Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | v-akt murine thymoma viral oncogene homolog 3 | Starlite/ChEMBL | References |
Homo sapiens | v-akt murine thymoma viral oncogene homolog 2 | Starlite/ChEMBL | References |
Homo sapiens | v-akt murine thymoma viral oncogene homolog 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | nervana 2 | 0.0083 | 0.0837 | 0.0837 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0088 | 0.0961 | 0.5188 |
Entamoeba histolytica | protein kinase, putative | 0.0126 | 0.1748 | 0.9433 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0083 | 0.0856 | 0.0856 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0083 | 0.0837 | 0.0837 |
Entamoeba histolytica | protein kinase, putative | 0.013 | 0.1853 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.0515 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0197 | 0.3261 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.013 | 0.1853 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.013 | 0.1853 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.0083 | 0.0856 | 0.4621 |
Trichomonas vaginalis | AGC family protein kinase | 0.013 | 0.1853 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.013 | 0.1853 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0088 | 0.0961 | 0.5188 |
Trichomonas vaginalis | AGC family protein kinase | 0.013 | 0.1853 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0048 | 0.0105 | 0.0567 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0126 | 0.1748 | 0.1748 |
Echinococcus granulosus | nervana 2 | 0.0083 | 0.0837 | 0.0837 |
Trichomonas vaginalis | AGC family protein kinase | 0.013 | 0.1853 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0197 | 0.3261 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.013 | 0.1853 | 0.1853 |
Trypanosoma cruzi | Protein kinase B | 0.0088 | 0.0961 | 0.0437 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0088 | 0.0961 | 0.0961 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0088 | 0.0961 | 0.0961 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0083 | 0.0837 | 0.0837 |
Giardia lamblia | Kinase, AGC PKA | 0.0083 | 0.0856 | 0.5 |
Echinococcus granulosus | nervana 2 | 0.0083 | 0.0837 | 0.0837 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0515 | 1 | 0.5 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0515 | 1 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.0515 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0515 | 1 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0515 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0515 | 1 | 0.5 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0083 | 0.0837 | 0.0837 |
Echinococcus multilocularis | nervana 2 | 0.0083 | 0.0837 | 0.0837 |
Trichomonas vaginalis | AGC family protein kinase | 0.013 | 0.1853 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0088 | 0.0961 | 0.0437 |
Schistosoma mansoni | dihydrofolate reductase | 0.0515 | 1 | 1 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0083 | 0.0837 | 0.0837 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0088 | 0.0961 | 0.0961 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0083 | 0.0856 | 0.0856 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0197 | 0.3261 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0083 | 0.0856 | 0.0856 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0126 | 0.1748 | 0.1748 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0515 | 1 | 1 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0197 | 0.3261 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0197 | 0.3261 | 1 |
Brugia malayi | Protein kinase domain containing protein | 0.013 | 0.1853 | 0.1853 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0197 | 0.3261 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.013 | 0.1853 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0088 | 0.0961 | 0.0961 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 63 nM | Inhibitory concentration against human Protein kinase B, alpha | ChEMBL. | 15664853 |
IC50 (binding) | = 63 nM | Inhibition of Akt1 (unknown origin) | ChEMBL. | 18054229 |
IC50 (binding) | = 63 nM | Inhibitory concentration against human Protein kinase B, alpha | ChEMBL. | 15664853 |
IC50 (binding) | = 63 nM | Inhibition of Akt1 (unknown origin) | ChEMBL. | 18054229 |
IC50 (binding) | = 65 nM | Inhibitory concentration against human Protein kinase B, Akt2 | ChEMBL. | 15664853 |
IC50 (binding) | = 65 nM | Inhibition of Akt2 (unknown origin) | ChEMBL. | 18054229 |
IC50 (binding) | = 65 nM | Inhibitory concentration against human Protein kinase B, Akt2 | ChEMBL. | 15664853 |
IC50 (binding) | = 65 nM | Inhibition of Akt2 (unknown origin) | ChEMBL. | 18054229 |
IC50 (binding) | = 1228 nM | Inhibitory concentration against human Protein kinase B, Akt3 | ChEMBL. | 15664853 |
IC50 (binding) | = 1228 nM | Inhibition of Akt3 (unknown origin) | ChEMBL. | 18054229 |
IC50 (binding) | = 1228 nM | Inhibitory concentration against human Protein kinase B, Akt3 | ChEMBL. | 15664853 |
IC50 (binding) | = 1228 nM | Inhibition of Akt3 (unknown origin) | ChEMBL. | 18054229 |
IC50 (binding) | > 50000 nM | Inhibition of PKA (unknown origin) | ChEMBL. | 18054229 |
IC50 (binding) | > 50000 nM | Inhibition of PKC (unknown origin) | ChEMBL. | 18054229 |
IC50 (binding) | > 50000 nM | Inhibition of SGK (unknown origin) | ChEMBL. | 18054229 |
IC50 (binding) | > 50000 nM | Inhibition of SGK (unknown origin) | ChEMBL. | 18054229 |
Solubility | = 18 mg/ml | Solubility at pH 7.4 in 98% saline | ChEMBL. | 18054229 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.