TDR Targets

Basic information

Technical information

TDR Targets ID: 317162
Name: 1-[1-[3-[5-acetyl-3-(4-chloro-3-methylphenyl) -6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]- 2-hydroxypropyl]piperidin-4-yl]-3-propan-2-yl benzimidazol-2-one
MW: 605.17 | Formula: C33H41ClN6O3
H donors: 1 H acceptors: 4 LogP: 3.66 Rotable bonds: 8
Rule of 5 violations (Lipinski): 2
SMILES: OC(Cn1nc(c2c1CCN(C2)C(=O)C)c1ccc(c(c1)C)Cl)CN1CCC(CC1)n1c(=O)n(c2c1cccc2)C(C)C
InChi: 1S/C33H41ClN6O3/c1-21(2)39-30-7-5-6-8-31(30)40(33(39)43)25-11-14-36(15-12-25)18-26(42)19-38-29-13-16-37(23(4)41)20-27(29)32(35-38)24-9-10-28(34)22(3)17-24/h5-10,17,21,25-26,42H,11-16,18-20H2,1-4H3
InChiKey: CBSIMORNOMWZGW-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

1-[1-[3-[5-acetyl-3-(4-chloro-3-methyl-phenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxy-propyl]-4-piperidyl]-3-isopropyl-benzimidazol-2-one
1-[1-[3-[5-acetyl-3-(4-chloro-3-methylphenyl)-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxypropyl]-4-piperidinyl]-3-isopropyl-2-benzimidazolone
1-[1-[3-[3-(4-chloro-3-methyl-phenyl)-5-ethanoyl-6,7-dihydro-4H-pyrazolo[4,3-c]pyridin-1-yl]-2-hydroxy-propyl]piperidin-4-yl]-3-propan-2-yl-benzimidazol-2-one
1-[1-[3-[5-acetyl-3-(4-chloro-3-methylphenyl)-6,7-dihydro-4H-pyrazolo[4,5-c]pyridin-1-yl]-2-hydroxypropyl]piperidin-4-yl]-3-propan-2-ylbenzimidazol-2-one
1-[1-[3-[5-acetyl-3-(4-chloro-3-methyl-phenyl)-6,7-dihydro-4H-pyrazolo[4,5-c]pyridin-1-yl]-2-hydroxy-propyl]-4-piperidyl]-3-isopropyl-benzimidazol-2-one
1-[1-[3-[5-acetyl-3-(4-chloro-3-methylphenyl)-6,7-dihydro-4H-pyrazolo[4,5-c]pyridin-1-yl]-2-hydroxypropyl]-4-piperidinyl]-3-isopropyl-2-benzimidazolone
1-[1-[3-[3-(4-chloro-3-methyl-phenyl)-5-ethanoyl-6,7-dihydro-4H-pyrazolo[4,5-c]pyridin-1-yl]-2-hydroxy-propyl]piperidin-4-yl]-3-propan-2-yl-benzimidazol-2-one

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	cathepsin S	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-4	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium berghei	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium parvum	cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium yoelii	berghepain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Papain family cysteine protease containing protein	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2b	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	ko:K01373 cathepsin F [EC3.4.22.41], putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 3	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	Cathepsin L-like proteinase precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-3	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	fibroinase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin L cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium falciparum	cysteine proteinase falcipain 2a	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania donovani	cysteine peptidase A (CBA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cruzipain precursor, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Toxoplasma gondii	cathepsin CPL	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Neospora caninum	Cathepsin L, related	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium vivax	vivapain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Plasmodium knowlesi	knowpain-2	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin L cysteine protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Cryptosporidium hominis	cryptopain precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Theileria parva	cysteine proteinase	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	ctsf protein	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus granulosus	cathepsin l1	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania infantum	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Entamoeba histolytica	cysteine proteinase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin L homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Schistosoma mansoni	cathepsin F (C01 family)	Get druggable targets OG5_126607	All targets in OG5_126607
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus		Get druggable targets OG5_126607	All targets in OG5_126607
Onchocerca volvulus	Cathepsin F homolog	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei gambiense	cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania braziliensis	cysteine peptidase A (CPA)	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma cruzi	cysteine peptidase, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania major	cathepsin L-like protease	Get druggable targets OG5_126607	All targets in OG5_126607
Echinococcus multilocularis	cathepsin l cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Brugia malayi	Cathepsin L-like precursor	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma congolense	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607
Leishmania mexicana	cathepsin L-like protease, putative	Get druggable targets OG5_126607	All targets in OG5_126607
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	Get druggable targets OG5_126607	All targets in OG5_126607

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Plasmodium falciparum	cysteine proteinase falcipain 1	cathepsin S	281 aa	226 aa	34.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	AGC/AKT protein kinase	0.0067	0.0105	0.0105
Echinococcus granulosus	NCK adaptor protein	0.0102	0.0321	0.0321
Brugia malayi	Carboxylesterase family protein	0.0623	0.3577	0.5161
Onchocerca volvulus		0.0054	0.0022	0.0459
Echinococcus multilocularis	ribosomal protein S6 kinase alpha 3	0.0067	0.0105	0.0105
Echinococcus multilocularis	nmda type glutamate receptor	0.0056	0.0035	0.0035
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0105	0.0344	0.0356
Loa Loa (eye worm)	TK/ROR protein kinase	0.0072	0.0139	0.0139
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Schistosoma mansoni	tyrosine kinase	0.0136	0.0536	0.0554
Schistosoma mansoni	shc transforming protein	0.0051	0.0008	0.0008
Echinococcus multilocularis	NCK adaptor protein	0.0102	0.0321	0.0321
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Schistosoma mansoni	tensin-related	0.0051	0.0008	0.0008
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0105	0.0344	0.0344
Echinococcus granulosus	epidermal growth factor receptor	0.0636	0.366	0.366
Trichomonas vaginalis	CMGC family protein kinase	0.0197	0.0914	0.5048
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0051	0.0008	0.0012
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0051	0.0008	0.0008
Loa Loa (eye worm)	acetylcholinesterase 1	0.0623	0.3577	0.3577
Echinococcus multilocularis	raf serine:threonine protein kinase	0.008	0.0188	0.0188
Brugia malayi	cell division control protein 2 homolog	0.0197	0.0914	0.1319
Echinococcus granulosus	tyrosine protein kinase HCK	0.0256	0.1284	0.1284
Echinococcus granulosus	roundabout 2	0.0079	0.0181	0.0181
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0051	0.0008	0.0008
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0076	0.0159	0.0159
Echinococcus granulosus	signal transduction protein lnk realted	0.0051	0.0008	0.0008
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0422	0.232	0.232
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0357	0.1918	0.1918
Loa Loa (eye worm)	AGC/PKN protein kinase	0.0067	0.0105	0.0105
Brugia malayi	SH2 domain containing protein	0.0051	0.0008	0.0012
Brugia malayi	SH2 domain containing protein	0.0051	0.0008	0.0012
Loa Loa (eye worm)	SH2 domain-containing protein	0.0051	0.0008	0.0008
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.006	0.006	0.0332
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0051	0.0008	0.0008
Leishmania major	phosphatidylinositol 3-kinase, putative	0.006	0.006	0.0658
Schistosoma mansoni	hypothetical protein	0.0051	0.0008	0.0008
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0307	0.1605	0.1605
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0105	0.0344	0.0356
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Brugia malayi	Carboxylesterase family protein	0.0105	0.0344	0.0497
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.1651	1	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0357	0.1918	0.1918
Loa Loa (eye worm)	TK/INSR protein kinase	0.039	0.212	0.212
Schistosoma mansoni	GTPase activating protein	0.0051	0.0008	0.0008
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0357	0.1918	0.1918
Brugia malayi	phosphatidylinositol 4-kinase, catalytic, alpha polypeptide	0.006	0.006	0.0087
Loa Loa (eye worm)	carboxylesterase	0.0105	0.0344	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0193	0.0893	0.0893
Brugia malayi	hypothetical protein	0.0105	0.0344	0.0497
Loa Loa (eye worm)	TK protein kinase	0.0072	0.0139	0.0139
Loa Loa (eye worm)	AGC/NDR protein kinase	0.0067	0.0105	0.0105
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.034	0.1811	1
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0097	0.0294	0.0294
Echinococcus granulosus	phosphatidylinositol 4 kinase alpha	0.006	0.006	0.006
Loa Loa (eye worm)	hypothetical protein	0.0633	0.364	0.364
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0197	0.0914	0.0914
Echinococcus granulosus	ribosomal protein S6 kinase alpha 3	0.0067	0.0105	0.0105
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0268	0.1363	0.7522
Brugia malayi	Carboxylesterase family protein	0.0105	0.0344	0.0497
Echinococcus multilocularis	cyclin dependent kinase 5	0.0197	0.0914	0.0914
Onchocerca volvulus		0.0105	0.0344	0.7266
Loa Loa (eye worm)	TK protein kinase	0.0256	0.1284	0.1284
Schistosoma mansoni	phosphatidylinositol 4-kinase	0.006	0.006	0.0062
Echinococcus granulosus	tyrosine protein kinase shark	0.0086	0.0223	0.0223
Brugia malayi	hypothetical protein	0.0051	0.0008	0.0012
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0307	0.1605	0.1605
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0061	0.0067	0.0067
Giardia lamblia	Kinase, CMGC CDK	0.0197	0.0914	0.8453
Schistosoma mansoni	glutamate receptor NMDA	0.0094	0.0275	0.0284
Brugia malayi	SH2 domain containing protein	0.0051	0.0008	0.0012
Onchocerca volvulus		0.0051	0.0008	0.0168
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0197	0.0914	0.0914
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.034	0.1811	1
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0086	0.0223	0.0223
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0051	0.0008	0.0008
Brugia malayi	Protein kinase c protein 2	0.0358	0.1924	0.2776
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0357	0.1918	0.1918
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0051	0.0008	0.0168
Loa Loa (eye worm)	hypothetical protein	0.0109	0.0368	0.0368
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0051	0.0008	0.0008
Echinococcus granulosus	N chimaerin	0.0097	0.0294	0.0294
Brugia malayi	Variant SH3 domain containing protein	0.0102	0.0321	0.0463
Echinococcus multilocularis	C2 calcium dependent membrane targeting	0.0055	0.0033	0.0033
Entamoeba histolytica	hypothetical protein	0.0293	0.1519	0.8384
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit gamma, putative	0.034	0.1811	1
Schistosoma mansoni	growth factor receptor-bound protein	0.0102	0.0321	0.0332
Schistosoma mansoni	tyrosine kinase	0.039	0.212	0.2191
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0357	0.1918	0.1918
Trypanosoma brucei	phosphatidylinositol 4-kinase alpha, putative	0.006	0.006	0.0658
Trypanosoma cruzi	phosphatidylinositol 4-kinase alpha, putative	0.006	0.006	0.0332
Brugia malayi	Tyrosine-protein kinase abl-1	0.0734	0.4274	0.6167
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.039	0.212	0.212
Schistosoma mansoni	tensin-related	0.0051	0.0008	0.0008
Brugia malayi	SH2 domain containing protein	0.0086	0.0223	0.0321
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Onchocerca volvulus		0.0105	0.0344	0.7266
Trypanosoma brucei	rac serine-threonine kinase, putative	0.0067	0.0105	0.1149
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0051	0.0008	0.0008
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0299	0.1556	0.1556
Schistosoma mansoni	tyrosine kinase	0.116	0.6931	0.7161
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0136	0.0536	0.0554
Schistosoma mansoni	tyrosine kinase	0.0136	0.0536	0.0554
Entamoeba histolytica	protein kinase, putative	0.0067	0.0105	0.058
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0188	0.0861	0.1242
Schistosoma mansoni	tyrosine kinase	0.0086	0.0223	0.023
Echinococcus granulosus	para nitrobenzyl esterase	0.0105	0.0344	0.0344
Echinococcus granulosus	neuroglian	0.0069	0.0118	0.0118
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0344	0.0344
Brugia malayi	SH2 domain containing protein	0.0051	0.0008	0.0012
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0051	0.0008	0.0012
Schistosoma mansoni	tyrosine kinase	0.0082	0.0202	0.0209
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0072	0.0139	0.0139
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Onchocerca volvulus		0.0055	0.0033	0.0693
Schistosoma mansoni	SH2A	0.0051	0.0008	0.0008
Echinococcus granulosus	neuroligin	0.0105	0.0344	0.0344
Echinococcus multilocularis	acetylcholinesterase	0.0623	0.3577	0.3577
Echinococcus granulosus	epidermal growth factor receptor	0.116	0.6931	0.6931
Brugia malayi	Protein kinase domain containing protein	0.039	0.212	0.3059
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0636	0.366	0.366
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0474	0.0474
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0105	0.0344	0.0344
Brugia malayi	Carboxylesterase family protein	0.0105	0.0344	0.0497
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Trichomonas vaginalis	CMGC family protein kinase	0.0197	0.0914	0.5048
Echinococcus multilocularis	phosphatidylinositol 4 phosphate 3 kinase C2	0.0178	0.0802	0.0802
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0357	0.1918	0.1918
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0086	0.0223	0.0223
Schistosoma mansoni	tyrosine kinase	0.0636	0.366	0.3781
Onchocerca volvulus		0.0086	0.0223	0.47
Schistosoma mansoni	serine/threonine protein kinase	0.0122	0.0451	0.0466
Schistosoma mansoni	tensin	0.0051	0.0008	0.0008
Echinococcus granulosus	Protein kinase C brain isozyme	0.0422	0.232	0.232
Onchocerca volvulus		0.0126	0.0474	1
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0097	0.0294	0.0294
Echinococcus multilocularis	roundabout 2	0.0079	0.0181	0.0181
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0357	0.1918	0.1918
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0256	0.1284	0.1284
Brugia malayi	SH2 domain containing protein	0.0051	0.0008	0.0012
Brugia malayi	Variant SH3 domain containing protein	0.0061	0.0067	0.0097
Schistosoma mansoni	tyrosine kinase	0.0357	0.1918	0.1982
Entamoeba histolytica	protein kinase, putative	0.0256	0.1284	0.7087
Brugia malayi	Sex muscle abnormal protein 5	0.0102	0.0321	0.0463
Echinococcus granulosus	ribosomal protein s6 kinase beta 1	0.0067	0.0105	0.0105
Brugia malayi	Protein kinase domain containing protein	0.0067	0.0105	0.0152
Brugia malayi	Carboxylesterase family protein	0.0623	0.3577	0.5161
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0344	0.0344
Onchocerca volvulus		0.0051	0.0008	0.0168
Schistosoma mansoni	hypothetical protein	0.0051	0.0008	0.0008
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0307	0.1605	0.1605
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0067	0.0105	0.0105
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0094	0.0275	0.0275
Onchocerca volvulus		0.0105	0.0344	0.7266
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0357	0.1918	0.1918
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0136	0.0536	0.0536
Entamoeba histolytica	protein kinase, putative	0.0067	0.0105	0.058
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0072	0.0139	0.0139
Echinococcus granulosus	protein kinase c epsilon type	0.0122	0.0451	0.0451
Echinococcus multilocularis	signal transduction protein lnk realted	0.0051	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0086	0.0223	0.0223
Brugia malayi	Protein kinase domain containing protein	0.0086	0.0223	0.0321
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Schistosoma mansoni	tyrosine kinase	0.0602	0.3445	0.3559
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0344	0.0344
Entamoeba histolytica	protein kinase, putative	0.0067	0.0105	0.058
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0344	0.0344
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0102	0.0321	0.0321
Echinococcus multilocularis	serine:threonine protein kinase N2	0.0067	0.0105	0.0105
Brugia malayi	Cation transporter family protein	0.0126	0.0474	0.0683
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.0107	0.0353	0.1948
Schistosoma mansoni	serine/threonine protein kinase	0.0422	0.232	0.2397
Echinococcus granulosus	tensin	0.0051	0.0008	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Echinococcus granulosus	NDR protein kinase	0.0067	0.0105	0.0105
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0051	0.0008	0.0008
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Giardia lamblia	Kinase, CMGC CDK	0.0197	0.0914	0.8453
Echinococcus multilocularis	unc 13 (munc13)	0.0055	0.0033	0.0033
Schistosoma mansoni	tyrosine kinase	0.039	0.212	0.2191
Brugia malayi	Variant SH3 domain containing protein	0.0102	0.0321	0.0463
Entamoeba histolytica	cell division protein kinase 2, putative	0.0197	0.0914	0.5048
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0102	0.0321	0.0321
Trichomonas vaginalis	phosphatidylinositol 4-kinase, putative	0.006	0.006	0.0332
Entamoeba histolytica	protein kinase, putative	0.0067	0.0105	0.058
Loa Loa (eye worm)	phosphatidylinositol 3	0.0495	0.2781	0.2781
Schistosoma mansoni	serine/threonine protein kinase	0.0197	0.0914	0.0945
Onchocerca volvulus	Tyrosine kinase homolog	0.0072	0.0139	0.2929
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0273	0.139	0.139
Schistosoma mansoni	nck2/grb4	0.0102	0.0321	0.0332
Schistosoma mansoni	glutamate receptor NMDA	0.0083	0.0206	0.0212
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0357	0.1918	0.1918
Echinococcus multilocularis	ribosomal protein s6 kinase beta 1	0.0067	0.0105	0.0105
Echinococcus granulosus	tyrosine protein kinase Blk	0.0307	0.1605	0.1605
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0076	0.0159	0.0229
Schistosoma mansoni	serine/threonine kinase	0.0067	0.0105	0.0109
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0105	0.0109
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0051	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0344	0.0344
Echinococcus multilocularis	cyclin dependent kinase 1	0.0197	0.0914	0.0914
Loa Loa (eye worm)	hypothetical protein	0.0162	0.0697	0.0697
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0105	0.0105
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0105	0.0109
Entamoeba histolytica	phosphatidylinositol-4,5-bisphosphate 3-kinase, putative	0.006	0.006	0.0332
Echinococcus granulosus	growth factor receptor bound protein 2	0.0102	0.0321	0.0321
Brugia malayi	Carboxylesterase family protein	0.0105	0.0344	0.0497
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0357	0.1918	0.1918
Trypanosoma cruzi	cdc2-related kinase 1	0.0197	0.0914	0.5048
Trichomonas vaginalis	CMGC family protein kinase	0.0197	0.0914	0.5048
Loa Loa (eye worm)	phosphatidylinositol 4-kinase type 3 alpha isoform 1	0.006	0.006	0.006
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0097	0.0294	0.0304
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0051	0.0008	0.0012
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0051	0.0008	0.0008
Brugia malayi	Protein kinase domain containing protein	0.0086	0.0223	0.0321
Echinococcus multilocularis	carboxylesterase 5A	0.0623	0.3577	0.3577
Loa Loa (eye worm)	AGC/RSK/MSK protein kinase	0.0067	0.0105	0.0105
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Brugia malayi	protein kinase C II.	0.0122	0.0451	0.0651
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Schistosoma mansoni	tyrosine kinase	0.0086	0.0223	0.023
Echinococcus granulosus	insulin receptor	0.039	0.212	0.212
Echinococcus granulosus	cyclin dependent kinase	0.0197	0.0914	0.0914
Onchocerca volvulus		0.0105	0.0344	0.7266
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0361	0.194	0.194
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0344	0.0344
Trichomonas vaginalis	serine/threonine-protein kinase sgk, putative	0.0063	0.0083	0.046
Schistosoma mansoni	suppressor of cytokine signaling	0.0051	0.0008	0.0008
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0132	0.0509	0.281
Entamoeba histolytica	phosphatidylinositol 3-kinase 1, putative	0.0327	0.1726	0.9532
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Echinococcus multilocularis	N chimaerin	0.0097	0.0294	0.0294
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0105	0.0344	0.0344
Echinococcus multilocularis		0.035	0.1875	0.1875
Brugia malayi	Tyrosine-protein kinase abl-1	0.0967	0.5726	0.8261
Echinococcus granulosus	C2 calcium dependent membrane targeting	0.0055	0.0033	0.0033
Schistosoma mansoni	tyrosine kinase	0.0357	0.1918	0.1982
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0105	0.0344	0.0356
Brugia malayi	SH2 domain containing protein	0.0051	0.0008	0.0012
Echinococcus multilocularis	acetylcholinesterase	0.0623	0.3577	0.3577
Entamoeba histolytica	SH2 domain containing protein	0.0051	0.0008	0.0044
Brugia malayi	Furin-like cysteine rich region family protein	0.116	0.6931	1
Onchocerca volvulus		0.0051	0.0008	0.0168
Echinococcus granulosus	unc 13 munc13	0.0055	0.0033	0.0033
Brugia malayi	Protein kinase domain containing protein	0.0086	0.0223	0.0321
Brugia malayi	SRC-1	0.0357	0.1918	0.2767
Echinococcus multilocularis	tensin	0.0051	0.0008	0.0008
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0051	0.0008	0.0008
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.039	0.212	0.212
Echinococcus multilocularis	c src tyrosine kinase	0.0136	0.0536	0.0536
Schistosoma mansoni	nAChR subunit (ShAR1-beta-like)	0.0126	0.0474	0.0489
Echinococcus granulosus	tyrosine protein kinase Srms	0.0086	0.0223	0.0223
Toxoplasma gondii	AGC kinase	0.0067	0.0105	0.0526
Onchocerca volvulus		0.0105	0.0344	0.7266
Schistosoma mansoni	tyrosine kinase	0.0636	0.366	0.3781
Echinococcus multilocularis	SHC transforming protein 3	0.0051	0.0008	0.0008
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0107	0.0353	0.1948
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0273	0.139	0.139
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0197	0.0914	1
Loa Loa (eye worm)	hypothetical protein	0.0178	0.0802	0.0802
Entamoeba histolytica	phosphatidylinositol 4-kinase, putative	0.006	0.006	0.0332
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0051	0.0008	0.0008
Schistosoma mansoni	vav2	0.0097	0.0294	0.0304
Echinococcus granulosus	phosphatidylinositol 3 kinase catalytic subunit	0.006	0.006	0.006
Echinococcus granulosus	tyrosine kinase	0.0307	0.1605	0.1605
Echinococcus multilocularis	tensin	0.0051	0.0008	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Schistosoma mansoni	unc-13 (munc13)	0.0055	0.0033	0.0034
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0122	0.0451	0.0451
Echinococcus multilocularis	neuroligin	0.0105	0.0344	0.0344
Echinococcus granulosus	phosphatidylinositol 4 phosphate 3 kinase C2	0.0178	0.0802	0.0802
Echinococcus multilocularis	intersectin 2	0.006	0.006	0.006
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.034	0.1811	0.2613
Trypanosoma cruzi	phosphatidylinositol 3-kinase vps34-like	0.0107	0.0353	0.1948
Echinococcus granulosus	serine:threonine protein kinase N2	0.0067	0.0105	0.0105
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0357	0.1918	0.1918
Echinococcus multilocularis	SH2 motif	0.0051	0.0008	0.0008
Echinococcus granulosus	SH2 motif	0.0051	0.0008	0.0008
Schistosoma mansoni	atypical protein kinase C	0.0113	0.0392	0.0405
Onchocerca volvulus		0.0086	0.0223	0.47
Echinococcus granulosus	hypothetical protein	0.0051	0.0008	0.0008
Echinococcus granulosus	nmda type glutamate receptor	0.0056	0.0035	0.0035
Onchocerca volvulus		0.0126	0.0474	1
Brugia malayi	SH2 domain containing protein	0.0086	0.0223	0.0321
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Echinococcus multilocularis	RNA directed DNA polymerase	0.0299	0.1556	0.1556
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0542	0.3074	0.3176
Schistosoma mansoni	signal transduction protein lnk-related	0.0051	0.0008	0.0008
Schistosoma mansoni	acetylcholinesterase	0.0105	0.0344	0.0356
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0094	0.0275	0.0275
Trypanosoma cruzi	cdc2-related kinase 3	0.0197	0.0914	0.5048
Schistosoma mansoni	serine/threonine protein kinase	0.0422	0.232	0.2397
Echinococcus multilocularis	Zinc finger, PHD finger	0.006	0.006	0.006
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0105	0.0344	0.0356
Brugia malayi	SH2 domain containing protein	0.0051	0.0008	0.0012
Trypanosoma cruzi	phosphatidylinositol 3-kinase, putative	0.0093	0.0268	0.1479
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0051	0.0008	0.0008
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0136	0.0536	0.0536
Schistosoma mansoni	tensin	0.0051	0.0008	0.0008
Brugia malayi	p70 ribosomal S6 kinase beta	0.0067	0.0105	0.0152
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0307	0.1605	0.1605
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0268	0.1363	0.7522
Loa Loa (eye worm)	hypothetical protein	0.0299	0.1556	0.1556
Brugia malayi	hypothetical protein	0.0086	0.0223	0.0321
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.006	0.006	0.0062
Echinococcus multilocularis	insulin receptor	0.039	0.212	0.212
Loa Loa (eye worm)	SRC-1	0.0357	0.1918	0.1918
Onchocerca volvulus		0.0086	0.0223	0.47
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0312	0.1637	0.1637
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0105	0.0344	0.5
Loa Loa (eye worm)	TK/EGFR protein kinase	0.116	0.6931	0.6931
Loa Loa (eye worm)	hypothetical protein	0.0102	0.0321	0.0321
Schistosoma mansoni	nephrin	0.0069	0.0118	0.0122
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.006	0.006	0.0332
Brugia malayi	protein-tyrosine kinase	0.0307	0.1605	0.2315
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0051	0.0008	0.0012
Echinococcus granulosus	expressed conserved protein	0.0051	0.0008	0.0008
Echinococcus multilocularis	tyrosine kinase	0.0086	0.0223	0.0223
Echinococcus granulosus	SHC transforming protein 3	0.0051	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Echinococcus multilocularis	serine threonine protein kinase	0.0376	0.2034	0.2034
Echinococcus granulosus	Ribosomal protein S6 kinase beta 2	0.0067	0.0105	0.0105
Trichomonas vaginalis	phosphatidylinositol kinase, putative	0.006	0.006	0.0332
Brugia malayi	Hr1 repeat family protein	0.0067	0.0105	0.0152
Entamoeba histolytica	protein kinase, putative	0.0055	0.003	0.0164
Entamoeba histolytica	cell division protein kinase 2, putative	0.0197	0.0914	0.5048
Echinococcus granulosus	acetylcholinesterase	0.0623	0.3577	0.3577
Onchocerca volvulus		0.0051	0.0008	0.0168
Brugia malayi	Protein kinase domain containing protein	0.0086	0.0223	0.0321
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.034	0.1811	1
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0105	0.0109
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Schistosoma mansoni	serine/threonine protein kinase	0.0067	0.0105	0.0109
Echinococcus multilocularis	phosphatidylinositol 4,5 bisphosphate 3 kinase	0.0542	0.3074	0.3074
Echinococcus multilocularis	cyclin dependent kinase 1	0.0197	0.0914	0.0914
Schistosoma mansoni	tyrosine kinase	0.0602	0.3445	0.3559
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0105	0.0344	0.5
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0197	0.0914	0.0914
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0051	0.0008	0.0008
Schistosoma mansoni	growth factor receptor-bound protein	0.0102	0.0321	0.0332
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Echinococcus granulosus	twitchin	0.0073	0.014	0.014
Echinococcus granulosus	carboxylesterase 5A	0.0623	0.3577	0.3577
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0197	0.0914	1
Echinococcus granulosus	cyclin dependent kinase 1	0.0197	0.0914	0.0914
Brugia malayi	Protein kinase domain containing protein	0.0086	0.0223	0.0321
Trypanosoma cruzi	cdc2-related kinase 1	0.0197	0.0914	0.5048
Trichomonas vaginalis	phopsphatidylinositol 3-kinase, drosophila, putative	0.034	0.1811	1
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0357	0.1918	0.1918
Onchocerca volvulus		0.0086	0.0223	0.47
Trypanosoma cruzi	phosphatidylinositol 3-kinase 2, putative	0.034	0.1811	1
Echinococcus multilocularis	protein kinase c epsilon type	0.0122	0.0451	0.0451
Trichomonas vaginalis	phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative	0.0107	0.0353	0.1948
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0086	0.0223	0.1229
Trichomonas vaginalis	phosphatidylinositol 3-kinase class, putative	0.0107	0.0353	0.1948
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0052	0.0009	0.0009
Echinococcus multilocularis	para nitrobenzyl esterase	0.0105	0.0344	0.0344
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0107	0.0353	0.1948
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0357	0.1918	0.1918
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0051	0.0008	0.0008
Leishmania major	phosphatidylinositol 4-kinase alpha, putative	0.006	0.006	0.0658
Schistosoma mansoni	phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K	0.0116	0.0412	0.0426
Brugia malayi	Protein kinase domain containing protein	0.0067	0.0105	0.0152
Echinococcus multilocularis	protein kinase c iota type	0.0113	0.0392	0.0392
Schistosoma mansoni	tyrosine kinase	0.16	0.9679	1
Echinococcus multilocularis	cyclin dependent kinase	0.0197	0.0914	0.0914
Loa Loa (eye worm)	SH2 domain-containing protein	0.0051	0.0008	0.0008
Schistosoma mansoni	tensin	0.0051	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Echinococcus granulosus	RNA directed DNA polymerase	0.0299	0.1556	0.1556
Schistosoma mansoni	nAChR subunit (ShAR1-alpha-like)	0.0126	0.0474	0.0489
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0105	0.0344	0.19
Loa Loa (eye worm)	hypothetical protein	0.0345	0.1843	0.1843
Loa Loa (eye worm)	hypothetical protein	0.0623	0.3577	0.3577
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0734	0.4274	0.4274
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0102	0.0321	0.0332
Loa Loa (eye worm)	carboxylesterase	0.0623	0.3577	0.3577
Loa Loa (eye worm)	hypothetical protein	0.0126	0.0474	0.0474
Brugia malayi	Tensin	0.0051	0.0008	0.0012
Schistosoma mansoni	suppressor of cytokine signaling	0.0051	0.0008	0.0008
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0051	0.0008	0.0008
Echinococcus multilocularis	epidermal growth factor receptor	0.116	0.6931	0.6931
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0357	0.1918	0.1918
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0102	0.0321	0.0321
Loa Loa (eye worm)	carboxylesterase	0.0105	0.0344	0.0344
Trypanosoma cruzi	cdc2-related kinase 3	0.0197	0.0914	0.5048
Echinococcus granulosus	protein kinase C gamma type	0.0376	0.2034	0.2034
Schistosoma mansoni	gliotactin	0.0105	0.0344	0.0356
Echinococcus multilocularis	epidermal growth factor receptor	0.0636	0.366	0.366
Echinococcus multilocularis	serine:threonine protein kinase 38	0.0067	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0105	0.0344	0.0344
Echinococcus multilocularis	Ribosomal protein S6 kinase beta 2	0.0067	0.0105	0.0105
Loa Loa (eye worm)	hypothetical protein	0.0055	0.0033	0.0033
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0051	0.0008	0.0168
Onchocerca volvulus		0.0051	0.0008	0.0168
Echinococcus granulosus	tyrosine kinase	0.0086	0.0223	0.0223
Entamoeba histolytica	phosphatidylinositol 3-kinase, putative	0.0293	0.1519	0.8384
Loa Loa (eye worm)	TK protein kinase	0.0307	0.1605	0.1605
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0197	0.0914	0.0914
Loa Loa (eye worm)	AGC/DMPK/GEK protein kinase	0.0067	0.0105	0.0105
Onchocerca volvulus		0.0126	0.0474	1
Echinococcus granulosus	c src tyrosine kinase	0.0136	0.0536	0.0536
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0051	0.0008	0.0008
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0055	0.003	0.0164
Echinococcus multilocularis		0.0051	0.0008	0.0008
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0051	0.0008	0.0008
Echinococcus granulosus	SH2 domain containing protein 7	0.0051	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0079	0.0181	0.0181
Mycobacterium ulcerans	carboxylesterase, LipT	0.0105	0.0344	0.5
Loa Loa (eye worm)	hypothetical protein	0.0623	0.3577	0.3577
Plasmodium falciparum	protein kinase 5	0.0197	0.0914	1
Brugia malayi	phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative	0.0202	0.0949	0.1369
Schistosoma mansoni	tyrosine kinase	0.0602	0.3445	0.3559
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0197	0.0914	1
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0051	0.0008	0.0008
Onchocerca volvulus		0.0051	0.0008	0.0168
Echinococcus multilocularis	tyrosine protein kinase shark	0.0086	0.0223	0.0223
Trichomonas vaginalis	AGC family protein kinase	0.0067	0.0105	0.058
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0097	0.0294	0.0304
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0105	0.0344	0.5
Plasmodium vivax	protein kinase Crk2	0.0197	0.0914	1
Schistosoma mansoni	serine/threonine protein kinase	0.008	0.0188	0.0194
Echinococcus multilocularis	SH2 motif	0.0051	0.0008	0.0008
Brugia malayi	RhoGAP domain containing protein	0.0097	0.0294	0.0425
Loa Loa (eye worm)	AGC/RSK/P70 protein kinase	0.0067	0.0105	0.0105
Giardia lamblia	Phosphoinositide-3-kinase, catalytic, alpha polypeptide	0.0221	0.107	1
Trichomonas vaginalis	spcc417.12 protein, putative	0.0105	0.0344	0.19
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Trypanosoma brucei	cdc2-related kinase 1	0.0197	0.0914	1
Schistosoma mansoni	serine/threonine protein kinase	0.0085	0.0215	0.0222
Echinococcus granulosus	acetylcholinesterase	0.0623	0.3577	0.3577
Brugia malayi	Protein kinase domain containing protein	0.0067	0.0105	0.0152
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0097	0.0294	0.0294
Loa Loa (eye worm)	AGC/RSK/RSK protein kinase	0.0067	0.0105	0.0105
Brugia malayi	Variant SH3 domain containing protein	0.0097	0.0294	0.0425
Echinococcus granulosus	cyclin dependent kinase 5	0.0197	0.0914	0.0914
Schistosoma mansoni	BC026374 protein (S09 family)	0.0105	0.0344	0.0356
Loa Loa (eye worm)	TK/ABL protein kinase	0.1651	1	1
Loa Loa (eye worm)	phosphatidylinositol 3	0.0093	0.0268	0.0268
Echinococcus multilocularis	phosphatidylinositol 4 kinase alpha	0.006	0.006	0.006
Echinococcus granulosus	SH2 motif	0.0051	0.0008	0.0008
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Trypanosoma brucei	phosphatidylinositol 3-kinase, putative	0.0107	0.0353	0.3859
Loa Loa (eye worm)	STAT protein	0.0051	0.0008	0.0008
Echinococcus multilocularis	SH2 motif	0.0051	0.0008	0.0008
Echinococcus granulosus	BC026374 protein S09 family	0.0105	0.0344	0.0344
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0623	0.3577	0.3696
Schistosoma mansoni	unc-13 (munc13)	0.0055	0.0033	0.0034
Loa Loa (eye worm)	TK/FER protein kinase	0.0086	0.0223	0.0223
Echinococcus multilocularis	neuroglian	0.0069	0.0118	0.0118
Schistosoma mansoni	adapter molecule crk	0.0102	0.0321	0.0332
Onchocerca volvulus		0.0086	0.0223	0.47
Echinococcus multilocularis	SH2 domain containing protein 7	0.0051	0.0008	0.0008
Echinococcus granulosus	phosphatidylinositol 45 bisphosphate 3 kinase	0.0542	0.3074	0.3074
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0107	0.0353	0.0509
Schistosoma mansoni	serine/threonine protein kinase	0.0197	0.0914	0.0945
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Loa Loa (eye worm)	SH2 domain-containing protein	0.0051	0.0008	0.0008
Echinococcus granulosus	protein kinase c iota type	0.0113	0.0392	0.0392
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0072	0.0139	0.02
Brugia malayi	Protein kinase domain containing protein	0.0197	0.0914	0.1319
Onchocerca volvulus		0.0086	0.0223	0.47
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0008	0.0008
Echinococcus granulosus	raf serine:threonine protein kinase	0.008	0.0188	0.0188
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0357	0.1918	0.1918
Echinococcus granulosus	intersectin 2	0.006	0.006	0.006
Schistosoma mansoni	protein kinase C	0.0055	0.0033	0.0034
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0357	0.1918	0.1918
Trypanosoma brucei	cdc2-related kinase 3	0.0197	0.0914	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 100 nM	Inhibitory concentration against cathepsin S	ChEMBL.	15745822
IC50 (binding)	= 100 nM	Inhibitory concentration against cathepsin S	ChEMBL.	15745822

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 22293860

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 317162