Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | growth hormone secretagogue receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | rhodopsin-like orphan GPCR | growth hormone secretagogue receptor | 289 aa | 243 aa | 23.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0414 | 0.0894 | 1 |
Echinococcus granulosus | nmda type glutamate receptor | 0.1021 | 0.7127 | 0.7016 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0414 | 0.0894 | 1 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0974 | 0.6645 | 0.6645 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0974 | 0.6645 | 0.6514 |
Loa Loa (eye worm) | hypothetical protein | 0.0882 | 0.5702 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1301 | 1 | 1 |
Leishmania major | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0882 | 0.5702 | 0.5 |
Echinococcus granulosus | hydroxymethylglutaryl coenzyme A reductase | 0.0882 | 0.5702 | 0.5535 |
Echinococcus multilocularis | protein patched | 0.0363 | 0.0373 | 0.0373 |
Brugia malayi | Hydroxymethylglutaryl-coenzyme A reductase family protein | 0.0882 | 0.5702 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.1021 | 0.7127 | 0.7127 |
Echinococcus multilocularis | protein dispatched 1 | 0.0363 | 0.0373 | 0.0373 |
Schistosoma mansoni | hydroxymethylglutaryl-CoA reductase (NADPH) | 0.0882 | 0.5702 | 0.6924 |
Mycobacterium ulcerans | hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase | 0.0882 | 0.5702 | 0.5 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0882 | 0.5702 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.1113 | 0.8069 | 1 |
Echinococcus multilocularis | hydroxymethylglutaryl coenzyme A reductase | 0.0882 | 0.5702 | 0.5702 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0363 | 0.0373 | 0.0373 |
Trypanosoma cruzi | 3-hydroxy-3-methylglutaryl-CoA reductase | 0.0882 | 0.5702 | 0.5 |
Trypanosoma brucei | 3-hydroxy-3-methylglutaryl-CoA reductase, putative | 0.0882 | 0.5702 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0363 | 0.0373 | 0.0373 |
Trichomonas vaginalis | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative | 0.0414 | 0.0894 | 1 |
Giardia lamblia | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | 0.0414 | 0.0894 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 39 nM | In vitro effective concentration against human growth hormone secretagogues | ChEMBL. | 15780609 |
EC50 (functional) | = 39 nM | In vitro effective concentration against human growth hormone secretagogues | ChEMBL. | 15780609 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.