Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Adenosine A2a receptor | Starlite/ChEMBL | References |
Rattus norvegicus | Adenosine A1 receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.002 | 0.033 | 0.033 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0019 | 0.0246 | 0.5 |
Echinococcus granulosus | neuroligin | 0.0019 | 0.0246 | 0.0246 |
Echinococcus multilocularis | para nitrobenzyl esterase | 0.0019 | 0.0246 | 0.0246 |
Schistosoma mansoni | acetylcholinesterase | 0.0019 | 0.0246 | 0.0246 |
Onchocerca volvulus | 0.0019 | 0.0246 | 0.5 | |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.002 | 0.033 | 0.033 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0019 | 0.0246 | 0.0246 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0068 | 0.542 | 0.542 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0019 | 0.0246 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0065 | 0.509 | 0.509 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.002 | 0.033 | 0.033 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0019 | 0.0246 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0246 | 0.0246 |
Brugia malayi | Carboxylesterase family protein | 0.0019 | 0.0246 | 0.0246 |
Schistosoma mansoni | BC026374 protein (S09 family) | 0.0019 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | carboxylesterase | 0.0112 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0.0246 | 0.5 | |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0019 | 0.0246 | 0.0246 |
Echinococcus multilocularis | acetylcholinesterase | 0.0112 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0112 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0112 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0112 | 1 | 1 |
Onchocerca volvulus | 0.0019 | 0.0246 | 0.5 | |
Echinococcus multilocularis | glutamate receptor 2 | 0.002 | 0.033 | 0.033 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.002 | 0.033 | 0.033 |
Schistosoma mansoni | neuroligin 3 (S09 family) | 0.0019 | 0.0246 | 0.0246 |
Onchocerca volvulus | 0.0019 | 0.0246 | 0.5 | |
Schistosoma mansoni | glutamate receptor NMDA | 0.0085 | 0.7158 | 0.7158 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0246 | 0.0246 |
Echinococcus multilocularis | family S9 non peptidase ue (S09 family) | 0.0019 | 0.0246 | 0.0246 |
Brugia malayi | Carboxylesterase family protein | 0.0019 | 0.0246 | 0.0246 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.002 | 0.033 | 0.033 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0019 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0246 | 0.0246 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0019 | 0.0246 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0071 | 0.5733 | 0.5733 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.002 | 0.033 | 0.033 |
Schistosoma mansoni | gliotactin | 0.0019 | 0.0246 | 0.0246 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0019 | 0.0246 | 0.0246 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0065 | 0.509 | 0.509 |
Echinococcus multilocularis | BC026374 protein (S09 family) | 0.0019 | 0.0246 | 0.0246 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0246 | 0.0246 |
Echinococcus granulosus | family S9 non peptidase ue S09 family | 0.0019 | 0.0246 | 0.0246 |
Echinococcus granulosus | glutamate receptor 2 | 0.002 | 0.033 | 0.033 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0019 | 0.0246 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0246 | 0.0246 |
Echinococcus granulosus | acetylcholinesterase | 0.0112 | 1 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.002 | 0.033 | 0.033 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 1 | 1 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.002 | 0.033 | 0.033 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0071 | 0.5733 | 0.5733 |
Echinococcus multilocularis | acetylcholinesterase | 0.0112 | 1 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0068 | 0.542 | 0.542 |
Echinococcus granulosus | BC026374 protein S09 family | 0.0019 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | carboxylesterase | 0.0019 | 0.0246 | 0.0246 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0246 | 0.0246 |
Brugia malayi | Carboxylesterase family protein | 0.0019 | 0.0246 | 0.0246 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0112 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0019 | 0.0246 | 0.5 |
Onchocerca volvulus | 0.0019 | 0.0246 | 0.5 | |
Echinococcus multilocularis | neuroligin | 0.0019 | 0.0246 | 0.0246 |
Brugia malayi | Carboxylesterase family protein | 0.0019 | 0.0246 | 0.0246 |
Echinococcus granulosus | carboxylesterase 5A | 0.0112 | 1 | 1 |
Echinococcus granulosus | para nitrobenzyl esterase | 0.0019 | 0.0246 | 0.0246 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 30 nM | Binding affinity towards Adenosine A2A receptor of rat brain tissues using [3H]-ZM-241,385 as radioligand | ChEMBL. | 15664803 |
Ki (binding) | = 30 nM | Binding affinity towards Adenosine A2A receptor of rat brain tissues using [3H]-ZM-241,385 as radioligand | ChEMBL. | 15664803 |
Ki (binding) | = 72 nM | Binding affinity towards Adenosine A1 receptor of rat cerebral cortex using [3H]-DPCPX as radioligand | ChEMBL. | 15664803 |
Ki (binding) | = 72 nM | Binding affinity towards Adenosine A1 receptor of rat cerebral cortex using [3H]-DPCPX as radioligand | ChEMBL. | 15664803 |
Ratio (binding) | = 2.4 | Ratio of binding affinity towards rat Adenosine A1 receptor to Adenosine A2A receptor was measured | ChEMBL. | 15664803 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.