Detailed information for compound 317625

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 297.309 | Formula: C16H15N3O3
  • H donors: 2 H acceptors: 1 LogP: 1.02 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1=C(N)C2C(C=C1N)Oc1c(C2)cc2c(c1)OCCO2
  • InChi: 1S/C16H15N3O3/c17-7-10-11(18)5-13-9(16(10)19)3-8-4-14-15(6-12(8)22-13)21-2-1-20-14/h4-6,9,13H,1-3,18-19H2
  • InChiKey: FTLFWYCUAOSWPL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0067 0.0771 0.077
Brugia malayi steroid hormone receptor 0.002 0.015 0.0149
Trypanosoma brucei serine/threonine protein phosphatase 5 0.0022 0.0182 0.1554
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0009 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1749 1
Onchocerca volvulus 0.0128 0.1595 1
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0022 0.0182 0.1528
Brugia malayi fructose-bisphosphate aldolase 1 0.0089 0.1072 0.1071
Brugia malayi orphan nuclear receptor NR2E1 0.0009 0.0011 0.001
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0089 0.1072 0.107
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0011 0.0007
Loa Loa (eye worm) hypothetical protein 0.002 0.015 0.015
Brugia malayi nuclear receptor RXR 0.001 0.0026 0.0025
Onchocerca volvulus 0.0028 0.0261 0.158
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0046 0.0497 0.0497
Loa Loa (eye worm) Ulp1 protease 0.0038 0.0391 0.0391
Echinococcus multilocularis expressed conserved protein 0.0132 0.1645 0.1644
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0067 0.0771 0.077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0009 0.0011 0.0008
Echinococcus multilocularis protein phosphatase 5 0.0021 0.0167 0.0165
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0771 0.1969
Trichomonas vaginalis rotamase, putative 0.0033 0.0322 0.0737
Loa Loa (eye worm) carboxylesterase 0.0128 0.1595 0.1595
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.001 0.0026 0.0022
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Trypanosoma cruzi serine/threonine protein phosphatase type 5, putative 0.0022 0.0182 0.1528
Schistosoma mansoni nuclear receptor 0.0009 0.0011 0.0007
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0038 0.0391 0.0927
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0089 0.1072 0.107
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH2 0.0067 0.0771 0.7149
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.015 0.0149
Brugia malayi nuclear receptor RXR 0.0009 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0011 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.015 0.0148
Brugia malayi Carboxylesterase family protein 0.0128 0.1595 0.1595
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.009 0.1089 0.2841
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1072 0.9834
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0021 0.016 0.1324
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.015 0.0146
Trypanosoma brucei fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1072 1
Echinococcus granulosus nuclear receptor nhr 48 0.0009 0.0011 0.0008
Brugia malayi Carboxylesterase family protein 0.0128 0.1595 0.1595
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0596 0.5485
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.015 0.0149
Brugia malayi glyceraldehyde 3-phosphate dehydrogenase 0.0021 0.016 0.016
Echinococcus granulosus para nitrobenzyl esterase 0.0128 0.1595 0.1593
Echinococcus granulosus neuroligin 0.0128 0.1595 0.1593
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.015 0.0148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.37 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.0466 0.0466
Brugia malayi nuclear hormone receptor 0.002 0.015 0.0149
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.015 0.0148
Onchocerca volvulus 0.0128 0.1595 1
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0771 0.1969
Plasmodium falciparum glyceraldehyde-3-phosphate dehydrogenase 0.0067 0.0771 0.6681
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.37 1
Echinococcus multilocularis acetylcholinesterase 0.076 1 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.076 1 1
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0128 0.1595 0.1593
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.0391
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0038 0.0391 0.0388
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.015 0.0148
Brugia malayi conserved hypotetical protein 0.0009 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0312 0.2783
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0038 0.0391 0.3538
Loa Loa (eye worm) nuclear hormone receptor 0.0009 0.0011 0.0011
Leishmania major SUMO1/Ulp2, putative,cysteine peptidase, Clan CA, family C48, putative 0.0038 0.0391 0.3538
Schistosoma mansoni thyroid hormone receptor 0.0143 0.1793 0.179
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.015 0.0148
Brugia malayi nuclear hormone receptor family member nhr-6 0.0009 0.0011 0.001
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0466 0.4175
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.015 0.0148
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.015 0.0148
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0771 0.703
Brugia malayi hypothetical protein 0.0009 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.002 0.015 0.015
Loa Loa (eye worm) Ulp1 protease 0.009 0.1089 0.1089
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0312 0.0709
Echinococcus multilocularis BC026374 protein (S09 family) 0.0128 0.1595 0.1593
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.37 1
Echinococcus granulosus sentrin specific protease 1 0.0038 0.0391 0.0389
Toxoplasma gondii serine/threonine protein phosphatase 0.0021 0.0167 0.1409
Loa Loa (eye worm) fructose-bisphosphate aldolase 1 0.0089 0.1072 0.1072
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Brugia malayi Carboxylesterase family protein 0.0128 0.1595 0.1595
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0128 0.1595 0.1592
Onchocerca volvulus 0.0038 0.0391 0.2402
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0067 0.0771 0.1969
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.015 0.0146
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0128 0.1595 0.4227
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1072 0.9834
Loa Loa (eye worm) hypothetical protein 0.002 0.015 0.015
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.015 0.0148
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.009 0.1089 0.1089
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0011 0.0008
Plasmodium vivax glyceraldehyde-3-phosphate dehydrogenase, putative 0.0067 0.0771 0.6681
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0312 0.2737
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Leishmania major fructose-1,6-bisphosphate aldolase 0.0089 0.1072 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.0771 0.703
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Loa Loa (eye worm) fructose-bisphosphate aldolase 2 0.0089 0.1072 0.1072
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0312 0.2737
Brugia malayi ecdysteroid receptor 0.002 0.015 0.0149
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0038 0.0391 0.0927
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.015 0.0146
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0771 0.703
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.0391
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.015 0.0149
Trichomonas vaginalis Sentrin-specific protease, putative 0.009 0.1089 0.2841
Brugia malayi nuclear receptor NHR-67 0.0009 0.0011 0.001
Loa Loa (eye worm) carboxylesterase 0.076 1 1
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0067 0.0771 0.077
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0067 0.0771 0.0768
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.001 0.0026 0.0026
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0038 0.0391 0.3538
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.015 0.0149
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.015 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.015 0.0149
Echinococcus multilocularis acetylcholinesterase 0.076 1 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1595 0.1595
Plasmodium falciparum fructose-bisphosphate aldolase 0.0089 0.1072 1
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0128 0.1595 0.1592
Onchocerca volvulus 0.0128 0.1595 1
Loa Loa (eye worm) hypothetical protein 0.0128 0.1595 0.1595
Brugia malayi CXXC zinc finger family protein 0.0028 0.0261 0.026
Echinococcus granulosus thyroid hormone receptor alpha 0.0009 0.0011 0.0008
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.016 0.1324
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0023 0.0191 0.0379
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Echinococcus granulosus expressed conserved protein 0.0132 0.1645 0.1644
Schistosoma mansoni acetylcholinesterase 0.0128 0.1595 0.1592
Brugia malayi hypothetical protein 0.001 0.0026 0.0025
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.015 0.0149
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.015 0.0146
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.37 1
Chlamydia trachomatis glyceraldehyde-3-phosphate dehydrogenase 0.0067 0.0771 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.015 0.0149
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0089 0.1072 0.107
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0038 0.0391 0.0391
Echinococcus granulosus dnaJ subfamily B 0.0401 0.5224 0.5223
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0067 0.0771 0.7149
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.015 0.0879
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.015 0.0879
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0067 0.0771 0.0768
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0011 0.0008
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0023 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0322 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.015 0.0149
Brugia malayi Ser/Thr protein phosphatase family protein 0.0009 0.0004 0.0003
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0009 0.0011 0.0011
Schistosoma mansoni zinc finger protein 0.0009 0.0011 0.0007
Schistosoma mansoni protein phosphatase-5 0.0022 0.0182 0.0179
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.37 1
Leishmania major serine/threonine protein phosphatase type 5, putative 0.0021 0.0167 0.1409
Loa Loa (eye worm) nuclear receptor NHR-67 0.0009 0.0011 0.0011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.37 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.015 0.0149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0009 0.0011 0.0008
Mycobacterium ulcerans carboxylesterase, LipT 0.0128 0.1595 0.8422
Brugia malayi Carboxylesterase family protein 0.0128 0.1595 0.1595
Loa Loa (eye worm) hypothetical protein 0.0128 0.1595 0.1595
Schistosoma mansoni nuclear receptor nhr-48 0.0009 0.0011 0.0007
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0038 0.0391 0.0927
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0771 0.703
Echinococcus multilocularis sentrin specific protease 1 0.0038 0.0391 0.0389
Echinococcus multilocularis cpg binding protein 0.003 0.0282 0.028
Loa Loa (eye worm) acetylcholinesterase 1 0.076 1 1
Trichomonas vaginalis spcc417.12 protein, putative 0.0128 0.1595 0.4227
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0322 0.0322
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.009 0.1089 0.2841
Echinococcus granulosus Nuclear hormone receptor HR96 0.0009 0.0011 0.0008
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0009 0.0011 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0026 0.0025
Brugia malayi serine/threonine protein phosphatase 5 0.0021 0.0167 0.0166
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1072 0.9834
Plasmodium vivax sentrin-specific protease 1, putative 0.0038 0.0391 0.2478
Loa Loa (eye worm) hypothetical protein 0.076 1 1
Loa Loa (eye worm) hypothetical protein 0.002 0.015 0.015
Brugia malayi hypothetical protein 0.0009 0.0011 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.37 1
Loa Loa (eye worm) serine/threonine protein phosphatase 5 0.0021 0.0167 0.0167
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0026 0.0022
Echinococcus granulosus fructose bisphosphate aldolase class I 0.0089 0.1072 0.107
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.015 0.0148
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0038 0.0391 0.0388
Brugia malayi Steroid receptor seven-up type 2 0.002 0.015 0.0149
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0067 0.0771 0.1969
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, cytosolic 0.0067 0.0771 0.7149
Schistosoma mansoni nuclear hormone receptor 0.002 0.015 0.0146
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.016 0.1324
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, putative 0.0021 0.016 0.1324
Trichomonas vaginalis rotamase, putative 0.0032 0.0312 0.0709
Echinococcus granulosus FTZ F1 alpha 0.002 0.015 0.0148
Brugia malayi nuclear hormone receptor family member odr-7 0.0009 0.0011 0.001
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0771 0.1969
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0089 0.1072 0.107
Echinococcus granulosus sentrin specific protease 7 0.017 0.2151 0.2149
Entamoeba histolytica glyceraldehyde-3-phosphate dehydrogenase, putative 0.0067 0.0771 0.1969
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.015 0.0146
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0391 0.0927
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.37 1
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0067 0.0771 0.7149
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.015 0.0149
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0128 0.1595 0.9009
Loa Loa (eye worm) hypothetical protein 0.0128 0.1595 0.1595
Brugia malayi fructose-bisphosphate aldolase 2 0.0089 0.1072 0.1071
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.015 0.0148
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0466 0.0225
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.015 0.015
Echinococcus granulosus fructose 16 bisphosphate aldolase 0.0089 0.1072 0.107
Echinococcus multilocularis thyroid hormone receptor alpha 0.0143 0.1793 0.1791
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0038 0.0391 0.0927
Loa Loa (eye worm) hypothetical protein 0.002 0.015 0.015
Echinococcus granulosus cpg binding protein 0.003 0.0282 0.028
Loa Loa (eye worm) hypothetical protein 0.002 0.015 0.015
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0038 0.0391 0.3538
Loa Loa (eye worm) hypothetical protein 0.0038 0.0391 0.0391
Loa Loa (eye worm) steroid hormone receptor 0.002 0.015 0.015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.37 1
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0089 0.1072 1
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0038 0.0391 0.0391
Schistosoma mansoni BC026374 protein (S09 family) 0.0128 0.1595 0.1592
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Loa Loa (eye worm) glyceraldehyde 3-phosphate dehydrogenase 0.0044 0.0466 0.0466
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0771 0.1969
Echinococcus granulosus carboxylesterase 5A 0.076 1 1
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0038 0.0391 0.0927
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0038 0.0391 0.0927
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.015 0.0149
Plasmodium vivax sentrin-specific protease 2, putative 0.0038 0.0391 0.2478
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.0466 0.0464
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0038 0.0391 0.0927
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0771 0.1969
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.015 0.0149
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.1529 0.1527
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.015 0.015
Loa Loa (eye worm) hypothetical protein 0.0128 0.1595 0.1595
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.1529 0.1527
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0009 0.0011 0.0008
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.015 0.0148
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.017 0.2151 0.2147
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0067 0.0771 0.0768
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.0771 0.703
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1749 1
Giardia lamblia Glyceraldehyde 3-phosphate dehydrogenase 0.0067 0.0771 0.1149
Schistosoma mansoni thyroid hormone receptor 0.0143 0.1793 0.179
Echinococcus multilocularis fructose bisphosphate aldolase class I 0.0089 0.1072 0.107
Schistosoma mansoni cpg binding protein 0.003 0.0282 0.0279
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0021 0.016 0.1324
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0009 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0123 0.1529 0.1526
Schistosoma mansoni coup transcription factor 0.002 0.015 0.0146
Brugia malayi ecdysone receptor 0.0009 0.0011 0.001
Wolbachia endosymbiont of Brugia malayi glyceraldehyde-3-phosphate dehydrogenase, GapA 0.0067 0.0771 1
Leishmania major glyceraldehyde-3-phosphate dehydrogenase-like protein 0.0044 0.0466 0.4245
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.015 0.015
Toxoplasma gondii fructose-bisphosphate aldolase, putative 0.0089 0.1072 1
Echinococcus multilocularis sentrin specific protease 8 0.009 0.1089 0.1088
Echinococcus multilocularis fructose 1,6 bisphosphate aldolase 0.0089 0.1072 0.107
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0026 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.015 0.0149
Schistosoma mansoni hypothetical protein 0.0401 0.5224 0.5222
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.015 0.015
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0038 0.0391 0.0927
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.015 0.0148
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0261 0.0261
Loa Loa (eye worm) hypothetical protein 0.0128 0.1595 0.1595
Echinococcus granulosus acetylcholinesterase 0.076 1 1
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0038 0.0391 0.0927
Brugia malayi Glyceraldehyde 3-phosphate dehydrogenase 0.0067 0.0771 0.0771
Mycobacterium tuberculosis Carboxylesterase LipT 0.0128 0.1595 0.9009
Trypanosoma brucei SUMO1/Ulp2, putative 0.0038 0.0391 0.3538
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.37 1
Schistosoma mansoni cpg binding protein 0.0028 0.0261 0.0257
Loa Loa (eye worm) glyceraldehyde-3-phosphate dehydrogenase 0.0046 0.0497 0.0497
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0466 0.1132
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0038 0.0391 0.0391
Echinococcus multilocularis para nitrobenzyl esterase 0.0128 0.1595 0.1593
Echinococcus multilocularis sentrin specific protease 7 0.017 0.2151 0.2149
Brugia malayi Carboxylesterase family protein 0.076 1 1
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, putative 0.0067 0.0771 0.703
Loa Loa (eye worm) hypothetical protein 0.001 0.0026 0.0026
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.009 0.1089 0.2841
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0089 0.1072 0.1068
Plasmodium falciparum sentrin-specific protease 1 0.0038 0.0391 0.2478
Loa Loa (eye worm) hypothetical protein 0.002 0.015 0.015
Echinococcus multilocularis glyceraldehyde 3 phosphate dehydrogenase 0.0067 0.0771 0.077
Onchocerca volvulus 0.0128 0.1595 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.015 0.015
Brugia malayi tailless protein 0.0009 0.0011 0.001
Schistosoma mansoni fructose 16-bisphosphate aldolase 0.0089 0.1072 0.1068
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.015 0.0148
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1749 1
Schistosoma mansoni cpg binding protein 0.003 0.0282 0.0279
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0009 0.0011 0.0007
Trichomonas vaginalis glyceraldehyde 3-phosphate dehydrogenase, putative 0.0044 0.0466 0.1132
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.015 0.0146
Onchocerca volvulus Bile acid receptor homolog 0.002 0.015 0.0879
Brugia malayi hypothetical protein 0.001 0.0026 0.0025
Loa Loa (eye worm) hypothetical protein 0.0128 0.1595 0.1595
Trichomonas vaginalis sentrin/sumo-specific protease, senp8, putative 0.0038 0.0391 0.0927
Trypanosoma cruzi SUMO1/Ulp2, putative 0.0038 0.0391 0.3479
Trypanosoma cruzi glyceraldehyde 3-phosphate dehydrogenase, cytosolic, putative 0.0067 0.0771 0.703
Schistosoma mansoni nuclear receptor 0.0009 0.0011 0.0007
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0128 0.1595 0.1592
Onchocerca volvulus 0.002 0.015 0.0879
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.001 0.0026 0.0023
Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) 0.0067 0.0771 0.0768
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.017 0.2151 0.5751
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.015 0.0146
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.001 0.0026 0.0023
Echinococcus granulosus BC026374 protein S09 family 0.0128 0.1595 0.1593
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0312 0.2783
Loa Loa (eye worm) hypothetical protein 0.076 1 1
Echinococcus granulosus protein phosphatase 5 0.0021 0.0167 0.0165
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.009 0.1089 0.1086
Loa Loa (eye worm) DR-78 0.0009 0.0011 0.0011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.015 0.0149
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.015 0.015
Trypanosoma cruzi hypothetical protein 0.009 0.1089 1
Toxoplasma gondii fructose-1,6-bisphosphate aldolase 0.0089 0.1072 1
Echinococcus multilocularis FTZ F1 alpha 0.002 0.015 0.0148
Schistosoma mansoni nuclear hormone receptor 0.0009 0.0011 0.0007
Brugia malayi hypothetical protein 0.0128 0.1595 0.1595
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0128 0.1595 0.9009
Schistosoma mansoni neuroligin 3 (S09 family) 0.0128 0.1595 0.1592
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0322 0.0321
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0038 0.0391 0.0927
Schistosoma mansoni gliotactin 0.0128 0.1595 0.1592
Echinococcus multilocularis carboxylesterase 5A 0.076 1 1
Echinococcus granulosus sentrin specific protease 8 0.009 0.1089 0.1088
Brugia malayi nuclear hormone receptor 0.0009 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.002 0.015 0.015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0681 0.0678
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0312 0.2783
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0128 0.1595 0.1593
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0002 0.0002
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0009 0.0011 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.015 0.015
Echinococcus multilocularis neuroligin 0.0128 0.1595 0.1593
Trypanosoma cruzi fructose-bisphosphate aldolase, glycosomal, putative 0.0089 0.1072 0.9834
Echinococcus granulosus expressed protein 0.0033 0.0322 0.032
Brugia malayi nuclear receptor NHR-88 0.0009 0.0011 0.001
Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0466 0.4175
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.015 0.0146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.37 1
Loa Loa (eye worm) hypothetical protein 0.0009 0.0011 0.0011
Trypanosoma brucei glyceraldehyde-3-phosphate dehydrogenase, putative 0.0044 0.0466 0.4245
Echinococcus multilocularis expressed protein 0.0033 0.0322 0.032
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.009 0.1089 0.2841
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.015 0.0146
Echinococcus multilocularis nuclear receptor nhr 48 0.0009 0.0011 0.0008
Leishmania major glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0067 0.0771 0.7149
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0009 0.0011 0.0008
Loa Loa (eye worm) protein phosphatase 5 0.0021 0.0163 0.0163
Plasmodium vivax fructose 1,6-bisphosphate aldolase, putative 0.0089 0.1072 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C48, putative 0.0038 0.0391 0.3479
Echinococcus multilocularis dnaJ subfamily B 0.0401 0.5224 0.5223
Toxoplasma gondii glyceraldehyde-3-phosphate dehydrogenase GAPDH1 0.0067 0.0771 0.7149
Brugia malayi Nuclear hormone receptor E75 0.0009 0.0011 0.001
Schistosoma mansoni rotamase 0.0033 0.0322 0.0318
Loa Loa (eye worm) carboxylesterase 0.0128 0.1595 0.1595
Trypanosoma brucei glyceraldehyde 3-phosphate dehydrogenase, glycosomal 0.0067 0.0771 0.7149
Echinococcus granulosus glyceraldehyde 3 phosphate dehydrogenase 0.0044 0.0466 0.0464
Brugia malayi nuclear receptor NHR-88 0.002 0.015 0.0149
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.015 0.0148
Onchocerca volvulus 0.0128 0.1595 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.37 1
Echinococcus granulosus acetylcholinesterase 0.076 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.49 uM Concentration of 50% inhibition by compound towards mitogen activated protein kinase -activated protein kinase 2 ChEMBL. 15745802
IC50 (functional) = 55.7 uM Inhibition of TNFalpha expression in U937 cells ChEMBL. 15745802

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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