TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 407.484 | Formula: C23H26FN5O
H donors: 2 H acceptors: 3 LogP: 4.72 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1ccccc1F)N[C@@H]1CC[C@@H](CC1)Nc1nc2ccccc2c(n1)N(C)C
InChi: 1S/C23H26FN5O/c1-29(2)21-18-8-4-6-10-20(18)27-23(28-21)26-16-13-11-15(12-14-16)25-22(30)17-7-3-5-9-19(17)24/h3-10,15-16H,11-14H2,1-2H3,(H,25,30)(H,26,27,28)/t15-,16+
InChiKey: AGEXNHZEGLFEDD-IYBDPMFKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	melanin-concentrating hormone receptor 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	importin subunit beta 1	0.0058	0.0355	0.0355
Plasmodium falciparum	histone acetyltransferase GCN5	0.0044	0.0238	0.67
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0076	0.0498	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1423	0.1472
Trichomonas vaginalis	conserved hypothetical protein	0.0031	0.0128	0.09
Plasmodium vivax	importin-beta 2, putative	0.0058	0.0355	1
Trypanosoma cruzi	trypanothione reductase, putative	0.0043	0.0233	0.8788
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0048	0.0271	0.3146
Echinococcus multilocularis	microtubule associated protein 2	0.1234	1	1
Toxoplasma gondii	HEAT repeat-containing protein	0.0058	0.0355	0.4126
Leishmania major	hypothetical protein, conserved	0.0028	0.011	0.1275
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0189	0.1423	0.1423
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0623	0.4986	0.5468
Echinococcus granulosus	thioredoxin glutathione reductase	0.0043	0.0233	0.0233
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0047	0.0265	0.1861
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0189	0.1423	1
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0189	0.1423	0.1423
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0034	0.0155	0.109
Schistosoma mansoni	importin beta-1	0.0058	0.0355	0.0355
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0498	0.0436
Schistosoma mansoni	hypothetical protein	0.0623	0.4986	0.4986
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.003	0.0122	0.4615
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0355	0.0275
Trypanosoma brucei	importin beta-1 subunit, putative	0.0058	0.0355	1
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0034	0.0155	0.0155
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0043	0.0233	0.1635
Trypanosoma cruzi	peptidyl-prolyl cis-trans isomerase	0.003	0.0122	0.4615
Entamoeba histolytica	acetyltransferase, GNAT family	0.0044	0.0238	0.3079
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0043	0.0229	0.0229
Giardia lamblia	Histone acetyltransferase GCN5	0.0044	0.0238	1
Brugia malayi	hypothetical protein	0.0189	0.1423	0.1576
Echinococcus granulosus	muscleblind protein	0.0168	0.1258	0.1258
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0015	0	0.5
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0189	0.1423	1
Brugia malayi	Muscleblind-like protein	0.0168	0.1258	0.1394
Toxoplasma gondii	aldehyde dehydrogenase	0.012	0.0861	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0427	0.3382	0.3382
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0034	0.0155	0.109
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.011	0.0779	1
Trichomonas vaginalis	conserved hypothetical protein	0.0034	0.0155	0.109
Trypanosoma brucei	importin beta-1 subunit, putative	0.0058	0.0355	1
Schistosoma mansoni	BC026374 protein (S09 family)	0.0189	0.1423	0.1423
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0034	0.0155	0.0155
Onchocerca volvulus		0.0189	0.1423	0.1626
Echinococcus multilocularis	expressed protein	0.0031	0.0128	0.0128
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0706	0.5667	0.5667
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0034	0.0155	0.0874
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0034	0.0155	0.0155
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0155	0.0051
Plasmodium vivax	glutathione reductase, putative	0.0043	0.0233	0.6548
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.012	0.0861	0.0861
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0099	0.0689	0.484
Echinococcus granulosus	para nitrobenzyl esterase	0.0189	0.1423	0.1423
Echinococcus multilocularis	muscleblind protein 1	0.0168	0.1258	0.1258
Loa Loa (eye worm)	hypothetical protein	0.1116	0.9028	1
Entamoeba histolytica	hypothetical protein	0.0047	0.0265	0.3789
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0034	0.0155	0.0155
Schistosoma mansoni	ran	0.0043	0.0229	0.0229
Echinococcus multilocularis	muscleblind protein	0.0168	0.1258	0.1258
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0034	0.0155	0.0155
Echinococcus multilocularis	ubiquitin specific protease 41	0.0034	0.0155	0.0155
Entamoeba histolytica	Acid sphingomyelinase-like phosphodiesterase, putative	0.0076	0.0498	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.011	0.309
Schistosoma mansoni	gliotactin	0.0189	0.1423	0.1423
Echinococcus granulosus	snurportin 1	0.0623	0.4986	0.4986
Echinococcus multilocularis	acetylcholinesterase	0.1116	0.9028	0.9028
Schistosoma mansoni	acetylcholinesterase	0.0189	0.1423	0.1423
Echinococcus multilocularis	acetylcholinesterase	0.1116	0.9028	0.9028
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0189	0.1423	1
Plasmodium vivax	thioredoxin reductase, putative	0.0043	0.0233	0.6548
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0048	0.0271	0.7625
Trichomonas vaginalis	rotamase, putative	0.003	0.0122	0.0859
Echinococcus granulosus	geminin	0.0156	0.1152	0.1152
Brugia malayi	Carboxylesterase family protein	0.0189	0.1423	0.1576
Schistosoma mansoni	hypothetical protein	0.0156	0.1152	0.1152
Schistosoma mansoni	hypothetical protein	0.0156	0.1152	0.1152
Leishmania major	importin beta-1 subunit, putative	0.0047	0.0265	0.3075
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1423	0.1472
Trichomonas vaginalis	importin beta-1, putative	0.0047	0.0265	0.1861
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0048	0.0271	0.0271
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0043	0.0229	0.0134
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0047	0.0265	1
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0189	0.1423	0.1423
Mycobacterium tuberculosis	Probable oxidoreductase	0.011	0.0779	0.5477
Schistosoma mansoni	aldehyde dehydrogenase	0.012	0.0861	0.0861
Brugia malayi	Importin beta-1 subunit	0.0058	0.0355	0.0394
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0034	0.0155	0.0155
Brugia malayi	Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1	0.0031	0.0128	0.0142
Plasmodium falciparum	glutathione reductase	0.0043	0.0233	0.6548
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0043	0.0229	0.0229
Schistosoma mansoni	rotamase	0.0031	0.0128	0.0128
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0189	0.1423	0.1423
Trypanosoma brucei	peptidyl-prolyl cis-trans isomerase/rotamase, putative	0.003	0.0122	0.3439
Echinococcus granulosus	neuropeptide receptor A26	0.0427	0.3382	0.3382
Onchocerca volvulus		0.0448	0.355	1
Brugia malayi	glutathione reductase	0.0043	0.0233	0.0258
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0189	0.1423	0.1423
Loa Loa (eye worm)	hypothetical protein	0.1116	0.9028	1
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0043	0.0229	0.8646
Mycobacterium tuberculosis	Probable dehydrogenase	0.0099	0.0689	0.484
Toxoplasma gondii	peptidylprolyl isomerase	0.003	0.0122	0.1419
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0163	0.1217	0.1217
Loa Loa (eye worm)	Pin1-type peptidyl-prolyl cis-trans isomerase	0.0031	0.0128	0.0021
Trypanosoma cruzi	GTP-binding nuclear protein rtb2, putative	0.0043	0.0229	0.8646
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.1116	0.9028	0.9028
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0189	0.1423	0.1423
Loa Loa (eye worm)	carboxylesterase	0.0189	0.1423	0.1472
Plasmodium falciparum	ataxin-2 like protein, putative	0.0028	0.011	0.309
Echinococcus multilocularis	carboxylesterase 5A	0.1116	0.9028	0.9028
Loa Loa (eye worm)	hypothetical protein	0.0168	0.1258	0.1288
Loa Loa (eye worm)	hypothetical protein	0.0138	0.101	0.1009
Leishmania major	peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative	0.003	0.0122	0.1419
Trypanosoma brucei	GTP-binding nuclear protein rtb2, putative	0.0043	0.0229	0.6443
Brugia malayi	acetyltransferase, GNAT family protein	0.0163	0.1217	0.1348
Plasmodium falciparum	thioredoxin reductase	0.0043	0.0233	0.6548
Onchocerca volvulus		0.0189	0.1423	0.1626
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0047	0.0265	0.1861
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1423	0.1472
Schistosoma mansoni	aldehyde dehydrogenase	0.012	0.0861	0.0861
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0099	0.0689	0.484
Loa Loa (eye worm)	hypothetical protein	0.0138	0.101	0.1009
Trichomonas vaginalis	ran, putative	0.0043	0.0229	0.1609
Echinococcus granulosus	BC026374 protein S09 family	0.0189	0.1423	0.1423
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0034	0.0155	0.0172
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.011	0.4147
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1423	0.1472
Mycobacterium tuberculosis	Probable reductase	0.0099	0.0689	0.484
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0034	0.0155	0.5857
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0048	0.0271	0.3146
Loa Loa (eye worm)	acetyltransferase	0.0163	0.1217	0.1242
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0099	0.0689	0.484
Brugia malayi	Thioredoxin reductase	0.0043	0.0233	0.0258
Loa Loa (eye worm)	thioredoxin reductase	0.0043	0.0233	0.0138
Plasmodium vivax	GTP-binding nuclear protein RAN/TC4, putative	0.0043	0.0229	0.6443
Plasmodium falciparum	importin beta, putative	0.0058	0.0355	1
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.012	0.0861	1
Echinococcus granulosus	ubiquitin specific protease 41	0.0034	0.0155	0.0155
Brugia malayi	Carboxylesterase family protein	0.0189	0.1423	0.1576
Schistosoma mansoni	ran	0.0043	0.0229	0.0229
Brugia malayi	GTP-binding nuclear protein RAN/TC4	0.0043	0.0229	0.0254
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0048	0.0271	0.1904
Onchocerca volvulus		0.0189	0.1423	0.1626
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	0.0861	0.6051
Brugia malayi	Carboxylesterase family protein	0.1116	0.9028	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1423	0.1472
Trypanosoma cruzi	PAB1-binding protein , putative	0.0028	0.011	0.4147
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0034	0.0155	0.6514
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0043	0.0233	0.0233
Trichomonas vaginalis	rotamase, putative	0.0031	0.0128	0.09
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0189	0.1423	1
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1423	0.1472
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.011	0.0779	0.5477
Brugia malayi	hypothetical protein	0.0138	0.101	0.1119
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0163	0.1217	0.1217
Echinococcus granulosus	neuroligin	0.0189	0.1423	0.1423
Brugia malayi	Carboxylesterase family protein	0.0189	0.1423	0.1576
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.012	0.0861	0.6051
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	0.0861	0.6051
Echinococcus granulosus	carboxylesterase 5A	0.1116	0.9028	0.9028
Loa Loa (eye worm)	acetylcholinesterase 1	0.1116	0.9028	1
Mycobacterium ulcerans	carboxylesterase, LipT	0.0189	0.1423	1
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0099	0.0689	0.484
Loa Loa (eye worm)	hypothetical protein	0.0448	0.355	0.3857
Echinococcus multilocularis	geminin	0.0156	0.1152	0.1152
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0048	0.0271	0.1904
Toxoplasma gondii	thioredoxin reductase	0.0043	0.0233	0.2702
Brugia malayi	Carboxylesterase family protein	0.1116	0.9028	1
Toxoplasma gondii	LsmAD domain-containing protein	0.0028	0.011	0.1275
Loa Loa (eye worm)	glutathione reductase	0.0043	0.0233	0.0138
Loa Loa (eye worm)	hypothetical protein	0.0168	0.1258	0.1288
Treponema pallidum	NADH oxidase	0.0015	0	0.5
Onchocerca volvulus		0.0189	0.1423	0.1626
Onchocerca volvulus		0.0189	0.1423	0.1626
Brugia malayi	RNA, U transporter 1	0.0166	0.1238	0.1371
Echinococcus granulosus	acetylcholinesterase	0.1116	0.9028	0.9028
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0034	0.0155	0.5857
Entamoeba histolytica	Ran family GTPase	0.0043	0.0229	0.2836
Echinococcus granulosus	neuropeptide s receptor	0.0427	0.3382	0.3382
Echinococcus multilocularis	neuropeptide s receptor	0.0427	0.3382	0.3382
Giardia lamblia	GTP-binding nuclear protein RAN/TC4	0.0043	0.0229	0.9616
Loa Loa (eye worm)	hypothetical protein	0.0189	0.1423	0.1472
Brugia malayi	hypothetical protein	0.0018	0.0027	0.003
Chlamydia trachomatis	dihydrolipoyl dehydrogenase	0.0015	0	0.5
Echinococcus granulosus	importin subunit beta 1	0.0058	0.0355	0.0355
Loa Loa (eye worm)	carboxylesterase	0.0189	0.1423	0.1472
Echinococcus granulosus	expressed protein	0.0031	0.0128	0.0128
Plasmodium vivax	ataxin-2 like protein, putative	0.0028	0.011	0.309
Trypanosoma brucei	trypanothione reductase	0.0043	0.0233	0.6548
Echinococcus multilocularis	para nitrobenzyl esterase	0.0189	0.1423	0.1423
Leishmania major	trypanothione reductase	0.0043	0.0233	0.2702
Brugia malayi	Carboxylesterase family protein	0.0189	0.1423	0.1576
Leishmania major	GTP-binding protein, putative	0.0043	0.0229	0.2659
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0034	0.0155	0.1801
Echinococcus granulosus	acetylcholinesterase	0.1116	0.9028	0.9028
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.011	0.0779	0.5477
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0034	0.0155	0.4365
Echinococcus multilocularis	snurportin 1	0.0623	0.4986	0.4986
Wolbachia endosymbiont of Brugia malayi	dihydrolipoamide dehydrogenase E3 component	0.0015	0	0.5
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0159	0.118	0.118
Mycobacterium ulcerans	aldehyde dehydrogenase	0.012	0.0861	0.6051
Trichomonas vaginalis	spcc417.12 protein, putative	0.0189	0.1423	1
Brugia malayi	hypothetical protein	0.0448	0.355	0.3932
Loa Loa (eye worm)	carboxylesterase	0.1116	0.9028	1
Brugia malayi	hypothetical protein	0.0028	0.011	0.0122
Echinococcus multilocularis	neuroligin	0.0189	0.1423	0.1423
Schistosoma mansoni	microtubule-associated protein tau	0.1234	1	1
Toxoplasma gondii	GTP-binding nuclear protein ran/tc4	0.0043	0.0229	0.2659
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.012	0.0861	0.0861
Trypanosoma brucei	PAB1-binding protein , putative	0.0028	0.011	0.309
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0189	0.1423	0.1423
Plasmodium falciparum	GTP-binding nuclear protein RAN/TC4	0.0043	0.0229	0.6443

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	nM	Inhibitory activity against Alpha-2A adrenergic receptor by using [3H]-MK912 as radioligand in COS-1 cells; Not evaluated	ChEMBL.	16002290
IC50 (binding)	nM	Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]-PYY as radioligand expressed in COS-1 cells; NE denotes not evaluated	ChEMBL.	16002290
IC50 (binding)	0 nM	Inhibitory activity against neuropeptide Y receptor type 5 by using [125I]-PYY as radioligand expressed in COS-1 cells; NE denotes not evaluated	ChEMBL.	16002290
IC50 (binding)	0 nM	Inhibitory activity against Alpha-2A adrenergic receptor by using [3H]-MK912 as radioligand in COS-1 cells; Not evaluated	ChEMBL.	16002290
IC50 (binding)	= 170 nM	Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells	ChEMBL.	16002290
IC50 (binding)	= 170 nM	Inhibitory activity against human CA-MCH-R1 (Melanin-concentrating hormone receptor 1) by using [125I](Phe13,Tyr19)MCH as radioligand expressed in HEK293 cells	ChEMBL.	16002290

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL367359

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 317360