Detailed information for compound 317723

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 470.684 | Formula: C30H46O4
  • H donors: 2 H acceptors: 4 LogP: 6.42 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1C=C2[C@@H]3CC(C)(C)CC[C@@]3(CC[C@]2([C@]2([C@H]1[C@@]1(C)CC[C@@H](C(C1CC2)(C)C)O)C)C)C(=O)O
  • InChi: 1S/C30H46O4/c1-25(2)12-14-30(24(33)34)15-13-28(6)18(19(30)17-25)16-20(31)23-27(5)10-9-22(32)26(3,4)21(27)8-11-29(23,28)7/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21?,22-,23+,27-,28+,29+,30-/m0/s1
  • InChiKey: ILTQYWVUOPDTOL-PEIOFAFPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0028 0.0073 0.0147
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0028 0.0073 0.1579
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0205 0.02
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0112 0.0581 0.1197
Entamoeba histolytica tubulin family protein 0.0035 0.0116 0.0839
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0073 0.1579
Echinococcus granulosus beta tubulin 0.0035 0.0116 0.0238
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0482
Schistosoma mansoni polycystin 1-related 0.0099 0.0501 0.1067
Loa Loa (eye worm) alpha-tubulin isotype 2 0.002 0.0022 0.0037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0173 0.0372
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0442 0.257 1
Echinococcus granulosus tubulin alpha chain 0.0028 0.0073 0.0147
Echinococcus multilocularis peroxisome assembly protein 26 0.0028 0.0073 0.0069
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0035 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.0069 0.0321 0.068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0173 0.0362
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0073 0.1579
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0173 0.0168
Echinococcus granulosus Niemann Pick C1 protein 0.0291 0.1656 0.3548
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Echinococcus granulosus Tubulin alpha 1 chain 0.0028 0.0073 0.0147
Schistosoma mansoni tubulin subunit beta 0.0035 0.0116 0.0238
Toxoplasma gondii beta tubulin 0.0035 0.0116 0.0365
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0199 0.0373
Schistosoma mansoni tubulin subunit beta 0.0035 0.0116 0.0238
Echinococcus multilocularis thymidylate synthase 0.0112 0.0581 0.0577
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0225 0.022
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0205 0.02
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0482
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0258
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0184 0.1013 0.1008
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0199 0.0694
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0173 0.0168
Echinococcus granulosus microtubule associated protein 2 0.0675 0.3974 0.8528
Echinococcus granulosus survival motor neuron protein 1 0.0488 0.2848 0.6109
Loa Loa (eye worm) dihydrofolate reductase 0.0789 0.4659 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0482
Entamoeba histolytica tubulin family protein 0.0035 0.0116 0.0839
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0053 0.0117
Entamoeba histolytica tubulin alpha chain, putative 0.0028 0.0073 0.0458
Trypanosoma brucei alpha tubulin 0.0028 0.0073 0.0199
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0073 0.1579
Brugia malayi DKFZp564C0469 protein 0.002 0.0027 0.0058
Echinococcus granulosus thymidylate synthase 0.0112 0.0581 0.1238
Brugia malayi Bromodomain containing protein 0.0073 0.0347 0.0744
Brugia malayi hypothetical protein 0.0099 0.0501 0.1076
Echinococcus multilocularis tubulin beta 1 chain 0.0035 0.0116 0.0111
Brugia malayi tubulin alpha chain - mouse 0.0028 0.0073 0.0158
Onchocerca volvulus 0.0049 0.0199 0.2253
Echinococcus multilocularis expressed conserved protein 0.0191 0.1056 0.1051
Echinococcus multilocularis tubulin gamma 1 chain 0.002 0.0023 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0199 0.0373
Echinococcus granulosus Tubulin beta 2C chain 0.0035 0.0116 0.0238
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0592 0.3476 0.3473
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Echinococcus granulosus alpha tubulin 0.0028 0.0073 0.0147
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0073 0.0069
Brugia malayi Tubulin alpha-2 chain 0.0028 0.0073 0.0158
Onchocerca volvulus 0.0099 0.0501 0.6195
Brugia malayi hypothetical protein 0.0099 0.0501 0.1076
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Echinococcus multilocularis beta tubulin 0.0035 0.0116 0.0111
Schistosoma mansoni hypothetical protein 0.0084 0.0411 0.0873
Loa Loa (eye worm) tubulin alpha-3 chain 0.0017 0.0006 0.0003
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0053 0.0117
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0205 0.043
Echinococcus multilocularis Tubulin beta 2C chain 0.0035 0.0116 0.0111
Echinococcus multilocularis replication factor c subunit 1 0.002 0.0027 0.0022
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0205 0.043
Mycobacterium ulcerans thymidylate synthase 0.0112 0.0581 0.1197
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0125 0.0212
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0053 0.0117
Plasmodium falciparum tubulin beta chain 0.0035 0.0116 0.0365
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0073 0.1579
Echinococcus multilocularis Tubulin alpha 1 chain 0.0028 0.0073 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0205 0.043
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.0508
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0173 0.0362
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0073 0.0069
Schistosoma mansoni tubulin subunit beta 0.0035 0.0116 0.0238
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0186 0.0181
Echinococcus multilocularis Niemann Pick C1 protein 0.0203 0.113 0.1126
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0199 0.1597
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Trichomonas vaginalis tubulin, putative 0.0035 0.0116 0.2574
Toxoplasma gondii alpha tubulin TUBA1 0.0028 0.0073 0.0199
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0225 0.0472
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0203 0.113 1
Echinococcus granulosus tubulin alpha chain 0.0028 0.0073 0.0147
Echinococcus granulosus tubulin alpha 1C chain 0.0028 0.0073 0.0147
Trichomonas vaginalis tubulin gamma chain, putative 0.0035 0.0116 0.2574
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0256 0.0252
Trichomonas vaginalis tubulin beta chain, putative 0.0035 0.0116 0.2574
Loa Loa (eye worm) hypothetical protein 0.0146 0.0785 0.1677
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.0508
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0053 0.0117
Schistosoma mansoni hypothetical protein 0.002 0.0026 0.0045
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0073 0.0069
Brugia malayi Dihydrofolate reductase 0.0789 0.4659 1
Loa Loa (eye worm) tubulin beta chain 0.0035 0.0116 0.0238
Loa Loa (eye worm) thymidylate synthase 0.0112 0.0581 0.1238
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0258
Loa Loa (eye worm) doublecortin family protein 0.0099 0.0501 0.1067
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0027 0.0017
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0073 0.1579
Echinococcus granulosus zinc finger protein 0.0019 0.002 0.0032
Entamoeba histolytica tubulin alpha-1 chain 0.0028 0.0073 0.0458
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0047
Plasmodium vivax replication factor C subunit 1, putative 0.002 0.0027 0.0017
Echinococcus granulosus Tubulin alpha 1 chain 0.0028 0.0073 0.0147
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0592 0.3476 0.7458
Giardia lamblia Beta tubulin 0.0035 0.0116 0.5101
Echinococcus multilocularis Polycystic kidney disease protein 0.0099 0.0501 0.0497
Schistosoma mansoni alpha tubulin 0.0028 0.0073 0.0147
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Trypanosoma brucei protein kinase, putative 0.005 0.0205 0.0715
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0125 0.0401
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0186 0.0388
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.01 0.0505 0.1083
Echinococcus granulosus peroxisome assembly protein 26 0.0028 0.0073 0.0147
Echinococcus multilocularis muscleblind protein 1 0.0146 0.0785 0.0781
Plasmodium falciparum replication factor C subunit 1, putative 0.002 0.0027 0.0017
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.002 0.0027 0.0038
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Trichomonas vaginalis tubulin epsilon chain, putative 0.0035 0.0116 0.2574
Echinococcus granulosus Tubulin beta 2C chain 0.0035 0.0116 0.0238
Trypanosoma cruzi beta tubulin, putative 0.0035 0.0116 0.0365
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0199 0.0428
Giardia lamblia Replication factor C, subunit 1 0.002 0.0027 0.0233
Plasmodium falciparum alpha tubulin 1 0.0028 0.0073 0.0199
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0125 0.0212
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0053 0.0117
Schistosoma mansoni tubulin subunit alpha 0.0028 0.0073 0.0147
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0442 0.257 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0482
Trichomonas vaginalis tubulin epsilon chain, putative 0.0035 0.0116 0.2574
Loa Loa (eye worm) tubulin alpha chain 0.0028 0.0073 0.0147
Echinococcus multilocularis tubulin alpha 1C chain 0.0028 0.0073 0.0069
Loa Loa (eye worm) hypothetical protein 0.0099 0.0501 0.1067
Echinococcus granulosus Niemann Pick C1 protein 0.0203 0.113 0.2417
Brugia malayi Tubulin alpha-2 chain 0.0028 0.0073 0.0158
Schistosoma mansoni topbp1 0.002 0.0027 0.0047
Brugia malayi tubulin alpha-2 chain 0.0028 0.0073 0.0158
Schistosoma mansoni bromodomain containing protein 0.0062 0.0277 0.0586
Loa Loa (eye worm) hypothetical protein 0.0053 0.0225 0.0472
Plasmodium vivax tubulin alpha chain, putative 0.0028 0.0073 0.0199
Brugia malayi topoisomerase 0.002 0.0027 0.0058
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0442 0.257 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0205 0.0715
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0156 0.0324
Echinococcus multilocularis microtubule associated protein 2 0.0675 0.3974 0.3971
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Brugia malayi beta-tubulin, identical 0.0035 0.0116 0.0248
Trichomonas vaginalis tubulin gamma chain, putative 0.002 0.0023 0.0382
Onchocerca volvulus 0.0147 0.0793 1
Echinococcus granulosus dihydrofolate reductase 0.0789 0.4659 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0028 0.0073 0.0147
Schistosoma mansoni alpha tubulin 0.0028 0.0073 0.0147
Echinococcus multilocularis beta tubulin 0.0035 0.0116 0.0111
Brugia malayi hypothetical protein 0.0147 0.0793 0.1702
Schistosoma mansoni survival motor neuron protein 0.01 0.0505 0.1074
Onchocerca volvulus 0.0099 0.0501 0.6195
Echinococcus multilocularis sterol regulatory element binding protein 0.0087 0.043 0.0426
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0053 0.0117
Echinococcus multilocularis Tubulin beta 2C chain 0.0035 0.0116 0.0111
Plasmodium vivax tubulin beta chain, putative 0.0035 0.0116 0.0365
Loa Loa (eye worm) tubulin alpha chain 0.0028 0.0073 0.0147
Trypanosoma cruzi FHA domain containing protein, putative 0.002 0.0027 0.0017
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0047
Trypanosoma brucei alpha tubulin 0.0028 0.0073 0.0199
Brugia malayi mbt repeat family protein 0.0047 0.0186 0.0398
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0186 0.0388
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0205 1
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Loa Loa (eye worm) hypothetical protein 0.0049 0.0199 0.0418
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0199 0.1597
Brugia malayi dihydrofolate reductase family protein 0.0789 0.4659 1
Echinococcus granulosus tubulin alpha 3 chain 0.0028 0.0073 0.0147
Loa Loa (eye worm) hypothetical protein 0.0087 0.043 0.0914
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0017
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0073 0.0069
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0125 0.0026
Schistosoma mansoni tubulin subunit epsilon 0.002 0.0023 0.0038
Echinococcus granulosus tubulin beta 4A class IVa 0.0035 0.0116 0.0238
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0262 0.0941
Trichomonas vaginalis tubulin epsilon chain, putative 0.0028 0.0073 0.1579
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0501 0.1067
Echinococcus granulosus Tubulin beta 2C chain 0.0035 0.0116 0.0238
Loa Loa (eye worm) tubulin alpha 2 0.002 0.0022 0.0037
Schistosoma mansoni hypothetical protein 0.0084 0.0411 0.0873
Brugia malayi hypothetical protein 0.0025 0.0053 0.0113
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0258
Brugia malayi hypothetical protein 0.0053 0.0226 0.0486
Schistosoma mansoni hypothetical protein 0.0084 0.0411 0.0873
Loa Loa (eye worm) tubulin beta-4 chain 0.0035 0.0116 0.0238
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0205 0.468
Loa Loa (eye worm) hypothetical protein 0.002 0.0022 0.0037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0199 0.0191
Onchocerca volvulus 0.0112 0.0581 0.7236
Brugia malayi thymidylate synthase 0.0112 0.0581 0.1247
Schistosoma mansoni chromosome transmission fidelity factor 0.002 0.0027 0.0047
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Echinococcus multilocularis RUN 0.0099 0.0501 0.0497
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0226 0.5187
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.002 0.0027 0.0058
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Entamoeba histolytica hypothetical protein 0.002 0.0027 0.0038
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0186 0.0388
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Schistosoma mansoni microtubule-associated protein tau 0.0675 0.3974 0.8528
Loa Loa (eye worm) hypothetical protein 0.004 0.0145 0.03
Loa Loa (eye worm) hypothetical protein 0.0146 0.0785 0.1677
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0205 0.0715
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0173 0.0362
Loa Loa (eye worm) tubulin beta-1 chain 0.0035 0.0116 0.0238
Plasmodium falciparum LCCL domain-containing protein 0.0099 0.0501 0.188
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0789 0.4659 1
Echinococcus granulosus tubulin alpha 0.002 0.0023 0.0038
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0026 0.0045
Echinococcus multilocularis Tubulin beta 2C chain 0.0035 0.0116 0.0111
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0199 0.0373
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0442 0.257 1
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0789 0.4659 1
Schistosoma mansoni DNA ligase IV 0.002 0.0027 0.0047
Schistosoma mansoni lipoxygenase 0.0414 0.2401 0.5149
Plasmodium vivax multidomain scavenger receptor, putative 0.0099 0.0501 0.188
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0173 0.0362
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0199 0.0373
Toxoplasma gondii beta-tubulin, putative 0.0035 0.0116 0.0365
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0205 0.0715
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0199 0.0428
Echinococcus multilocularis tubulin epsilon chain 0.002 0.0023 0.0018
Echinococcus multilocularis Tubulin alpha 1 chain 0.0028 0.0073 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0262 0.0508
Schistosoma mansoni patched 1 0.0087 0.043 0.0914
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0087 0.043 0.0914
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0047
Trypanosoma brucei beta tubulin 0.0035 0.0116 0.0365
Brugia malayi hypothetical protein 0.002 0.0027 0.0058
Toxoplasma gondii ATPase, AAA family protein 0.002 0.0027 0.0017
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0501 0.0497
Schistosoma mansoni tubulin subunit beta 0.0035 0.0116 0.0238
Loa Loa (eye worm) hypothetical protein 0.0107 0.0549 0.1168
Schistosoma mansoni hypothetical protein 0.0099 0.0501 0.1067
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0225 0.0472
Trypanosoma brucei beta tubulin 0.0035 0.0116 0.0365
Mycobacterium tuberculosis Hypothetical protein 0.0053 0.0226 0.025
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0225 0.022
Mycobacterium tuberculosis Probable oxidoreductase 0.0342 0.1965 0.4074
Plasmodium falciparum alpha tubulin 2 0.0028 0.0073 0.0199
Echinococcus granulosus tubulin alpha 3 chain 0.0028 0.0073 0.0147
Echinococcus multilocularis Tubulin beta 2C chain 0.0035 0.0116 0.0111
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0047
Echinococcus granulosus Tubulin beta 2C chain 0.0035 0.0116 0.0238
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0262 0.0553
Schistosoma mansoni hypothetical protein 0.0284 0.1614 0.3458
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0225 0.0472
Brugia malayi Niemann-Pick C1 protein precursor 0.0203 0.113 0.2425
Loa Loa (eye worm) alpha-tubulin 0.0028 0.0073 0.0147
Echinococcus granulosus Tubulin beta 2C chain 0.0035 0.0116 0.0238
Echinococcus multilocularis tubulin alpha 3 chain 0.0028 0.0073 0.0069
Schistosoma mansoni loxhd1 0.0099 0.0501 0.1067
Brugia malayi CHE-14 protein 0.0087 0.043 0.0924
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0027 0.0482
Echinococcus multilocularis tubulin alpha 0.002 0.0023 0.0018
Schistosoma mansoni zinc finger protein 0.0019 0.002 0.0032
Loa Loa (eye worm) MBCTL1 0.0053 0.0225 0.0472
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0199 0.0373
Chlamydia trachomatis dihydrofolate reductase 0.0789 0.4659 1
Echinococcus multilocularis tubulin subunit TubB 0.0028 0.0073 0.0069
Echinococcus granulosus tubulin alpha chain 0.0028 0.0073 0.0147
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0199 0.0373
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0199 0.1597
Schistosoma mansoni rab6-interacting 0.0099 0.0501 0.1067
Loa Loa (eye worm) hypothetical protein 0.0047 0.0186 0.0388
Echinococcus granulosus replication factor c subunit 1 0.002 0.0027 0.0047
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0186 0.0388
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0199 0.0694
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0186 0.2072
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0262 0.0258
Loa Loa (eye worm) hypothetical protein 0.0049 0.0199 0.0418
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0206 0.1149 0.2458
Schistosoma mansoni tubulin subunit beta 0.0035 0.0116 0.0238
Loa Loa (eye worm) beta-tubulin 0.0035 0.0116 0.0238
Loa Loa (eye worm) alpha-tubulin 0.0028 0.0073 0.0147
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0442 0.257 1
Onchocerca volvulus 0.0047 0.0186 0.2072
Brugia malayi PHD-finger family protein 0.0024 0.0051 0.011
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0186 0.0181
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0027 0.0017
Brugia malayi MAP kinase sur-1 0.005 0.0205 0.044
Loa Loa (eye worm) hypothetical protein 0.0099 0.0501 0.1067
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0037 0.007
Onchocerca volvulus 0.01 0.0505 0.6239
Echinococcus granulosus tubulin alpha chain 0.0028 0.0073 0.0147
Plasmodium vivax tubulin alpha chain, putative 0.0028 0.0073 0.0199
Trichomonas vaginalis replication factor C large subunit, putative 0.002 0.0027 0.0482
Echinococcus granulosus tubulin subunit beta 0.0035 0.0116 0.0238
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0262 0.0941
Toxoplasma gondii alpha-tubulin I, putative 0.0028 0.0073 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0199 0.0428
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.002 0.0022 0.0367
Echinococcus multilocularis nibrin 0.002 0.0027 0.0022
Loa Loa (eye worm) BEN-1 protein 0.0035 0.0116 0.0238
Giardia lamblia Beta tubulin 0.0035 0.0116 0.5101
Echinococcus granulosus tubulin subunit TubB 0.0028 0.0073 0.0147
Echinococcus granulosus beta tubulin 0.0035 0.0116 0.0238
Brugia malayi Pax transcription activation domain interacting protein 0.002 0.0027 0.0058
Echinococcus multilocularis Niemann Pick C1 protein 0.0291 0.1656 0.1652
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0205 0.0715
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0262 0.0553
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0053 0.0226 0.08
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0173 0.0362
Loa Loa (eye worm) hypothetical protein 0.0488 0.2848 0.6109
Trypanosoma brucei alpha tubulin 0.0028 0.0073 0.0199
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.002 0.0027 0.0482
Loa Loa (eye worm) tubulin alpha 2 0.002 0.0022 0.0037
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.002 0.0027 0.5
Echinococcus granulosus tubulin gamma 1 chain 0.002 0.0023 0.0038
Echinococcus granulosus tubulin alpha chain 0.0028 0.0073 0.0147
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Loa Loa (eye worm) hypothetical protein 0.0038 0.0131 0.027
Treponema pallidum ATP-binding protein (ylxH-1) 0.1395 0.8318 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0262 0.0329
Echinococcus multilocularis Tubulin alpha 1 chain 0.0028 0.0073 0.0069
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0116 0.0111
Echinococcus multilocularis tubulin alpha 3 chain 0.0028 0.0073 0.0069
Trichomonas vaginalis tubulin alpha chain, putative 0.0035 0.0116 0.2574
Echinococcus multilocularis survival motor neuron protein 1 0.0488 0.2848 0.2845
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0205 0.0715
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0116 0.0239
Echinococcus multilocularis zinc finger protein 0.0019 0.002 0.0015
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0186 0.0388
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0262 0.0553
Trypanosoma cruzi alpha tubulin, putative 0.0028 0.0073 0.0199
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.002 0.0027 0.0017
Brugia malayi alpha-tubulin 0.0028 0.0073 0.0158
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0205 0.468
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0258
Echinococcus multilocularis hypothetical protein 0.0028 0.0073 0.0069
Trypanosoma brucei beta tubulin 0.0035 0.0116 0.0365
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0199 0.0373
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0205 0.468
Brugia malayi Muscleblind-like protein 0.0146 0.0785 0.1685
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0112 0.0581 0.1238
Brugia malayi Tubulin beta-1 chain 0.0035 0.0116 0.0248
Onchocerca volvulus 0.0023 0.0042 0.0196
Schistosoma mansoni topbp1 0.002 0.0027 0.0047
Echinococcus multilocularis dihydrofolate reductase 0.0789 0.4659 0.4657
Brugia malayi hypothetical protein 0.0488 0.2848 0.6113
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0199 0.0373
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0125 0.0401
Echinococcus granulosus nibrin 0.002 0.0027 0.0047
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0027 0.0482
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Echinococcus granulosus sterol regulatory element binding protein 0.0087 0.043 0.0914
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.002 0.0027 0.0482
Giardia lamblia Beta tubulin 0.0035 0.0116 0.5101
Loa Loa (eye worm) tubulin alpha-2 chain 0.0028 0.0073 0.0147
Schistosoma mansoni tubulin subunit alpha 0.0028 0.0073 0.0147
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0205 0.043
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0205 0.468
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0008 0.0008
Schistosoma mansoni lipoxygenase 0.0592 0.3476 0.7458
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0186 0.0388
Trichomonas vaginalis conserved hypothetical protein 0.0087 0.043 1
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0073 0.1579
Echinococcus multilocularis muscleblind protein 0.0146 0.0785 0.0781
Loa Loa (eye worm) tubulin beta-2A chain 0.0035 0.0116 0.0238
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0258
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0256 0.054
Loa Loa (eye worm) hypothetical protein 0.0147 0.0793 0.1693
Giardia lamblia Alpha-tubulin 0.0028 0.0073 0.2786
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0199 0.0373
Giardia lamblia Alpha-tubulin 0.0028 0.0073 0.2786
Trichomonas vaginalis tubulin beta chain, putative 0.0028 0.0073 0.1579
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0442 0.257 1
Brugia malayi Bromodomain containing protein 0.0037 0.013 0.0279
Loa Loa (eye worm) hypothetical protein 0.002 0.0027 0.0047
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0037 0.007
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0112 0.0581 0.103
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0789 0.4659 1
Brugia malayi Doublecortin family protein 0.0099 0.0501 0.1076
Brugia malayi mbt repeat family protein 0.0047 0.0186 0.0398
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Echinococcus granulosus Polycystic kidney disease protein 0.0099 0.0501 0.1067
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0199 0.0191
Echinococcus granulosus tubulin epsilon chain 0.002 0.0023 0.0038
Brugia malayi hypothetical protein 0.002 0.0027 0.0058
Loa Loa (eye worm) tubulin gamma chain 0.002 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0025 0.0053 0.0102
Brugia malayi Tubulin alpha chain 0.0028 0.0073 0.0158
Echinococcus multilocularis lipoxygenase domain containing protein 0.0099 0.0501 0.0497
Echinococcus multilocularis Tubulin beta 2C chain 0.0035 0.0116 0.0111
Schistosoma mansoni dihydrofolate reductase 0.0789 0.4659 1
Echinococcus multilocularis tubulin subunit beta 0.0035 0.0116 0.0111
Echinococcus granulosus lipoxygenase domain containing protein 0.0099 0.0501 0.1067
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Schistosoma mansoni hypothetical protein 0.01 0.0505 0.1074
Echinococcus granulosus tubulin alpha 1C chain 0.0028 0.0073 0.0147
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0184 0.1013 0.2166
Schistosoma mansoni tubulin subunit beta 0.0035 0.0116 0.0238
Echinococcus granulosus Protein patched homolog 1 0.0087 0.043 0.0914
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Trichomonas vaginalis tubulin gamma chain, putative 0.002 0.0023 0.0382
Mycobacterium ulcerans short chain dehydrogenase 0.0342 0.1965 0.4184
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0225 0.0482
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0037 0.0032
Echinococcus multilocularis tubulin alpha 1C chain 0.0028 0.0073 0.0069
Schistosoma mansoni tubulin subunit alpha 0.0028 0.0073 0.0147
Echinococcus multilocularis tubulin alpha chain 0.0028 0.0073 0.0069
Echinococcus granulosus muscleblind protein 0.0146 0.0785 0.1677
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0003
Trypanosoma brucei beta tubulin 0.0035 0.0116 0.0365
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0027 0.0482
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0199 0.0694
Leishmania major hypothetical protein, conserved 0.0025 0.0053 0.0117
Echinococcus granulosus tubulin beta 1 chain 0.0035 0.0116 0.0238
Mycobacterium ulcerans hypothetical protein 0.0049 0.0199 0.0373
Schistosoma mansoni tubulin subunit gamma 0.002 0.0023 0.0038
Echinococcus multilocularis protein dispatched 1 0.01 0.0505 0.05
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Loa Loa (eye worm) hypothetical protein 0.0049 0.0199 0.0418
Schistosoma mansoni rab6-interacting 0.0099 0.0501 0.1067
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0205 0.0715
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0053 0.0117
Schistosoma mansoni hypothetical protein 0.0084 0.0411 0.0873
Echinococcus granulosus RUN 0.0099 0.0501 0.1067
Leishmania major alpha tubulin 0.0028 0.0073 0.0199
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0205 0.0715
Brugia malayi Tubulin gamma chain 0.002 0.0023 0.0049
Leishmania major beta tubulin 0.0035 0.0116 0.0365
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.002 0.0027 0.0017
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0173 0.0362
Schistosoma mansoni alpha tubulin 0.0028 0.0073 0.0147
Toxoplasma gondii beta-1 tubulin, putative 0.0035 0.0116 0.0365
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0205 0.0715
Echinococcus granulosus expressed conserved protein 0.0191 0.1056 0.2258
Trichomonas vaginalis tubulin alpha chain, putative 0.002 0.0023 0.0382
Loa Loa (eye worm) BEN-1 protein 0.0035 0.0116 0.0238
Loa Loa (eye worm) hypothetical protein 0.0203 0.113 0.2417
Trypanosoma brucei alpha tubulin 0.0028 0.0073 0.0199
Echinococcus multilocularis protein patched 0.0087 0.043 0.0426

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 38.5 % Percent inhibition of tartrate resistant acid phosphatase positive osteoclast like multinucleated cells formation by 1alpha, 25-dihydroxy vitamin D3 in mouse bone marrow cells ChEMBL. 15745811

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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