Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | kinase, PfkB family | 0.0059 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.052 | 1 | 1 |
Mycobacterium leprae | Probable adenosine kinase adk | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1315 | 0.1315 |
Mycobacterium tuberculosis | 6-phosphofructokinase PfkB (phosphohexokinase) (phosphofructokinase) | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.0106 | 0.1025 | 0.1176 | |
Entamoeba histolytica | Hypothetical protein T24C12.3, putative | 0.0059 | 0 | 0.5 |
Echinococcus granulosus | adenosine kinase | 0.052 | 1 | 1 |
Leishmania major | adenosine kinase, putative | 0.052 | 1 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0059 | 0 | 0.5 |
Mycobacterium ulcerans | fructokinase, PfkB | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | tagatose-6-phosphate kinase, putative | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.012 | 0.1315 | 0.1315 |
Loa Loa (eye worm) | hypothetical protein | 0.012 | 0.1315 | 0.1315 |
Mycobacterium ulcerans | carbohydrate kinase CbhK | 0.0059 | 0 | 0.5 |
Onchocerca volvulus | 0.012 | 0.1315 | 0.1509 | |
Echinococcus multilocularis | adenosine kinase | 0.052 | 1 | 1 |
Entamoeba histolytica | fructokinase, putative | 0.0059 | 0 | 0.5 |
Trypanosoma brucei | adenosine kinase, putative | 0.052 | 1 | 1 |
Mycobacterium tuberculosis | Adenosine kinase | 0.0059 | 0 | 0.5 |
Toxoplasma gondii | kinase, pfkB family protein | 0.052 | 1 | 1 |
Trichomonas vaginalis | ribokinase, putative | 0.0059 | 0 | 0.5 |
Mycobacterium tuberculosis | Ribokinase RbsK | 0.0059 | 0 | 0.5 |
Schistosoma mansoni | adenosine kinase | 0.052 | 1 | 1 |
Onchocerca volvulus | 0.046 | 0.8714 | 1 | |
Giardia lamblia | Ribokinase | 0.0059 | 0 | 0.5 |
Entamoeba histolytica | ribokinase, putative | 0.0059 | 0 | 0.5 |
Trichomonas vaginalis | ribokinase, putative | 0.0059 | 0 | 0.5 |
Trypanosoma cruzi | adenosine kinase, putative | 0.052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.052 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.012 | 0.1315 | 0.1315 |
Schistosoma mansoni | adenosine kinase | 0.052 | 1 | 1 |
Trypanosoma cruzi | adenosine kinase, putative | 0.052 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5 nM | Tested in vitro for the inhibitory potency against Coagulation factor Xa | ChEMBL. | 11965378 |
Ki (binding) | = 5 nM | Tested in vitro for the inhibitory potency against Coagulation factor Xa | ChEMBL. | 11965378 |
Ki (binding) | = 10 nM | Tested in vitro for the selectivity against trypsin (Trp) | ChEMBL. | 11965378 |
Ki (binding) | = 10 nM | Tested in vitro for the selectivity against trypsin (Trp) | ChEMBL. | 11965378 |
Ki (binding) | > 5000 nM | Tested in vitro for the selectivity against thrombin (IIa) | ChEMBL. | 11965378 |
Ki (binding) | > 5000 nM | Tested in vitro for the selectivity against thrombin (IIa) | ChEMBL. | 11965378 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.