Detailed information for compound 31750

Basic information

Technical information
  • TDR Targets ID: 31750
  • Name: 5-[4-[4-(2-benzyl-1-benzofuran-3-yl)phenyl]ph enoxy]sulfonyl-2-hydroxybenzoic acid
  • MW: 576.615 | Formula: C34H24O7S
  • H donors: 2 H acceptors: 5 LogP: 8.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)c1cc(ccc1O)S(=O)(=O)Oc1ccc(cc1)c1ccc(cc1)c1c(Cc2ccccc2)oc2c1cccc2
  • InChi: 1S/C34H24O7S/c35-30-19-18-27(21-29(30)34(36)37)42(38,39)41-26-16-14-24(15-17-26)23-10-12-25(13-11-23)33-28-8-4-5-9-31(28)40-32(33)20-22-6-2-1-3-7-22/h1-19,21,35H,20H2,(H,36,37)
  • InChiKey: AWKBGZZJBRFEPL-UHFFFAOYSA-N  

Network

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Synonyms

  • 5-[4-[4-(2-benzylbenzofuran-3-yl)phenyl]phenoxy]sulfonyl-2-hydroxy-benzoic acid
  • 5-[4-[4-(2-benzyl-3-benzofuranyl)phenyl]phenoxy]sulfonyl-2-hydroxybenzoic acid
  • 2-hydroxy-5-[4-[4-[2-(phenylmethyl)-1-benzofuran-3-yl]phenyl]phenoxy]sulfonyl-benzoic acid
  • 2-hydroxy-5-[4-[4-[2-(phenylmethyl)-1-benzofuran-3-yl]phenyl]phenoxy]sulfonylbenzoic acid
  • 2-hydroxy-5-[4-[4-[2-(phenylmethyl)benzofuran-3-yl]phenyl]phenoxy]sulfonyl-benzoic acid
  • 2-hydroxy-5-[4-[4-[2-(phenylmethyl)-3-benzofuranyl]phenyl]phenoxy]sulfonylbenzoic acid
  • 5-[4-[4-[2-(benzyl)benzofuran-3-yl]phenyl]phenoxy]sulfonyl-2-hydroxy-benzoic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens protein tyrosine phosphatase, non-receptor type 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K05696 protein tyrosine phosphatase, non-receptor type 1, putative Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 Get druggable targets OG5_133865 All targets in OG5_133865
Loa Loa (eye worm) protein-tyrosine phosphatase Get druggable targets OG5_133865 All targets in OG5_133865
Echinococcus multilocularis tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865
Schistosoma japonicum expressed protein Get druggable targets OG5_133865 All targets in OG5_133865
Brugia malayi Protein-tyrosine phosphatase containing protein Get druggable targets OG5_133865 All targets in OG5_133865
Echinococcus granulosus tyrosine protein phosphatase non receptor type Get druggable targets OG5_133865 All targets in OG5_133865

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0356 0.3278 0.4761
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0158 0.1346 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0428 0.0696
Loa Loa (eye worm) uridine phosphorylase 0.0028 0.0079 0.0057
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0428 0.0688
Loa Loa (eye worm) hypothetical protein 0.1044 1 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0126 0.0106
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0441 0.0642
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0441 0.0642
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0136 0.1133 0.8319
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0079 0.0095
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0428 0.0623
Echinococcus multilocularis neuroglian 0.0039 0.0192 0.0203
Schistosoma mansoni methylthioadenosine phosphorylase 0.0028 0.0079 0.0115
Echinococcus multilocularis tumor protein p63 0.0354 0.3265 0.4711
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0428 0.0623
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0441 0.0642
Brugia malayi hypothetical protein 0.0029 0.0089 0.0067
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.029 0.2634 0.3785
Echinococcus granulosus roundabout 2 0.0044 0.0231 0.0317
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0028 0.0079 0.0057
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0158 0.1346 1
Brugia malayi Rhodanese-like domain containing protein 0.012 0.0974 0.0954
Echinococcus multilocularis m phase inducer phosphatase(cdc25) 0.012 0.0974 0.135
Echinococcus multilocularis protein patched 0.0119 0.097 0.1345
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0038 0.0179 0.0158
Schistosoma mansoni nephrin 0.0039 0.0192 0.0279
Echinococcus granulosus twitchin 0.0039 0.0192 0.0259
Mycobacterium leprae Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) 0.0028 0.0079 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0067
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0428 0.1365
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0126 0.0163
Loa Loa (eye worm) RNA binding protein 0.0065 0.0441 0.042
Echinococcus granulosus geminin 0.0183 0.1593 0.2304
Echinococcus multilocularis uridine phosphorylase 1 0.0028 0.0079 0.0038
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0441 0.042
Loa Loa (eye worm) hypothetical protein 0.0071 0.0497 0.0476
Brugia malayi MTAP 0.0028 0.0079 0.0057
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.029 0.2634 0.3834
Schistosoma mansoni methylthioadenosine phosphorylase 0.0028 0.0079 0.0115
Echinococcus granulosus Protein patched homolog 1 0.0119 0.097 0.1395
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0817 0.0797
Echinococcus granulosus Immunoglobulin 0.0029 0.0089 0.0109
Brugia malayi uridine phosphorylase family protein 0.0028 0.0079 0.0057
Trichomonas vaginalis cdc25b, putative 0.012 0.0974 0.7066
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0067
Onchocerca volvulus 0.012 0.0974 1
Echinococcus multilocularis microtubule associated protein 2 0.0724 0.687 1
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0079 0.0038
Loa Loa (eye worm) hypothetical protein 0.0044 0.0231 0.021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0709 0.1014
Brugia malayi RNA binding protein 0.0065 0.0441 0.042
Trichomonas vaginalis cdc25b, putative 0.012 0.0974 0.7066
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0079 0.0038
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0067
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0356 0.3278 0.473
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0079 0.0038
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0089 0.0067
Echinococcus granulosus methylthioadenosine phosphorylase 0.0028 0.0079 0.0095
Toxoplasma gondii Purine nucleoside phosphorylase 0.0158 0.1346 1
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.029 0.2634 0.3821
Echinococcus multilocularis roundabout 2 0.0044 0.0231 0.0261
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0126 0.0104
Loa Loa (eye worm) hypothetical protein 0.0044 0.0231 0.021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0428 0.0688
Schistosoma mansoni cellular tumor antigen P53 0.0052 0.0312 0.0455
Onchocerca volvulus 0.012 0.0974 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.012 0.0974 0.7066
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0119 0.097 0.1412
Echinococcus granulosus sterol regulatory element binding protein 0.0119 0.097 0.1395
Schistosoma mansoni patched 1 0.0119 0.097 0.1412
Plasmodium falciparum purine nucleoside phosphorylase 0.0158 0.1346 0.5
Mycobacterium ulcerans hydrolase/amidase 0.0547 0.5146 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0356 0.3278 0.4761
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0423 0.3937 0.5731
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0158 0.1346 0.5
Schistosoma mansoni hypothetical protein 0.0183 0.1593 0.2319
Loa Loa (eye worm) hypothetical protein 0.0052 0.0312 0.0291
Schistosoma mansoni uridine phosphorylase 0.0028 0.0079 0.0115
Echinococcus granulosus defective proboscis extension response 0.0029 0.0089 0.0109
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0441 0.042
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0079 0.0095
Schistosoma mansoni hypothetical protein 0.0183 0.1593 0.2319
Brugia malayi Fibronectin type III domain containing protein 0.0029 0.0089 0.0067
Echinococcus multilocularis GPCR, family 2 0.0033 0.0126 0.0106
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0079 0.0095
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0079 0.0095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0067
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0709 0.1032
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0709 0.0962
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0441 0.042
Mycobacterium tuberculosis Probable oxidoreductase 0.0541 0.5085 1
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.097 0.1395
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0817 0.0797
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0079 0.0095
Schistosoma mansoni cell adhesion molecule 0.0033 0.0128 0.0186
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.012 0.0974 0.7066
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0079 0.0095
Entamoeba histolytica rodhanase-like domain containing protein 0.012 0.0974 0.7066
Brugia malayi Immunoglobulin I-set domain containing protein 0.0366 0.3381 0.3367
Loa Loa (eye worm) hypothetical protein 0.0033 0.0126 0.0104
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0079 0.0095
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0441 0.0642
Echinococcus multilocularis Immunoglobulin 0.0029 0.0089 0.0052
Echinococcus multilocularis sterol regulatory element binding protein 0.0119 0.097 0.1345
Schistosoma mansoni purine nucleoside phosphorylase 0.0028 0.0079 0.0115
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.029 0.2634 0.5042
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0423 0.3937 0.5722
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.029 0.2634 1
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0029 0.0089 0.0129
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.029 0.2634 1
Mycobacterium leprae probable uridine phosphorylase 0.0028 0.0079 0.5
Schistosoma mansoni purine nucleoside phosphorylase 0.0028 0.0079 0.0115
Schistosoma mansoni m-phase inducer phosphatase(cdc25) 0.012 0.0974 0.1418
Entamoeba histolytica rodhanase-like domain containing protein 0.012 0.0974 0.7066
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0079 0.0038
Schistosoma mansoni hypothetical protein 0.0033 0.0126 0.0183
Loa Loa (eye worm) hypothetical protein 0.011 0.0883 0.0863
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0441 0.0568
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0709 0.1014
Echinococcus multilocularis geminin 0.0183 0.1593 0.2259
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0158 0.1346 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0126 0.0163
Onchocerca volvulus 0.0052 0.0312 0.2607
Trichomonas vaginalis conserved hypothetical protein 0.0119 0.097 0.7037
Loa Loa (eye worm) hypothetical protein 0.012 0.0974 0.0954
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0817 0.0797
Schistosoma mansoni vesicular amine transporter 0.0029 0.0089 0.0129
Echinococcus granulosus tar DNA binding protein 0.0065 0.0441 0.0623
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0029 0.0089 0.0129
Schistosoma mansoni hypothetical protein 0.0033 0.0126 0.0183
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0126 0.0104
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0119 0.097 0.095
Schistosoma mansoni hypothetical protein 0.0071 0.0497 0.0723
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0079 0.0038
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0428 0.0688
Brugia malayi TAR-binding protein 0.0065 0.0441 0.042
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0126 0.0104
Echinococcus granulosus uridine phosphorylase 1 0.0028 0.0079 0.0095
Echinococcus multilocularis methylthioadenosine phosphorylase 0.0028 0.0079 0.0038
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.0028 0.0079 0.0057
Trichomonas vaginalis m-phase inducer phosphatase, putative 0.012 0.0974 0.7066
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0709 0.0962
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0423 0.3937 0.3924
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0428 0.0549
Echinococcus granulosus GPCR family 2 0.0033 0.0126 0.0163
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0106
Loa Loa (eye worm) hypothetical protein 0.029 0.2634 0.2618
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0423 0.3937 0.5698
Schistosoma mansoni microtubule-associated protein tau 0.0724 0.687 1
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0136 0.1133 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0817 0.0797
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0709 0.1032
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0158 0.1346 1
Onchocerca volvulus 0.012 0.0974 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0709 0.1032
Loa Loa (eye worm) hypothetical protein 0.011 0.0883 0.0863
Brugia malayi CHE-14 protein 0.0119 0.097 0.095
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0158 0.1346 1
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.012 0.0974 0.7066
Schistosoma mansoni uridine phosphorylase 0.0028 0.0079 0.0115
Echinococcus multilocularis protein dispatched 1 0.0119 0.097 0.1345
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0423 0.3937 0.3924
Treponema pallidum uridine phosphorylase (udp) 0.0158 0.1346 1
Onchocerca volvulus 0.012 0.0974 1
Brugia malayi Rhodanese-like domain containing protein 0.012 0.0974 0.0954
Loa Loa (eye worm) TK protein kinase 0.0366 0.3381 0.3367
Schistosoma mansoni methylthioadenosine phosphorylase 0.0028 0.0079 0.0115
Echinococcus granulosus neuroglian 0.0039 0.0192 0.0259
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0029 0.0089 0.0052
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.029 0.2634 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.097 0.1345
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0428 0.2753
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0441 0.0642
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0136 0.1133 0.8319
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0428 0.0604
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0126 0.0106
Echinococcus granulosus m phase inducer phosphatasecdc25 0.012 0.0974 0.14
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.029 0.2634 1
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.029 0.2634 0.2618
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0067
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0709 0.0689
Loa Loa (eye worm) hypothetical protein 0.0119 0.097 0.095
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0356 0.3278 0.473
Loa Loa (eye worm) hypothetical protein 0.0029 0.0089 0.0067
Echinococcus multilocularis purine nucleoside phosphorylase 0.0028 0.0079 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0497 0.0476
Schistosoma mansoni tyrosine kinase 0.0356 0.3278 0.4771
Brugia malayi Immunoglobulin I-set domain containing protein 0.0038 0.0179 0.0158
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0136 0.1133 0.8319
Loa Loa (eye worm) hypothetical protein 0.012 0.0974 0.0954
Schistosoma mansoni hypothetical protein 0.0033 0.0126 0.0183
Echinococcus granulosus purine nucleoside phosphorylase 0.0028 0.0079 0.0095
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0033 0.0128 0.0166
Chlamydia trachomatis AMP nucleosidase 0.0028 0.0079 0.5
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0709 0.0689
Trichomonas vaginalis mitotic inducer phosphatase CDC25, putative 0.012 0.0974 0.7066
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0025 0.0053 0.0058
Schistosoma mansoni hypothetical protein 0.0033 0.0126 0.0183
Echinococcus multilocularis Immunoglobulin 0.0029 0.0089 0.0052
Echinococcus granulosus microtubule associated protein 2 0.0724 0.687 1
Trichomonas vaginalis cdc25c, putative 0.012 0.0974 0.7066
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0025 0.0053 0.0078
Echinococcus granulosus tumor protein p63 0.0354 0.3265 0.4742
Mycobacterium ulcerans short chain dehydrogenase 0.0541 0.5085 0.988
Entamoeba histolytica rodhanase-like domain containing protein 0.012 0.0974 0.7066

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = -1.56 Concentration required for 50% inhibition of tyrosine phosphatase 1B ChEMBL. 15537353
IC50 (binding) = 0.026 uM In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B) ChEMBL. 10753467
IC50 (binding) = 0.026 uM In vitro inhibitory activity against human recombinant protein tyrosine phosphatase 1b (PTP1B) ChEMBL. 10753467
Log IC50 (binding) = 1.56 Concentration required for 50% inhibition of tyrosine phosphatase 1B ChEMBL. 15537353

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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