis glutamate receptor 2 0.0299 0.2705 0.2681
Loa Loa (eye worm) hypothetical protein 0.0124 0.1037 0.1476
Onchocerca volvulus 0.0153 0.1318 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0766 0.7154 1
Schistosoma mansoni glutamate receptor NMDA 0.0299 0.2705 0.3929
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0299 0.2705 0.2681
Entamoeba histolytica hypothetical protein 0.0196 0.1723 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.014 0.0157
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0195 0.1714 0.2472
Schistosoma mansoni hypothetical protein 0.0393 0.3606 0.5255
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.014 0.0553
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0452 0.4164 0.4145
Brugia malayi hypothetical protein 0.0153 0.1318 0.189
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0766 0.7154 1
Schistosoma mansoni hypothetical protein 0.0195 0.1714 0.2472
Echinococcus multilocularis snurportin 1 0.0195 0.1714 0.1687
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0055 0.0379 0.0413
Echinococcus multilocularis beta LACTamase domain containing family member 0.0029 0.014 0.0107
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0766 0.7154 1
Mycobacterium tuberculosis Conserved protein 0.0029 0.014 0.0074
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0061 0.0437 0.0495
Plasmodium vivax glutathione reductase, putative 0.0024 0.0087 0.0217
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.014 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0055 0.0379 0.0413
Brugia malayi Glutamate receptor 2 precursor 0.0299 0.2705 0.3929
Mycobacterium leprae Probable lipase LipE 0.0029 0.014 0.0046
Plasmodium vivax hypothetical protein, conserved 0.0029 0.014 0.0429
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0196 0.1723 0.1696
Schistosoma mansoni glutamate receptor AMPA 0.0299 0.2705 0.3929
Onchocerca volvulus 0.0124 0.1037 0.7725
Echinococcus multilocularis tyrosine kinase 0.0153 0.1318 0.1289
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0029 0.014 0.0074
Echinococcus granulosus glutamate receptor subunit protein glur 0.0299 0.2705 0.2681
Loa Loa (eye worm) beta-lactamase 0.0029 0.014 0.0157
Echinococcus multilocularis L aminoadipate semialdehyde 0.0093 0.0747 0.0717
Brugia malayi dihydrofolate reductase family protein 0.0732 0.6833 1
Loa Loa (eye worm) hypothetical protein 0.0093 0.0747 0.1051
Loa Loa (eye worm) glutamate receptor 1 0.0299 0.2705 0.3929
Echinococcus granulosus thioredoxin glutathione reductase 0.0024 0.009 0.0057
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0196 0.1723 0.1696
Loa Loa (eye worm) hypothetical protein 0.0153 0.1318 0.189
Mycobacterium tuberculosis Probable lipase LipD 0.0029 0.014 0.0074
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0452 0.4164 0.4145
Onchocerca volvulus 0.0029 0.014 0.047
Brugia malayi Glutamate receptor 1 precursor 0.0299 0.2705 0.3929
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0153 0.1318 0.189
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.028 0.2526 1
Schistosoma mansoni metabotropic glutamate receptor 0.0153 0.1318 0.189
Plasmodium falciparum thioredoxin reductase 0.0024 0.0087 0.0217
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0299 0.2705 0.2681
Echinococcus granulosus glutamate receptor 2 0.0153 0.1318 0.1289
Echinococcus granulosus glutamate NMDA receptor subunit 0.0299 0.2705 0.2681
Echinococcus granulosus survival motor neuron protein 1 0.0115 0.095 0.092
Onchocerca volvulus 0.0153 0.1318 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0452 0.4164 0.4145
Leishmania major extracellular receptor, putative 0.0153 0.1318 0.5219
Loa Loa (eye worm) hypothetical protein 0.0153 0.1318 0.189
Echinococcus granulosus metabotropic glutamate receptor 2 0.0153 0.1318 0.1289
Mycobacterium tuberculosis Probable oxidoreductase 0.0061 0.0437 0.0495
Schistosoma mansoni transcription factor LCR-F1 0.0196 0.1723 0.2486
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0732 0.6833 1
Schistosoma mansoni metabotropic glutamate receptor 0.0153 0.1318 0.189
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0299 0.2705 0.2681
Echinococcus granulosus L aminoadipate semialdehyde 0.0093 0.0747 0.0717
Brugia malayi beta-lactamase 0.0029 0.014 0.0157
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0109 0.5
Echinococcus granulosus potassium voltage gated channel protein 0.0104 0.0847 0.0817
Echinococcus multilocularis potassium voltage gated channel protein 0.0104 0.0847 0.0817
Brugia malayi MH2 domain containing protein 0.0151 0.1298 0.186
Plasmodium vivax thioredoxin reductase, putative 0.0024 0.0087 0.0217
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0153 0.1318 0.1289
Brugia malayi beta-lactamase family protein 0.0029 0.014 0.0157
Brugia malayi Receptor family ligand binding region containing protein 0.0153 0.1318 0.189
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0766 0.7154 1
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0299 0.2705 0.2681
Schistosoma mansoni protein kinase 0.0153 0.1318 0.189
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0023 0.0082 0.0072
Loa Loa (eye worm) hypothetical protein 0.0153 0.1318 0.189
Trichomonas vaginalis D-aminoacylase, putative 0.0029 0.014 1
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.1064 1 1
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.028 0.2526 1
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0099 0.0804 0.0773
Loa Loa (eye worm) MH2 domain-containing protein 0.0151 0.1298 0.186
Trichomonas vaginalis esterase, putative 0.0029 0.014 1
Mycobacterium ulcerans lipase LipD 0.0029 0.014 0.0044
Echinococcus granulosus glutamate receptor 2 0.0452 0.4164 0.4145
Echinococcus granulosus receptor type guanylyl cyclase 0.0153 0.1318 0.1289
Echinococcus granulosus dihydrofolate reductase 0.0732 0.6833 0.6823
Echinococcus multilocularis dihydrofolate reductase 0.0732 0.6833 0.6823
Schistosoma mansoni hypothetical protein 0.0299 0.2705 0.3929
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0153 0.1318 1
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.028 0.2526 1
Brugia malayi RNA, U transporter 1 0.0052 0.0353 0.0471
Loa Loa (eye worm) hypothetical protein 0.0153 0.1318 0.189
Trypanosoma brucei trypanothione reductase 0.0024 0.0087 0.0217
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0029 0.014 0.0157
Brugia malayi hypothetical protein 0.0124 0.1037 0.1476
Mycobacterium ulcerans esterase/lipase LipP 0.0029 0.014 0.0044
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0157
Brugia malayi Dihydrofolate reductase 0.0732 0.6833 1
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0153 0.1318 0.189
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0061 0.0437 0.0495
Echinococcus multilocularis NMDA receptor 0.0299 0.2705 0.2681
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0157
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0452 0.4164 0.4145
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0452 0.4164 0.4145
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0109 0.0305
Loa Loa (eye worm) glutamate receptor 2 0.0299 0.2705 0.3929
Mycobacterium tuberculosis Conserved protein 0.0029 0.014 0.0074
Toxoplasma gondii thioredoxin reductase 0.0024 0.0087 0.0217
Onchocerca volvulus 0.0093 0.0747 0.5384
Mycobacterium ulcerans beta-lactamase 0.0029 0.014 0.0044
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0109 0.0305
Mycobacterium ulcerans hypothetical protein 0.0029 0.014 0.0044
Schistosoma mansoni voltage-gated potassium channel 0.0104 0.0847 0.1197
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0153 0.1318 0.1289
Echinococcus multilocularis thioredoxin glutathione reductase 0.0024 0.009 0.0057
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0109 0.0031
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0029 0.014 0.0044
Brugia malayi hypothetical protein 0.0115 0.095 0.1349
Echinococcus multilocularis glutamate receptor 2 0.0452 0.4164 0.4145
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0029 0.014 0.0157
Echinococcus granulosus tyrosine kinase 0.0153 0.1318 0.1289
Echinococcus granulosus beta LACTamase domain containing family member 0.0029 0.014 0.0107
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.028 0.2526 1
Echinococcus multilocularis nmda type glutamate receptor 0.1064 1 1
Loa Loa (eye worm) hypothetical protein 0.0153 0.1318 0.189
Loa Loa (eye worm) RGC/RGC protein kinase 0.0153 0.1318 0.189
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0029 0.014 0.0157
Schistosoma mansoni glutamate receptor NMDA 0.0452 0.4164 0.6075
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0029 0.014 0.0074
Echinococcus granulosus atrial natriuretic peptide receptor 0.0153 0.1318 0.1289
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0093 0.0747 0.1051
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0188 0.1652 0.2214
Echinococcus granulosus metabotropic glutamate receptor 5 0.0153 0.1318 0.1289
Loa Loa (eye worm) hypothetical protein 0.0153 0.1318 0.189
Brugia malayi metabotropic glutamate receptor type 2 0.0153 0.1318 0.189
Echinococcus granulosus snurportin 1 0.0195 0.1714 0.1687
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.028 0.2526 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0732 0.6833 0.9546
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0055 0.0379 0.0402
Mycobacterium tuberculosis Probable esterase LipL 0.0029 0.014 0.0074
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0061 0.0437 0.0488
Echinococcus multilocularis survival motor neuron protein 1 0.0115 0.095 0.092
Mycobacterium leprae conserved hypothetical protein 0.0029 0.014 0.0046
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0732 0.6833 0.9545
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0109 0.0305
Brugia malayi Thioredoxin reductase 0.0024 0.0087 0.008
Entamoeba histolytica hypothetical protein 0.0196 0.1723 1
Mycobacterium tuberculosis Probable lipase LipE 0.0029 0.014 0.0074
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0157
Schistosoma mansoni dihydrofolate reductase 0.0732 0.6833 1
Schistosoma mansoni hypothetical protein 0.0393 0.3606 0.5255
Echinococcus multilocularis receptor type guanylyl cyclase 0.0153 0.1318 0.1289
Schistosoma mansoni hypothetical protein 0.0196 0.1723 0.2486
Schistosoma mansoni tyrosine kinase 0.0153 0.1318 0.189
Entamoeba histolytica hypothetical protein 0.0196 0.1723 1
Schistosoma mansoni glutamate receptor kainate 0.0299 0.2705 0.3929
Loa Loa (eye worm) transcription factor SMAD2 0.0151 0.1298 0.186
Trypanosoma cruzi hypothetical protein, conserved 0.0029 0.014 0.0553
Mycobacterium tuberculosis Probable reductase 0.0055 0.0379 0.0413
Plasmodium falciparum glutathione reductase 0.0024 0.0087 0.0217
Loa Loa (eye worm) dihydrofolate reductase 0.0732 0.6833 1
Schistosoma mansoni glutamate receptor AMPA 0.0299 0.2705 0.3929
Echinococcus multilocularis glutamate receptor 2 0.0153 0.1318 0.1289
Trypanosoma cruzi trypanothione reductase, putative 0.0024 0.0087 0.0345
Echinococcus granulosus nmda type glutamate receptor 0.0153 0.1318 0.1289
Loa Loa (eye worm) glutathione reductase 0.0024 0.0087 0.008
Schistosoma mansoni glutamate receptor kainate 0.0299 0.2705 0.3929
Loa Loa (eye worm) hypothetical protein 0.0153 0.1318 0.189
Chlamydia trachomatis glutamine binding protein 0.0766 0.7154 1
Onchocerca volvulus 0.0029 0.014 0.047
Schistosoma mansoni tyrosine kinase 0.0153 0.1318 0.189
Trichomonas vaginalis penicillin-binding protein, putative 0.0029 0.014 1
Schistosoma mansoni hypothetical protein 0.0023 0.0082 0.0072
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0157
Loa Loa (eye worm) RGC/RGC protein kinase 0.0153 0.1318 0.189
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0055 0.0379 0.0413
Echinococcus granulosus geminin 0.0393 0.3606 0.3585
Onchocerca volvulus 0.0029 0.014 0.047
Loa Loa (eye worm) hypothetical protein 0.0029 0.014 0.0157
Loa Loa (eye worm) thioredoxin reductase 0.0024 0.0087 0.008
Mycobacterium tuberculosis Probable dehydrogenase 0.0055 0.0379 0.0413
Brugia malayi beta-lactamase family protein 0.0029 0.014 0.0157
Schistosoma mansoni glutamate receptor kainate 0.0299 0.2705 0.3929
Leishmania major dihydrofolate reductase-thymidylate synthase 0.028 0.2526 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0847 0.1197
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0153 0.1318 0.1289
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.014 0.0429

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 150 nM Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cells ChEMBL. 15603971
IC50 (functional) = 150 nM Inhibition of voltage-gated potassium channel subunit Kv1.3 in chinese hamster ovary cells ChEMBL. 15603971

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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