Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0062 | 0.0626 | 0.5 | |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0062 | 0.0626 | 0.0626 |
Echinococcus granulosus | carboxylesterase 5A | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0369 | 1 | 1 |
Schistosoma mansoni | acetylcholinesterase | 0.0062 | 0.0626 | 0.0626 |
Schistosoma mansoni | hypothetical protein | 0.0065 | 0.0704 | 0.0704 |
Onchocerca volvulus | 0.0062 | 0.0626 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0626 | 0.0626 |
Echinococcus granulosus | acetylcholinesterase | 0.0369 | 1 | 1 |
Echinococcus multilocularis | small conductance calcium activated potassium | 0.0065 | 0.0704 | 0.0083 |
Schistosoma mansoni | gliotactin | 0.0062 | 0.0626 | 0.0626 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0062 | 0.0626 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0626 | 0.0626 |
Echinococcus granulosus | acetylcholinesterase | 0.0369 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0369 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.0626 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0369 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0062 | 0.0626 | 0.5 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0062 | 0.0626 | 0.0626 |
Loa Loa (eye worm) | carboxylesterase | 0.0369 | 1 | 1 |
Onchocerca volvulus | 0.0062 | 0.0626 | 0.5 | |
Onchocerca volvulus | 0.0062 | 0.0626 | 0.5 | |
Echinococcus multilocularis | carboxylesterase 5A | 0.0369 | 1 | 1 |
Schistosoma mansoni | calcium-activated potassium channel | 0.0065 | 0.0704 | 0.0704 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0062 | 0.0626 | 0.0626 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0062 | 0.0626 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0062 | 0.0626 | 0.5 |
Echinococcus granulosus | small conductance calcium activated potassium | 0.0065 | 0.0704 | 0.0083 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0.0626 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0369 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0704 | 0.0083 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0062 | 0.0626 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0369 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logP (ADMET) | = 2.54 | Partition coefficient (logP) | ChEMBL. | 15664807 |
MIC (functional) | = 50 ug ml-1 | In vitro minimum inhibiting concentration for the development of ring stage parasite into the schizont stage during 40 h incubation | ChEMBL. | 15664807 |
MIC (functional) | = 50 ug ml-1 | In vitro minimum inhibiting concentration for the development of ring stage parasite into the schizont stage during 40 h incubation | ChEMBL. | 15664807 |
PKa (ADMET) | = 3.95 | In vitro PKa value of the compound was determined | ChEMBL. | 15664807 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.