TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 492.012 | Formula: C27H30ClN5O2
H donors: 1 H acceptors: 3 LogP: 4.93 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: CCN(CCOc1ccc(cc1)Nc1ncc2c(n1)n(C)c(=O)c(c2C)c1ccccc1Cl)CC
InChi: 1S/C27H30ClN5O2/c1-5-33(6-2)15-16-35-20-13-11-19(12-14-20)30-27-29-17-22-18(3)24(21-9-7-8-10-23(21)28)26(34)32(4)25(22)31-27/h7-14,17H,5-6,15-16H2,1-4H3,(H,29,30,31)
InChiKey: XPRLKGXPWFZGHU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	WEE1 G2 checkpoint kinase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Leishmania major	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma congolense	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania braziliensis	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania donovani	protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania mexicana	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma brucei gambiense	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania infantum	protein kinase, putative,serine/threonine protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania major	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma brucei	wee1-like protein kinase	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania braziliensis	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Trypanosoma cruzi	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania donovani	Wee1-like protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania mexicana	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875
Leishmania infantum	serine/threonine-protein kinase, putative,protein kinase, putative	Get druggable targets OG5_129875	All targets in OG5_129875

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0203	0.1826	0.1826
Schistosoma mansoni	tyrosine kinase	0.0221	0.2031	0.2099
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Echinococcus multilocularis	cyclin dependent kinase 5	0.0187	0.1648	0.1648
Loa Loa (eye worm)	hypothetical protein	0.0055	0.018	0.0146
Brugia malayi	Tyrosine-protein kinase abl-1	0.0548	0.5674	0.8219
Giardia lamblia	Kinase, CMGC CDK	0.0187	0.1648	0.5
Leishmania major	cell division protein kinase 2,cdc2-related kinase	0.0187	0.1648	1
Loa Loa (eye worm)	TK protein kinase	0.0145	0.1185	0.1154
Echinococcus multilocularis	acetylcholinesterase	0.0326	0.3199	0.3199
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0174	0.1509	0.1509
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0048	0.0105	0.0105
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0077	0.0428	0.0443
Onchocerca volvulus		0.0049	0.0112	0.5265
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0361	0.3588	0.3588
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0055	0.018	0.018
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0203	0.1826	0.1826
Schistosoma mansoni	tyrosine kinase	0.0049	0.0112	0.0115
Brugia malayi	hypothetical protein	0.0049	0.0112	0.0112
Schistosoma mansoni	acetylcholinesterase	0.0055	0.018	0.0187
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0155	0.1289	0.1289
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0203	0.1826	0.1826
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Schistosoma mansoni	tyrosine kinase	0.0049	0.011	0.0113
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0055	0.018	0.018
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0118	0.0083
Brugia malayi	Carboxylesterase family protein	0.0326	0.3199	0.4612
Loa Loa (eye worm)	carboxylesterase	0.0326	0.3199	0.3175
Echinococcus multilocularis	N chimaerin	0.0048	0.0105	0.0105
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0112	0.0112
Brugia malayi	Carboxylesterase family protein	0.0055	0.018	0.0212
Loa Loa (eye worm)	hypothetical protein	0.0359	0.3568	0.3545
Trypanosoma brucei	cdc2-related kinase 1	0.0187	0.1648	1
Echinococcus multilocularis	cyclin dependent kinase 1	0.0187	0.1648	0.1648
Echinococcus granulosus	cyclin dependent kinase 1	0.0187	0.1648	0.1648
Brugia malayi	Variant SH3 domain containing protein	0.0058	0.0208	0.0253
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0203	0.1826	0.1826
Onchocerca volvulus		0.0049	0.0112	0.5265
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0048	0.0105	0.0105
Echinococcus multilocularis	NCK adaptor protein	0.0058	0.0208	0.0208
Onchocerca volvulus		0.0055	0.018	1
Schistosoma mansoni	tyrosine kinase	0.0361	0.3588	0.3708
Echinococcus granulosus	neuroligin	0.0055	0.018	0.018
Schistosoma mansoni	hypothetical protein	0.018	0.1573	0.1626
Echinococcus granulosus	NCK adaptor protein	0.0058	0.0208	0.0208
Echinococcus granulosus	roundabout 2	0.0049	0.0118	0.0118
Loa Loa (eye worm)	SRC-1	0.0203	0.1826	0.1797
Loa Loa (eye worm)	TK/ABL protein kinase	0.0936	1	1
Onchocerca volvulus		0.0049	0.0112	0.5265
Brugia malayi	Sex muscle abnormal protein 5	0.0058	0.0208	0.0253
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0203	0.1826	0.1826
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0112	0.0112
Leishmania major	cell division related protein kinase 2,cdc2-related kinase	0.0187	0.1648	1
Echinococcus multilocularis	para nitrobenzyl esterase	0.0055	0.018	0.018
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0203	0.1826	0.1826
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0658	0.6896	0.6885
Echinococcus granulosus	carboxylesterase 5A	0.0326	0.3199	0.3199
Loa Loa (eye worm)	carboxylesterase	0.0055	0.018	0.0146
Trypanosoma cruzi	cdc2-related kinase 1	0.0187	0.1648	1
Schistosoma mansoni	serine/threonine protein kinase	0.0177	0.1545	0.1597
Schistosoma mansoni	nephrin	0.0043	0.0043	0.0045
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0203	0.1826	0.1826
Echinococcus multilocularis	tyrosine kinase	0.0049	0.0112	0.0112
Echinococcus granulosus	para nitrobenzyl esterase	0.0055	0.018	0.018
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0203	0.1826	0.1826
Schistosoma mansoni	tyrosine kinase	0.0221	0.2031	0.2099
Loa Loa (eye worm)	hypothetical protein	0.0125	0.0958	0.0926
Schistosoma mansoni	growth factor receptor-bound protein	0.0058	0.0208	0.0215
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0047	0.009	0.008
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0187	0.1648	0.1619
Trypanosoma cruzi	cdc2-related kinase 3	0.0187	0.1648	1
Schistosoma mansoni	tyrosine kinase	0.0049	0.0112	0.0115
Echinococcus multilocularis	insulin receptor	0.0221	0.2031	0.2031
Loa Loa (eye worm)	TK protein kinase	0.0174	0.1509	0.148
Brugia malayi	Carboxylesterase family protein	0.0055	0.018	0.0212
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0042	0.0035	0.0035
Echinococcus granulosus	twitchin	0.0046	0.0078	0.0078
Echinococcus multilocularis		0.0199	0.178	0.178
Onchocerca volvulus		0.0055	0.018	1
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.1648	0.1703
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0055	0.018	0.0187
Echinococcus granulosus	tyrosine protein kinase HCK	0.0145	0.1185	0.1185
Echinococcus granulosus	Protein kinase C brain isozyme	0.0177	0.1545	0.1545
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0058	0.0208	0.0215
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0058	0.0208	0.0174
Echinococcus granulosus	tyrosine protein kinase Srms	0.0049	0.0112	0.0112
Schistosoma mansoni	hypothetical protein	0.018	0.1573	0.1626
Trichomonas vaginalis	CMGC family protein kinase	0.0187	0.1648	1
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0055	0.018	0.5
Brugia malayi	protein kinase C II.	0.0053	0.0154	0.0174
Echinococcus granulosus	growth factor receptor bound protein 2	0.0058	0.0208	0.0208
Echinococcus granulosus	epidermal growth factor receptor	0.0658	0.6896	0.6896
Plasmodium falciparum	protein kinase 5	0.0187	0.1648	0.5
Loa Loa (eye worm)	hypothetical protein	0.0326	0.3199	0.3175
Loa Loa (eye worm)	AGC/PKC/ALPHA protein kinase	0.0132	0.1037	0.1005
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0055	0.018	0.018
Loa Loa (eye worm)	hypothetical protein	0.0055	0.018	0.0146
Echinococcus multilocularis	protein kinase c iota type	0.0049	0.011	0.011
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0203	0.1826	0.1826
Schistosoma mansoni	tyrosine kinase	0.0658	0.6896	0.7128
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0203	0.1826	0.1826
Brugia malayi	Tyrosine-protein kinase abl-1	0.0416	0.4209	0.6084
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0049	0.0112	0.0112
Brugia malayi	cell division control protein 2 homolog	0.0187	0.1648	0.2351
Brugia malayi	SH2 domain containing protein	0.0049	0.0112	0.0112
Trichomonas vaginalis	CMGC family protein kinase	0.0187	0.1648	1
Trypanosoma cruzi	cdc2-related kinase 3	0.0187	0.1648	1
Echinococcus granulosus	geminin	0.018	0.1573	0.1573
Loa Loa (eye worm)	CMGC/CDK/CDC2 protein kinase	0.0187	0.1648	0.1619
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0203	0.1826	0.1826
Schistosoma mansoni	serine/threonine protein kinase	0.0048	0.0104	0.0107
Trypanosoma cruzi	cdc2-related kinase 1	0.0187	0.1648	1
Giardia lamblia	Kinase, CMGC CDK	0.0187	0.1648	0.5
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0112	0.0112
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0203	0.1826	0.1826
Brugia malayi	SRC-1	0.0203	0.1826	0.2611
Schistosoma mansoni	serine/threonine protein kinase	0.0177	0.1545	0.1597
Trypanosoma brucei	cdc2-related kinase 3	0.0187	0.1648	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0048	0.0105	0.0108
Loa Loa (eye worm)	hypothetical protein	0.0055	0.018	0.0146
Loa Loa (eye worm)	CMGC/CDK/CDK5 protein kinase	0.0187	0.1648	0.1619
Loa Loa (eye worm)	hypothetical protein	0.0055	0.018	0.0146
Onchocerca volvulus		0.0055	0.018	1
Schistosoma mansoni	tyrosine kinase	0.0077	0.0428	0.0443
Schistosoma mansoni	tyrosine kinase	0.0907	0.9675	1
Echinococcus granulosus	BC026374 protein S09 family	0.0055	0.018	0.018
Echinococcus multilocularis	cyclin dependent kinase	0.0187	0.1648	0.1648
Loa Loa (eye worm)	carboxylesterase	0.0055	0.018	0.0146
Brugia malayi	Protein kinase domain containing protein	0.0221	0.2031	0.2909
Brugia malayi	hypothetical protein	0.0055	0.018	0.0212
Schistosoma mansoni	gliotactin	0.0055	0.018	0.0187
Onchocerca volvulus		0.0055	0.018	1
Onchocerca volvulus		0.0055	0.018	1
Schistosoma mansoni	tyrosine kinase	0.0361	0.3588	0.3708
Echinococcus multilocularis	telomerase reverse transcriptase subunit	0.0125	0.0958	0.0958
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0203	0.1826	0.1826
Schistosoma mansoni	serine/threonine protein kinase	0.0187	0.1648	0.1703
Echinococcus granulosus	5'partial\|cyclin dependent kinase 1	0.0187	0.1648	0.1648
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0203	0.1826	0.1826
Brugia malayi	Carboxylesterase family protein	0.0326	0.3199	0.4612
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0145	0.1185	0.1185
Schistosoma mansoni	growth factor receptor-bound protein	0.0058	0.0208	0.0215
Echinococcus multilocularis	RNA directed DNA polymerase	0.0125	0.0958	0.0958
Schistosoma mansoni	tyrosine kinase	0.0077	0.0428	0.0443
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0206	0.1861	0.1861
Echinococcus multilocularis	epidermal growth factor receptor	0.0361	0.3588	0.3588
Onchocerca volvulus		0.0049	0.0112	0.5265
Echinococcus granulosus	acetylcholinesterase	0.0326	0.3199	0.3199
Echinococcus granulosus	RNA directed DNA polymerase	0.0125	0.0958	0.0958
Mycobacterium ulcerans	carboxylesterase, LipT	0.0055	0.018	0.5
Schistosoma mansoni	tyrosine kinase	0.0341	0.3368	0.3481
Brugia malayi	Furin-like cysteine rich region family protein	0.0658	0.6896	1
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.0221	0.2031	0.2031
Onchocerca volvulus		0.0049	0.0112	0.5265
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0048	0.0105	0.007
Brugia malayi	protein-tyrosine kinase	0.0174	0.1509	0.2149
Echinococcus granulosus	protein kinase c iota type	0.0049	0.011	0.011
Entamoeba histolytica	cell division protein kinase 2, putative	0.0187	0.1648	1
Echinococcus granulosus	tyrosine kinase	0.0049	0.0112	0.0112
Loa Loa (eye worm)	AGC/PKC/ETA protein kinase	0.0053	0.0154	0.0119
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0058	0.0208	0.0208
Brugia malayi	Carboxylesterase family protein	0.0055	0.018	0.0212
Schistosoma mansoni	serine/threonine protein kinase	0.0053	0.0154	0.0159
Echinococcus granulosus	acetylcholinesterase	0.0326	0.3199	0.3199
Plasmodium vivax	protein kinase Crk2	0.0187	0.1648	0.5
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0042	0.0035	0.0035
Echinococcus granulosus	tyrosine protein kinase Blk	0.0174	0.1509	0.1509
Loa Loa (eye worm)	hypothetical protein	0.0184	0.1613	0.1584
Loa Loa (eye worm)	hypothetical protein	0.0055	0.018	0.0146
Echinococcus granulosus	epidermal growth factor receptor	0.0361	0.3588	0.3588
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0058	0.0208	0.0174
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0055	0.018	0.5
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0208	0.0174
Echinococcus granulosus	protein kinase c epsilon type	0.0053	0.0154	0.0154
Trichomonas vaginalis	CMGC family protein kinase	0.0187	0.1648	1
Echinococcus multilocularis	epidermal growth factor receptor	0.0658	0.6896	0.6896
Brugia malayi	Protein kinase domain containing protein	0.0187	0.1648	0.2351
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0112	0.0112
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0047	0.009	0.0055
Brugia malayi	Protein kinase domain containing protein	0.0049	0.0112	0.0112
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0203	0.1826	0.1826
Schistosoma mansoni	tyrosine kinase	0.0203	0.1826	0.1888
Schistosoma mansoni	atypical protein kinase C	0.0049	0.011	0.0113
Echinococcus multilocularis	carboxylesterase 5A	0.0326	0.3199	0.3199
Brugia malayi	Carboxylesterase family protein	0.0055	0.018	0.0212
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Loa Loa (eye worm)	acetylcholinesterase 1	0.0326	0.3199	0.3175
Echinococcus multilocularis	roundabout 2	0.0049	0.0118	0.0118
Echinococcus multilocularis	cyclin dependent kinase 1	0.0187	0.1648	0.1648
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0049	0.0112	0.0112
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0055	0.018	0.0187
Echinococcus multilocularis	Protein kinase C, brain isozyme	0.0177	0.1545	0.1545
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0118	0.0083
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0416	0.4209	0.4209
Echinococcus multilocularis	acetylcholinesterase	0.0326	0.3199	0.3199
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0155	0.1289	0.1289
Onchocerca volvulus		0.0049	0.0112	0.5265
Loa Loa (eye worm)	hypothetical protein	0.0144	0.1171	0.114
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0936	1	1
Echinococcus granulosus	neuroglian	0.0043	0.0043	0.0043
Echinococcus granulosus	N chimaerin	0.0048	0.0105	0.0105
Schistosoma mansoni	tyrosine kinase	0.0341	0.3368	0.3481
Brugia malayi	SH2 domain containing protein	0.0049	0.0112	0.0112
Brugia malayi	Variant SH3 domain containing protein	0.0048	0.0105	0.0102
Loa Loa (eye worm)	TK/INSR protein kinase	0.0221	0.2031	0.2003
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0055	0.018	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0203	0.1826	0.1826
Echinococcus granulosus	tyrosine kinase	0.0174	0.1509	0.1509
Brugia malayi	Protein kinase c protein 2	0.0151	0.125	0.1771
Echinococcus multilocularis	c src tyrosine kinase	0.0077	0.0428	0.0428
Schistosoma mansoni	adapter molecule crk	0.0058	0.0208	0.0215
Brugia malayi	RhoGAP domain containing protein	0.0048	0.0105	0.0102
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0174	0.1509	0.1509
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0048	0.0105	0.0108
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0174	0.1509	0.1509
Entamoeba histolytica	protein kinase, putative	0.0145	0.1185	0.6985
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Schistosoma mansoni	BC026374 protein (S09 family)	0.0055	0.018	0.0187
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.0221	0.2031	0.2031
Loa Loa (eye worm)	hypothetical protein	0.0326	0.3199	0.3175
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0077	0.0428	0.0428
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0055	0.018	0.0187
Echinococcus multilocularis	protein kinase c epsilon type	0.0053	0.0154	0.0154
Schistosoma mansoni	tyrosine kinase	0.0341	0.3368	0.3481
Echinococcus granulosus	c src tyrosine kinase	0.0077	0.0428	0.0428
Schistosoma mansoni	vav2	0.0048	0.0105	0.0108
Brugia malayi	Variant SH3 domain containing protein	0.0058	0.0208	0.0253
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0077	0.0428	0.0428
Echinococcus granulosus	cyclin dependent kinase	0.0187	0.1648	0.1648
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0112	0.0077
Echinococcus granulosus	cyclin dependent kinase 5	0.0187	0.1648	0.1648
Schistosoma mansoni	tyrosine kinase	0.0203	0.1826	0.1888
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0174	0.1509	0.1509
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Echinococcus multilocularis	neuroglian	0.0043	0.0043	0.0043
Echinococcus multilocularis	tyrosine protein kinase shark	0.0049	0.0112	0.0112
Schistosoma mansoni	nck2/grb4	0.0058	0.0208	0.0215
Loa Loa (eye worm)	hypothetical protein	0.0055	0.018	0.0146
Echinococcus multilocularis	serine threonine protein kinase	0.0158	0.1332	0.1332
Echinococcus granulosus	protein kinase C gamma type	0.0158	0.1332	0.1332
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0055	0.018	0.0187
Echinococcus granulosus	insulin receptor	0.0221	0.2031	0.2031
Toxoplasma gondii	cell-cycle-associated protein kinase CDK, putative	0.0187	0.1648	0.5
Entamoeba histolytica	cell division protein kinase 2, putative	0.0187	0.1648	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0049	0.0112	0.0112
Loa Loa (eye worm)	TK/FER protein kinase	0.0049	0.0112	0.0077
Loa Loa (eye worm)	hypothetical protein	0.0055	0.018	0.0146
Echinococcus multilocularis	geminin	0.018	0.1573	0.1573
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0326	0.3199	0.3306
Echinococcus multilocularis	neuroligin	0.0055	0.018	0.018

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.55 uM	Inhibition of checkpoint kinase Wee1	ChEMBL.	15780636
IC50 (binding)	= 0.55 uM	Inhibition of checkpoint kinase Wee1	ChEMBL.	15780636
IC50 (binding)	> 50 uM	Inhibition of c-Src tyrosine kinase	ChEMBL.	15780636

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL181017

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 317502