Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor VII (serum prothrombin conversion accelerator) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Echinococcus granulosus | glycoprotein Antigen 5 | coagulation factor VII (serum prothrombin conversion accelerator) | 466 aa | 384 aa | 23.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0302 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0302 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0302 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0051 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.0123 | 0.2891 | 0.2891 |
Brugia malayi | Carboxylesterase family protein | 0.0302 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.2891 | 0.2891 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0123 | 0.2891 | 0.2891 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.2891 | 0.2891 |
Echinococcus granulosus | acetylcholinesterase | 0.0302 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0302 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0302 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0302 | 1 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0302 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0051 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0302 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0051 | 0 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.221 | 0.7646 | |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.2891 | 0.2891 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0051 | 0 | 0.5 |
Onchocerca volvulus | 0.0123 | 0.2891 | 1 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0051 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.27 uM | The value of binding constant measured against human Thrombin | ChEMBL. | 15664864 |
Ki (binding) | = 0.27 uM | The value of binding constant measured against human Thrombin | ChEMBL. | 15664864 |
Ki (binding) | = 0.58 uM | The value of binding constant measured against human trypsin | ChEMBL. | 15664864 |
Ki (binding) | = 0.58 uM | The value of binding constant measured against human trypsin | ChEMBL. | 15664864 |
Ki (binding) | = 1 uM | The value of binding constant measured against coagulation factor VII | ChEMBL. | 15664864 |
Ki (binding) | = 1 uM | The value of binding constant measured against coagulation factor VII | ChEMBL. | 15664864 |
Ki (binding) | = 1.2 uM | The value of binding constant measured against coagulation factor X (factor Xa) | ChEMBL. | 15664864 |
Ki (binding) | = 1.2 uM | The value of binding constant measured against coagulation factor X (factor Xa) | ChEMBL. | 15664864 |
Ratio (binding) | = 0.3 uM | The ratio of binding constants of Thrombin to coagulation factor VII | ChEMBL. | 15664864 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.