Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | retinoic acid receptor, gamma | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, alpha | Starlite/ChEMBL | References |
Homo sapiens | retinoic acid receptor, beta | Starlite/ChEMBL | References |
Homo sapiens | retinoid X receptor, alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | ecdysteroid receptor | retinoid X receptor, alpha | 435 aa | 352 aa | 23.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0791 | 0.9641 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0791 | 0.9641 | 0.5 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0141 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0165 | 0.0359 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0165 | 0.0359 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AC50 (binding) | = 5 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR-alpha | ChEMBL. | 10890152 |
AC50 (binding) | = 5 nM | Transcriptional activation in CV-1 cells expressing Retinoid X receptor RXR-alpha | ChEMBL. | 10890152 |
AC50 (binding) | = 17 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 10890152 |
AC50 (binding) | = 17 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR beta | ChEMBL. | 10890152 |
AC50 (binding) | > 1000 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 10890152 |
AC50 (binding) | > 1000 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 10890152 |
AC50 (binding) | > 1000 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR alpha | ChEMBL. | 10890152 |
AC50 (binding) | > 1000 nM | Transcriptional activation in CV-1 cells expressing Retinoic acid receptor RAR gamma | ChEMBL. | 10890152 |
Activation (binding) | = 16 % | Percent transcriptional activation of Retinoic acid receptor RAR gamma receptor at 1 uM compared to 1 uM trans-retinoic acid | ChEMBL. | 10890152 |
Activation (binding) | = 16 % | Percent transcriptional activation of Retinoic acid receptor RAR gamma receptor at 1 uM compared to 1 uM trans-retinoic acid | ChEMBL. | 10890152 |
Activation (binding) | = 19 % | Percent transcriptional activation of Retinoic acid receptor RAR alpha at 1 uM compared to 1 uM trans-retinoic acid | ChEMBL. | 10890152 |
Activation (binding) | = 19 % | Percent transcriptional activation of Retinoic acid receptor RAR alpha at 1 uM compared to 1 uM trans-retinoic acid | ChEMBL. | 10890152 |
Activation (binding) | = 85 % | Percent transcriptional activation of Retinoic acid receptor beta at 1 uM compared to 1 uM trans-retinoic acid | ChEMBL. | 10890152 |
Activation (binding) | = 85 % | Percent transcriptional activation of Retinoic acid receptor beta at 1 uM compared to 1 uM trans-retinoic acid | ChEMBL. | 10890152 |
Activation (binding) | = 118 % | Percent transcriptional activation of Retinoic acid receptor RXR-alpha at 1 uM compared to 1 uM 9-cis-retinoic acid | ChEMBL. | 10890152 |
Activation (binding) | = 118 % | Percent transcriptional activation of Retinoic acid receptor RXR-alpha at 1 uM compared to 1 uM 9-cis-retinoic acid | ChEMBL. | 10890152 |
IC50 (functional) | = 1.1 uM | Inhibition of MDA-MB-231 cell proliferation after seven days | ChEMBL. | 10890152 |
IC50 (functional) | = 1.1 uM | Inhibition of MDA-MB-231 cell proliferation after seven days | ChEMBL. | 10890152 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 10890152 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.