Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | dihydrofolate reductase | 0.3075 | 1 | 0.5 |
Echinococcus multilocularis | caspase | 0.0242 | 0.0225 | 0.0225 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.1176 | 0.3447 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.1176 | 0.3447 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.3075 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.3075 | 1 | 1 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.3075 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.3075 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.3075 | 1 | 0.5 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.0242 | 0.0225 | 0.0225 |
Echinococcus granulosus | caspase | 0.0242 | 0.0225 | 0.0225 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.0242 | 0.0225 | 0.0225 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.0242 | 0.0225 | 0.0225 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.0242 | 0.0225 | 0.0225 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1176 | 0.3447 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.1176 | 0.3447 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.3075 | 1 | 0.5 |
Onchocerca volvulus | Cell death protein 3 homolog | 0.0177 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.1176 | 0.3447 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.3075 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.3075 | 1 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.1176 | 0.3447 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.007 uM | Inhibitory concentration to inhibit chymotrypsin-like activity of 20S proteasome prepared from human leukemia HL-60 cells was determined | ChEMBL. | 15780623 |
IC50 (functional) | = 1.2 uM | Inhibitory concentration to inhibit trypsin-like activity of 20S proteasome from human leukemia HL-60 cellswas determined | ChEMBL. | 15780623 |
IC50 (functional) | = 4.9 uM | Inhibitory concentration to inhibit the PGPH activity of 20S proteasome prepared from human leukemia HL-60 cells was determined | ChEMBL. | 15780623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.