Detailed information for compound 317395

Basic information

Technical information
  • TDR Targets ID: 317395
  • Name: 5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-N-p iperidin-1-ylpyridine-3-carboxamide
  • MW: 460.783 | Formula: C23H20Cl3N3O
  • H donors: 1 H acceptors: 2 LogP: 6.38 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1cc(cnc1c1ccc(cc1Cl)Cl)C(=O)NN1CCCCC1
  • InChi: 1S/C23H20Cl3N3O/c24-17-6-4-15(5-7-17)20-12-16(23(30)28-29-10-2-1-3-11-29)14-27-22(20)19-9-8-18(25)13-21(19)26/h4-9,12-14H,1-3,10-11H2,(H,28,30)
  • InChiKey: OVRQUZLLFSEDLA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-N-(1-piperidyl)pyridine-3-carboxamide
  • 5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-N-(1-piperidyl)-3-pyridinecarboxamide
  • 5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-N-piperidin-1-yl-pyridine-3-carboxamide
  • 5-(4-chlorophenyl)-6-(2,4-dichlorophenyl)-N-piperidino-nicotinamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cannabinoid receptor 1 (brain) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0283 0.0575
Wolbachia endosymbiont of Brugia malayi DNA gyrase subunit A 0.0025 0.0464 0.3578
Brugia malayi nuclear receptor NHR-88 0.002 0.0323 0.0413
Loa Loa (eye worm) glutaminase 2 0.0268 0.7802 1
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0323 0.0413
Echinococcus multilocularis GPCR, family 2 0.0015 0.0179 0.0378
Loa Loa (eye worm) hypothetical protein 0.006 0.1535 0.1967
Trypanosoma brucei DNA topoisomerase III, putative 0.0014 0.0127 0.0107
Schistosoma mansoni hypothetical protein 0.0033 0.072 0.0923
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0283 0.0248
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0283 0.0363
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0035 0.0044
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0044
Echinococcus multilocularis Ankyrin 0.0017 0.0213 0.045
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0323 0.0413
Loa Loa (eye worm) hypothetical protein 0.0015 0.0179 0.0229
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0323 0.0682
Trypanosoma brucei unspecified product 0.0013 0.0106 0.0043
Schistosoma mansoni ankyrin 23/unc44 0.0016 0.0208 0.0267
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0323 0.0413
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0014 0.0127 0.0107
Leishmania major mitochondrial DNA topoisomerase II 0.0107 0.2955 0.86
Loa Loa (eye worm) hypothetical protein 0.002 0.0323 0.0413
Echinococcus granulosus poly adp ribose polymerase 2 0.0026 0.0489 0.1034
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0018 0.0269 0.0345
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0044
Echinococcus multilocularis DNA topoisomerase 3 beta 1 0.0014 0.0127 0.0269
Loa Loa (eye worm) hypothetical protein 0.002 0.0323 0.0413
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0106 0.0043
Plasmodium vivax DNA gyrase subunit B, putative 0.0045 0.1069 0.2539
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0323 0.0682
Mycobacterium ulcerans DNA gyrase subunit A 0.0025 0.0464 0.0439
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0483 0.1175
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0323 0.0413
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0422 0.0429
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0323 0.0682
Plasmodium falciparum flap endonuclease 1 0.0026 0.0483 0.1246
Brugia malayi Probable DNA topoisomerase II 0.0137 0.3836 0.4917
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0283 0.0575
Echinococcus granulosus dna polymerase eta 0.0044 0.1037 0.2194
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0323 0.0413
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0016 0.0208 0.0267
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0283 0.0599
Leishmania major DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0011 0.0036 0.0077
Echinococcus multilocularis geminin 0.0166 0.4727 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0283 0.0363
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0323 0.0682
Trypanosoma cruzi DNA topoisomerase II, putative 0.0123 0.3421 1
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0323 0.0413
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0137 0.3836 0.4917
Trichomonas vaginalis DNA topoisomerase II, putative 0.0137 0.3836 0.4856
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0179 0.0378
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0323 0.0413
Mycobacterium ulcerans glutaminase 0.0268 0.7802 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0489 0.0627
Loa Loa (eye worm) hypothetical protein 0.0029 0.0593 0.076
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0483 0.1246
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0323 0.1194
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0283 0.0575
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0323 0.0682
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0323 0.0413
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0483 0.0507
Schistosoma mansoni glutaminase 0.0268 0.7802 1
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0025 0.0464 0.2303
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0323 0.0413
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0483 0.0959
Loa Loa (eye worm) RecQ helicase 0.0024 0.0422 0.0541
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0022 0.0384 0.0492
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0005 0.0007
Plasmodium falciparum DNA gyrase subunit B 0.0045 0.1069 0.2777
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0643 0.1665
Schistosoma mansoni hypothetical protein 0.0166 0.4727 0.6058
Plasmodium vivax DNA topoisomerase II, putative 0.0137 0.3836 1
Schistosoma mansoni DNA helicase recq1 0.001 0.0005 0.0007
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0179 0.0378
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0483 0.1021
Loa Loa (eye worm) hypothetical protein 0.001 0.0005 0.0007
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0045 0.1069 0.2777
Brugia malayi DNA topoisomerase III beta-1 0.0014 0.0127 0.0163
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0422 0.0541
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0483 0.1175
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0035 0.0044
Echinococcus granulosus bloom syndrome protein 0.0024 0.0422 0.0894
Loa Loa (eye worm) hypothetical protein 0.0033 0.072 0.0923
Loa Loa (eye worm) hypothetical protein 0.0049 0.1187 0.1522
Loa Loa (eye worm) hypothetical protein 0.0092 0.2479 0.3177
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0047 0.1126 0.1443
Brugia malayi hypothetical protein 0.0011 0.0035 0.0044
Giardia lamblia DNA topoisomerase II 0.013 0.3654 0.365
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0323 0.0682
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0323 0.0413
Trypanosoma cruzi DNA topoisomerase III, putative 0.0014 0.0127 0.0107
Trypanosoma brucei DNA topoisomerase III, putative 0.0014 0.0127 0.0107
Echinococcus granulosus poly (ADP ribose) polymerase 0.0015 0.0151 0.032
Echinococcus granulosus death domain containing protein 0.0016 0.0208 0.0441
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0005 0.0011
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0179 0.0229
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0323 0.0413
Giardia lamblia DINP protein human, muc B family 0.0019 0.0283 0.0278
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0323 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0323 0.0413
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0777 0.1643
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0323 0.0682
Loa Loa (eye worm) glutaminase 0.0268 0.7802 1
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0014 0.0127 0.0163
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0422 0.0429
Entamoeba histolytica DNA topoisomerase III, putative 0.0014 0.0127 0.0036
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0099 0.2702 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0106 0.0043
Echinococcus multilocularis dna polymerase eta 0.0044 0.1037 0.2194
Schistosoma mansoni DNA helicase recq5 0.001 0.0005 0.0007
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0323 0.1194
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0099 0.2702 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0323 0.0413
Schistosoma mansoni hypothetical protein 0.0166 0.4727 0.6058
Loa Loa (eye worm) hypothetical protein 0.002 0.0323 0.0413
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0323 0.0682
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0323 0.0682
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.1037 0.284
Echinococcus multilocularis rho GTPase activating protein 20 0.0014 0.0127 0.0269
Loa Loa (eye worm) hypothetical protein 0.002 0.0323 0.0413
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.1187 0.1522
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0777 0.0996
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0323 0.1194
Plasmodium falciparum DNA topoisomerase 2 0.0137 0.3836 1
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0026 0.0489 0.1194
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0323 0.0682
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0323 0.0413
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.0192 0.0176
Plasmodium falciparum DNA gyrase subunit A 0.0025 0.0464 0.1198
Brugia malayi ecdysteroid receptor 0.002 0.0323 0.0413
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.1187 0.1522
Loa Loa (eye worm) hypothetical protein 0.0092 0.2479 0.3177
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0336 0.0864
Leishmania major DNA polymerase eta, putative 0.0044 0.1037 0.284
Loa Loa (eye worm) hypothetical protein 0.002 0.0323 0.0413
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0422 0.0894
Trypanosoma cruzi DNA topoisomerase II, putative 0.0123 0.3421 1
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0016 0.0208 0.0441
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0123 0.3421 1
Echinococcus granulosus netrin receptor unc 5 0.0016 0.0208 0.0441
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.0007
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0643 0.1657
Brugia malayi hypothetical protein 0.0011 0.0035 0.0044
Trypanosoma brucei poly(adp-ribose) polymerase 0.0026 0.0489 0.1194
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0323 0.0682
Brugia malayi Flap endonuclease-1 0.0026 0.0483 0.0619
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0283 0.0203
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Brugia malayi WGR domain containing protein 0.0026 0.0489 0.0627
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0323 0.0682
Brugia malayi Uncoordinated protein 44 0.0016 0.0208 0.0267
Chlamydia trachomatis DNA gyrase subunit B 0.0074 0.195 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0323 0.0413
Brugia malayi Protein kinase domain containing protein 0.0016 0.0208 0.0267
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0283 0.0193
Schistosoma mansoni prokaryotic DNA topoisomerase 0.0014 0.0127 0.0163
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0005 0.0011
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0017 0.0213 0.0272
Plasmodium vivax DNA gyrase subunit A, putative 0.0025 0.0464 0.0909
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Toxoplasma gondii DNA gyrase/topoisomerase IV, A subunit domain-containing protein 0.0025 0.0464 0.1198
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0137 0.3836 0.4917
Echinococcus granulosus poly ADP ribose polymerase 1 0.0047 0.1126 0.2382
Onchocerca volvulus 0.002 0.0323 0.1194
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0323 0.0413
Entamoeba histolytica hypothetical protein 0.0035 0.0777 0.0691
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0099 0.2702 1
Toxoplasma gondii DNA topoisomerase family protein 0.0014 0.0127 0.0318
Mycobacterium ulcerans DNA gyrase subunit B 0.0045 0.1069 0.1227
Brugia malayi DNA topoisomerase III 0.0014 0.0127 0.0163
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0273 0.035
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0035 0.0073
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0323 0.0413
Plasmodium falciparum DNA topoisomerase 3, putative 0.0014 0.0127 0.0318
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0323 0.0413
Loa Loa (eye worm) DNA topoisomerase III 0.0014 0.0127 0.0163
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.002 0.0323 0.0413
Entamoeba histolytica hypothetical protein 0.0035 0.0777 0.0691
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0137 0.3836 0.8115
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0323 0.0413
Brugia malayi hypothetical protein 0.0035 0.0777 0.0996
Entamoeba histolytica hypothetical protein 0.0035 0.0777 0.0691
Echinococcus granulosus GPCR family 2 0.0015 0.0179 0.0378
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.1037 0.1329
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0049 0.1181 0.3071
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0483 0.0395
Schistosoma mansoni DNA polymerase eta 0.0044 0.1037 0.1329
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0107 0.2955 0.86
Giardia lamblia DNA topoisomerase III 0.0014 0.0127 0.0122
Schistosoma mansoni hypothetical protein 0.0015 0.0179 0.0229
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0016 0.0208 0.0441
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0044
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0035 0.0044
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0283 0.0248
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0047 0.1126 0.1044
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0323 0.0413
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0283 0.0203
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0005 0.0011
Leishmania major DNA topoisomerase ii 0.0123 0.3421 1
Onchocerca volvulus 0.0014 0.0127 0.047
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0084 0.2254 0.4769
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0323 0.0682
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0323 0.0413
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0283 0.0363
Trypanosoma brucei unspecified product 0.0013 0.0106 0.0043
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0483 0.1175
Loa Loa (eye worm) hypothetical protein 0.002 0.0323 0.0413
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.072 0.0923
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0179 0.0378
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0045 0.1069 1
Schistosoma mansoni coup transcription factor 0.002 0.0323 0.0413
Echinococcus multilocularis netrin receptor unc 5 0.0016 0.0208 0.0441
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0323 0.0413
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0323 0.0413
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0283 0.0599
Schistosoma mansoni DNA topoisomerase II 0.0137 0.3836 0.4917
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0044
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0026 0.0489 0.1194
Echinococcus granulosus WGR domain containing protein 0.0015 0.0151 0.032
Giardia lamblia DNA repair protein RAD52 0.0341 1 1
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.0014 0.0127 0.0318
Brugia malayi Immunoglobulin I-set domain containing protein 0.0016 0.0208 0.0267
Chlamydia trachomatis DNA gyrase subunit A 0.0025 0.0464 0.1849
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0283 0.0363
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0047 0.1126 0.2382
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.00000000034866
Trypanosoma brucei DNA topoisomerase IA, putative 0.0014 0.0127 0.0107
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0323 0.0682
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0005 0.0007
Brugia malayi GRF zinc finger family protein 0.0014 0.0127 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Schistosoma mansoni thyroid hormone receptor 0.002 0.0323 0.0413
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0323 0.0413
Leishmania major DNA polymerase eta, putative 0.0031 0.0643 0.1657
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0097 0.2639 0.2571
Trypanosoma cruzi DNA topoisomerase III, putative 0.0014 0.0127 0.0107
Trypanosoma cruzi DNA topoisomerase IA, putative 0.0014 0.0127 0.0107
Loa Loa (eye worm) hypothetical protein 0.0011 0.0035 0.0044
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0137 0.3836 0.8115
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0323 0.0413
Schistosoma mansoni flap endonuclease-1 0.0023 0.0409 0.0524
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0106 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Echinococcus granulosus FTZ F1 alpha 0.002 0.0323 0.0682
Schistosoma mansoni hypothetical protein 0.0016 0.0208 0.0267
Echinococcus granulosus DNA topoisomerase 3 beta 1 0.0014 0.0127 0.0269
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0123 0.3421 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0179 0.0378
Schistosoma mansoni hypothetical protein 0.0035 0.0777 0.0996
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0323 0.0413
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.1037 0.284
Loa Loa (eye worm) DNA topoisomerase III beta-1 0.0014 0.0127 0.0163
Loa Loa (eye worm) hypothetical protein 0.0029 0.0593 0.076
Loa Loa (eye worm) hypothetical protein 0.002 0.0323 0.0413
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0283 0.0599
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0045 0.1069 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0323 0.0413
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0483 0.0478
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0323 0.0413
Entamoeba histolytica DNA topoisomerase III, putative 0.0014 0.0127 0.0036
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0179 0.0229
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0483 0.0619
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0179 0.0229
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0014 0.0127 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0323 0.0413
Schistosoma mansoni hypothetical protein 0.0015 0.0179 0.0229
Chlamydia trachomatis DNA gyrase subunit A 0.0025 0.0464 0.1849
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.1187 0.1522
Loa Loa (eye worm) TOPoisomerase family member 0.0137 0.3836 0.4917
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0323 0.0413
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0323 0.0413
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0035 0.0044
Echinococcus granulosus geminin 0.0166 0.4727 1
Entamoeba histolytica hypothetical protein 0.0035 0.0777 0.0691
Toxoplasma gondii DNA topoisomerase 2, putative 0.0137 0.3836 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0788 0.1011
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0323 0.0413
Trypanosoma brucei DNA topoisomerase ii 0.0107 0.2955 0.86
Loa Loa (eye worm) hypothetical protein 0.0044 0.1037 0.1329
Brugia malayi steroid hormone receptor 0.002 0.0323 0.0413
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0035 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Chlamydia trachomatis DNA gyrase subunit B 0.0045 0.1069 0.5167
Leishmania major DNA topoisomerase III, putative 0.0014 0.0127 0.0107
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0026 0.0489 0.0627
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0323 0.0682
Echinococcus granulosus DNA topoisomerase 3 alpha 0.0014 0.0127 0.0269
Loa Loa (eye worm) hypothetical protein 0.006 0.1535 0.1967
Loa Loa (eye worm) hypothetical protein 0.0017 0.0213 0.0272
Giardia lamblia DNA topoisomerase III 0.0014 0.0127 0.0122
Brugia malayi WGR domain containing protein 0.0047 0.1126 0.1443
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0323 0.0413
Schistosoma mansoni hypothetical protein 0.0015 0.0179 0.0229
Trichomonas vaginalis prokaryotic DNA topoisomerase, putative 0.0014 0.0127 0.0046
Schistosoma mansoni netrin receptor unc5 0.0016 0.0208 0.0267
Mycobacterium leprae Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( 0.0014 0.0127 0.5
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0035 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0777 0.1643
Brugia malayi nuclear hormone receptor 0.002 0.0323 0.0413
Echinococcus granulosus dna polymerase kappa 0.0019 0.0283 0.0599
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0107 0.2955 0.86
Entamoeba histolytica DNA topoisomerase II, putative 0.0137 0.3836 0.3779
Echinococcus granulosus Ankyrin 0.0017 0.0213 0.045
Loa Loa (eye worm) hypothetical protein 0.0029 0.0593 0.076
Trichomonas vaginalis glutaminase, putative 0.0268 0.7802 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0283 0.0575
Loa Loa (eye worm) hypothetical protein 0.0118 0.3288 0.4214
Brugia malayi nuclear receptor RXR 0.0011 0.0035 0.0044
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0045 0.1069 1
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0026 0.0489 0.1034
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0187 0.0474
Trypanosoma brucei unspecified product 0.0019 0.0283 0.0575
Schistosoma mansoni nuclear hormone receptor 0.002 0.0323 0.0413
Brugia malayi Death domain containing protein 0.0016 0.0208 0.0267
Brugia malayi glutaminase DH11.1 0.0268 0.7802 1
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0323 0.0682
Loa Loa (eye worm) hypothetical protein 0.0016 0.0208 0.0267
Onchocerca volvulus Netrin receptor homolog 0.0016 0.0208 0.0771
Trypanosoma cruzi DNA topoisomerase III, putative 0.0014 0.0127 0.0107
Schistosoma mansoni hypothetical protein 0.0015 0.0179 0.0229
Echinococcus granulosus nuclear factor of activated T cells 5 0.0084 0.2254 0.4769
Leishmania major DNA topoisomerase III, putative 0.0014 0.0127 0.0107
Echinococcus granulosus flap endonuclease 1 0.0026 0.0483 0.1021
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0323 0.0682
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0283 0.0575
Treponema pallidum DNA gyrase, subunit A (gyrA) 0.0025 0.0464 0.3578
Entamoeba histolytica hypothetical protein 0.0097 0.2639 0.2571
Leishmania major DNA topoisomerase 1A 0.0014 0.0127 0.0107

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 480 nM Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1) ChEMBL. 15664830
IC50 (binding) = 480 nM Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1) ChEMBL. 15664830

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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