TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 362.405 | Formula: C19H14N4O2S
H donors: 1 H acceptors: 4 LogP: 2.52 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CC(=O)Nc1cccc(c1)c1ccnc2n1ncc2C(=O)c1cccs1
InChi: 1S/C19H14N4O2S/c1-12(24)22-14-5-2-4-13(10-14)16-7-8-20-19-15(11-21-23(16)19)18(25)17-6-3-9-26-17/h2-11H,1H3,(H,22,24)
InChiKey: KZQWYRRAKXJLDE-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0729	0.559	0.6955
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0496	0.3738	0.4651
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0044	0.005
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Loa Loa (eye worm)	hypothetical protein	0.0282	0.2039	0.2262
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0046	0.0173	0.0215
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0146	0.0964	0.1199
Trypanosoma cruzi	hypothetical protein, conserved	0.0282	0.2039	0.2308
Schistosoma mansoni	family A2 unassigned peptidase (A02 family)	0.0234	0.166	0.166
Trichomonas vaginalis	DNA polymerase eta, putative	0.004	0.0121	0.015
Trypanosoma brucei	unspecified product	0.0033	0.007	0.008
Echinococcus multilocularis	protein farnesyltransferase subunit beta	0.1038	0.8038	1
Schistosoma mansoni	cpg binding protein	0.0033	0.0068	0.0068
Entamoeba histolytica	protein farnesyltransferase beta subunit, putative	0.1038	0.8038	1
Leishmania major	CYC2-like cyclin, putative,cyclin 6, putative	0.0044	0.0157	0.0196
Schistosoma mansoni	hypothetical protein	0.0103	0.0621	0.0621
Echinococcus multilocularis	inhibitor of apoptosis protein	0.0107	0.0652	0.0811
Trypanosoma cruzi	lanosterol synthase, putative	0.1139	0.8837	1
Echinococcus granulosus	glutamate NMDA receptor subunit	0.0131	0.0843	0.1049
Echinococcus granulosus	glutamate receptor ionotrophic AMPA 3	0.0146	0.0964	0.1199
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Onchocerca volvulus		0.0031	0.0054	0.0152
Toxoplasma gondii	aspartyl proteinase (eimepsin), putative	0.0051	0.0207	0.0258
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0157	0.0174
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0072	0.008
Brugia malayi	Probable ATP-dependent helicase DHX35	0.0034	0.0072	0.009
Schistosoma mansoni	protein farnesyltransferase alpha subunit	0.0729	0.559	0.559
Trichomonas vaginalis	cyclin B, putative	0.0044	0.0157	0.0196
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0044	0.0157	0.0196
Plasmodium falciparum	plasmepsin IV	0.0051	0.0207	0.0258
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0496	0.3738	0.4651
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0031	0.0054	0.006
Echinococcus multilocularis	integrin alpha ps	0.0338	0.2485	0.3091
Plasmodium falciparum	protein farnesyltransferase subunit beta	0.1038	0.8038	1
Leishmania major	D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative	0.0045	0.0166	0.0206
Giardia lamblia	Rab geranylgeranyltransferase	0.0475	0.3572	0.4333
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.1038	0.8038	1
Plasmodium vivax	geranylgeranyl transferase type2 beta subunit, putative	0.0282	0.2039	0.2537
Echinococcus multilocularis	geranylgeranyl transferase type I beta subunit	0.0282	0.2039	0.2537
Trypanosoma brucei	CHAP domain containing protein, putative	0.0045	0.0166	0.0188
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Giardia lamblia	Prenyltransferase	0.1038	0.8038	1
Loa Loa (eye worm)	hypothetical protein	0.0176	0.1201	0.1332
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0135	0.0876	0.109
Echinococcus multilocularis	geranylgeranyl transferase type 2 subunit alpha	0.0475	0.3572	0.4444
Plasmodium vivax	conserved Plasmodium protein, unknown function	0.0756	0.5805	0.7222
Echinococcus multilocularis	glutamate receptor subunit protein glur	0.0067	0.0338	0.0421
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0173	0.0192
Leishmania major	lanosterol synthase, putative	0.0857	0.6604	0.8217
Trypanosoma brucei	glutathionylspermidine synthetase, putative	0.0045	0.0166	0.0188
Trypanosoma cruzi	trypanothione synthetase-like protein, putative	0.0045	0.0166	0.0188
Plasmodium vivax	protein prenyltransferase alpha subunit, putative	0.0475	0.3572	0.4444
Schistosoma mansoni	integrin beta subunit	0.0184	0.1262	0.1262
Echinococcus granulosus	glutamate receptor 2	0.0146	0.0964	0.1199
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0475	0.3572	0.4042
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0051	0.0207	0.0258
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.1038	0.8038	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0146	0.0965	0.1071
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0121	0.0137
Loa Loa (eye worm)	hypothetical protein	0.003	0.0044	0.0049
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0475	0.3572	0.4042
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Schistosoma mansoni	hypothetical protein	0.0107	0.0652	0.0652
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0046	0.0173	0.0215
Echinococcus granulosus	integrin alpha ps	0.0162	0.109	0.1356
Trypanosoma brucei	RNA helicase, putative	0.0103	0.0621	0.0703
Plasmodium vivax	aspartyl proteinase, putative	0.0051	0.0207	0.0258
Schistosoma mansoni	cathepsin D (A01 family)	0.0149	0.0988	0.0988
Echinococcus multilocularis	expressed protein	0.0382	0.2838	0.353
Echinococcus multilocularis	glutamate receptor 2	0.0146	0.0964	0.1199
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Loa Loa (eye worm)	angiotensin-converting enzyme family protein	0.0627	0.4778	0.53
Trichomonas vaginalis	cyclins, putative	0.0044	0.0157	0.0196
Toxoplasma gondii	aspartyl protease ASP1	0.0051	0.0207	0.0258
Trypanosoma cruzi	glutathionylspermidine synthase, putative	0.0736	0.5646	0.6388
Schistosoma mansoni	hypothetical protein	0.0162	0.109	0.109
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0571	0.4337	0.4337
Echinococcus granulosus	GPCR family 2	0.0046	0.0173	0.0215
Echinococcus multilocularis	glutamate receptor, ionotrophic, AMPA 3	0.0146	0.0964	0.1199
Echinococcus granulosus	furin	0.0571	0.4337	0.5396
Echinococcus granulosus	geranylgeranyl transferase type I beta subunit	0.0282	0.2039	0.2537
Trichomonas vaginalis	cyclin B, putative	0.0044	0.0157	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0028	0.0031	0.0035
Trypanosoma cruzi	hypothetical protein, conserved	0.0475	0.3572	0.4042
Echinococcus granulosus	protein farnesyltransferase alpha subunit	0.0729	0.559	0.6955
Brugia malayi	celfurPC protein	0.0461	0.3461	0.4306
Trypanosoma cruzi	cyclin 6, putative	0.0044	0.0157	0.0178
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0076	0.0409	0.0463
Leishmania major	trypanothione synthetase-like protein	0.0045	0.0166	0.0206
Leishmania major	trypanothione synthetase, putative	0.0045	0.0166	0.0206
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0146	0.0965	0.1201
Echinococcus multilocularis		0.0461	0.3461	0.4306
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0066	0.0332	0.0332
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0135	0.0876	0.109
Echinococcus granulosus	cyclin B	0.0044	0.0157	0.0196
Plasmodium falciparum	plasmepsin I	0.0051	0.0207	0.0258
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.0282	0.2039	0.2537
Loa Loa (eye worm)	endoprotease bli-4	0.0571	0.4337	0.4811
Onchocerca volvulus		0.0044	0.0157	0.044
Trypanosoma cruzi	protein farnesyltransferase alpha subunit, putative	0.0475	0.3572	0.4042
Echinococcus granulosus	cpg binding protein	0.0033	0.0068	0.0085
Toxoplasma gondii	hypothetical protein	0.0475	0.3572	0.4444
Schistosoma mansoni	hypothetical protein	0.0046	0.0173	0.0173
Schistosoma mansoni	hypothetical protein	0.0046	0.0173	0.0173
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.0282	0.2039	0.2262
Loa Loa (eye worm)	prenyltransferase and squalene oxidase repeat family protein	0.1038	0.8038	0.8915
Loa Loa (eye worm)	hypothetical protein	0.0571	0.4337	0.4811
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Giardia lamblia	Rab geranylgeranyltransferase	0.0729	0.559	0.6894
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.1038	0.8038	1
Toxoplasma gondii	Rab geranylgeranyl transferase type II beta subunit, putative	0.0282	0.2039	0.2537
Leishmania major	protein farnesyltransferase alpha subunit, putative	0.0475	0.3572	0.4444
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0475	0.3572	0.4444
Loa Loa (eye worm)	integrin beta-2	0.0312	0.2278	0.2527
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0729	0.559	0.6955
Trichomonas vaginalis	geranylgeranyl transferase type I beta subunit, putative	0.0282	0.2039	0.2537
Schistosoma mansoni	hypothetical protein	0.01	0.0599	0.0599
Trypanosoma brucei	mitotic cyclin 6	0.0044	0.0157	0.0178
Schistosoma mansoni	subfamily A1A unassigned peptidase (A01 family)	0.0051	0.0207	0.0207
Entamoeba histolytica	Rab geranylgeranyltransferase beta subunit, putative	0.0282	0.2039	0.2388
Trichomonas vaginalis	cyclins, putative	0.0044	0.0157	0.0196
Schistosoma mansoni	cyclin B	0.0044	0.0157	0.0157
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0282	0.2039	0.2537
Echinococcus multilocularis	nmda type glutamate receptor	0.0143	0.0941	0.1171
Plasmodium falciparum	plasmepsin VI	0.0051	0.0207	0.0258
Echinococcus multilocularis	Ribosomal protein S1, RNA binding domain	0.0067	0.0338	0.0421
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0282	0.2039	0.2039
Schistosoma mansoni	glutamate receptor kainate	0.0131	0.0843	0.0843
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0135	0.0876	0.109
Trypanosoma cruzi	hypothetical protein, conserved	0.0475	0.3572	0.4042
Toxoplasma gondii	histone lysine methyltransferase SET1	0.0059	0.0276	0.0343
Loa Loa (eye worm)	DEAH box polypeptide 35	0.0034	0.0072	0.008
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0146	0.0964	0.1199
Schistosoma mansoni	ATP-binding cassette transporter	0.0131	0.0843	0.0843
Schistosoma mansoni	glutamate receptor AMPA	0.0131	0.0843	0.0843
Leishmania major	cyclin	0.0044	0.0157	0.0196
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0076	0.0409	1
Mycobacterium leprae	PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3)	0.0024	0	0.5
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0076	0.0409	0.5
Trypanosoma brucei	amidase, putative	0.0045	0.0166	0.0188
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Giardia lamblia	Furin precursor putative serine protease	0.0111	0.0683	0.0667
Echinococcus multilocularis	NMDA receptor	0.0067	0.0338	0.0421
Schistosoma mansoni	integrin alpha-ps	0.0176	0.1201	0.1201
Trypanosoma cruzi	protein farnesyltransferase, putative	0.1038	0.8038	0.9095
Trypanosoma cruzi	CYC2-like cyclin, putative	0.0044	0.0157	0.0178
Entamoeba histolytica	protein farnesyltransferase alpha subunit, putative	0.0729	0.559	0.6894
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0076	0.0409	0.5
Echinococcus granulosus	nmda type glutamate receptor	0.0143	0.0941	0.1171
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0143	0.0941	0.1171
Brugia malayi	Glutamate receptor 2 precursor	0.0131	0.0843	0.1049
Trypanosoma brucei	lanosterol synthase	0.1139	0.8837	1
Echinococcus granulosus	protein prenyltransferase alpha subunit	0.0475	0.3572	0.4444
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0121	0.2954
Echinococcus granulosus	Furin 1	0.0135	0.0876	0.109
Schistosoma mansoni	geranylgeranyl transferase type II beta subunit	0.0282	0.2039	0.2039
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0182	0.0202
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0051	0.0207	0.023
Echinococcus granulosus	integrin alpha ps	0.0338	0.2485	0.3091
Schistosoma mansoni	hypothetical protein	0.0111	0.0683	0.0683
Trichomonas vaginalis	cyclin A, putative	0.0044	0.0157	0.0196
Brugia malayi	Prenyltransferase and squalene oxidase repeat family protein	0.0282	0.2039	0.2537
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0146	0.0964	0.1199
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Leishmania major	trypanothione synthetase, putative	0.0142	0.0929	0.1155
Trypanosoma brucei	trypanothione synthetase	0.0142	0.0929	0.1051
Echinococcus granulosus	Glutamate receptor ionotropic kainate 2	0.0146	0.0964	0.1199
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0045	0.0166	0.0188
Trypanosoma cruzi	subtilisin-like serine peptidase, putative	0.0028	0.0031	0.0035
Brugia malayi	Integrin alpha pat-2 precursor	0.0753	0.5781	0.7192
Trypanosoma cruzi	trypanothione synthetase	0.0142	0.0929	0.1051
Trichomonas vaginalis	cyclins, putative	0.0044	0.0157	0.0196
Brugia malayi	polk-prov protein	0.003	0.0044	0.0055
Loa Loa (eye worm)	hypothetical protein	0.0162	0.109	0.1209
Loa Loa (eye worm)	hypothetical protein	0.057	0.4326	0.4798
Echinococcus multilocularis	integrin alpha ps	0.0338	0.2485	0.3091
Echinococcus granulosus	geranylgeranyl transferase type 2 subunit alpha	0.0475	0.3572	0.4444
Brugia malayi	Kelch motif family protein	0.0051	0.0213	0.0265
Trypanosoma cruzi	trypanothione synthetase, putative	0.0045	0.0166	0.0188
Loa Loa (eye worm)	hypothetical protein	0.0282	0.2039	0.2262
Schistosoma mansoni	geranylgeranyl transferase type I beta subunit	0.0282	0.2039	0.2039
Trichomonas vaginalis	protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative	0.0255	0.1825	0.227
Plasmodium vivax	plasmepsin IV, putative	0.0051	0.0207	0.0258
Trichomonas vaginalis	geranylgeranyl transferase type beta subunit, putative	0.1038	0.8038	1
Schistosoma mansoni	cathepsin D (A01 family)	0.0149	0.0988	0.0988
Echinococcus granulosus	glutamate receptor subunit protein glur	0.0067	0.0338	0.0421
Trichomonas vaginalis	Clan AA, family A1, cathepsin D-like aspartic peptidase	0.0051	0.0207	0.0258
Brugia malayi	latrophilin 2 splice variant baaae	0.01	0.0599	0.0745
Loa Loa (eye worm)	hypothetical protein	0.0224	0.1584	0.1756
Trichomonas vaginalis	cyclin B, putative	0.0044	0.0157	0.0196
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Loa Loa (eye worm)	hypothetical protein	0.0592	0.4497	0.4988
Loa Loa (eye worm)	integrin alpha pat-2	0.1161	0.9016	1
Schistosoma mansoni	glutamate receptor NMDA	0.0146	0.0964	0.0964
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0107	0.0652	0.0811
Trypanosoma cruzi	Protein prenyltransferase alpha subunit repeat, putative	0.0475	0.3572	0.4042
Toxoplasma gondii	hypothetical protein	0.0255	0.1825	0.227
Schistosoma mansoni	glutamate receptor kainate	0.0131	0.0843	0.0843
Trichomonas vaginalis	protein farnesyltransferase beta subunit, putative	0.0282	0.2039	0.2537
Echinococcus multilocularis	glutamate receptor 2	0.0131	0.0843	0.1049
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0596	0.453	0.5637
Trypanosoma brucei	DNA polymerase kappa, putative	0.003	0.0044	0.005
Brugia malayi	Inhibitor of Apoptosis domain containing protein	0.0107	0.0652	0.0811
Plasmodium vivax	farnesyltransferase beta subunit, putative	0.1038	0.8038	1
Brugia malayi	Protein prenyltransferase alpha subunit repeat containing protein	0.0729	0.559	0.6955
Echinococcus granulosus	expressed protein	0.0382	0.2838	0.353
Schistosoma mansoni	inhibitor of apoptosis (iap) domain family member	0.0107	0.0652	0.0652
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Brugia malayi	hypothetical protein	0.0047	0.0182	0.0226
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0046	0.0173	0.0215
Schistosoma mansoni	integrin alpha	0.0753	0.5781	0.5781
Echinococcus multilocularis	integrin beta 2	0.0231	0.1638	0.2037
Brugia malayi	Cyclin, N-terminal domain containing protein	0.0044	0.0157	0.0196
Trichomonas vaginalis	cyclins, putative	0.0044	0.0157	0.0196
Brugia malayi	Probable protein farnesyltransferase beta subunit, putative	0.0282	0.2039	0.2537
Echinococcus multilocularis	cpg binding protein	0.0033	0.0068	0.0085
Echinococcus granulosus	inhibitor of apoptosis protein	0.0107	0.0652	0.0811
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0046	0.0173	0.0192
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0157	0.0174
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Schistosoma mansoni	hypothetical protein	0.0067	0.0338	0.0338
Trypanosoma cruzi	trypanothione synthetase, putative	0.0045	0.0166	0.0188
Plasmodium vivax	geranylgeranyltransferase, putative	0.0282	0.2039	0.2537
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Onchocerca volvulus		0.0475	0.3572	1
Plasmodium falciparum	protein farnesyltransferase subunit alpha	0.0729	0.559	0.6955
Echinococcus multilocularis	integrin alpha ps	0.0162	0.109	0.1356
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0475	0.3572	0.4444
Echinococcus granulosus	glutamate receptor ionotropic kainate 3	0.0067	0.0338	0.0421
Onchocerca volvulus		0.0107	0.0652	0.1825
Echinococcus granulosus	glutamate receptor ionotropic kainate	0.0067	0.0338	0.0421
Echinococcus granulosus	Ribosomal protein S1 RNA binding domain	0.0067	0.0338	0.0421
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0146	0.0964	0.1199
Trypanosoma cruzi	cyclin, putative	0.0044	0.0157	0.0178
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0347	0.256	0.3185
Trypanosoma brucei	serine peptidase, clan SB, family S8-like protein	0.0028	0.0031	0.0035
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0135	0.0876	0.109
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.1038	0.8038	1
Entamoeba histolytica	Rab geranylgeranyltransferase alpha subunit, putative	0.0475	0.3572	0.4333
Echinococcus granulosus	baculoviral IAP repeat containing protein	0.0107	0.0652	0.0811
Schistosoma mansoni	glutamate receptor kainate	0.0131	0.0843	0.0843
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0051	0.0207	0.0258
Trypanosoma cruzi	trypanothione synthetase	0.0142	0.0929	0.1051
Echinococcus multilocularis	glutamate receptor ionotropic kainate	0.0067	0.0338	0.0421
Trichomonas vaginalis	cyclins, putative	0.003	0.0046	0.0058
Loa Loa (eye worm)	proprotein convertase 2	0.0135	0.0876	0.0972
Entamoeba histolytica	geranylgeranyl transferase beta subunit	0.0282	0.2039	0.2388
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0135	0.0876	0.0876
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0076	0.0409	0.5
Plasmodium falciparum	geranylgeranyl transferase type2 beta subunit, putative	0.0282	0.2039	0.2537
Echinococcus multilocularis	glutamate (NMDA) receptor subunit	0.0131	0.0843	0.1049
Loa Loa (eye worm)	glutamate receptor 2	0.0131	0.0843	0.0935
Loa Loa (eye worm)	hypothetical protein	0.0729	0.559	0.62
Chlamydia trachomatis	glutamine binding protein	0.0076	0.0409	0.5
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0652	0.0723
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0045	0.0166	0.0188
Mycobacterium ulcerans	DNA polymerase IV	0.004	0.0121	0.2954
Schistosoma mansoni	glutamate receptor NMDA	0.0131	0.0843	0.0843
Leishmania major	D-alanyl-glycyl endopeptidase-like protein,cysteine peptidase, Clan CA, family C51, putative	0.0045	0.0166	0.0206
Plasmodium vivax	prenyltransferase alpha subunit, putative	0.0729	0.559	0.6955
Trichomonas vaginalis	type I geranylgeranyltransferase beta subunit, putative	0.1038	0.8038	1
Trypanosoma brucei	geranylgeranyl transferase type II beta subunit, putative	0.0282	0.2039	0.2308
Echinococcus granulosus	integrin beta 2	0.0231	0.1638	0.2037
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Schistosoma mansoni	integrin alpha-ps	0.0338	0.2485	0.2485
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0135	0.0876	0.109
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0111	0.0683	0.0849
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0347	0.256	0.3185
Loa Loa (eye worm)	hypothetical protein	0.0416	0.3102	0.3441
Trypanosoma brucei	protein farnesyltransferase beta subunit	0.1038	0.8038	0.9095
Toxoplasma gondii	prenyltransferase and squalene oxidase repeat-containing protein	0.1038	0.8038	1
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0475	0.3572	0.3962
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0135	0.0876	0.109
Echinococcus multilocularis	glutamate receptor 2	0.0079	0.0432	0.0537
Echinococcus multilocularis	neuroendocrine convertase 2	0.0359	0.2654	0.3302
Schistosoma mansoni	cpg binding protein	0.0033	0.0068	0.0068
Echinococcus granulosus	protein farnesyltransferase subunit beta	0.1038	0.8038	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Schistosoma mansoni	cpg binding protein	0.0031	0.0054	0.0054
Brugia malayi	Glutamate receptor 1 precursor	0.0131	0.0843	0.1049
Onchocerca volvulus	Deterin homolog	0.0107	0.0652	0.1825
Trypanosoma brucei	cysteine peptidase, Clan CA, family C51, putative	0.0045	0.0166	0.0188
Echinococcus multilocularis	Furin 1	0.0135	0.0876	0.109
Echinococcus granulosus	glutamate receptor 2	0.0079	0.0432	0.0537
Leishmania major	farnesyltransferase beta subunit	0.1038	0.8038	1
Leishmania major	hypothetical protein, conserved	0.0045	0.0166	0.0206
Echinococcus multilocularis	GPCR, family 2	0.0046	0.0173	0.0215
Echinococcus multilocularis	protein prenyltransferase alpha subunit	0.0475	0.3572	0.4444
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0045	0.0166	0.0188
Loa Loa (eye worm)	kelch domain-containing protein family protein	0.0051	0.0213	0.0236
Echinococcus granulosus	integrin alpha 3	0.0578	0.4386	0.5457
Mycobacterium leprae	PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5)	0.0024	0	0.5
Mycobacterium tuberculosis	Halimadienyl diphosphate synthase	0.1139	0.8837	1
Trypanosoma brucei	protein farnesyltransferase alpha subunit, putative	0.0475	0.3572	0.4042
Loa Loa (eye worm)	glutamate receptor 1	0.0131	0.0843	0.0935
Trichomonas vaginalis	conserved hypothetical protein	0.0111	0.0683	0.0849
Echinococcus multilocularis	Rab geranylgeranyltransferase, beta subunit	0.0282	0.2039	0.2537
Schistosoma mansoni	furin-1 (S08 family)	0.0249	0.1777	0.1777
Trypanosoma cruzi	geranylgeranyl transferase type II beta subunit, putative	0.0282	0.2039	0.2308
Echinococcus multilocularis	dna polymerase kappa	0.004	0.0121	0.015
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0011	0.0012
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0045	0.0166	0.0188
Trypanosoma brucei	trypanothione synthetase, putative	0.0142	0.0929	0.1051
Echinococcus granulosus	dna polymerase kappa	0.004	0.0121	0.015
Trypanosoma brucei	hypothetical protein, conserved	0.0475	0.3572	0.4042
Mycobacterium leprae	Possible secreted protease	0.0024	0	0.5
Plasmodium falciparum	plasmepsin II	0.0051	0.0207	0.0258
Brugia malayi	Integrin alpha cytoplasmic region family protein	0.057	0.4326	0.5382
Brugia malayi	endoprotease bli-4 precursor	0.0571	0.4337	0.5396
Schistosoma mansoni	glutamate receptor AMPA	0.0131	0.0843	0.0843
Leishmania major	geranylgeranyltransferase, putative	0.0282	0.2039	0.2537
Trichomonas vaginalis	geranylgeranyl transferase type II beta subunit, putative	0.1038	0.8038	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0282	0.2039	0.2308
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0207	0.023
Loa Loa (eye worm)	hypothetical protein	0.0596	0.453	0.5025
Brugia malayi	Integrin beta pat-3 precursor	0.0312	0.2278	0.2834
Trichomonas vaginalis	cyclin B, putative	0.0044	0.0157	0.0196
Trypanosoma cruzi	protein farnesyltransferase, putative	0.1038	0.8038	0.9095
Giardia lamblia	High cysteine membrane protein Group 2	0.0212	0.149	0.1691
Loa Loa (eye worm)	hypothetical protein	0.01	0.0599	0.0664
Echinococcus multilocularis	cyclin B	0.0044	0.0157	0.0196
Schistosoma mansoni	hypothetical protein	0.0046	0.0173	0.0173
Echinococcus multilocularis	protein farnesyltransferase alpha subunit	0.0729	0.559	0.6955
Trypanosoma cruzi	hypothetical protein, conserved	0.0045	0.0166	0.0188
Echinococcus multilocularis	integrin alpha 3	0.0578	0.4386	0.5457
Schistosoma mansoni	rab geranylgeranyl transferase alpha subunit	0.0489	0.3683	0.3683
Trypanosoma cruzi	cysteine peptidase, Clan CA, family C51, putative	0.0045	0.0166	0.0188
Brugia malayi	Latrophilin receptor protein 2	0.0046	0.0173	0.0215
Brugia malayi	CXXC zinc finger family protein	0.0031	0.0054	0.0067
Schistosoma mansoni	hypothetical protein	0.0046	0.0173	0.0173
Trypanosoma cruzi	lanosterol synthase, putative	0.1139	0.8837	1
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0111	0.0683	0.0849
Loa Loa (eye worm)	prenyltransferase alpha subunit repeat containing protein	0.0729	0.559	0.62
Trypanosoma cruzi	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0347	0.256	0.3185
Echinococcus multilocularis	baculoviral IAP repeat containing protein	0.0107	0.0652	0.0811
Trypanosoma brucei	cysteine peptidase, Clan CA, family C51, putative	0.0045	0.0166	0.0188
Echinococcus granulosus	neuroendocrine convertase 2	0.0359	0.2654	0.3302
Loa Loa (eye worm)	hypothetical protein	0.0107	0.0652	0.0723
Trypanosoma brucei	DNA polymerase IV, putative	0.0033	0.007	0.008
Trypanosoma cruzi	cyclin, putative	0.0044	0.0157	0.0178
Trichomonas vaginalis	hypothetical protein	0.0111	0.0683	0.0849
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0347	0.256	0.3185
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0111	0.0683	0.0849
Plasmodium falciparum	geranylgeranyl transferase type-2 subunit alpha, putative	0.0475	0.3572	0.4444
Trypanosoma brucei	DNA polymerase kappa, putative	0.004	0.0121	0.0137
Plasmodium falciparum	geranylgeranyltransferase, putative	0.0282	0.2039	0.2537
Brugia malayi	proprotein convertase 2	0.0359	0.2654	0.3302
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 2	0.0146	0.0964	0.1199
Giardia lamblia	Rab geranylgeranyltransferase	0.0282	0.2039	0.2388
Brugia malayi	neuroendocrine convertase 1 precursor	0.0359	0.2654	0.3302
Schistosoma mansoni	protein farnesyltransferase subunit beta	0.1038	0.8038	0.8038
Trichomonas vaginalis	protein farnesyltransferase alpha subunit, putative	0.0729	0.559	0.6955
Trypanosoma brucei	DNA polymerase IV, putative	0.004	0.0121	0.0137
Brugia malayi	Angiotensin-converting enzyme family protein	0.0627	0.4778	0.5945
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.004	0.0121	0.015
Trypanosoma brucei	Protein prenyltransferase alpha subunit repeat, putative	0.0475	0.3572	0.4042
Schistosoma mansoni	inhibitor of apoptosis protein	0.0107	0.0652	0.0652

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 12 uM	Inhibitory concentration of the compound against p21 deficient 80S14 cell line	ChEMBL.	15745803
IC50 (functional)	> 20 uM	Inhibitory concentration of the compound against p21 proficient HCT116 cell line	ChEMBL.	15745803
IC50 (functional)	> 20 uM	Inhibitory concentration of the compound against p21 proficient HCT116 cell line	ChEMBL.	15745803
Ratio (functional)	> 2 uM	Ratio of inhibitory concentration of the compound against p21 proficient HCT116 cell line to that of p21 deficient 80S14 cell line	ChEMBL.	15745803
Ratio (functional)	> 2 uM	Ratio of inhibitory concentration of the compound against p21 proficient HCT116 cell line to that of p21 deficient 80S14 cell line	ChEMBL.	15745803

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 317730